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| 1 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 2 | Potential predictors for mental stress-induced myocardial ischemia in patients with coronary artery disease显示文摘Background: Mental stress-induced myocardial ischemia (MSIMI) is closely associated with adverse cardiac events in patients with coronary artery disease (CAD) and we aimed to determine whether biomarkers and blood pressure could be potential predictors of MSIMI. Methods: This study enrolled 82 patients with documented CAD between June 1, 2017 and November 9, 2017. Patient blood samples were obtained at resting period and at the end of mental arithmetic. Then, patients were assigned to MSIMI positive group and MSIMI negative group. The main statistical methods included linear regression, receiver operating characteristic (ROC) curves, and logistic regression. Results: Patients with CAD with MSIMI had significantly greater median resting N-terminal pro-brain natriuretic peptide (NT-proBNP, 141.02 [45.85–202.76] pg/mL vs. 57.95 [27.06–117.64] pg/mL;Z =-2.23, P = 0.03) and mean systolic blood pressure (SBP)(145.56 ± 16.87 mmHg vs. 134.92 ± 18.16 mmHg, Z =-2.13, P = 0.04) when compared with those without MSIMI. After 5-min mental stress task, those who developed MSIMI presented higher elevation of median post-stressor high sensitivity cardiac troponin I (hs-cTnI, 0.020 [0.009–0.100] ng/mL vs. 0.009 [0.009–0.010] ng/mL;Z =-2.45, P = 0.01), post-stressor NT-proBNP (138.96 [39.93–201.56] pg/mL vs. 61.55 [25.66–86.50] pg/mL;Z =-2.15, P = 0.03) compared with those without MSIMI. Using the ROC curves, and after the adjustment for basic characteristics, the multiple logistic regression analysis showed that patients presenting a post-stressor hs-cTnI ≥ 0.015 ng/mL had seven-fold increase in the risk of developing MSIMI (odds ratio [OR]: 7.09;95% confidence interval [CI]: 1.65–30.48;P = 0.009), a rest NT-proBNP ≥ 80.51 pg/mL had nearly eight-fold increase (OR: 7.85;95% CI: 1.51–40.82;P = 0.014), a post-stressor NT-proBNP ≥ 98.80 pg/mL had 35-fold increase (OR: 34.96;95% CI: 3.72– 328.50;P = 0.002), a rest SBP ≥ 129.50 mmHg had 11-fold increase (OR: 11.42;95% CI: 1.21–108.17;P = 0.034). Conclusions: The present study shows that CAD patients with higher hs-cTnI level, and/or greater NT-proBNP and/or SBP are at higher risk of suffering from MSIMI when compared with those without MSIMI, indicating that hs-cTnI, NT-proBNP, SBP might be potential predictors of MSIMI. | Mei-Yan Liu Ya Yang Li-Jun Zhang Li-Hong Pu Dong-Fang He Jian-Yang Liu Adam Hafeez Yu-Chuan Ding Huan Ma Qing-Shan Geng | 2019 | Chinese Medical Journal2019，，12： | 7 |
| 3 | Safety of endovascular therapy for symptomatic intracranial artery stenosis:a national prospective registry显示文摘Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment. | Yabing Wang Tao Wang Adam Andrew Dmytriw Kun Yang Liqun Jiao Huaizhang Shi Jie Lu Tianxiao Li Yujie Huang Zhenwei Zhao Wei Wu Jieqing Wan Qinjian Sun Bo Hong Yongli Li Liyong Zhang Jianfeng Chu Qiong Cheng Yiling Cai Pengfei Wang Qi Luo Hua Yang Baijing Dong Yang Zhang Jun Zhao Zuoquan Chen Wei Li Xiaoxin Bai Weiwen He Xueli Cai Maimai Ti Osama O Zaidat | 2022 | Stroke & Vascular Neurology2022，7，2： | 3 |
| 4 | Postzygotic single-nucleotide mosaicisms in whole-genome sequences of clinically unremarkable individuals显示文摘 | August Y Huang Xiaojing Xu Adam Y Ye Qixi Wu Linlin Yan Boxun Zhao Xiaoxu Yang Yao He Sheng Wang Zheng Zhang Bowen Gu Han-Qing Zhao Meng Wang Hua Gao Ge Gao Zhichao Zhang Xiaoling Yang Xiru Wu Yuehua Zhang Liping Wei | 2014 | Cell Research2014，24，11： | 2 |
| 5 | Pituitary tumour in the elderly:A 20-year experience显示文摘 | Turner HE Adams CB Wass JA | 1999 | Eur J Endocrinol1999，140，5： | 1 |
| 6 | Use of High-pressure Processing for Oyster Shucking and Shelf- life Extension 显示文摘 | H He R M Adams D F Farkas | 2002 | Journal of food science2002，67，2： | 1 |
| 7 | Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication显示文摘 | Kristoff Jan Haret-Richter George Ma Dongzhu Ribeiro Ruy M Xu Cuiling Cornell Elaine Stock Jennifer L He Tianyu Mobley Adam D Ross Samantha Trichel Anita Wilson Cara Tracy Russell Landay Alan Apetrei Cristian Pandrea Ivona | 2014 | Journal of Clinical Investigation2014，，： | 1 |
| 8 | Genetic ba- sis of multidrug resistant in Acinetobacter baumannii clinical iso lates at a tertiary medical center in Pennsylvania显示文摘 | Adams Haduch JM Paterson DL Sidjabat HE | 2008 | Antimicrob Agents Chemother2008，52，11： | 1 |
| 9 | Coumarins from Cnidium monnieri and their antiosteoporotic activity显示文摘 | Zhang Q Qin L He W Van Puyvelde L Maes D Adams A Zheng H De Kimpe N | 2007 | Planta Med2007，73，1： | 1 |
| 10 | The Position of Arginine 124 Controls the Rate of Iron Release From the N-lobe of Human Serum Transferring显示文摘 | Adams TE Mason A B He QY | 2003 | Journal Biological Chemistry2003，278，： | 1 |
| 11 | Polymer nanoparticles: shape-directed monomer-to-particle synthesis 显示文摘 | HE T ADAMS D J BUTLER M F | 2009 | J Am Chem Soc2009，131，4： | 1 |
| 12 | A more efficient biofeedback procedure for the treatment of nocturnal bruxism显示文摘 | Moss RA Hammer D Adams HE | 1982 | J Oral Rehabli1982，9，2： | 1 |
| 13 | Perfusion preservation maintains myocardial ATP levels and reduces apoptosis in an ex vivo rat heart transplantation model显示文摘 | Peltz M He TT Adams GA 4th | 2005 | Surgery2005，138，4： | 1 |
| 14 | Isolation and characterization of an extracellular heat-stable lipase produced by Pseudomonas fluorescens MC50显示文摘 | Bozoglu F Swaisgood HE Adams DM Jr | 1984 | Agricultural and Food Chemistry1984，32，1： | 1 |
| 15 | Transcriptional analysis of Ralstonia eutropha genes related to poly-(R)-3-hydroxybutyrate homeostasis during batch fermentation显示文摘 | Adam G. Lawrence Joerg Schoenheit Aimin He Jiamin Tian Pinghua Liu JoAnne Stubbe Anthony J. Sinskey | 2005 | Applied Microbiology and Biotechnology2005，，5： | 1 |
| 16 | Use of high-pressure processing for oyster shucking and shelf-life extension 显示文摘 | He H Adams R M Farkas D F | 2002 | J Food Sci2002，67，2： | 1 |
| 17 | Per'fusion preservation maintains myocardial ATP levels and reduces apoptosis in an ex vivo rat heart transplantation model 显示文摘 | Peltz M He TT Adams GA 4th | 2005 | Surgery2005，138，4： | 1 |
| 18 | Usc of high-pressure processing for oyster shucking and shelf- life extension 显示文摘 | He H Adams R M Farkas D F | 2002 | Food Engineering and Physical Properties2002，67，2： | 1 |
| 19 | Use of high-pressure processing for oyster shucking and shelf-life extension显示文摘 | He H Adams R M Farkas D F | 2002 | J of Food Sci2002，67，： | 1 |
| 20 | Trans-sphenoidal surgery for microp- rolaetinoma:an acceptable alternative to dopamine agonists? 显示文摘 | Turner HE Adams CB Wass JA | 1999 | Eur J Endocrinol1999，140，1： | 1 |
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