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| 1 | Inhibition of Alveolar Macrophage Pyroptosis Reduces Lipopolysaccharide-induced Acute Lung Injury in Mice显示文摘 | Dong-Dong Wu Pin-Hua Pan Ben Liu Xiao-Li Su Le-Meng Zhang Hong-Yi Tan ZU Cao Zuo-Ren Zhou Hai-Tao Li Hao-Si Li Li Huang Yuan-Yuan Li | 2015 | Chinese Medical Journal2015，，19： | 39 |
| 2 | Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG显示文摘Osteoporosis is a debilitating bone disease affecting millions of people. Here, we used human urine-derived stem cells(USCs),which were noninvasively harvested from unlimited and easily available urine, as a 'factory' to obtain extracellular vesicles(USCEVs) and demonstrated that the systemic injection of USC-EVs effectively alleviates bone loss and maintains bone strength in osteoporotic mice by enhancing osteoblastic bone formation and suppressing osteoclastic bone resorption. More importantly, the anti-osteoporotic properties of USC-EVs are not notably disrupted by the age, gender, or health condition(with or without osteoporosis) of the USC donor. Mechanistic studies determined that collagen triple-helix repeat containing 1(CTHRC1) and osteoprotegerin(OPG) proteins are enriched in USC-EVs and required for USC-EV-induced pro-osteogenic and anti-osteoclastic effects. Our results suggest that autologous USC-EVs represent a promising novel therapeutic agent for osteoporosis by promoting osteogenesis and inhibiting osteoclastogenesis by transferring CTHRC1 and OPG. | Chun-Yuan Chen Shan-Shan Rao Yi-Juan Tan Ming-Jie Luo Xiong-Ke Hu Hao Yin Jie Huang Yin Hu Zhong-Wei Luo Zheng-Zhao Liu Zhen-Xing Wang Jia Cao Yi-Wei Liu Hong-Ming Li Yang Chen Wei Du Jiang-Hua Liu Yan Zhang Tuan-Hui Chen Hao-Ming Liu Ben Wu Tao Yue Yi-Yi Wang Kun Xia Peng-Fei Lei Si-Yuan Tang Hui Xie | 2019 | Bone Research2019，7，3： | 14 |
| 3 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 4 | OsDMI3 Is a Novel Component of Abscisic Acid Signaling in the Induction of Antioxidant Defense in Leaves of Rice显示文摘Ca2+ 和 calmodulin (凸轮) 被看了抗氧化剂防卫到在 abscisic 酸(骆驼毛的织物) 的一个重要角色导致了的玩。然而, Ca2+/CaM-dependent 蛋白质 kinase (CCaMK ) 是否涉及这个过程,是未知的。在现在的学习,米饭 CCaMK 的角色, OsDMI3,在导致骆驼毛的织物的抗氧化剂,防卫在米饭(Oryza sativa ) 的叶子被调查植物。有骆驼毛的织物, H2O2,和聚乙烯乙二醇(木钉) 的处理导致了 OsDMI3 和 OsDMI3 的活动的表示,并且 H2O2 在水应力下面为表示和 OsDMI3 的活动的导致骆驼毛的织物的增加被要求。Subcellular 本地化分析证明 OsDMI3 位于原子核,细胞质,和血浆膜。在米饭原物和在米饭原物的 OsDMI3 的 silencing 显示出的 RNA 干扰(RNAi ) 的 OsDMI3 的短暂表示的分析那 OsDMI3 为表示和 superoxide dismutase (草皮) 和过氧化氢酶(猫) 的活动的导致骆驼毛的织物的增加被要求。进一步,氧化损坏由木钉的更高的集中导致了, H2O2 在 OsDMI3 的异种被加重。而且,在原物和 OsDMI3 的异种的 OsDMI3 的 RNAi silencing 的分析证明 H2O2 累积的高水平要求在骆驼毛的织物发信号的 OsDMI3 激活,而是起始的 H2O2 生产导致了由骆驼毛的织物不依赖于在米饭植物的叶子的 OsDMI3 的激活。我们的数据表明 OsDMI3 是在在米饭的导致骆驼毛的织物的抗氧化剂防卫的一个重要部件。 | Ben Shi Lan Ni Aying Zhang Jianmei Cao Hong Zhang Tingting Qin Mingpu Tan Jianhua Zhang Mingyi-Jiang | 2012 | Molecular Plant2012，5，6： | 10 |
| 5 | Room temperature phosphorescence from natural products: Crystallization matters显示文摘Efficient room temperature phosphorescence is observed in natural compounds and polymers such as starch, cellulose, bovine serum albumin (BSA), and some other carbohydrates. Whereas being practically nonluminescent in solutions and TLC plates, they emit bright phosphorescence in the crystalline states with lifetime up to microseconds, exhibiting crystallization-induced phosphorescence (CIP) characteristics. The CIP of these natural products without any conventional chromophores offers a new platform for the exploration of conceptually novel luminogens. | GONG YongYang TAN YeQiang MEI Ju ZHANG YiRen YUAN WangZhang ZHANG YongMing SUN JingZhi TANG Ben Zhong | 2013 | Science China Chemistry2013，56，9： | 8 |
| 6 | Crystallization-induced phosphorescence of benzils at room temperature显示文摘Efficient room temperature phosphorescence (RTP) is rarely observed in pure organic luminogens. However, we have newly observed that benzil and its derivatives are nonluminescent in solvents and thin layer chromatography (TLC) plates, but become highly phosphorescent in crystal state at room temperature, exhibiting typical crystallization-induced phosphorescence (CIP) characteristics. The CIP phenomenon is ascribed to the restriction of intramolecular rotations in crystals owing to effective intermolecular interactions. Such intermolecular interactions greatly rigidify the molecular conformation and significantly decrease the nonradiative deactivation channels of the triplet excitons, thus giving boosted phosphorescent emission at room temperature. | GONG YongYang TAN YeQiang LI Hong ZHANG YiRen YUAN WangZhang ZHANG YongMing SUN JingZhi TANG Ben Zhong | 2013 | Science China Chemistry2013，56，9： | 6 |
| 7 | 2002~2005年期间萨斯喀彻温省儿科三级医疗中心因呼吸道合胞病毒感染住院的儿童病例分析(英文)显示文摘中文概呼吸道合胞病毒(RSV)是2岁以下儿童呼吸道感染最常见的病原体,也是引起婴儿病毒感染所致死亡的主要原因。到目前为止,尚未见加拿大萨斯喀彻温省RSV流行病学的研究报道。本研究的目的是描述2002年7月至2005年6月期间在萨斯喀彻温省的两个儿科三级医疗中心,即皇家大学医院(RUH)和萨斯卡通和里贾纳总医院(RGH),因RSV感染住院的儿童的流行病学特点及疾病严重程度,其中部分患儿有帕利珠单抗(palivizumab)预防史。 在上述2个医疗中心住院时间≥24h的儿童(年龄:从出生到16岁11个月)经实验室病毒鉴定确诊为RSV感染的儿童纳入本研究。在RUH中心,患儿鼻咽部分泌物经直接荧光抗体(DFA)检测阳性者确诊为RSV感染。如果DFA为阴性,则对该标本进行病毒培养。在RGH中心,所有患儿鼻咽部分泌物标本均进行DFA检测和病毒培养。确诊后对患儿的健康记录进行回顾性分析,内容包括患儿的人口统计信息、转诊模式、帕利珠单抗预防史、感染严重程度及转归。目前尚无统一的感染严重程度的判断标准,本研究根据住院时间、是否需要小儿重症监护及持续时间、是否机械通气等进行评估。在研究期间,萨斯喀彻温省的帕利珠单抗预防的标准与加拿大儿科学会(CPS)的建议一致。 2002年7月至2005年6月3年期间,总共有590名RSV儿童(包括324名男童)住院治疗,共602次住院记录,其中12名儿童住院1次以上。入院时患儿中位实足年龄为5.3个月,平均住院时间为4.0d(范围:〈1d至121.2个月)。82.4%的患儿出生时胎龄≥36周,7.5%为33-35周,9.5%≤32周。RSV感染住院情况呈现季节性模式,其中大部分发生在三月和六月。患儿最常见的临床表现为细支气管炎(70.2%),38.1%表现为肺炎,17.3%为上呼吸道感染,0.5%表现为哮吼(患儿可能同时有1个以上的临床表现)。478例(81.0%)为RSV轻度至中度感染,110例(18.6%)为重度感染。25.1%的患儿有继发性细菌感染。共有39例(6.7%)需要入住儿科重症监护病房(PICU),中位入住时间为5.0d。其中,22例重症患儿(56%)需要机械通气(通气时间中位数6.0d),14例重症患儿(36%)有继发性细菌感染。与入住普通病房的患儿比较,PICU患儿大多有如下情况:入院时年龄较小(P〈0.01),有潜在的肺部疾病(P〈0.01)或先天性心脏疾病(P=0.01),有两个或更多潜在的疾病(P〈0.01),与其他儿童共同居住(P=0.02)。在本研究过程中,2例儿童死亡,但均与RSV感染无关。 本研究有22例患儿在入院前接受过帕利珠单抗预防RSV感染,其中18例已完成至少2个月的剂量,17例(77%)有1个或以上的慢性疾病,14例(64%)出生时胎龄不超过32周。入院时中位实足年龄为5.6个月(范围0-27.5个月),中位住院时间为9.5d(范围2-271d)。大多数儿童(17/22)为轻度至中度RSV感染。 小结:RSV在萨斯喀彻温省保持较高的发病率,男性、实足年龄小于1岁的足月儿或晚期早产儿发病率较高。细支气管炎是最常见的临床表现。大多数患儿呈轻度至中度感染,但约7%的患儿需要重症监护。较小的实足年龄、潜在的肺部或心脏疾病或多个潜在疾病等因素均有可能导致患儿需要重症监护。此外,与其他孩子同住也有可能是导致患儿需要重症监护的一个因素。需要重症监护的患儿往往胎龄大于35周。虽然部分接受过帕利珠单抗预防的患儿也感染了RSV,但是其大部分患儿的病情为轻度至中度。这些曾接受过帕利珠单抗预防的患儿更可能有潜在疾病,并且出生时胎龄往往小于32周。在本研究中,无一例因RSV感染而引起的死亡病例。本研究尚浅,需要开展更深入的研究,以进一步确定RSV患儿,特别是PICU患儿以及曾接受过帕利珠单抗预防却仍然受到RSV感染的患儿的特征。 | Ayisha Kurji Ben Tan Jaya Bodani Bonnie Janzen Athena McConnell Rachana Bodani Derek Rajakumar Anil Sharma Koravangattu Sankaran | 2014 | 中国当代儿科杂志2014，16，10： | 3 |
| 8 | Synthesis and antibacterial activity of new layered perovskite compounds,Ag_xNa_(2-x)La_2Ti_3O_(10)显示文摘有 Ruddlesden 扑扑儿(R-P ) 的三种新分层的 perovskite 混合物分阶段执行, AgxNa2 ? xLa2Ti3O10 (x = 0.2, 0.3 和 0.5 ) ,被 Na2La2Ti3O10 的离子交换反应与 AgNO3 综合答案。混合物的结构被 EDX 和 XRD 描绘,并且他们的抗菌活性和轻抵抗的性质被评估。结果显示 AgxNa2 的分子式 ? xLa2Ti3O10 (x = 0.2, 0.3 和 0.5 ) 被证实,并且 Na2La2Ti3O10 的晶体结构不是,这显然由银离子的交换影响了。对大肠杆菌关口 i 的 Ag0.3Na1.7La2Ti3O10 的最小的禁止的集中(MIC )(E。关口 i ) ,葡萄球菌 aureus (S。aureus ) 分别地,当它的褪色没在 24 h 光老化试验以后被观察时,是 180 μ g /mL 和 240 μ g /mL。 | Shao Zao Tan Liu Cai Ding Ying Liang Liu You Sheng Ouyang Yi Ben Chen | 2007 | Chinese Chemical Letters2007，18，1： | 2 |
| 9 | Traversing knowledge networks:an algorithmic historiography of extant literature on the Internet of Things(IoT)显示文摘Research on the Internet of Things(IoT)has been booming for the past 6 years due to technological advances and potential for application.Nonetheless,the rapid growth of IoT articles and the heterogeneous nature of IoT pose challenges to conducting a systematic review of IoT literature.This study seeks to address the abovementioned challenges by reviewing 1065 IoT articles retrieved from the International Statistical Institute Web of Science via a blend of quantitative citation analysis and qualitative content analysis.For the former,we generated a historiography of IoT research,a citation network,in which we tried to identify main paths of codification and diffusion,as well as path-dependent transitions.For the latter,we explicated the progression of knowledge through 30 central IoT articles in chronological order regarding infrastructures,enabling technologies,potential technologies,and research challenges.Findings from this study contribute to both IoT research and management. | Fei Liu Chee-Wee Tan Eric T.K.Lim Ben Choi | 2017 | Journal of Management Analytics2017，4，1： | 1 |
| 10 | Approximate Solution to Vec- tor Radiative Transfer in a Gradient-Index Medium 显示文摘 | Ben X Yi HL Tan HP | 2014 | Applied Optics2014，53，： | 1 |
| 11 | Polarized Radiative Transfer in an Arbitrary Multilayer Semitransparent Medium 显示文摘 | Ben X Yi HL Tan HP | 2014 | Ap- plied Optics2014，53，： | 1 |
| 12 | EPHX1 polymorphisms do not modify esophageal carcinoma susceptibilityin Dutch Caucasians显示文摘 | Polat Dura Caro Bregitha Rene Te Morsche Hennie Roelofs Jon Kristinsson Theo Wobbes Ben Witteman Adriaan Tan Joost Drenth Wilbert Peters | 2012 | Oncology Reports2012，，6： | 1 |
| 13 | A Review of Bacterial Foraging Optimization Part I: Background and Development 显示文摘 | Ben Niu Yan Fan Lijing Tan | 2010 | Advanced Intelligent Computing Theories and Applications Communications in Computer and Information Science2010，，93： | 1 |
| 14 | Hydrogen-rich saline attenuates postoperative liver failure after major hepatectomy in rats显示文摘 | Yun Chang Tan Feng Xie Hui Lu Zhang Yu Li Zhu Ke Chen Hua Min Tan Ben Shun Hu Jia Mei Yang Jing Wang Tan | 2013 | Clinics and Research in Hepatology and Gastroenterology2013，，： | 1 |
| 15 | The key success factars,distinctive capabilities,and strategic thrusts of top SMEs in Singapore显示文摘 | B.C Ghosh Tan Wee Liang Tan Teck Meng Ben Chanv | | 0，，03： | 1 |
| 16 | The key success factors, distinctive capabilities, and strategic thrusts of top SMEs in Singapore显示文摘 | B.C Ghosh Tan Wee Liang Tan Teck Meng Ben Chan | 2000 | Journal of Business Research2000，，3： | 1 |
| 17 | Multi-objective bacterial foraging optimization显示文摘 | Ben Niu Hong Wang Jingwen Wang Lijing Tan | 2013 | Neurocomputing2013，，： | 1 |
| 18 | High efficiency D-A structured luminogen with aggregation-induced emission and mechanochromic characteristics显示文摘A novel luminogen, CZ2TPAN, with typical D-A architecture was obtained. It shows intramolecular charge transfer and aggregation-induced emission characteristics with high solid-state efficiency of 65.3%. Moreover, it exhibits reversible mechanochromic behavior between crystalline and amorphous states with remarkable emission color change from green (504 nm) to yellow (545nm). | LU YaWei TAN YeQiang GONG YongYang LI Hong YUAN WangZhang ZHANG YongMing TANG Ben Zhong | 2013 | Chinese Science Bulletin2013，58，22： | 1 |
| 19 | Semi-supervised elastic net for pedestrian counting显示文摘 | Tan Ben Zhang Junping Wang Liang | 2011 | Pattern Recognition2011，44，10： | 1 |
| 20 | 晚期早产儿呼吸道合胞病毒感染的预防显示文摘1引言
绝大部分儿童上呼吸道和下呼吸道感染病原体为病毒。呼吸道合胞病毒(RSV)是这类急性疾病最常见的病原体,主要影响呼吸系统,且病程各异。50%~90%的细支气管炎住院病例和25%的肺炎住院病例均由RSV所致。在新生儿中,小于32周的早产儿和有慢性呼吸功能不全(支气管肺发育不良或慢性肺疾病)或有明显血流动力学异常的先天性心脏缺陷等异常的孩子特别容易感染RSV。 | Koravangattu SANKARAN Mila KALAPPURACKAL Ben TAN | 2013 | 中国当代儿科杂志2013，15，4： | 0 |
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