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| 1 | Liver metastases:Contrast-enhanced ultrasound compared with computed tomography and magnetic resonance显示文摘The development of ultrasound contrast agents with excellent tolerance and safety profiles has notably improved liver evaluation with ultrasound(US)for several applications,especially for the detection of metastases.In particular,contrast enhanced ultrasonography(CEUS)allows the display of the parenchymal microvasculature,enabling the study and visualization of the enhancement patterns of liver lesions in real time and in a continuous manner in all vascular phases,which is similar to contrast-enhanced computed tomography(CT)and contrast-enhanced magnetic resonance imaging.Clinical studies have reported that the use of a contrast agent enables the visualization of more metastases with significantly improved sensitivity and specificity compared to baseline-US.Furthermore,studies have shown that CEUS yields sensitivities comparable to CT.In this review,we describe the state of the art of CEUS for detecting colorectal liver metastases,the imaging features,the literature reports of metastases in CEUS as well as its technique,its clinical role and its potential applications.Additionally,the updated international consensus panel guidelines are reported in this review with the inherent limitations of this technique and best practice experiences. | Vito Cantisani Hektor Grazhdani Cristina Fioravanti Maria Rosignuolo Fabrizio Calliada Daniela Messineo Maria Giulia Bernieri Adriano Redler Carlo Catalano Ferdinando D’Ambrosio | 2014 | World Journal of Gastroenterology2014，20，29： | 16 |
| 2 | Relationship of MTHFR gene polymorphisms with renal and cardiac disease显示文摘AIM: To investigate the effects of different methylenetetrahydrofolate reductase(MTHFR) 677C>T gene polymorphism and hyperhomocysteinemia for the development of renal failure and cardiovascular events, which are controversial.METHODS: We challenged the relationship, if any, of MTHFR 677C>T and MTHFR 1298A>C polymorphisms with renal and heart function. The present article is a reappraisal of these concepts, investigating within a larger population, and including a subgroup of dialysis patients, if the two most common MTHFR polymorphisms, C677 T and A1298 C, as homozygous, heterozygous or with a compound heterozygous state, show different association with chronic renal failure requiring hemodialysis. MTHFR polymorphism could be a favorable evolutionary factor, i.e., a protective factor for many ominous conditions, like cancer and renal failure. A similar finding was reported in fatty liver disease in which it is suggested that MTHFR polymorphisms could have maintained and maintain their persistence by an heterozygosis advantage mechanism. We studied a total of 630 Italian Caucasian subject aged 54.60 ± 16.35 years, addressing to the increased hazard of hemodialysis, if any, according to the studied MTHFR genetic polymorphisms. RESULTS: A favorable association with normal renal function of MTHFR polymorphisms, and notably of MTHFR C677 T is present independently of the negative effects of left ventricular hypertrophy, increased IntraRenal arterial Resistance and hyperparathyroidism. CONCLUSION: MTHFR gene polymorphisms could have a protective role on renal function as suggested by their lower frequency among our dialysis patients in end-stage renal failure; differently, the association with left ventricular hypertrophy and reduced left ventricular relaxation suggest some type of indirect, or concurrent mechanism. | Francesca M Trovato Daniela Catalano Angela Ragusa G Fabio Martines Clara Pirri Maria Antonietta Buccheri Concetta Di Nora Guglielmo M Trovato | 2015 | World Journal of Nephrology2015，4，1： | 10 |
| 3 | Neglected features of lifestyle: Their relevance in nonalcoholic fatty liver disease显示文摘AIM To investigated in non-alcoholic-fatty-liver-disease(NAFLD), with ultrasound(US)-detected fatty liver, and in a group of non-alcoholic and otherwise healthy subjects, relationship of neglected features of lifestyle with NAFLD and obesity. METHODS Five hundred and thirty-two NAFLD and 667 non-NAFLD healthy subjects, age 21-60 years were studied. Severity of liver steatosis was assessed by US bright liver score. The adherence to mediterranean diet score(AMDS) was assessed on the basis of a 1-wk recall computerized questionnaire which included a detailed physical activity reports(Baecke questionnaire). The western dietary profile score, as a simplified paradigm of unhealthy diet, a questionnaire quantifying sun exposure score and a sleep habits questionnaires provided a further comprehensive lifestyle assessment.RESULTS Body mass index(BMI), insulin resistance(HOMA), and triglycerides, poorer adherence to a mediterranean diet profile, sedentary habits, minor sun exposure and use of 'western diet' foods are greater in NAFLD. Multiplelinear regression analysis, weighted by years of age, displays BMI, HOMA and AMDS as the most powerful independent predictors of fatty liver severity; however, also the physical activity score, the western diet habit and the sun exposure score are acting inside the model with significant independent effects.CONCLUSION Articulated clinical intervention, according to our results, are justified in NAFLD and can be pursued addressing by focused intervention nutritional profile, physical exercise mainly in open-air subsets for enhancing sun exposure and healthier sleep duration and rhythm. | Francesca M Trovato Giuseppe Fabio Martines Daniela Brischetto Guglielmo Trovato Daniela Catalano | 2016 | World Journal of Hepatology2016，8，33： | 4 |
| 4 | Thoracic ultrasound: An adjunctive and valuable imaging tool in emergency,resource-limited settings and for a sustainable monitoring of patients显示文摘Imaging workup of patients referred for elective assessment of chest disease requires an articulated approach: Imaging is asked for achieving timely diagnosis. The concurrent or subsequent use of thoracic ultrasound(TUS) with conventional(chest X-rays-) and more advanced imaging procedures(computed tomography and magnetic resonance imaging) implies advantages, limitations and actual problems. Indeed, despite TUS may provide useful imaging of pleura, lung and heart disease, emergency scenarios are currently the most warranted field of application of TUS: Pleural effusion, pneumothorax, lung consolidation. This stems from its role in limited resources subsets; actually, ultrasound is an excellent risk reducing tool, which acts by:(1) increasing diagnostic certainty;(2) shortening time to definitive therapy; and(3) decreasing problems from blind procedures that carry an inherent level of complications. In addition, paediatric and newborn disease are particularly suitable for TUS investigation, aimed at the detection of congenital or acquired chest disease avoiding, limiting or postponing radiological exposure. TUS improves the effectiveness of elective medical practice, in resource-limited settings, in small point of care facilities and particularly in poorer countries. Quality and information provided by the procedure are increased avoiding whenever possible artefacts that can prevent or mislead the achievement of the correct diagnosis. Reliable monitoring of patients is possible, taking into consideration that appropriate expertise, knowledge, skills, training, and even adequate equipment's suitability are not always and everywhere affordable or accessible. TUS is complementary imagingprocedure for the radiologist and an excellent basic diagnostic tool suitable to be shared with pneumologists, cardiologists and emergency physicians. | Francesca M Trovato Daniela Catalano Guglielmo M Trovato | 2016 | World Journal of Radiology2016，8，9： | 3 |
| 5 | ADV36 adipogenic adenovirus in human liver disease显示文摘obesity and liver steatosis are usually described as related diseases.obesity is regarded as exclusive consequence of an imbalance between food intake and physical exercise,modulated by endocrine and genetic factors.Non-alcoholic fatty liver disease(NAFLD),is a condition whose natural history is related to,but not completely explained by over-nutrition,obesity and insulin resistance.There is evidence that environmental infections,and notably adipogenic adenoviruses(ADV)infections in humans,are associated not only with obesity,which is sufficiently established,but also with allied conditions,such as fatty liver.In order to elucidate the role,if any,of previous ADV36 infection in humans,we investigated association of ADV36-ADV37 seropositivity with obesity and fatty liver in humans.Moreover,the possibility that lifestyle-nutritional intervention in patients with NAFLD and different ADV36 seropositive status,achieves different clinical outcomes on ultrasound bright liver imaging,insulin resistance and obesity was challenged.ADV36 seropositive patientshave a more consistent decrease in insulin resistance,fatty liver severity and body weight in comparison with ADV36 seronegative patients,indicating a greater responsiveness to nutritional intervention.These effects were not dependent on a greater pre-interventional body weight and older age.These results imply that no obvious disadvantage-and,seemingly,that some benefit-is linked to ADV36 seropositivity,at least in NAFLD.ADV36 previous infection can boost weight loss and recovery of insulin sensitivity under interventional treatment. | Francesca M Trovato Daniela Catalano Adriana Garozzo G Fabio Martines Clara Pirri Guglielmo M Trovato | 2014 | World Journal of Gastroenterology2014，20，40： | 1 |
| 6 | Challenges of liver cancer:Future emerging tools in imaging and urinary biomarkers显示文摘Chronic liver disease has become a global health problem as a result of the increasing incidence of viral hepatitis, obesity and alcohol misuse. Over the past three decades, in the United Kingdom alone, deaths from chronic liver disease have increased both in men and in women. Currently, 2.5% of deaths worldwide are attributed to liver disease and projected figures suggest a doubling in hospitalisation and associated mortality by 2020. Chronic liver diseases vary for clinical manifestations and natural history, with some individuals having relatively indolent disease and others with a rapidly progressive course. About 30% of patients affected by hepatitis C has a progressive disease and develop cirrhosis over a 20 years period from the infection, usually 5-10 years after initial medical presentation. The aim of the current therapeutic strategies is preventing the progression from hepatitis to fibrosis and subsequently, cirrhosis. Hepatic steatosis is a risk factor for chronic liver disease and is affecting about the half of patients who abuse alcohol. Moreover non-alcoholic fatty liver disease is part of the metabolic syndrome, associated with obesity, hypertension, type Ⅱ diabetes mellitus and dyslipidaemia, and a subgroup of patients develops non-alcoholic steatohepatitis and fibrosis with subsequent cirrhosis. The strengths and pitfalls of liver biopsy are discussed and a variety of new techniques to assess liver damage from transient elastography to experimental techniques, such as in vitro urinary nuclear magnetic resonance spectroscopy. Some of the techniques and tests described are already suitable for more widespread clinical application, as is the case with ultrasound-based liver diagnostics, but others, such as urinary metabonomics, requires a period of critical evaluation or development to take them from the research arena to clinical practice. | Francesca M Trovato Joshua M Tognarelli Mary ME Crossey Daniela Catalano Simon D Taylor-Robinson Guglielmo M Trovato | 2015 | World Journal of Hepatology2015，7，26： | 1 |
| 7 | Leptin increases HER2 protein levels through a STAT3-mediated up-regulation of Hsp90 in breast cancer cells显示文摘 | Cinzia Giordano Donatella Vizza Salvatore Panza Ines Barone Daniela Bonofiglio Marilena Lanzino Diego Sisci Francesca De Amicis Suzanne A.W. Fuqua Stefania Catalano Sebastiano Andò | 2013 | Molecular Oncology2013，，3： | 1 |
| 8 | Identification of bioactive constituents of Ziziphus jujube fruit extracts exerting antiproliferative and apoptotic effects in human breast cancer cells显示文摘 | Pierluigi Plastina Daniela Bonofiglio Donatella Vizza Alessia Fazio Daniela Rovito Cinzia Giordano Ines Barone Stefania Catalano Bartolo Gabriele | 2012 | Journal of Ethnopharmacology2012，，2： | 1 |
| 9 | Mediterranean diet and non-alcoholic fatty liver disease.显示文摘 | Francesca M. Trovato Daniela Catalano G. Fabio Martines Patrizia Pace Guglielmo M. Trovato | 2014 | Clinical Nutrition2014，，： | 1 |
| 10 | Re: “Relation of the Traditional Mediterranean Diet to Cerebrovascular Disease in a Mediterranean Population”显示文摘 | Guglielmo M. Trovato Giuseppe Fabio Martines Francesca M. Trovato Daniela Catalano | 2013 | American Journal of Epidemiology2013，，4： | 1 |
| 11 | Comment on: Lin et al. Long-Term Changes in Adiposity and Glycemic Control Are Associated With Past Adenovirus Infection. Diabetes Care 2013;36:701–707显示文摘 | Guglielmo M. Trovato Daniela Catalano G. Fabio Martines Francesca M. Trovato | 2013 | Diabetes Care2013，，10： | 1 |
| 12 | Mediterranean diet and physical activity: An intervention study. Does olive oil exercise the body through the mind?显示文摘 | Daniela Catalano Guglielmo M. Trovato Patrizia Pace Giuseppe Fabio Martines Francesca M. Trovato | 2013 | International Journal of Cardiology2013，，： | 1 |
| 13 | Renal Resistive Index and Parathyroid Hormone Relationship with Renal Function in Nondiabetic Patients显示文摘 | Guglielmo M. Trovato Giuseppe Fabio Martines Francesca M. Trovato Clara Pirri Patrizia Pace Daniela Catalano | 2012 | Endocrine Research2012，，2： | 1 |
| 14 | Adenovirus-36 Seropositivity Enhances Effects of Nutritional Intervention on Obesity, Bright Liver, and Insulin Resistance显示文摘 | Guglielmo M. Trovato Giuseppe Fabio Martines Francesca M. Trovato Clara Pirri Patrizia Pace Adriana Garozzo Angelo Castro Daniela Catalano | 2012 | Digestive Diseases and Sciences2012，，2： | 1 |
| 15 | Lifestyle Interventions, Insulin Resistance, and Renal Artery Stiffness in Essential Hypertension显示文摘 | Guglielmo M. Trovato Clara Pirri Giuseppe Fabio Martines Antonia Tonzuso Francesca Trovato Daniela Catalano | 2010 | Clinical and Experimental Hypertension2010，，5： | 1 |
| 16 | Protective Role of Coffee in Non-alcoholic Fatty Liver Disease (NAFLD)显示文摘 | Daniela Catalano Giuseppe Fabio Martines Antonia Tonzuso Clara Pirri Francesca M. Trovato Guglielmo M. Trovato | 2010 | Digestive Diseases and Sciences2010，，11： | 1 |
| 17 | Leptin increases HER2 protein levels through a STAT3-mediated up-regulation of Hsp90 in breast cancer cells显示文摘 | Cinzia Giordano Donatella Vizza Salvatore Panza Ines Barone Daniela Bonofiglio Marilena Lanzino Diego Sisci Francesca De Amicis Suzanne A.W. Fuqua Stefania Catalano Sebastiano Andò | 2013 | Molecular Oncology2013，，3： | 1 |
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