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| 1 | The influence of stage at diagnosis and molecular subtype on breast cancer patient survival: a hospital.based multi.center study显示文摘Background: Stage at diagnosis and molecular subtype are important clinical factors associated with breast cancer patient survival. However, subgroup survival data from a large study sample are limited in China.To estimate the survival differences among patients with different stages and various subtypes of breast cancer, we conducted a hospital-based multi-center study on breast cancer in Beijing, China.Methods: All resident patients diagnosed with primary, invasive breast cancer between January 1,2006 and December 31,2010 from four selected hospitals in Beijing were included and followed up until December 31,2015. Hospitalbased data of stage at diagnosis, hormone receptor status, and selected clinical characteristics, including body mass index(BMI), menopausal status, histological grade, and histological type, were collected from the medical records of the study subjects. Overall survival(OS) and cancer-specific survival(CSS) were estimated. Cox proportional hazards models were employed to evaluate the associations of stage at diagnosis and molecular subtype with patient survival.Results: The 5-year OS and CSS rates for all patients were 89.4% and 90.3%. Survival varied by stage and molecular subtype. The 5-year OS rates for patients with stage I, Ⅱ, Ⅲ, and IV diseases were 96.5%, 91.6%, 74.8%, and 40.7%,respectively, and the corresponding estimates of 5-year CSS rates were 97.1%, 92.6%, 75.6%, and 42.7%, respectively.The 5-year OS rates for patients with luminal A, luminal B, HER2, and triple-negative subtypes of breast cancer were92.6%, 88.4%, 83.6%, and 82.9%, respectively, and the corresponding estimates of 5-year CSS rates were 93.2%, 89.1 %,85.4%, and 83.5%, respectively. Multivariate analysis showed that stage at diagnosis and molecular subtype were important prognostic factors for breast cancer.Conclusions: Survival of breast cancer patients varied significantly by stage and molecular subtype. Cancer screening is encouraged for the early detection and early diagnosis of breast cancer. More advanced therapies and health care policies are needed on HER2 and triple-negative subtypes. | Tingting Zuo Hongmei Zeng Huichao Li Shuo Liu Lei Yang Changfa Xia Rongshou Zheng Fei Ma Lifang Liu Ning Wang Lixue Xuan Wanqing Chen | 2017 | Chinese Journal of Cancer2017，36，11： | 18 |
| 2 | Comparison of cancer incidence and mortality in three GDP per capita levels in China, 2013显示文摘Objective:In this research,the patterns of cancer incidence and mortality in areas with different gross domestic product per capita(GDPPC)levels in China were explored,using data from population-based cancer registries in 2013,collected by the National Central Cancer Registry(NCCR).Methods:Data from 255 cancer registries were qualified and included in this analysis.Based on the GDPPC data of 2014,cities/counties were divided into 3 levels:high-,middle-and low-GDPPC areas,with 40,000 and 80,000 RMB per year as cut points.We calculated cancer incidences and mortalities in these three levels,stratified by gender and age group.The national population of the Fifth Census in 2000 and Segi’s population were applied for age-standardized rates.Results:The crude incidence and mortality rates as well as age-standardized incidence rate(ASIR)showed positive associations with GDPPC level.The age-standardized mortality rate(ASMR)nevertheless showed a negative association with GDPPC level.The ASMR in high-,middle-and low-GDPPC areas was 103.12/100,000,112.49/100,000 and 117.43/100,000,respectively.Lung cancer was by far the most common cancer in all three GDPPC levels.It was also the leading cause of cancer death,regardless of gender and GDPPC level.Negative associations with GDPPC level were found for the ASIRs of lung,stomach,esophageal and liver cancer,whereas colorectal and breast cancer showed positive associations.Except for breast cancer,the ASMRs of the other five cancers were always higher in middle-and low-GDPPC areas than in high-GDPPC areas.Conclusions:The economic development is one of the main factors of the heavy cancer burden on Chinese population.It would be reasonable to implement cancer control strategies referring to the local GDPPC level. | Zhixun Yang Rongshou Zheng Siwei Zhang Hongmei Zeng Changfa Xia He Li Li Wang Yanhong Wang Wanqing Chen | 2017 | Chinese Journal of Cancer Research2017，29，5： | 13 |
| 3 | Trends in geographical disparities for cervical cancer mortality in China from 1973 to 2013:a subnational spatio-temporal study显示文摘Objective: This study was designed to explore the time trends in geographical variations of cervical cancer mortality in China's Mainland over the period 1973 to 2013,to provide subnational spatio-temporal patterns for targeted promotion of human papillomavirus vaccine in China.Methods: Data were extracted from three national retrospective death surveys and cancer registry.The rate ratio(RR) was estimated for the aggregated data for seven geographical regions using generalized linear models to evaluate time trends in geographical disparities of cervical cancer mortality.Results: There was a significant decrease in cervical cancer mortality in China from 1973–1975 to 2004–2005,but leveled off thereafter to 2011–2013.Compared to the period 1973–1975 the RR for the three last time periods were 0.33 [95% confidence interval(95% CI): 0.30–0.37] for 1990–1992,0.21(95% CI: 0.19–0.24) for 2004–2005 and 0.24(95% CI: 0.22–0.26) for 2011–2013.Females living in the Northwest China and Central China have a high risk of mortality from cervical cancer compared to the nationwide,with the RR being 2.09(95% CI:1.83–2.38) and 1.26(95% CI: 1.11–1.44) respectively,while the RRs for South China,Northeast China and Southwest China were below 1.00,indicating the lower death risk.Despite the mortality rate had increased slightly from 2004 to 2013,there was an encouraging sign that the geographical disparities in cervical cancer mortality had gradually narrowed over time across China.Conclusions: Although cervical cancer mortality in China has reduced to very low levels,the high risk of cervical cancer in Northwest China and Central China is still noteworthy.Public health policies including the promotion of vaccine should be targeted to further reduction of geographical disparities in cervical cancer mortality. | Changfa Xia Chao Ding Rongshou Zheng Siwei Zhang Hongmei Zeng Jinfeng Wang Yilan Liao Ningxu Zhang Zhixun Yang Wanqing Chen | 2017 | Chinese Journal of Cancer Research2017，29，6： | 13 |
| 4 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 5 | Aortic reoperation in a patient with Loeys-Dietz syndrome显示文摘Loeys-Dietz syndrome (LDS,OMIM #609192) is a recently recognized connective tissue disorder with clinical characteristics similar to Marfan syndrome.Aggressive aortic pathologies in LDS makes timely diagnosis and surgical intervention crucial compared to other genetic syndromes.We report a young man with LDS confirmed by genetic testing who twice underwent surgical operations to repair aortic aneurysm. In August 2000,a 14-year-old boy was admitted to our institute with significant aortic regurgitation.Preoperative echocardiogram revealed an aortic root aneurysm 5 cm in diameter and severe aortic insufficiency.He underwent composite graft replacement (Bentall procedure) with a 27 mm Medtronic Hall valved conduit (Medtronic,Inc.,Minneapolis,MN,USA).He had an uneventful postoperative course and was discharged after nine days. | Wang Chunsheng Li Jun Lai Hao Sun Yongxin Guo Changfa Yin Kanhua Zhu Kai | 2014 | Chinese Medical Journal2014，，12： | 1 |
| 6 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 7 | Multiple promoters and targeted micro RNA s direct the expressions of HMGB 3 gene transcripts in dairy cattle显示文摘 | Liming Li Jinming Huang Zhihua Ju Qiuling Li Changfa Wang Chao Qi Yan Zhang Qinlei Hou Suqin Hang Jifeng Zhong | 2012 | Anim Genet2012，，3： | 1 |
| 8 | THE CONSTRUCTION OF THE EAST ASIA MERIDINA CHAIN OF GEOMAGNETIC OBSERVATORIES显示文摘In Order to study the Global Characteristics of Solar-terrestrial System in the 22th Solar Cycle, our Institute has built up a few geomagnetic observatories recently years at Mohe, Beijing (Ming Toms), Sanya (Hainan Insland) in the torritorg of China. These stations together with some old stations close to 120° E meridian and form the East Asia Meridian Chain of Geomagnetic Observatories. In the meantime we were set up also a observatory of the Chinese Great Wall Station in Antarctica. According to theather character of different area we designed and built the house with different structural style.The magnetic recording house is the under ground in Mohe, the semi-under ground in Beijing, the ground in sanya of China.The recording and the absolute houses are all built on stilts in the Chinese Great Wall Station of Antarctica. All buildins are made of non magnetic materials, Such as limestone, sun-dried mud brick, wood, copper and Aluminum etc.Therefore there are not affects of the magnetic materiat | Liu Changfa, Wang Juyi, Zhang Weixi, Dou Shaopu, Zhang PingInstitute of Geophysics, Chinese Academy of Sciences | 1990 | 天文研究与技术1990，，4： | 1 |
| 9 | Myoblast Transplantation for Cardiac Repair: From Automyoblast to Allomyoblast Transplantation显示文摘 | Changfa Guo Husnain Kh. Haider Chunsheng Wang Ru-San Tan Winston S.N. Shim Philip Wong Eugene K.W. Sim | 2008 | The Annals of Thoracic Surgery2008，，6： | 1 |
| 10 | Electrochemical sensor for the determination of parathion based on p-tert-butylcalix arene-1,4-crown-4 sol-gel film and its characterization by electrochemical methods 显示文摘 | Li Chunya Wang Changfa Zhang Yangyang | 2005 | Sensors and Actuators B2005，107，1： | 1 |
| 11 | Construction of a novel molecularly imprinted sensor for the determination of O, O-dimethyl-( 2,4-dichlorophenoxyacetoxyl ) ( 3'-nitrophenyl ) methinephosphonate 显示文摘 | Li Chunya Wang Changfa Wang Chenghang | 2005 | Analytiea Chimica Acta2005，545，2： | 1 |
| 12 | Six novel single-nucleotide polymorphisms in SPAG11 gene and their association with sperm quality traits in Chinese Holstein bulls显示文摘 | Xinyan Liu Zhihua Ju Lingling Wang Yan Zhang Jingmin Huang Qiuling Li Jianbin Li Jifeng Zhong Liguo An Changfa Wang | 2011 | Animal Reproduction Science2011，，1： | 1 |
| 13 | A novel amperometric sensor and chromatographic detector for determination of parathion显示文摘 | Li Chunya Wang Changfa Ma Yong | 2005 | Anal Bioanal Chem2005，381，： | 1 |
| 14 | Morphology changes of polyvinylidene fluoride membrane under different phase separation mechanisms显示文摘 | Xianfeng Li Yonggang Wang Xiaolong Lu Changfa Xiao | 2008 | Journal of Membrane Science2008，，1： | 1 |
| 15 | A new planar artificial transmission line and its application to a miniaturized Butler matrix显示文摘 | Wang Chaowei Ma Tzyh-Ghuang Yang Changfa | 2007 | IEEE Trans on Microwave Theory and Techniques2007，55，12： | 1 |
| 16 | Presence and induction by bacteria of D-galactoside-specific lectins in the humoral fluids of amphioxus Branchiostoma belcheri tsingtauense显示文摘 | Changfa Wang Shicui Zhang Yi Luo Tongtong Xu | 2001 | Inflammopharmacology2001，，3： | 1 |
| 17 | Development of a parathion sensor based on molecularly imprinted nano-TiO2 self- assembled film electrode显示文摘 | LI Chunya WANG Changfa WANG Chenghang | 2006 | Sensors and Actuators B: Chemical2006，117，1： | 1 |
| 18 | DM Code Key Point Detection Algorithm Based on CenterNet显示文摘Data Matrix(DM)codes have been widely used in industrial production.The reading of DM code usually includes positioning and decoding.Accurate positioning is a prerequisite for successful decoding.Traditional image processing methods have poor adaptability to pollution and complex backgrounds.Although deep learning-based methods can automatically extract features,the bounding boxes cannot entirely fit the contour of the code.Further image processing methods are required for precise positioning,which will reduce efficiency.Because of the above problems,a CenterNet-based DM code key point detection network is proposed,which can directly obtain the four key points of the DM code.Compared with the existing methods,the degree of fitness is higher,which is conducive to direct decoding.To further improve the positioning accuracy,an enhanced loss function is designed,including DM code key point heatmap loss,standard DM code projection loss,and polygon Intersection-over-Union(IoU)loss,which is beneficial for the network to learn the spatial geometric characteristics of DM code.The experiment is carried out on the self-made DM code key point detection dataset,including pollution,complex background,small objects,etc.,which uses the Average Precision(AP)of the common object detection metric as the evaluation metric.AP reaches 95.80%,and Frames Per Second(FPS)gets 88.12 on the test set of the proposed dataset,which can achieve real-time performance in practical applications. | Wei Wang Xinyao Tang Kai Zhou Chunhui Zhao Changfa Liu | 2023 | Computers, Materials & Continua2023，77，11： | 0 |
| 19 | Animal models for COVID-19:advances,gaps and perspectives显示文摘COVID-19,caused by SARS-CoV-2,is the most consequential pandemic of this century.Since the outbreak in late 2019,animal models have been playing crucial roles in aiding the rapid development of vaccines/drugs for prevention and therapy,as well as understanding the pathogenesis of SARS-CoV-2 infection and immune responses of hosts.However,the current animal models have some deficits and there is an urgent need for novel models to evaluate the virulence of variants of concerns(VOC),antibodydependent enhancement(ADE),and various comorbidities of COVID-19.This review summarizes the clinical features of COVID-19 in different populations,and the characteristics of the major animal models of SARS-CoV-2,including those naturally susceptible animals,such as non-human primates,Syrian hamster,ferret,minks,poultry,livestock,and mouse models sensitized by genetically modified,AAV/adenoviral transduced,mouse-adapted strain of SARS-CoV-2,and by engraftment of human tissues or cells.Since understanding the host receptors and proteases is essential for designing advanced genetically modified animal models,successful studies on receptors and proteases are also reviewed.Several improved alternatives for future mouse models are proposed,including the reselection of alternative receptor genes or multiple gene combinations,the use of transgenic or knock-in method,and different strains for establishing the next generation of genetically modified mice. | Changfa Fan Yong Wu Xiong Rui Yuansong Yang Chen Ling Susu Liu Shunan Liu Youchun Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 20 | Correlation Study on Body Size,Sexual Behavior and Semen Quality of Dezhou Donkey显示文摘[Objective] The study was to explore whether the body size,sexual behavior of male donkey had certain correlation with reproductive traits. [Method] The data of body weight,body size and sexual behavior of male donkey during production were collected,combining with the semen quality data of ejaculation volume,density,motility and frozen-thawed semen motility were conducted the statistical analysis. [Results]( 1) Single ejaculation volume had a positive correlation with body height( r=0. 423,P=0. 044) and penis circumference( r=0. 495,P=0. 043),and total number of sperm per ejaculate had a positive correlation with body weight( r=0. 444,P=0. 036) and scrotal circumference( r=0. 520,P=0. 039);( 2) Ejaculation volume was negatively correlated with mount times( r=-0. 159,P=0. 035) and erection time( r =-0. 181,P=0. 023),semen density was negatively correlated with mating time( r=-0. 211,P=0. 004),and total sperm count was negatively correlated with erection time( r=-0. 159,P=0. 047). [Conclusion]The quality of semen had a certain correlation with body size,body weight and sexual behavior. | Zhang Ruitao Zhang Yan Zhang Shuai Huang Jinming Wang Changfa | 2017 | Animal Husbandry and Feed Science2017，9，3： | 0 |
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