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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | Matrix metalloproteinase 2 and 9 activity in patients with colorectal cancer liver metastasis 显示文摘 | Waas ET Wobbes T Lomme RM | 2003 | Br J Surg2003，90，12： | 1 |
| 3 | Epitheli- oid sarcoma: Still an only surgically curable disease 显示文摘 | de Visscher S A van Ginkel R J Wobbes T etal | 2006 | Cancer2006，107，3： | 1 |
| 4 | The significance of microcalcifications without palpable mass in the diagnosis of breast cancer显示文摘 | Tinnemans JG Wobbes T Lubbers E J | 1986 | Surgery1986，99，6： | 1 |
| 5 | Chlamydia pneumoniae infection promotes a proliferative phenotype in the vasculature through Egr-1 activation in vitro and in vivo显示文摘 | Rupp J Hellwig-Burgel T Wobbe V | 2005 | Proc Natl Acad Sci USA2005，102，9： | 1 |
| 6 | Epithelioid sarcoma:still an only SUr cally curable disease显示文摘 | de Visscher S A van Ginkel R J Wobbes T | 2006 | Cancer2006，107，3： | 1 |
| 7 | Magnetic resonance guided biopsies and localizations of the breast:initial experiences using an open breast coil and compatible intervention device显示文摘 | Veltman J Boetes C Wobbes T | 2005 | Invest Ra- diol2005，40，6： | 1 |
| 8 | Epithelioid sarcoma:still an only surgically curable disease显示文摘 | de Visscher SA van Ginkel RJ Wobbes T | 2006 | Cancer2006，107，3： | 1 |
| 9 | Matrix meatalloproteinase 2 and 9 activity in patients with colorectal cancer live metastasis显示文摘 | Waas ET Wobbes T Lomme RM | 2003 | Br J Surg2003，90，12： | 1 |
| 10 | Malignant Adenomyoepithelioma of the breast with metastasis in the thyroid gland 12 years after excision of the primary tumor显示文摘 | Bult P Verwiel J M Wobbes T | 2000 | Virchows Arch2000，436，2： | 1 |
| 11 | Evaluation of seven tumor markers (CA 50, CA 19-9, CA 19-9 Tru- Quant, CA 72-4, CA 195, carcinoembryonic antigen, and tissue polypeptide antigen) in the pretreatment sera of pa- tients with gastric carcinoma显示文摘 | Wobbes T Thomas CM Segers MF | 1992 | Cancer1992，69，8： | 1 |
| 12 | Malignant adenomyoepitheli- oma of the breast with metastasis in the thyroid gland 12 years after excision of the primary tumor Case report and review of the literature 显示文摘 | Buh P Verwiel JM Wobbes T | 2000 | Virchows Arch2000，436，2： | 1 |
| 13 | In vivo destruction of tumor tissue by cryoblation can induce inhibition of secondary tumor growth:an experiment study显示文摘 | Muijen GN Wobbes T | 2001 | Cryobiology2001，1，： | 1 |
| 14 | Epithelioid sarco-ma :still an only surgically curable disease显示文摘 | de Visscher SA’van Ginkel RJ Wobbes T | 2006 | Cancer2006，107，： | 1 |
| 15 | Epithelioid sarco- ma : still an only surgically curable disease 显示文摘 | de Visscher SA van Ginkel R J Wobbes T | 2006 | Cancer2006，107，60： | 1 |
| 16 | Outgrowth of human liver metastases after resection of the primary colorectal tumor:a shift in the balance between apoptosis and proliferation显示文摘 | Peeters CF De Waal RM Wobbes T el al | 2006 | Int J Cancer2006，119，6： | 1 |
| 17 | Matrix meatalloproteinase 2 and 9 activity in patients with colorectal cancer live metastasis显示文摘 | Waas ET Wobbes T Lomme RM | 2003 | Br J Surg2003，90，12： | 1 |
| 18 | Epithelioid sarcoma: Still an only surgically curable disease 显示文摘 | de Visscher SA van Ginkel R J Wobbes T | 2006 | Cancer2006，107，3： | 1 |
| 19 | Estrogen and proestin receptors in colonic canc- er 显示文摘 | Wobbes T | 1982 | Dis colon rectum1982，27，9： | 1 |
| 20 | Epithelioid sarcoma : Still an only surgically curable disease 显示文摘 | de Visscher SA van Ginkel RJ Wobbes T | 2006 | Cancer2006，107，3： | 1 |
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