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| 1 | Relationship of MTHFR gene polymorphisms with renal and cardiac disease显示文摘AIM: To investigate the effects of different methylenetetrahydrofolate reductase(MTHFR) 677C>T gene polymorphism and hyperhomocysteinemia for the development of renal failure and cardiovascular events, which are controversial.METHODS: We challenged the relationship, if any, of MTHFR 677C>T and MTHFR 1298A>C polymorphisms with renal and heart function. The present article is a reappraisal of these concepts, investigating within a larger population, and including a subgroup of dialysis patients, if the two most common MTHFR polymorphisms, C677 T and A1298 C, as homozygous, heterozygous or with a compound heterozygous state, show different association with chronic renal failure requiring hemodialysis. MTHFR polymorphism could be a favorable evolutionary factor, i.e., a protective factor for many ominous conditions, like cancer and renal failure. A similar finding was reported in fatty liver disease in which it is suggested that MTHFR polymorphisms could have maintained and maintain their persistence by an heterozygosis advantage mechanism. We studied a total of 630 Italian Caucasian subject aged 54.60 ± 16.35 years, addressing to the increased hazard of hemodialysis, if any, according to the studied MTHFR genetic polymorphisms. RESULTS: A favorable association with normal renal function of MTHFR polymorphisms, and notably of MTHFR C677 T is present independently of the negative effects of left ventricular hypertrophy, increased IntraRenal arterial Resistance and hyperparathyroidism. CONCLUSION: MTHFR gene polymorphisms could have a protective role on renal function as suggested by their lower frequency among our dialysis patients in end-stage renal failure; differently, the association with left ventricular hypertrophy and reduced left ventricular relaxation suggest some type of indirect, or concurrent mechanism. | Francesca M Trovato Daniela Catalano Angela Ragusa G Fabio Martines Clara Pirri Maria Antonietta Buccheri Concetta Di Nora Guglielmo M Trovato | 2015 | World Journal of Nephrology2015，4，1： | 10 |
| 2 | Repression of the Auxin Response Pathway Increases Arabidopsis Susceptibility to Necrotrophic Fungi显示文摘在植物,到 necrotrophic 病原体的抵抗取决于在不同荷尔蒙系统之间的相互影响,例如水杨酸调整的那些酸(SA ) , jasmonic 酸(JA ) ,乙烯,和 abscisic 酸。由 SA 小径发信号的植物生长素的压抑最近被显示贡献抗菌剂抵抗。这里,我们表明表明在刺激植物生长素的 SCF (Skp1CullinF 盒子) ubiquitination 小径展览有缺点的异种 axr1, axr2,和 axr6 的那 Arabidopsis 植物生长素增加的危险性到 necrotrophic 真菌 Plectosphaerella cucumerina 和 Botrytis cinerea。另外,被 SCF-ubiquitin/proteasome 机械通常为移动指向的植物生长素 transcriptional 抑压者 AXR3 的稳定发生在 P 之上。cucumerina 感染。植物生长素运输或 proteasome 功能的药理学抑制各作为在非对待的植物生长素反应异种损害野类型的植物的 necrotroph 抵抗到类似的程度。这些结果建议植物生长素发信号为到 necrotrophic 真菌 P 的抵抗是重要的。cucumerina 和 B。cinerea。SGT1b (编码 HSP90/HSC70 合作女伴的二 Arabidopsis SGT1 基因之一) 在某些抵抗(R) 基因调节到 biotrophic 病原体的植物生长素和 JA 回答和抵抗支持 SCF E3-ubiquitin ligase 建筑群的功能。我们发现 sgt1b 异种对 P 同样抵抗。是的 cucumerina 野类型的植物。相反地, auxin/SCF 发信号异种在到 obligate biotrophic oomycete 的被触发 RPP4 的抵抗是不妥协的, Hyaloperonospora parasitica。因此,在到 oomycetes 的 R 调节基因的抵抗的 SGT1b 的占优势的行动看起来在除帮助 SCF E3-ubiquitin ligases 以外的一个地点。然而, sgt1b axr1 的基因添加在到 H 的危险性的两倍异种。一旦 plantpathogen 相容性被建立, parasitica 建议调停 SCF 的 ubiquitination 贡献限制 biotrophic 病原体殖民。 | Francisco Llorente Paul M usksktt Andrea Sanchez-Vallet Gemma Lopez Brisa Ramos Clara Sanchez-Rodriguez Lucia Jorda Jane Parker Antonio Molina | 2008 | Molecular Plant2008，1，3： | 8 |
| 3 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 4 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 5 | Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis显示文摘BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(H.pylori)-induced chronic gastritis.Clinical practice guidelines currently recommend H.pylori eradication as the preferred initial treatment for early-stage GML.To determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is imperative.AIM To perform a meta-analysis to assess the rate of complete remission(CR)of H.pylori-positive early-stage GML following bacterial eradication.METHODS We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September 2022.Prospective and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in H.pylori-positive patients.The risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal Tools.The pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects model.Heterogeneity and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P<0.01 and I²>50%,respectively.Subgroup and meta-regression analyses were conducted to explore potential sources of heterogeneity.RESULTS The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text reading.Finally,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational studies.The overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 H.pylori-positive early-stage GML patients,in whom H.pylori was successfully eradicated,were included in the analysis.The pooled CR of H.pylori-positive early-stage GML after bacterial eradication was 75.18%(95%CI:70.45%-79.91%).P-MA indicated the substantial heterogeneity in CR reported across studies(I2=92%;P<0.01).Meta-regression analysis identified statistically significant effect modifiers,including the proportion of patients with t(11;18)(q21;q21)-positive GML and the risk of bias in each study.CONCLUSION Comprehensive synthesis of available evidence suggests that H.pylori eradication is effective as the sole initial therapy for early-stage GML.Although the substantial heterogeneity observed across studies limits the interpretation of the pooled overall CR,the present study is a relevant to informing clinical practice. | Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Mariana Santos Calmon Marcel Silva Luz Samuel Luca Rocha Pinheiro Clara Faria Souza Mendes dos Santos Gabriel Lima Correa Santos Hanna Santos Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2023 | World Journal of Gastroenterology2023，29，14： | 2 |
| 6 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 7 | Removal of selected phormaceuticals, fragrances and enclocrine disrupting compounds in a membrane bioreactor and conventional wastewater treatment plants 显示文摘 | Clara M Strem B Gans O | 2005 | Water Res2005，39，19： | 1 |
| 8 | Establishment of a Cre/loxP recombination system for N-terminal epitope tag- ging of genes in Tetrahymena显示文摘 | Clara J L Busch M Alexander V | 2010 | Microbiol2010，10，46： | 1 |
| 9 | Adsorption of bisphenol-A, 17 beta-estradiole and 17 alphaethinylestradiole to sewage sludge 显示文摘 | Clara M Strenn B Saracevic E | 2004 | Chemosphere2004，56，9： | 1 |
| 10 | Comparison of the behaviour of selected micropollutants in a membrane bioreactor and a conventional wastewater treatment plant显示文摘 | Clara M Strenn B Kreuzinger N | 2004 | Water Science and Technology2004，50，5： | 1 |
| 11 | Development of self-assembled bacterial cellulose-starch nanocomposites 显示文摘 | Cristian J Grande Fernando G Torres Clara M Gomez | 2009 | Materials Science and Engineering C2009，29，4： | 1 |
| 12 | Adsorption of bisphenol-A, 17β-estradlole and 17α-ethinylestradiole to sewage sludge 显示文摘 | Clara M Strenn B Saracevic E | 2004 | Chemosphere2004，56，9： | 1 |
| 13 | Adsorption of bisphenol- A, 17β-estradiole and 17α-ethinylestradiole to sewage sludge 显示文摘 | Clara M Strenn B Saracevic E | 2004 | Chemosphere2004，56，9： | 1 |
| 14 | Growth inhibition by gamma rays affects lipids and fatty acids in garlic sprouts during storage显示文摘 | Mónica B. Pérez Marta I. Avelda?o Clara A. Croci | 2007 | Postharvest Biology and Technology2007，，2： | 1 |
| 15 | Left Atrial Function After Ablation for Paroxysmal Atrial Fibrillation显示文摘 | Ana Clara Tude Rodrigues Mauricio I. Scannavacca Márcia Azevedo Caldas Viviane Tiemi Hotta Cristiano Pisani Eduardo A. Sosa Wilson Mathias | 2009 | The American Journal of Cardiology2009，，3： | 1 |
| 16 | Identification of relevant micropollutants in Austrian municipal wastewater and their behaviour during wastewater treatment显示文摘 | CLARA M WINDHOFER G WEILGONY P | 2012 | Chemosphere2012，87，11： | 1 |
| 17 | Development of self-assembled bacterial cellulose-starch nanocomposites显示文摘 | Cristian J Grande Femando G Torres Clara M Gomez | 2009 | Materials Science and Engineering C2009，29，4： | 1 |
| 18 | Postoperative pain management: epidural analgesia 显示文摘 | Gianferrari P Voholina M Clara ME | 2003 | Minerva Chir2003，58，6： | 1 |
| 19 | Relevance of the sludge retention time (SRT) as design criteria for wastewater treatment plants for the removal of endocrine disruptors and pharmaceuticals from wastewater 显示文摘 | KREUZINGER N CLARA M STRENN B | 2004 | Water Sci Technol2004，50，： | 1 |
| 20 | Effects of near- surface soil moisture on GPS SNR data: development of a retrieval algorithm for soil moisture显示文摘 | Clara C C Erie E S Kristine M | 2014 | IEEE Transactions on Geoscience and Remote Sensing2014，52，1： | 1 |
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