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| 1 | The roles of MAPKs in disease显示文摘印射响应许多 ligands 和房间刺激涉及大量的细胞的小径和功能的家族 ases transduce 信号。MAPK 的异常或不恰当的功能现在在从癌症到煽动性的疾病到肥胖和糖尿病的疾病被识别了。在许多房间类型, MAPK ERK1/2 被连接到细胞增殖。因为在地岬和 B-Raf 的变化,能激活 ERK1/2 串联,在许多人的肿瘤被发现, ERK1/2 被认为在一些癌症起一个作用。发信号的反常 ERK1/2 也在 polycystic 肾疾病被发现了,并且象 cardio-facio-cutaneous 症候群那样的严肃的发展混乱在 ERK1/2 串联的部件从变化产生。ERK1/2 在区分得好的房间是必要的并且在神经原并且在上皮的极性的维护被连接了到长期的 potentiation。另外, ERK1/2 为在胰腺的贝它房间的胰岛素基因抄写是重要的,它响应传播葡萄糖的增加生产胰岛素在有机体允许有效葡萄糖利用和存储。导致或镇压的营养素和荷尔蒙胰岛素分泌物以在贝它房间上反映能分泌的需求的一种方式激活或禁止 ERK1/2。在这和另外的规章的小径的骚乱可以导致对某些人的混乱的病原学的 ERK1/2 的贡献。 | Michael C Lawrence Arif Jivan Chunli Shao Lingling Duan Daryl Goad Elma Zaganjor Jihan Osborne Kathleen McGlynn Steve Stippec Svetlana Earnest Wei Chen Melanie H Cobb | 2008 | Cell Research2008，18，4： | 64 |
| 2 | Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease: a randomized controlled clinical study显示文摘OBJECTIVE: To assess the efficacy and safety of Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease(HFMD). METHODS: A stratified-block randomized, double-blind, parallel-controlled, and multicenter clinical trial was conducted with 360 patients in five hospitals across China: Quanzhou Children's Hospital, Shijiazhuang No. 5 Hospital, Shanghai Public Health Centre, Hunan Provincial Children's Hospital, and Kaifeng Children's Hospital. Patients were randomized into three groups with 120 in each. Group A was treated with Western Medicine, group B with Reduning injection, a Chinese herbal medicine, and group C with both Reduning injection and Western Medicine. Results were compared for treatment efficacy and safety on HFMD. The clinical outcomes were observed as follows: fever and onset time of antifebrile effect(time to bring the body temperature down ≥0.5℃ after medication); cumulative time for fever recovery(body temperature recovering to normal and lasting more than 24 h without medication); cumulative time for rash disappearance(without new rashes or ulcers appearing and the original ones fading away); and cumulative time for mouth ulcer disappearance. RESULTS: For the onset time of the antifebrile effect, there was no statistical difference between groups A and B(P>0.05) and groups B and C(P> 0.05). However, there was a statistical difference between groups A and C(P<0.05), and the effect in group C was the best. For the cumulative time for rash disappearance, there was no statistical difference between groups A and B(P>0.05). There were statistical differences between groups A and C, and groups B and C(P<0.05), and the effect in group C was the best. For the cumulative time for mouth ulcers disappearance, there were no statistical differences among the three groups(P>0.05). CONCLUSION: Reduning injection with Western Medicine for symptomatic treatment is most effective for mild HFMD. No adverse reactions were observed. | Guoliang Zhang Jie Zhao Liyun He Shiyan Yan Ziqiang Zhuo Haojie Zheng Yongping Mu Shuangjie Li Xi Zhang Jihan Huang Xiuhui Li Jianping Liu Hehe Wan Chaoyu Wei Wei Xiao | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 7 |
| 3 | Signal control through Raf: in sickness and in health显示文摘细胞外的调整信号的 kinase 1/2 (ERK1/2 ) 串联是原型表明调整很多进程,包括的增长,区别,幸存,移植,压力回答和 apoptosis 的串联的哺乳动物的激活 mitogen 的蛋白质 kinase (MAPK ) 。这看起来线性的串联怎么被调制完成特定的细胞的功能,是这块地的一个主要焦点。在这评论,我们经由 MAP3Ks 在正常和疾病状态在 ERK1/2 小径的规定描述新以及旧的调查结果。 | Jihan K Osbome Elma Zaganjor Melanie H Cobb | 2012 | Cell Research2012，22，1： | 6 |
| 4 | Xiyanping injection therapy for children with mild hand foot and mouth disease:a randomized controlled trial显示文摘OBJECTIVE: To evaluate the clinical effects of Xiyan-ping injection intervention in pediatric patients with mild hand foot and mouth disease(HFMD).METHODS: A total of 329 patients were stratified and block-randomized for symptomatic treatment of HFMD and assigned to one of the following groups: Western Medicine(group A, n = 103), Xiyanping injection(group B, n = 109), or Xiyanping injection and symptomatic treatment using Western Medicine(group C, n = 117). During the trial, fever,rash, ulcers of the mouth were observed among participants in each group before and after treatment, and conversion rates from mild to severe HFMD were measured.RESULTS: After 3-7 days' treatment, no significant differences in the conversion rates from mild to severe HFMD were observed among the three groups(P > 0.05). There was a significantly low number of patients with the onset time of antifebrile effect,vanished time of hand and foot rashes and cumulative time for the ulcers in the mouth vanished,among the three groups(P < 0.05, P < 0.01). The onset time of antifebrile effect of patients in groups B and C were markedly shorter compared with those in group A(P < 0.05, P < 0.01); there was no statically significant difference observed between groups B and C(P > 0.05). No significant differences were observed in the time for body temperature recovery among the three groups(P > 0.05). There were no significant differences in adverse effects among the three groups(P > 0.05).CONCLUSION: Xiyanping injection together with use of Western Medicine is most effective for symptomatic treatment of mild HFMD. No severe adverse reactions were observed. | Zhang Guoliang He Liyun Tang Liuping Yang Tong Zou Xinying Zhu Qingxiong Yan Shiyan Hou Yong Huang Baoju Zhao Jindong Li Yan Huang Jihan | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 4 |
| 5 | Metabolic syndrome does not affect sustained virologic response of direct-acting antivirals while hepatitis C clearance improves hemoglobin A1c显示文摘AIM To determine whether successful treatment with direc-tacting antivirals(DAA) is associated with improvements in hemoglobin A1 c(HbA1 c) and if type 2 diabetes mellitus(T2 DM) or metabolic syndrome affects sustained virologic response(SVR).METHODS We performed a retrospective analysis of all hepatitis C virus(HCV) patients at the VA Greater Los Angeles Healthcare System treated with varying DAA therapy between 2014-2016. Separate multivariable logistic regression was performed to determine predictors of HbA1 c decrease ≥ 0.5 after DAA treatment and predictors of SVR 12-wk post treatment(SVR12).RESULTS A total of 1068 patients were treated with DAA therapy between 2014-2016. The presence of T2 DM or metabolic syndrome did not adversely affect SVR12. 106 patients had both HCV and T2 DM. Within that cohort,patients who achieved SVR12 had lower mean HbA1 c pre treatment(7.35 vs 8.60,P = 0.02),and lower mean HbA1 c post-treatment compared to non-responders(6.55 vs 8.61,P = 0.01). The mean reduction in HbA1 c after treatment was greater for those who achieved SVR12 than for non-responders(0.79 vs 0.01,P = 0.03). In adjusted models,patients that achieved SVR12 were more likely to have a HbA1 c decrease of ≥ 0.5 than those that did not achieve SVR12(adjusted OR = 7.24,95%CI: 1.22-42.94). CONCLUSION In HCV patients with T2 DM,successful treatment with DAA was associated with a significant reduction in HbA1 c suggesting that DAA may have a role in improving insulin sensitivity. Furthermore,the presence of T2 DM or metabolic syndrome does not adversely affect SVR12 rates in patients treated with DAA. | Tien S Dong Elizabeth S Aby Jihane N Benhammou Jenna Kawamoto Steven-Huy Han Folasade P May Joseph R Pisegna | 2018 | World Journal of Hepatology2018，10，9： | 4 |
| 6 | Pregnancy and inflammatory bowel disease: Do we provide enough patient education? A British study of 1324 women显示文摘AIM To examine patient knowledge and factors influencing knowledge about pregnancy in British women with inflammatory bowel disease(IBD).METHODS This is a post hoc analysis of a study of female members of Crohn's and Colitis United Kingdom, aged 18-45 years who were sent an online questionnaire recording patient demographics, education, employment, marital status, and disease characteristics. Disease related pregnancy knowledge was recorded using Crohn's and colitis pregnancy knowledge score(CCPKnow).RESULTS Of 1324 responders, 776(59%) suffered from Crohn's disease, 496(38%) from ulcerative colitis and 52(4%) from IBD-uncategorised. CCPKnow scores were poor(0-7) in 50.8%, adequate(8-10) in 23.6%, good(11-13) in 17.7% and very good(≥ 14) in 7.8%. Multiple linear regression analysis revealed that higher CCPKnow scores were independently associated with higher educational achievement(P < 0.001), younger age at diagnosis(P = 0.003) and having consulted a health care professional about pregnancy and IBD(P = 0.001). CONCLUSION Knowledge was poor in 50%. Speaking with healthcare professionals was a modifiable factor associated with better knowledge. This illustrates the importance of disease related pregnancy | Isabel Carbery Jihane Ghorayeb Anna Madill Christian P Selinger | 2016 | World Journal of Gastroenterology2016，22，36： | 4 |
| 7 | Noninvasive scores for the prediction of esophageal varices and risk stratification in patients with cirrhosis显示文摘The primary purpose of variceal screening in patients with cirrhosis is to detect gastroesophageal varices at high risk of hemorrhage and implement preventative intervention(s).It was previously recommended that all patients with cirrhosis undergo initial and periodic longitudinal variceal screening via upper endoscopy.However,there has been growing interest and methods to identify patients with cirrhosis who may not have clinically significant portal hypertension and therefore be unlikely to have varices requiring intervention or benefit from upper endoscopy.Because the population of patients with compensated advanced chronic liver disease continues to grow,it is neither beneficial nor cost-effective to perform endoscopic variceal screening in all patients.Therefore,there is ongoing research into the development of methods to non-invasively risk stratify patients with cirrhosis for the presence of high-risk esophageal varices and effectively limit the population that undergoes endoscopic variceal screening.This is particularly important and timely in light of increasing healthcare reform and barriers to healthcare.In this review,we discuss and compare,with respect to test characteristics and clinical applicability,the available methods used to noninvasively predict the presence of esophageal varices. | Saroja Bangaru Jihane N Benhammou James H Tabibian | 2020 | World Journal of Hepatology2020，12，11： | 3 |
| 8 | Association between physical activity and digestive-system cancer: An updated systematic review and meta-analysis显示文摘Background:Physical activity(PA)may have an impact on digestive-system cancer(DSC)by improving insulin sensitivity and anticancer immune function and by reducing the exposure of the digestive tract to carcinogens by stimulating gastrointestinal motility,thus reducing transit time.The current study aimed to determine the effect of PA on different types of DSC via a systematic review and meta-analysis.Methods:In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,we searched for relevant studies in PubMed,Embase,Web of Science,Cochrane Library,and China National Knowledge Infrastructure.Using a random effects model,the relationship between PA and different types of DSC was analyzed.Results:The data used for meta-analysis were derived from 161 risk estimates in 47 studies involving 5,797,768 participants and 55,162 cases.We assessed the pooled associations between high vs.low PA levels and the risk of DSC(risk ratio(RR)=0.82,95%confidence interval(95%CI):0.79-0.85),colon cancer(RR=0.81,95%CI:0.76-0.87),rectal cancer(RR=0.88,95%CI:0.80-0.98),colorectal cancer(RR=0.77,95%CI:0.69-0.85),gallbladder cancer(RR=0.79,95%CI:0.64-0.98),gastric cancer(RR=0.83,95%CI:0.76-0.91),liver cancer(RR=0.73,0.60-0.89),oropharyngeal cancer(RR=0.79,95%CI:0.72-0.87),and pancreatic cancer(RR=0.85,95%CI:0.78-0.93).The findings were comparable between case-control studies(RR=0.73,95%CI:0.68-0.78)and prospective cohort studies(RR=0.88,95%CI:0.80-0.91).The meta-analysis of 9 studies reporting low,moderate,and high PA levels,with 17 risk estimates,showed that compared to low PA,moderate PA may also reduce the risk of DSC(RR=0.89,95%CI:0.80-1.00),while compared to moderate PA,high PA seemed to slightly increase the risk of DSC,although the results were not statistically significant(RR=1.11,95%CI:0.94-1.32).In addition,limited evidence from 5 studies suggested that meeting the international PA guidelines might not significantly reduce the risk of DSC(RR=0.96,95%CI:0.91-1.02).Conclusion:Compared to previous research,this systematic review has provided more comprehensive information about the inverse relationship between PA and DSC risk.The updated evidence from the current meta-analysis indicates that a moderate-to-high PA level is a common protective factor that can significantly lower the overall risk of DSC.However,the reduction rate for specific cancers may vary.In addition,limited evidence suggests that meeting the international PA guidelines might not significantly reduce the risk of DSC.Thus,future studies must be conducted to determine the optimal dosage,frequency,intensity,and duration of PA required to reduce DSC risk effectively. | Fangfang Xie Yanli You Jihan Huang Chong Guan Ziji Chen Min Fang Fei Yao Jia Han | 2021 | Journal of Sport and Health Science2021，10，1： | 3 |
| 9 | Serial blood concentration of polyethoxylated tallow amine and clinical presentations in acute herbicide poisoning显示文摘Most commercially available herbicides contain surfactants as co-formulants to increase adhesion and absorption by plant leaves.Ethoxylated amines,one of the most used surfactants,are non-ionic and derived from animal fats.They represent a class of surfactants with similar structural features,including polyethoxylated tallow amine(POEA).POEA is widely used in glyphosate,glufosinate-containing herbicides.In 2015,the European Food Safety Society(EFSA)concluded that POEA was more toxic than glyphosate when tested in glyphosate-based formulations.[1]They also attributed the poisoning following ingestion by humans to the presence of POEA. | Jungsoo Park Sun Cheun Kim Youngjoon Jeon Yong Chul Cho Changshin Kang Yeonho You Hong Joon Ahn Seung Ryu Jihan Lee Wonjoon Jeong | 2022 | World Journal of Emergency Medicine2022，13，4： | 2 |
| 10 | Preharvest application of 1-methylcyclopropene and Ethephon altered cuticular wax biosynthesis and fruit quality of apples at harvest and during cold storage显示文摘To investigate the roles of Harvista(a sprayable 1-methylcyclopropene,1-MCP,available component is 150 g·hm^(-2))and Ethephon(1 mL·L^(-1))applied at preharvest in apple(Malus domestica Borkh.'Golden Delicious')fruit cuticular wax biosynthesis,the expression of genes related to fruit cuticular wax biosynthesis and ethylene biosynthesis and signaling,ethylene production rate,respiration rate,wax constituents and structure,and fruit quality were determined at harvest and during cold storage.The results showed that 1-MCP inhibited the expression levels of ethylene biosynthesis and signaling-related genes,decreased fruit ethylene production,and inhibited the expression of Md LACS1,Md CER6,Md CER4 and Md WSD1,which resulted in decreases in alcohols,acids,and esters content in fruit cuticular wax.1-MCP also reduced fruit dropping rate from 17.17%to 12%;maintained fruit firmness,soluble solids,titratable acidity during cold storage;showed about as one fifth in the total length and one third in the widest width of wax crack as that in control at harvest.In contrast,Ethephon produced the opposite effects.In conclusion,1-MCP inhibited fruit ethylene biosynthesis and signaling,and influenced fruit cuticular wax biosynthesis.Thus,the fruit cuticular wax constituents and structure was altered,and the fruit quality were maintained at harvest and during cold storage.The results provide a new technology for improving apple fruit harvest and postharvest quality by preharvest application of sprayable 1-MCP. | Fujun Li Xinyue Zhang Jihan Wang Yaping Jiang Xinhua Zhang Xiaoan Li | 2022 | Horticultural Plant Journal2022，8，2： | 2 |
| 11 | Investigation on the photo-induced de-oxygenation process of myoglobin in aqueous solution by use of fluorescence spectroscopy显示文摘A photo-induced de-oxygenation process of myoglobin (Mb) in aqueous solution was investigated by use of fluorescence spectroscopy. The spectra are characterized by the fluorescence intensity declining gradually after each scan,and the decay of fluorescence intensity being significant in each scan,which is assigned to the release of oxygen from the opening of the heme-pockets induced by illumination. More illumination will cause more release of oxygen; if the temperature of an Mb solution is increased when it is illuminated,the rate of de-oxygenation will be higher. It was found that ligand-oxygen in Fe-porphyrin could be removed from Mb by nitrogen. This indicates that the interac-tion between oxy-Mb and other different gases can be tested by the method of fluorescence spectros-copy. In addition,fluorescence spectroscopy can be employed to probe the energy transfer between Fe-porphyrin and tryptophan or tyrosine in Mb molecules. | MA JunYan ZHENG XueFang TANG Qian MA Jing GAO DaBin HU JiHan | 2008 | Science China Chemistry2008，51，5： | 2 |
| 12 | Sox2 expression defines a heterogeneous population of neurosphere‐forming cells in the adult murine brain显示文摘 | Christine Y.Brazel Tobi L.Limke Jihan K.Osborne TakumiMiura JingliCai LarysaPevny Mahendra S.Rao | 2005 | Aging Cell2005，，4： | 1 |
| 13 | Integrating INS sensors with GPS measurements for continuous estimation of vehicle sideslip,roll,and tire comering stiffness显示文摘 | DAVID M BEVLY JIHAN RYU CHRISTIAN GERDES J | 2006 | IEEE Transactions on intelligent transportation system2006，4，7： | 1 |
| 14 | The Relationships of Coping, Negative Thinking, Life Satisfaction, Social Support, and Selected Demographics With Anxiety of Young Adult College Students显示文摘 | Jihan S. R. Mahmoud Ruth “Topsy” Staten Terry A. Lennie Lynne A. Hall | 2015 | J Child Adolesc Psychiatr Nurs2015，，2： | 1 |
| 15 | FDI影响发展中东道国股市发展的实证分析——以摩洛哥卡萨布兰卡证券交易所为例显示文摘研究外商直接投资(FDI)对发展中东道国股市发展的影响,对于促进发展中国家经济健康发展具有重要意义。本文以摩洛哥卡萨布兰卡证券交易所为例进行实证检验,以股市发展为被解释变量,以FDI为解释变量,以国内储蓄和汇率为控制变量,依据1993—2013年的时间序列数据,采用多元回归分析(OLS)方法,探讨FDI与股市发展之间的关系。结果表明,FDI与卡萨布兰卡股市发展之间负相关,而国内储蓄和汇率与股市发展之间则正相关。 | Jihane Aayale 胡燕 | 2017 | 当代经济2017，34，10： | 1 |
| 16 | Risk factors for pulmonary hemorrhage following ultrasound-guided percutaneous biopsy of peripheral lung lesions显示文摘Lung cancer is a leading cause of cancer-associated death worldwide,and the morbidity and mortality of lung cancer have increased over the past few decades.Imaging techniques are limited in providing a definitive diagnosis,which requires a tissue sample for pathologic evaluation.Adenocarcinomas account for 40%of all lung cancers and tend to occur peripherally in the lung,[1]making them amenable to ultrasound-guided percutaneous biopsy for pathologic diagnosis.Peripheral lung cancers are usually close to the pleura,enabling ultrasound to clearly show the internal structure of the lesion,its blood supply,and its relationship with surrounding tissues.Although ultrasound-guided transthoracic cutting needle biopsy is considered a safe and efficient method for obtaining a definitive pathologic diagnosis,the technique is associated with several complications,including air embolism,pneumothorax,pulmonary hemorrhage,and tumor seeding.[1]Severe hemoptysis can necessitate endobronchial tamponade,arterial embolization,or surgery and can be life-threatening.[2]Data regarding the risk factors for pulmonary hemorrhage after ultrasound-guided percutaneous lung biopsy are scarce. | Qing Li Zhixian Li Xinhong Liao Li Zhang Lei Wang Shi Tang Xiyue Yang Jihan Wang | 2022 | Chinese Medical Journal2022，，1： | 1 |
| 17 | Integrating INS sensors with GPS measurements for continuous estimation of vehicle sideslip,roll and tire cornering stiffness显示文摘 | BEVLY David M RYU Jihan | 2006 | IEEE Transactions on Intelligent Transportation Systems2006，7，4： | 1 |
| 18 | Evolutionary and Functional Analysis of Celiac Risk Loci Reveals SH2B3 as a Protective Factor against Bacterial Infection显示文摘 | Alexandra Zhernakova Clara C. Elbers Bart Ferwerda Jihane Romanos Gosia Trynka Patrick C. Dubois Carolien G.F. de Kovel Lude Franke Marije Oosting Donatella Barisani Maria Teresa Bardella Leo A.B. Joosten Paivi Saavalainen David A. van Heel Carlo Catassi | 2010 | The American Journal of Human Genetics2010，，6： | 1 |
| 19 | Allele and haplotype frequencies for HLA-DQ in Iranian celiac disease patients显示文摘AIM:To assess the distribution of human leukocyteantigen(HLA)-DQ2 and-DQ8 in Iranian celiac disease(CD)patients and compare them to healthy Iranian controls.METHODS:To predict the HLA-DQA1 and-DQB1genes,we used six previously reported HLA-tagging single nucleotide polymorphism to determine HLA genotypes in 59 Iranian patients with‘biopsy-confirmed’CD and in 151 healthy Iranian individuals.To test the transferability of the method,50 cases and controls were also typed using a commercial kit that identifies individual carriers of DQ2,DQ7 and DQ8 alleles.RESULTS:In this pilot study 97%of CD cases(n=57)and 58%of controls(n=87)were carriers of HLADQ2 and/or HLA-DQ8 heterodimers,either in the homozygous or heterozygous state.The HLA-DQ pattern of these 57 CD patients:heterozygous DQ2.2(n=14)and homozygous DQ2.2(n=1),heterozygous DQ2.5(n=33)and homozygous DQ2.5(n=8),heterozygous DQ8(n=13)and homozygous DQ8(n=2).Two CD patients were negative for both DQ2 and DQ8(3%).CONCLUSION:The prevalence of DQ8 in our CD population was higher than that reported in other populations(25.4%).As reported in other populations,our results underline the primary importance of HLA-DQ alleles in the Iranian population’s susceptibility to CD. | Mohammad Rostami-Nejad Jihane Romanos Kamran Rostami Azita Ganji Mohammad Javad Ehsani-Ardakani Ali-Reza Bakhshipour Homayoun Zojaji Seyed Reza Mohebbi Mohammad-Reza Zali Cisca Wijmenga | 2014 | World Journal of Gastroenterology2014，20，20： | 1 |
| 20 | Aberrant expression of microRNAs in gastric cancer and biological significance of miR-574-3p显示文摘 | Yingying Su Zhaohui Ni Guoqing Wang Juan Cui Chengguo Wei Jihan Wang Qing Yang Ying Xu Fan Li | 2012 | International Immunopharmacology2012，，4： | 1 |
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