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| 1 | Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity显示文摘Cereal crops and cereal consumption have had a vital role in Mankind's history. In the recent years gluten ingestion has been linked with a range of clinical disorders. Gluten-related disorders have gradually emerged as an epidemiologically relevant phenomenon with an estimated global prevalence around 5%. Celiac disease, wheat allergy and non-celiac gluten sensitivity represent different gluten-related disorders. Similar clinical manifestations can be observed in these disorders, yet there are peculiar pathogenetic pathways involved in their development. Celiac disease and wheat allergy have been extensively studied, while non-celiac gluten sensitivity is a relatively novel clinical entity, believed to be closely related to other gastrointestinal functional syndromes. The diagnosis of celiac disease and wheat allergy is based on a combination of findings from the patient's clinical history and specific tests, including serology and duodenal biopsies in case of celiac disease, or laboratory and functional assays for wheat allergy. On the other hand, non-celiac gluten sensitivity is still mainly a diagnosis of exclusion, in the absence of clear-cut diagnostic criteria. A multimodal pragmatic approach combining findings from the clinical history, symptoms, serological and histological tests is required in order to reach an accurate diagnosis. A thorough knowledge of the differences and overlap in clinical presentation among gluten-related disorders, and between them and other gastrointestinal disorders, will help clinicians in the process of differential diagnosis. | Luca Elli Federica Branchi Carolina Tomba Danilo Villalta Lorenzo Norsa Francesca Ferretti Leda Roncoroni Maria Teresa Bardella | 2015 | World Journal of Gastroenterology2015，21，23： | 8 |
| 2 | Cytoskeleton reorganization and ultrastructural damage induced by gliadin in a three-dimensional in vitro model显示文摘AIM: To evaluate the interplay between gliadin and LoVo cells and the direct effect of gliadin on cytoskeletal patterns.METHODS: We treated LoVo multicellular spheroids with digested bread wheat gliadin in order to investigate their morphology and ultrastructure (by means of light microscopy and scanning electron microscopy), and the effect of gliadin on actin (phalloidin fluorescence)and the tight-junction protein occludin and zonula occluden-1.RESULTS: The treated spheroids had deep holes and surface blebs, whereas the controls were smoothly surfaced ovoids. The incubation of LoVo spheroids with gliadin decreased the number of intracellular actin filaments, impaired and disassembled the integrity of the tight-junction system.CONCLUSION: Our data obtained from an 'in vivolike' polarized culture system confirm the direct noxious effect of gliadin on the cytoskeleton and tight junctions of epithelial cells. Unlike two-dimensional cell culture systems, the use of multicellular spheroids seems to provide a suitable model for studying cell-cell interactions. | Ersilia Dolfini Leda Roncoroni Luca Elli Chiara Fumagalli Roberto Colombo Simona Ramponi Fabio Forlani Maria Teresa Bardella | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 3 | Circulating ghrelin levels in patients with inflammatory bowel disease 显示文摘 | Peracchi M Bardella MT Caprioli F | 2006 | Gut2006，55，3： | 1 |
| 4 | Possible protective effect of 5-aminosalicylic acid on Helicobacter pylori infection in patients with inflammatory bowel disease显示文摘 | PIODI L P BARDELLA M ROCCHIA C | 2003 | J Clin Gastroenterol2003，36，： | 1 |
| 5 | RSS-Based Ranging by Multichannel RSS Averaging显示文摘 | ZANELLA A BARDELLA A | 2014 | IEEE Wireless Commu- nications Letters2014，3，1： | 1 |
| 6 | The therapeutic potential of hepatocyte growth factor to sensitize ovarian cancer cells to cisplatin and paclitaxel in vivo 显示文摘 | Bardella C Dettori D Olivero M | 2007 | Clin Cancer Res2007，13，7： | 1 |
| 7 | On the elastic behavior of syntactic foams 显示文摘 | Bardella L Genna F | 2001 | International Journal of Solids and Structures2001，38，： | 1 |
| 8 | Celiac disease: in vivo diagnosis by confocal endomicroscopy显示文摘 | Cristina Trovato Angelica Sonzogni Davide Ravizza Giancarla Fiori Marzia Rossi Darina Tamayo Mara Jo Miller Maria Teresa Bardella Cristiano Crosta | 2007 | Gastrointestinal Endoscopy2007，，7： | 1 |
| 9 | On the Elastic Behavior of Syntactic Foams显示文摘 | Bardella L Genna F | 2001 | International Journal of Solids&Structures2001，38，40： | 1 |
| 10 | Transglutaminases in inflammation and fibrosis of the gastrointestinal tract and the liver显示文摘 | Elli L Bergamini CM Bardella MT | 2009 | Dig Liver Dis2009，41，8： | 1 |
| 11 | Searching for coeliac disease in patients with non-alcoholic fatty liver disease显示文摘 | Bardella MT Valenti L Pagliari C | 2004 | Dig Liver Dis2004，36，： | 1 |
| 12 | Expression and functional pharmacology of the bradykinin B I receptor in the normal and in- flamed human gallbladder 显示文摘 | Andre E Gazzieri D BardeLla E | 2008 | Gut2008，57，5： | 1 |
| 13 | Gastric emptying and plasma neurotensin levels in untreated celiac patients显示文摘 | Bardella M T Fraquelli M Peracchi M | 2000 | Scandinavian journal of gastroenterology2000，35，3： | 1 |
| 14 | Enteroscopy for the early detection of small bowel tumours in at-risk celiac patients显示文摘 | Tomba C Elli L Bardella MT | 2014 | Dig Liver Dis2014，46，5： | 1 |
| 15 | Searching for coeliac disease in patients with non-alcoholic fatty liver disease显示文摘 | Bardella MT Enti L Agliari C | 2004 | Dig Liver Dis2004，36，5： | 1 |
| 16 | Mechanisms of interleukin-6 protection against ischemia-reperfusion injury in rat liver显示文摘 | Tiberio L Tiberio G A Bardella L | 2006 | Cytokine2006，34，34： | 1 |
| 17 | Evolutionary and Functional Analysis of Celiac Risk Loci Reveals SH2B3 as a Protective Factor against Bacterial Infection显示文摘 | Alexandra Zhernakova Clara C. Elbers Bart Ferwerda Jihane Romanos Gosia Trynka Patrick C. Dubois Carolien G.F. de Kovel Lude Franke Marije Oosting Donatella Barisani Maria Teresa Bardella Leo A.B. Joosten Paivi Saavalainen David A. van Heel Carlo Catassi | 2010 | The American Journal of Human Genetics2010，，6： | 1 |
| 18 | On the elastic behavior of syntactic foams显示文摘 | Bardella L Genna F | 2001 | Int J Solids Struct2001，38，： | 1 |
| 19 | Evolutionary and Functional Analysis of Celiac Risk Loci Reveals SH2B3 as a Protective Factor against Bacterial Infection显示文摘 | Alexandra Zhernakova Clara C. Elbers Bart Ferwerda Jihane Romanos Gosia Trynka Patrick C. Dubois Carolien G.F. de Kovel Lude Franke Marije Oosting Donatella Barisani Maria Teresa Bardella Leo A.B. Joosten Paivi Saavalainen David A. van Heel Carlo Catassi | 2010 | The American Journal of Human Genetics2010，，6： | 1 |
| 20 | Reevaluation of duodenal endoscopic markers in the diagnosis of celiac disease显示文摘 | Maria Teresa Bardella Giorgio Minoli Franco Radaelli Maurizio Quatrini Paolo A. Bianchi Dario Conte | 2000 | Gastrointestinal Endoscopy2000，，6： | 1 |
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