|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement显示文摘Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China.Among the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 died.And among these cases,a total of 28 children aged from 1 month to 17 years have been reported in China.For standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus statement.This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections.The present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children. | Kunling Shen Yonghong Yang Tianyou Wang Dongchi Zhao Yi Jiang Runming Jin Yuejie Zheng Baoping Xu Zhengde Xie Likai Lin Yunxiao Shang Xiaoxia Lu Sainan Shu Yan Bai Jikui Deng Min Lu Leping Ye Xuefeng Wang Yongyan Wang Liwei Gao | 2020 | World Journal of Pediatrics2020，16，3： | 56 |
| 2 | Green fluorescent protein (GFP) as a vital marker for studying the interaction of Phytophthora sojae and soybean显示文摘Transgenic Phytophthora sojae strains that produce green fluorescent protein (GFP) were obtained after stable DNA integration using the Hsp70 promoter and the Ham34 terminator of Bremia lactucae. The expression of GFP during different developmental stages of P. sojae was observed using fluorescent microscopy. Based on this reporter system, the histopathologic events caused by the pathogen in soybean leaves, hypocotyls and roots were monitored. Meanwhile, the difference in resistance between different soybean cultivars against P. sojae was analyzed microscopically in roots. The results indicate that GFP can be stably expressed in zoosporangia, zoospores, cysts, hyphae and oospores of P. sojae. Using the GFP marker, the infecting pathogens in leaves, hypocotyls and roots of host could be distinctly visualized. The germ tube length of cysts germinating on the roots of resistant cultivar Nannong 8848 was longer than that on the roots of susceptible cultivar Hefeng 35. These results show for the first time that this eukaryotic reporter can be used in P. sojae as a stable and vital marker, allowing the study of genetics of this hemibiotrophic pathogen. | CHEN XiaoRen CHENG BaoPing WANG XinLe DONG SuoMeng WANG YongLin ZHENG XiaoBo WANG YuanChao | 2009 | Chinese Science Bulletin2009，54，16： | 3 |
| 3 | Derivation and characterization of human embryonic stem cell lines from poor quality embryos显示文摘Poor quality embryos discarded from in vitro fertilization (IVF) laboratories are good sources for deriving human embryonic stem cell (hESC) lines. In this study, 166 poor quality embryos donated from IVF centers on day 3 were cultured in a blastocyst medium for 2 days, and 32 early blastocysts were further cultured in a blastocyst optimum culture medium for additional 2 days so that the inner cell masses (ICMs) could be identified and isolated easily. The ICMs of 17 blastocysts were isolated by a mechanical method, while those of the other 15 blastocysts were isolated by immunosurgery. All isolated ICMs were inoculated onto a feeder layer for subcultivation. The rates of ICM at- tachment, primary ICM colony formation and the efficiency of hESC derivation were similar between the ICMs isolated by the two methods (P>0.05). As a result, four new hESC lines were established. Three cell lines had normal karyotypes and one had an unbalanced Robertsonian translocation. All cell lines showed normal hESC characteristics and had the differentiation ability. In conclusion, we established a stable and effective method for hESC isolation and culture, and it was confirmed that the mechanical isolation was an effective method to isolate ICMs from poor embryos. These results further indicate that hESC lines can be derived from poor quality embryos discarded by IVF laboratories. | Weiqiang Liu, Yifei Yin, Xiaolin Long, Yumei Luo, Yonghua Jiang, Wenhong Zhang, Hongzi Du, Shaoying Li, Yuhong Zheng, Qing Li, Xinjie Chen, Baoping Liao, Guohong Xiao, Weihua Wang, Xiaofang Sun Guangzhou Key Laboratory of Reproductive and Genetics Institute of Gynecology and Obstetrics, The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China | 2009 | Journal of Genetics and Genomics2009，36，4： | 3 |
| 4 | Heavy ion and X-ray irradiation alter the cytoskeleton and cytomechanics of cortical neurons显示文摘Heavy ion beams with high linear energy transfer exhibit more beneficial physical and biological performance than conventional X-rays, thus improving the potential of this type of radiotherapy in the treatment of cancer. However, these two radiotherapy modalities both cause inevitable brain injury. The objective of this study was to evaluate the effects of heavy ion and X-ray irradiation on the cytoskeleton and cytomechanical properties of rat cortical neurons, as well as to determine the potential mechanism of neuronal injury after irradiation. Cortical neurons from 30 new-born mice were irradiated with heavy ion beams at a single dose of 2 Gy and X-rays at a single dose of 4 Gy; subsequent evaluation of their effects were carried out at 24 hours after irradiation. An immunofluorescence assay showed that after irradiation with both the heavy ion beam and X-rays, the number of primary neurons was significantly decreased, and there was evidence of apoptosis. Radiation-induced neuronal injury was more apparent after X-irradiation. Under atomic force microscopy, the neuronal membrane appeared rough and neuronal rigidity had increased. These cell changes were more apparent following exposure to X-rays. Our findings indicated that damage caused by heavy ion and X-ray irradiation resulted in the structural distortion and rearrangement of the cytoskeleton, and affected the cytomechanical properties of the cortical neurons. Moreover, this radiation injury to normal neurons was much severer after irradiation with X-rays than after heavy ion beam irradiation. | Yuting Du Jie Zhang Qian Zheng Mingxin Li Yang Liu Baoping Zhang Bin Liu Hong Zhang Guoying Miao | 2014 | Neural Regeneration Research2014，9，11： | 3 |
| 5 | Multi-fluid Eulerian simulation of binary particles mixing and gas–solids contacting in high solids-flux downer reactor equipped with a lateral particle feeding nozzle显示文摘The performance of binary particles mixing and gas-solids contacting,which is considered qualitatively to have a significant influence on the heat transfer in internal heated circulating fluidized beds,is carefully investigated by means of a numerical approach in the newly developed high solids-flux downer lignite pyrolyzer(φ0.1 m×6.5 m).Since binary particles are used in this system,a reasonably validated 3 D,transient,multi-fluid model,in which three heat transfer modes relating to the convection,conduction and radiation are considered,is adopted to simulate the flow behavior,temperature profiles as well as volatile contents.The simulation results showed that the solids stream impinges the left wall surface initially and turns towards the right wall in the further downward direction and then shrinks during this process resulting in that the solids concentrate a little more at the central region.In the further downward section of the downer,the particle flow disperses near the right wall and develops uniformly.Meanwhile,the coal phase is slowly heated in the downer and it is found that most of the heat absorbed by the coal is from the convection heat transfer mode.To explore the heat transfer mechanism more quantitatively,two indexes(mixing index and contacting index)are proposed,and it is found that the mixing index initially increased fast and later remained at a relatively flat state.For the contact index,it shows a trend with a first rising and then falling,finally rising continuously.Also,it is found that the convection heat transfer is closely correlated to the contacting status of gas-coal which indicates that the improving of the gas-coal contacting efficiency should be an effective way to strengthen the coal particle heating process. | Qiang Zheng Jingxuan Yang Wenhao Lian Baoping Zhang Xueer Pan Zhonglin Zhang Xiaogang Hao Guoqing Guan | 2021 | Chinese Journal of Chemical Engineering2021，34，7： | 2 |
| 6 | STK 11 Domain XI Mutations: Candidate Genetic Drivers Leading to the Development of Dysplastic Polyps in P eutz– J eghers Syndrome显示文摘 | Zhiqing Wang Baoping Wu Rebecca A. Mosig Yulan Chen Fei Ye Yali Zhang Wei Gong Lanbo Gong Fei Huang Xinying Wang Biao Nie Haoxuan Zheng Miao Cui Yadong Wang Juan Wang Chudi Chen Alexandros D. Polydorides David Y. Zhang John A. Martignetti Bo Jiang | 2014 | Human Mutation2014，，7： | 1 |
| 7 | Polariton lasing in InGaN quantum wells at room temperature显示文摘In this paper,we report the exciton polaritons in both positive and negative detuning micro cavities based on InGaN multi-quantum wells(MQWs)and the first polariton lasing in InGaN/GaN MQWs at room temperature by utilizing a 4.5λFabry-Perot(F-P)cavity with double dielectric distributed Bragg reflectors(DBRs).Double thresholds corresponding respectively to polariton lasing and photonic lasing are observed along with half-width narrowing and peak blue-shifts.The threshold of polariton lasing is about half of the threshold of photonic lasing.Our results paved a substantial way for ultra-low threshold lasers and room temperature Bose-Einstein Condensate(BEC)in nitride semiconductors. | Jinzhao Wu Hao Long Xiaoling Shi Song Luo Zhanghai Chen Zhechuan Feng Leiying Ying Zhiwei Zheng Baoping Zhang | 2019 | Opto-Electronic Advances2019，2，12： | 1 |
| 8 | Highly durable machine-learned waterproof electronic glove based on low-cost thermal transfer printing for amphibious wearable applications显示文摘Gesture recording,modeling,and understanding based on a robust electronic glove(E-glove)are of great significance for efficient human-machine cooperation in harsh environments.However,such robust edge-intelligence interfaces remain challenging as existing E-gloves are limited in terms of integration,waterproofness,scalability,and interface stability between different components.Here,we report on the design,manufacturing,and application scenarios for a waterproof E-glove,which is of low cost,lightweight,and scalable for mass production,as well as environmental robustness,waterproofness,and washability.An improved neural network architecture is proposed to implement environment-adaptive learning and inference for hand gestures,which achieves an amphibious recognition accuracy of 100%in 26 categories by analyzing 2,600 hand gesture patterns.We demonstrate that the E-glove can be used for amphibious remote vehicle navigation via hand gestures,potentially opening the way for efficient human-human and human-machine cooperation in harsh environments. | Shengshun Duan Jiayi Wang Yong Lin Jianlong Hong Yucheng Lin Yier Xia Yinghui Li Di Zhu Wei Lei Wenming Su Baoping Wang Zheng Cui Wei Yuan Jun Wu | 2023 | Nano Research2023，16，4： | 0 |
| 9 | Epidemiological characteristics and clinical manifestations of pediatric patients with COVID-19 in China: A multicenter retrospective study显示文摘Importance:The Coronavirus disease 2019(COVID-19)global pandemic poses a considerable challenge for pediatricians.Objective:This study aimed to identify the epidemiological characteristics and clinical features of pediatric patients with COVID-19 in China.Methods:This multicenter retrospective study included pediatric patients from 46 hospitals in China,covering 12 provinces and two municipalities.Epidemiological,demographic,clinical,laboratory,treatment,and outcome data were analyzed.Results:In total,211 pediatric patients with COVID-19 were included in this study.The median age was 7.0 years(range:22 days to 18 years).Approximately 16.3%of the patients exhibited asymptomatic infections,23.0%had upper respiratory tract infections,and 60.7%had pneumonia,including two with severe pneumonia and one with critical illness.Approximately 78.7%of the pediatric patients occurred in familial clusters.The most three common symptoms or signs at onset in children with COVID-19 were fever(54.5%),cough(49.3%),and pharyngeal congestion(20.8%).Only 17.6%of the patients presented with decreased lymphocyte count,whereas 13.6%had increased lymphocyte count.Among the patients with pneumonia who exhibited abnormal chest computed tomography findings,18.2%(23/127)of the patients had no other symptoms.Generally,the chest radiographs showed abnormalities that affected both lungs(49.6%);ground-glass opacity(47.2%)was the most common manifestation.The cure and improvement rates were 86.7%(183/211)and 13.3%(28/211),respectively.Only one patient with an underlying condition received invasive mechanical ventilation;none of the patients died.Interpretation:Similar to adults,children of all age groups are susceptible to COVID-19.Fortunately,most pediatric patients have mild symptoms or remain asymptomatic,despite the high incidence of pneumonia.Decreased proportions of white blood cells and lymphocytes are less frequent in children than in adults. | Yan Bai Liwei Gao Xianfeng Wang Lili Zhong Jingfeng Li Shenggang Ding Yuejie Zheng Jun Liu Yuxia Cui Lina Wang Mingfeng Han Jun Liu Xinping Jiang Min Jiang Junhua Li Ning Chen Yunxiao Shang Hourong Zhou Yi Xu Gen Lu Xing Chen Jizhi Xu Qihong Fan Yu Tang Jiang Wu Cen Li Xiaoxiang Yang Chunxi Chen Yonghong Yang Gary Wing-Kin Wong Adong Shen Tianyou Wang Runming Jin Baoping Xu Kunling Shen | 2021 | Pediatric Investigation2021，5，3： | 0 |
| 10 | dbSCI:A manually curated database of SARS-CoV-2 inhibitors for COVID-19显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the pathogen of the ongoing coronavirus disease 2019(COVID-19)global pandemic.Here,by centralizing published cell-based experiments,clinical trials,and virtual drug screening data from the NCBI PubMed database,we developed a database of SARS-CoV-2 inhibitors for COVID-19,dbSCI,which includes 234 SARS-CoV-2 inhibitors collected from publications based on cell-based experiments,81 drugs of COVID-19 in clinical trials and 1305 potential SARS-CoV-2 inhibitors from bioinformatics analyses.dbSCI provides four major functions:(1)search the drug target or its inhibitor for SARS-CoV-2,(2)browse target/inhibitor information collected from cell experiments,clinical trials,and virtual drug screenings,(3)download,and(4)submit data.Each entry in dbSCI contains 18 types of information,including inhibitor/drug name,targeting protein,mechanism of inhibition,experimental technique,experimental sample type,and reference information.In summary,dbSCI provides a relatively comprehensive,credible repository for inhibitors/drugs against SARS-CoV-2 and their potential targeting mechanisms and it will be valuable for further studies to control COVID-19. | QIANG WANG GUO ZHAO LONGXIANG XIE XUAN LI XIXI YU QIONGSHAN LI BAOPING ZHENG ZULIPINUER WUSIMAN XIANGQIAN GUO | 2023 | BIOCELL2023，47，2： | 0 |
| 11 | Effect of grain refinement on cutting force of difficult-to-cut metals in ultra-precision machining显示文摘The nickel-based superalloy Inconel 718 is treated with Coupled Ultrasonic and Electric Pulse Treatment(CUEPT),and the surface grain is refined from the average size of 9550.0 nm to287.9,216.3,150.5,126.3,25.8 nm by different effective treatment currents,respectively.The ultraprecision turning experiments are carried out on the processed workpiece after CUEPT.The experimental results show that the average cutting force increases with the decrease of surface grain size.Moreover,a mathematical model that can describe the relationship between grain size and cutting force is established,and the calculated results match the experimental results well.The calculated results also indicate that the variation of cutting force caused by the same variation of grain size decreases as the degree of grain refinement increases.Finally,the influence mechanism of grain refinement on cutting force is analyzed.The improvement of stability of grain boundaries and the increase of number of grain boundaries cause the increase of cutting force after grain refinement. | Renjie JI Qian ZHENG Yonghong LIU Hui JIN Fan ZHANG Shenggui LIU Baokun WANG Shuaichen LU Baoping CAI Xiaopeng LI | 2022 | Chinese Journal of Aeronautics2022，35，3： | 0 |
| 12 | Achieving ultra-stable and superior electricity generation by integrating transistor-like design with lubricant armor显示文摘Extensive work have been done to harvest untapped water energy in formats of raindrops,flows,waves,and others.However,attaining stable and efficient electricity generation from these low-frequency water kinetic energies at both individual device and large-scale system level remains challenging,partially owing to the difficulty in designing a unit that possesses stable liquid and charge transfer properties,and also can be seamlessly integrated to achieve preferential collective performances without the introduction of tortuous wiring and redundant node connection with external circuit.Here,we report the design of water electricity generators featuring the combination of lubricant layer and transistor-like electrode architecture that endows enhanced electrical performances in different working environments.Such a design is scalable in manufacturing and suitable for facile integration,characterized by significant reduction in the numbers of wiring and nodes and elimination of complex interfacing problems,and represents a significant step toward large-scale,real-life applications. | Yuxin Song Wanghuai Xu Yuan Liu Huanxi Zheng Miaomiao Cui Yongsen Zhou Baoping Zhang Xiantong Yan Lili Wang Pengyu Li Xiaote Xu Zhengbao Yang Zuankai Wang | 2022 | The Innovation2022，3，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员