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| 1 | The Chrysanthemum nankingense Genome Provides Insights into the Evolution and Diversification of Chrysanthemum Flowers and Medicinal Traits显示文摘The Asteraceae (Compositae),a large plant family of approximately 24 000-35 000 species,accounts for^10% of all angiosperm species and contributes a lot to plant diversity.The most representative members of the Asteraceae are the economically important chrysanthemums (Chrysanthemum L.)that diversified through reticulate evolution.Biodiversity is typically created by multiple evolutionary mechanisms such as wholegenome duplication 0NGD)or polyploidization and locally repetitive genome expansion.However,the lack of genomic data from chrysanthemum species has prevented an in-depth analysis of the evolutionary mechanisms involved in their diversification.Here,we used Oxford Nanopore long-read technologyto sequence the diploid Chrysanthemum nankingense genome,which represents one of the progenitor genomes of domesticated chrysanthemums.Our analysis revealed that the evolution of the C.nankingense genome was driven by bursts of repetitive element expansion and WGD events including a recentWGD that distinguishes chrysanthemum from sunflower,which diverged from chrysanthemum approximately 38.8 million years ago.Variations of ornamental and medicinal traits in chrysanthemums are linked to the expansion of candidate gene families by duplication events including paralogous gene duplication.Collectively,our study of the assembled reference genome offers new knowledge and resources to dissect the history and pattern of evolution and diversification of chrysanthemum plants,and also to accelerate their breeding and improvement. | Chi Song Yifei Liu Aiping Song Gangqiang Dong Hongbo Zhao Wei Sun Shyam Ramakrishnan Ying Wang Shuaibin Wang Tingzhao Li Yan Niu Jiafu Jiang Bin Dong Ye Xia Sumei Chen Zhigang Hu Fadi Chen Shilin Chen | 2018 | Molecular Plant2018，11，12： | 24 |
| 2 | Genome-wide association study identifies favorable SNP alleles and candidate genes for waterlogging tolerance in chrysanthemums显示文摘Chrysanthemums are sensitive to waterlogging stress,and the development of screening methods for tolerant germplasms or genes and the breeding of tolerant new varieties are of great importance in chrysanthemum breeding.To understand the genetic basis of waterlogging tolerance(WT)in chrysanthemums,we performed a genome-wide association study(GWAS)using 92,811 single nucleotide polymorphisms(SNPs)in a panel of 88 chrysanthemum accessions,including 64 spray cut and 24 disbud chrysanthemums.The results showed that the average MFVW(membership function value of waterlogging)of the disbud type(0.65)was significantly higher than that of the spray type(0.55)at P<0.05,and the MFVW of the Asian accessions(0.65)was significantly higher than that of the European accessions(0.48)at P<0.01.The GWAS performed using the general linear model(GLM)and mixed linear model(MLM)identified 137 and 14 SNP loci related to WT,respectively,and 11 associations were commonly predicted.By calculating the phenotypic effect values for 11 common SNP loci,six highly favorable SNP alleles that explained 12.85—21.85%of the phenotypic variations were identified.Furthermore,the dosage-pyramiding effects of the favorable alleles and the significant linear correlations between the numbers of highly favorable alleles and phenotypic values were identified(r2=0.45;P<0.01).A major SNP locus(Marker6619-75)was converted into a derived cleaved amplified polymorphic sequence(dCAPS)marker that cosegregated with WT with an average efficiency of 78.9%.Finally,four putative candidate genes in the WT were identified via quantitative real-time PCR(qRT-PCR).The results presented in this study provide insights for further research on WT mechanisms and the application of molecular marker-assisted selection(MAS)in chrysanthemum WT breeding programs. | Jiangshuo Su Fei Zhang Xinran Chong Aiping Song Zhiyong Guan Weimin Fang Fadi Chen | 2019 | Horticulture Research2019，6，1： | 9 |
| 3 | The complete mitochondrial genome sequence of Geisha distinctissima (Hemiptera: Flatidae) and comparison with other hemipteran insects显示文摘艺妓 distinctissima 的 mitochondrial 染色体(mitogenome ) 的完全的核苷酸顺序(半翅类:Flatidae ) 在这研究被决定了。染色体是有 75.1% 的一个全部的 A+T 内容的 15,971 bp 的一个圆形的分子。基因内容,顺序,和结构与果蝇 yakuba 染色体结构和假设祖先的节肢动物染色体安排一致。所有 13 编码蛋白质的基因被观察有一通常认为,是的 inframe ATR 蛋氨酸或 ATT 异白氨酸 codons 开始信号。正规 TAA 和标签结束 codons 在九编码蛋白质的基因,并且留下被发现四(cox1, atp6, cox3,和 nad4 ) 有不完全的结束 codons。所有转移 RNA (tRNAs ) 的反密码子与在 D 观察的那些相同。yakuba 和 Philaenus spumarius,和罐头除了 tRNASer (AGN ) 在典型四叶苜蓿形的立体道路交叉点结构形式被合拢。主要非编码的区域(A +T 富有的区域或通常认为的控制区域) 在小 ribosomal 之间,子单元和 tRNAIle 基因包括重复区域的二个集合。第一个重复区域由重复联合起来在 srRNA 基因结束附近定位了的直接 152-bp 组成,并且第二个重复区域是向 tRNAIle 定位的 19 bp 的一个直接重复单位镇静基因。越过顺序的基因可变性的比较建议基因内容和 G 的安排。distinctissima mitogenome 类似于另外的 hemipteran 昆虫。 | Nan Song Aiping Liang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，3： | 7 |
| 4 | Effects of long-term fertilization with different substitution ratios of organic fertilizer on paddy soil显示文摘In recent years,the abuse of chemical fertilizers has caused numerous environmental problems,such as soil acidification and compaction.Replacing chemical fertilizers with organic fertilizers can effectively alleviate these problems.However,the effects of alternative organic fertilizers remain unclear.To explore the effects of organic fertilizer substitution on rice yield and paddy soil physicochemical properties and bacterial community structure,we conducted a 5-year experiment using different proportions of organic fertilizer substitution in a double-cropping rice field in Jiangxi,China.Our results showed that replacing chemical fertilizers with organic fertilizers can reduce soil acidification,increase soil organic matter content,nutrient contents,and enzyme activities,improve soil physicochemical properties and microbial community,and enhance soil metabolism.Appropriate organic substitution also had positive effects on rice production.These findings enhance our understanding of the effects of different alternative organic fertilization methods and have important theoretical significance for the promotion of the use of organic fertilizers in the future. | Weifeng SONG Aiping SHU Jiai LIU Wenchong SHI Mingcong LI Wenxue ZHANG Zuzhang LI Guangrong LIU Fusheng YUAN Shuxin ZHANG Zengbing LIU Zheng GAO | 2022 | Pedosphere2022，32，4： | 7 |
| 5 | Computational analysis of antigenic epitopes of avian influenza A (H7N9) viruses显示文摘Influenza virus can rapidly change its antigenicity, via mutation in the hemagglutinin(HA) protein, to evade host immunity. The emergence of the novel human-infecting avian H7N9 virus in China has caused widespread concern. However, evolution of the antigenicity of this virus is not well understood. Here, we inferred the antigenic epitopes of the HA protein from all H7 viruses, based on the five well-characterized HA epitopes of the human H3N2 virus. By comparing the two major H7 phylogenetic lineages, i.e., the Eurasian lineage and the North American lineage, we found that epitopes A and B are more frequently mutated in the Eurasian lineage, while epitopes B and C are more frequently mutated in the North American lineage. Furthermore, we found that the novel H7N9 virus(derived from the Eurasian lineage) isolated in China in the year 2013, contains six frequently mutated sites on epitopes that include site 135, which is located in the receptor binding domain. This indicates that the novel H7N9 virus that infects human may already have been subjected to gradual immune pressure and receptor-binding variation. Our results not only provide insights into the antigenic evolution of the H7 virus but may also help in the selection of suitable vaccine strains. | LIU Mi SONG TingRui HUA Sha WU AiPing JIANG TaiJiao | 2015 | Science China(Life Sciences)2015，58，7： | 6 |
| 6 | Overexpression of CmMYB15 provides chrysanthemum resistance to aphids by regulating the biosynthesis of lignin显示文摘MYB transcription factors are widely involved in the development of and physiological processes in plants.Here,we isolated the chrysanthemum R2R3-MYB family transcription factor CmMYB15,a homologous gene of AtMYB15.It was demonstrated that CmMYB15 expression was induced by aphids and that CmMYB15 could bind to AC elements,which usually exist in the promoter of lignin biosynthesis genes.Overexpression of CmMYB15 in chrysanthemum enhanced the resistance of aphids.Additionally,the content of lignin and the expression of several lignin biosynthesis genes increased.In summary,the results indicate that CmMYB15 regulates lignin biosynthesis genes that enhance the resistance of chrysanthemum to aphids. | Cong An Liping Sheng Xinping Du Yinjie Wang Yi Zhang Aiping Song Jiafu Jiang Zhiyong Guan Weimin Fang Fadi Chen Sumei Chen | 2019 | Horticulture Research2019，6，1： | 6 |
| 7 | Regulation of flowering time in chrysanthemum by the R2R3 MYB transcription factor CmMYB2 is associated with changes in gibberellin metabolism显示文摘The switch from vegetative growth to reproductive growth is a key event in the development of a plant.Here,the product of the chrysanthemum gene CmMYB2,an R2R3 MYB transcription factor that is localized in the nucleus,was shown to be a component of the switching mechanism.Plants engineered to overexpress CmMYB2 flowered earlier than did wild-type plants,while those in which CmMYB2 was suppressed flowered later.In both the overexpression and RNAi knockdown plants,a number of genes encoding proteins involved in gibberellin synthesis or signaling,as well as in the response to photoperiod,were transcribed at a level that differed from that in the wild type.Both yeast two-hybrid and bimolecular fluorescence complementation assays revealed that CmMYB2 interacts with CmBBX24,a zinc-finger transcription factor known to regulate flowering by its influence on gibberellin synthesis. | Lu Zhu Yunxiao Guan Yanan Liu Zhaohe Zhang Muhammad Abuzar Jaffar Aiping Song Sumei Chen Jiafu Jiang Fadi Chen | 2020 | Horticulture Research2020，7，1： | 5 |
| 8 | A temporal gene expression map of Chrysanthemum leaves infected with Alternaria alternata reveals different stages of defense mechanisms显示文摘Chrysanthemum(Chrysanthemum morifolium)black spot disease(CBS)poses a major threat to Chrysanthemum cultivation owing to suitable climate conditions and current lack of resistant cultivars for greenhouse cultivation.In this study,we identified a number of genes that respond to Alternaria alternata infection in resistant and susceptible Chrysanthemum cultivars.Based on RNA sequencing technology and a weighted gene coexpression network analysis(WGCNA),we constructed a model to elucidate the response of Chrysanthemum leaves to A.alternata infection at different stages and compared the mapped response of the resistant cultivar‘Jinba’to that of the susceptible cultivar‘Zaoyihong’.In the early stage of infection,when lesions had not yet formed,abscisic acid(ABA),salicylic acid(SA)and EDS1-mediated resistance played important roles in the Chrysanthemum defense system.With the formation of necrotic lesions,ethylene(ET)metabolism and the Ca^(2+)signal transduction pathway strongly responded to A.alternata infection.During the late stage,when necrotic lesions continued to expand,members of the multidrug and toxic compound extrusion(MATE)gene family were highly expressed,and their products may be involved in defense against A.alternata invasion by exporting toxins produced by the pathogen,which plays important roles in the pathogenicity of A.alternata.Furthermore,the function of hub genes was verified by qPCR and transgenic assays.The identification of hub genes at different stages,the comparison of hub genes between the two cultivars and the highly expressed genes in the resistant cultivar‘Jinba’provide a theoretical basis for breeding cultivars resistant to CBS. | Ye Liu Jingjing Xin Lina Liu Aiping Song Zhiyong Guan Weimin Fang Fadi Chen | 2020 | Horticulture Research2020，7，1： | 4 |
| 9 | Comparison of clinical outcomes of Chinese men and women after coronary stenting for coronary artery disease:a multi-center retrospective analysis of 4,334 patients显示文摘The outcome differences between Chinese male and female patients within one-year follow-up after percutaneous coronary intervention(PCI) with stent remain unclear.The present study was aimed to compare clinical outcomes in such two populations.From May 1999 to December 2009,4,334 patients with acute myocardial infarction(MI),unstable angina,stable angina,or silent ischemia,who underwent PCI,were registered at our centers.Among these,3,089 were men and 1,245 were women.We compared these groups with respect to the primary outcomes of MI and secondary outcomes including a composite of major adverse cardiac events(MACE) including cardiac death,MI,target lesion revascularization,target vessel revascularization(TVR),stent thrombosis(ST),definite ST and probable ST at one-year follow-up.Chinese male patients had a higher MACE rate(13%vs.10.7%,P =0.039),mainly led by TVR(9.09%vs.6.98%,P=0.024) at one year,which was significantly different than female patients.Chinese male and female patients showed a significant difference on MACEs.However,there was no significant difference with respect to MI between these groups. | Rajiv Shrestha Jing Xu Dujiang Xie Zhizhong Liu Tian Xu Fei Ye Shiqing Din Xuesong Qian Song Yang Yueqiang Liu Feng Li Aiping Zhang Shaoliang Chen | 2014 | The Journal of Biomedical Research2014，28，5： | 3 |
| 10 | Association oftransforming growth factor-β1 gene variants with risk of coal workers'pneumoconiosis显示文摘Objective:The aim of this case-control study was to explore whether five tagging single nucleotide polymorphisms(tSNPs)within the transforming growth factor-β1(TGF-β1)gene were involved in manifestation of inflammatory and fibrotic processes associated with coal workers'pneumoconiosis(CWP).Methods:The study included 508 CWP patients and 526 controls who were underground coal miners from Xuzhou Mining Business Group.Five tSNPs were selected from the HapMap and detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)method.Results:The single SNP analysis showed that the genotype frequencies of SNP2(rs1800470,+869T/C,extron 1)and SNP5(rs11466345,intron 5)in CWP cases were sig- nificantly different from those in controls.Multivariate logistic regression analysis revealed that SNP2(rs1800470) CC genotype was associated with decreased risk of CWP(OR=0.50,95%CI=0.32-0.78),which was evident among subgroups of those never smoke(OR=0.40,95%CI=0.24-0.66),cases with stageⅡ(OR=0.41,95%CI =0.22-0.76)and exposure period(<28 y:OR=0.54,95%CI=0.31-0.95;≥28 y:OR=0.52,95%CI=0.32-0.96). However,the SNP5(rs11466345)GG genotype was associated with an increased risk of CWP(OR=2.5,95%CI =1.36-4.57),and further stratification analysis showed that the risk of CWP was increased in both smoking and nonsmoking groups,shorter and longer exposure groups,while the risk of CWP was only increased in patients with stageⅠandⅡ.Conclusion:This study suggests that TGF-β1 polymorphisms may contribute to susceptibility of CWP. | Haiyang Qian Zhifang Song Meilin Wang Xiaomin Jia Aiping Li Ye Yang Lianlian Shen Shasha Wang Chunhui Ni Jianwei Zhou | 2010 | The Journal of Biomedical Research2010，24，4： | 3 |
| 11 | Core-shell lipid-polymer nanoparticles as a promising ocular drug delivery system to treat glaucoma显示文摘Nowadays,tremendous researches have been focused on the core-shell lipid-polymer nanoparticles(LPNs) due to the advantages of both liposomes and polymer nanoparticles.In this work,LPNs were applied to encapsulate brinzolamide(Brz-LPNs) for achieving sustained drug release,improving drug corneal permeation and enhancing drug topical therapeutic effect.The structure of Brz-LPNs was composed of poly(lactic-co-glycolic) acid(PLGA) nanocore which encapsulated Brz(Brz-NPs) and lipid shell around the core.Brz-LPNs were prepared by a modified thin-film dispersion method.With the parameters optimization of Brz-LPNs,optimal Brz-LPNs showed an average particle size of151.23±1.64 nm with a high encapsulation efficiency(EE) of 86.7%±2.28%.The core-shell structure of Brz-LPNs were confirmed by transmission electronic microscopy(TEM).Fourier transformed infrared spectra(FTIR) analysis proved that Brz was successfully entrapped into Brz-LPNs.Brz-LPNs exhibited obvious sustained release of Brz,compared with AZOPT^■ and Brz-LPs.Furthermore,the corneal accumulative permeability of Brz-LPNs significantly increased compared to the commercial available formulation(AZOPT^■) in vitro.Moreover,Brz-LPNs(1 mg/mL Brz) showed a more sustained and effective intraocular pressure(IOP) reduction than Brz-LPs(1 mg/mL) and AZOPT^■(10 mg/mL Brz) in vivo.In conclusion,Brz-LPNs,as promising ocular drug delivery systems,are well worth developing in the future for glaucoma treatment. | Yang Zhou Aiping Fang Fazhan Wang Huili Li Quansheng Jin Lingjing Huang Chunmei Fu Jun Zeng Zhaohui Jin Xiangrong Song | 2020 | Chinese Chemical Letters2020，31，2： | 3 |
| 12 | Preparation and Investigation of Arsenic Trioxide-loaded Polylactic Acid/Magnetic Hybrid Nanoparticles显示文摘 | SONG Xiaoli YOU Juan WANG Juan ZHU Aiping JI Lijun GUO Rong | 2014 | Chemical Research in Chinese Universities2014，30，2： | 3 |
| 13 | Overexpression of the CmJAZ1-like gene delays flowering in Chrysanthemum morifolium显示文摘Chrysanthemum(Chrysanthemum morifolium)is one of the four major cut-flower plants worldwide and possesses both high ornamental value and cultural connotation.As most chrysanthemum varieties flower in autumn,it is costly to achieve annual production.JAZ genes in the TIFY family are core components of the jasmonic acid(JA)signaling pathway;in addition to playing a pivotal role in plant responses to defense,they are also widely implicated in regulating plant development processes.Here,we characterized the TIFY family gene CmJAZ1-like from the chrysanthemum cultivar‘Jinba’.CmJAZ1-like localizes in the nucleus and has no transcriptional activity in yeast.Tissue expression pattern analysis indicated that CmJAZ1-like was most active in the root and shoot apex.Overexpressing CmJAZ1-like with Jas domain deletion in chrysanthemum resulted in late flowering.RNA-Seq analysis of the overexpression lines revealed some differentially expressed genes(DEGs)involved in flowering,such as the homologs of the flowering integrators FT and SOC1,an FUL homolog involved in flower meristem identity,AP2 domain-containing transcription factors,MADS box genes,and autonomous pathway-related genes.Based on KEGG pathway enrichment analysis,the differentially transcribed genes were enriched in carbohydrate metabolic and fatty acid-related pathways,which are notable for their role in flowering in plants.This study preliminarily verified the function of CmJAZ1-like in chrysanthemum flowering,and the results can be used in molecular breeding programs aimed at flowering time regulation of chrysanthemum. | Yunxiao Guan Lian Ding Jiafu Jiang Yuanyue Shentu Wenqian Zhao Kunkun Zhao Xue Zhang Aiping Song Sumei Chen Fadi Chen | 2021 | Horticulture Research2021，8，1： | 3 |
| 14 | First Imported Case of SARS-CoV-2 Omicron Subvariant BA.2.12.1-Guangdong Province,China,April 30,2022显示文摘On April 23,2022,an international flight KQ880 from Nairobi,Kenya arrived at Guangzhou Baiyun International Airport,Guangzhou City,Guangdong Province.All passengers were transferred to the quarantine hotel for routine 14-day medical observation and regularly tested of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)nucleic acid.One of the patients,a 27-year-old Chinese male,reported positive SARS-CoV-2 nucleic acid on April 27,2022.The patient had a history of full coronavirus disease 2019(COVID-19)vaccination and denied exposure to other COVID-19 cases in the past 14 days.After diagnosis,he was transferred to Guangzhou Eighth People’s Hospital for treatment. | Lijun Liang Xiang Zhao Aiping Deng Kuibiao Li Jiajun Liu Fangzhu Ouyang Qianfang Guo Jing Xu Shen Huang Lirong Zou Yang Song Kai Nie Baisheng Li | 2022 | China CDC weekly2022，4，31： | 2 |
| 15 | First Imported Case of SARS-CoV-2 Omicron Subvariant BA.4-Guangdong Province,China,May 4,2022显示文摘On April 29,2022,a flight arrived at Baiyun International Airport,Guangzhou City,Guangdong Province,and departed from Amsterdam Schiphol Airport,Netherlands.After the first test of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)nucleic acid at the Baiyun International Airport,all passengers were admitted to a quarantine hotel for a routine 14-day medical observation.On April 30,one of the passengers(a 20-year-old Chinese female)was reported positive for coronavirus disease 2019(COVID-19),and then a nasopharyngeal swab sample was immediately retested on May 1 and reported positive. | Qianfang Guo Changcheng Wu Aiping Deng Jingtao Liang Xiang Zhao Ruhan A Jiajun Liu Fangzhu Ouyang Jing Xu Shen Huang Yang Song Lirong Zou Xiaoling Deng Kai Nie Baisheng Li | 2022 | China CDC weekly2022，4，40： | 2 |
| 16 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 17 | CYP2A6 Polymorphisms Associate with Outcome of S-1 Plus Oxaliplatin Chemotherapy in Chinese Gastric Cancer Patients显示文摘Gastric carcinoma is a heterogeneous malignant disease involving genetic factors. To identify predictive markers for gastric cancer treatment in Chinese patients, we evaluated the association between polymorphisms of the gene encoding cytochrome P450 2A6(CYP2A6) and outcomes of S-1 plus oxaliplatin(SOX) chemotherapy treatment. Clinical data on 60 consecutive gastric cancer patients receiving SOX regimen were collected prospectively. We sequenced all exons of CYP2A6 and a total of 22 different polymorphisms were detected in the present study. Comprehensive analyses of these genetic polymorphisms were performed to determine their association with both safety and efficacy of SOX regimen. Our results showed that polymorphisms of CYP2A6 were associated with the safety and efficacy of SOX treatment. Among them, missense mutations CYP2A6 rs60823196 and rs138978736 could be possible risk factors(P < 0.05) for severe diarrhea induced by SOX, whereas CYP2A6 rs138978736 could be a conceivable predictor for overall survival of patients treated with SOX adjuvant chemotherapy. Further large-scale randomized prospective studies are warranted to confirm these findings. | Lin Yang Shanshan Zou Chang Shu Yan Song Yong-Kun Sun Wen Zhang Aiping Zhou Xinghua Yuan Yi Yang Songnian Hu | 2017 | Genomics, Proteomics & Bioinformatics2017，15，4： | 2 |
| 18 | Tailoring Practically Accessible Polymer/Inorganic Composite Electrolytes for All-Solid-State Lithium Metal Batteries:A Review显示文摘Solid-state electrolytes(SSEs)are widely considered the essential components for upcoming rechargeable lithium-ion batteries owing to the potential for great safety and energy density.Among them,polymer solid-state electrolytes(PSEs)are competitive candidates for replacing commercial liquid electrolytes due to their flexibility,shape versatility and easy machinability.Despite the rapid development of PSEs,their practical application still faces obstacles including poor ionic conductivity,narrow electrochemical stable window and inferior mechanical strength.Polymer/inorganic composite electrolytes(PIEs)formed by adding ceramic fillers in PSEs merge the benefits of PSEs and inorganic solid-state electrolytes(ISEs),exhibiting appreciable comprehensive properties due to the abundant interfaces with unique characteristics.Some PIEs are highly compatible with high-voltage cathode and lithium metal anode,which offer desirable access to obtaining lithium metal batteries with high energy density.This review elucidates the current issues and recent advances in PIEs.The performance of PIEs was remarkably influenced by the characteristics of the fillers including type,content,morphology,arrangement and surface groups.We focus on the molecular interaction between different components in the composite environment for designing high-performance PIEs.Finally,the obstacles and opportunities for creating high-performance PIEs are outlined.This review aims to provide some theoretical guidance and direction for the development of PIEs. | Hongmei Liang Li Wang Aiping Wang Youzhi Song Yanzhou Wu Yang Yang Xiangming He | 2023 | Nano-Micro Letters2023，15，3： | 2 |
| 19 | The opposite prognostic significance of nuclear and cytoplasmic p21 expression in resectable gastric cancer patients显示文摘 | Yefei Huang Weimin Wang Yansu Chen Yulin Huang Jianbing Zhang Song He Yongfei Tan Fulin Qiang Aiping Li Oluf Dimitri R?e Shouyu Wang Yan Zhou Jianwei Zhou | 2014 | Journal of Gastroenterology2014，，11： | 2 |
| 20 | A novel transcription factor CmMYB012 inhibits flavone and anthocyanin biosynthesis in response to high temperatures in chrysanthemum显示文摘Flavones are among the major colorless pigments synthesized through branches of the flavonoid pathway in plants.However,due to the absence of a gene encoding flavone synthase(FNS)in the model plant Arabidopsis thaliana species,the regulatory mechanism of FNS-catalyzed flavone biosynthesis has rarely been studied in plants.Here,it was found that flavones play a predominant role in the elimination of excess reactive oxygen species(ROS)at high temperatures in colorless plant organs.A novel atypical subgroup 7(SG7)R2R3-MYB transcription factor,CmMYB012,was found to be induced in response to prolonged high temperatures and to inhibit flavone biosynthesis by directly regulating CmFNS.Moreover,CmMYB012 was also found to inhibit anthocyanin biosynthesis by suppressing the expression of CmCHS,CmDFR,CmANS,and CmUFGT.CmMYB012 overexpression exerted a negative in fluence on plant fitness and pink flower color formation,while CmMYB012 suppression had the opposite effect in response to high temperatures.Our findings provide new insights into the mechanisms by which high temperatures regulate the metabolism of flavones and anthocyanins to affect plant fitness and flower color formation. | Li-Jie Zhou Zhiqiang Geng Yuxi Wang Yiguang Wang Shenhui Liu Chuwen Chen Aiping Song Jiafu Jiang Sumei Chen Fadi Chen | 2021 | Horticulture Research2021，8，1： | 2 |
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