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| 1 | Postzygotic single-nucleotide mosaicisms in whole-genome sequences of clinically unremarkable individuals显示文摘 | August Y Huang Xiaojing Xu Adam Y Ye Qixi Wu Linlin Yan Boxun Zhao Xiaoxu Yang Yao He Sheng Wang Zheng Zhang Bowen Gu Han-Qing Zhao Meng Wang Hua Gao Ge Gao Zhichao Zhang Xiaoling Yang Xiru Wu Yuehua Zhang Liping Wei | 2014 | Cell Research2014，24，11： | 2 |
| 2 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 3 | SCN1A, SCN1B, and GABRG2 gene mutation analysis in Chinese families with generalized epilepsy with febrile seizures plus显示文摘 | Huihui Sun Yuehua Zhang Jianmin Liang Xiaoyan Liu Xiuwei Ma Husheng Wu Keming Xu Jiong Qin Yu Qi Xiru Wu | 2008 | Journal of Human Genetics2008，，8： | 1 |
| 4 | Bushen Yizhi Formula regulates the IRE1αpathway to alleviate endoplasmic reticulum stress in an Alzheimer’s disease rat model显示文摘While the Bushen Yizhi Formula can treat Alzheimer’s disease(AD),the yet to be ascertained specific mechanism of action was explored in this work.Methods:Different concentrations of the Bushen Yizhi Formula and amyloid-beta peptide(Aβ)were used to treat rat pheochromocytoma cells(P12)and human neuroblastoma cells(SH-SY5Y).Cell morphological changes were observed to determine the in vitro cell damage.Cell Counting Kit(CCK)-8 assay and flow cytometry were employed to identify cell viability and apoptosis/cell cycle,respectively.Western blotting and immunohistochemistry were employed to measure the expressions of endoplasmic reticulum stress(ERS)-related proteins(GRP78 and CHOP),p-IRE1α,IRE1α,ASK1,p-JNK,JNK,Bax,Bcl-2,XBP-1,and Bim.Fura 2-acetoxymethyl ester(Fura-2/AM)was used to determine the intracellular calcium(Ca^(2+))concentration.Also,an AD model was constructed by injecting Aβinto the CA1 area of the hippocampus in Sprague Dawley rats.AD model rats were gavaged with different concentrations of Bushen Yizhi Formula for 14 consecutive days.The Morris water maze experiment was conducted to test the learning and memory of rats.Hematoxylin&Eosin(H&E)and Terminal-deoxynucleotidyl Transferase(TdT)-mediated dUTP Nick-End Labeling(TUNEL)staining were done to determine histopathological changes in the brain.Results:Bushen Yizhi Formula relieved the Aβ-induced effects including cell injury,decreased viability,increased apoptosis,G0/G1 phase cell cycle arrest,upregulation of GRP78,CHOP,p-IRE1α,p-JNK,Bax,XBP-1 and Bim,as well as down-regulation of Bcl-2.These results were also seen with IRE1αsilencing.While Aβsuppressed the learning and memory abilities of rats,the Bushen Yizhi Formula alleviated these effects of Aβ.Brain nerve cell injury induced by Aβcould also be treated with Bushen Yizhi Formula.Conclusion:Bushen Yizhi Formula could influence ERS through the IRE1αsignaling pathway to achieve its therapeutic effects on AD. | XIRU XU YUAN FANG BIAO ZHANG SHICHAO TENG XIANG WU JING ZHANG XIAOQUN GU MEIXIA MA | 2023 | BIOCELL2023，47，7： | 0 |
| 5 | Effect of Semi-solid Isothermal Heat Treatment on Microstructure of VW63Z Alloy显示文摘The effects of isothermal heat treatment on the semi-solid microstructure evolution of VW63Z(Mg-6Gd-3Y-0.4Zr,wt.%)alloy are studied.It shows that the microstructure of VW63Z alloy could transform from equiaxed crystal to semi-solid spherical crystal after isothermal heat treatment above 620℃.With the heating temperature elevating from 620℃ to 635℃ and the holding time prolonging from 10 min to 35 min,the liquid fraction increases gradually.The semi-solid microstructure evolution of VW63Z alloy can be divided into three stages,i.e.,particle coarsening and spheroidization;particle necking,coalescence,and Ostwald ripening;and dynamic equilibrium.The semi-solid process window of VW63Z alloy ranges from 620℃ to 635℃,where the best process parameters are holding at 635℃ for 20 min-30 min.The solid fraction,the average particle size,and the shape factor are 41.1%-53.8%,81.5μm-83.2μm,and 0.70-0.75,respectively.The maximum relative deviations of the solid fraction,the particle size,and the shape factor at different heights of the same billet are 44.6%,17.4%,and 16.6%,respectively,which means that it should pay attention to the uniformity of edge and core of VW63Z alloy during isothermal heat treatment.The driving force of microstructure is supposed to be the reduction of solid-liquid interface free energy. | GONG Zhengxuan PANG Song JI Song DONG Xiwang HOU Xiangwu CHEN Ge HUA Xiru WU Lili JIANG Shanyao XIAO Lü | 2022 | 上海航天(中英文)2022，39，1： | 0 |
| 6 | Long-term outcomes of intraoperative radiotherapy for early-stage breast cancer in China: amulticenter real-world study显示文摘Dear Editor,Intraoperative radiotherapy(IORT)is an accelerated par-tial breast irradiation(APBI)treatment that is accom-plished intraoperatively.Numerous clinical trials indicate that IORT is safe and effective,non-inferior to standard whole-breast external beam radiotherapy(EBRT)for low-risk patients who receive breast-conserving surgery[1-3].Nevertheless,these studies mainly included non-Asians and thus lack adequate evidence to support the value of IORT in Asian patients with breast cancer. | Xin Wang Kexin Feng Wenyan Wang Xiangzhi Meng Jiaqi Liu Yang Yang Yuting Zhong Jingruo Li Shikai Wu Minghui Li Pan Ma Qinfu Feng Hongmei Zeng Yuanting Gu Xiru Li Zhaoqing Fan Xiang Wang | 2022 | Cancer Communications2022，42，3： | 0 |
| 7 | Robust fuzzy control of Takagi-Sugeno fuzzy neural networks with discontinuous activation functions and time delays显示文摘The problem of global robust asymptotical stability for a class of Takagi-Sugeno fuzzy neural networks(TSFNN) with discontinuous activation functions and time delays is investigated by using Lyapunov stability theory.Based on linear matrix inequalities(LMIs),we originally propose robust fuzzy control to guarantee the global robust asymptotical stability of TSFNNs.Compared with the existing literature,this paper removes the assumptions on the neuron activations such as Lipschitz conditions,bounded,monotonic increasing property or the right-limit value is bigger than the left one at the discontinuous point.Thus,the results are more general and wider.Finally,two numerical examples are given to show the effectiveness of the proposed stability results. | Yaonan Wang Xiru Wu Yi Zuo | 2011 | Journal of Systems Engineering and Electronics2011，22，3： | 0 |
| 8 | Effects of physical exercise on the developmental expression of hippocampal zinc transporter 1 and glutamate receptor subunit 2, and on cognitive function in a rat model of recurrent neonatal seizure显示文摘BACKGROUND: Developmental seizures are pathologically characterized by regenerative sprouting of hippocampal mossy fibers rich in Zn2+. Zn2+ metabolism in the mossy fiber pathway, and Zn2+ accumulation in presynaptic membrane vesicles, are dependent on zinc transporter 1 (ZnT1) and glutamate receptor subunit 2 (GluR2). OBJECTIVE: To investigate the effects of long-term recurrent neonatal seizure, in the presence and absence of physical exercise, on the developmental expression of hippocampal zinc transporter 1 (ZnT1) and GluR2, and on cognitive function in rats. DESIGN, TIME AND SETTING: Based on behavioral examination and molecular biological research, a randomized, controlled animal experiment was performed at the Department of Neurobiology, Medical College of Soochow University, between January 2007 and April 2008. MATERIALS: Twenty-one 6-day-old Sprague Dawley rats of either gender were employed in this study. ZnT1 mRNA in situ hybridization kit was provided by Tianjin Haoyang Biological Manufacture Co.,Ltd., China. Rabbit anti-GluR2 was purchased from Santa Cruz Biotech, Inc, USA. METHODS: Rats were randomly divided into a recurrent seizure group (n = 11) and a control group (n = 10). In the recurrent seizure group, 30-minute seizure was induced by flurothyl gas inhalation for a total of 6 consecutive days. Rats from the control group underwent experimental procedures similar to the recurrent seizure group, with the exception of flurothyl gas inhalation. Thirty minutes of treadmill exercise was performed daily by all rats at postnatal days 51–56. MAIN OUTCOME MEASURES: At postnatal day 82, rat hippocampal tissue was harvested for analysis of hippocampal ZnT1 and GluR2 expression by in situ hybridization and immunohistochemistry, respectively. Rat learning and memory capabilities were examined using the Y-maze test. RESULTS: In the recurrent seizure group, the gray scale value of ZnT1 in situ hybridization positive neurons in the hippocampal CA3 region was significantly greater (P < 0.05), while the gray scale value of GluR2 immunoreactive neurons in the hippocampal hilus and dentate gyrus was significantly lower (P < 0.05), than in the control group. At postnatal days 29–35, numbers of trials to criteria for successful learning were greater in the recurrent seizure group than in the control group (P < 0.05); at postnatal days 61–67, the numbers of trials to criteria for successful learning were similar between the two groups (P > 0.05). At postnatal days 29–35 and 61–67, there was no significant difference in memory capability between the recurrent seizure and control groups (P > 0.05). CONCLUSION: Physical exercise likely improves the learning deficits caused by recurrent neonatal seizure in rats during brain development by modulating ZnT1 and GluR2 expression. | Hong Ni Yuwu Jiang Weiming Jiang Zhedong Wang Xiru Wu | 2009 | Neural Regeneration Research2009，4，1： | 0 |
| 9 | Zinc transporter-3 expression and long-term cognitive impairments in a rat model of neonatal concurrent seizure显示文摘BACKGROUND:Developmental seizures,which are pathologically characterized by regenerative sprouting of hippocampal mossy fibers,cause long-term damaging effects to synaptic plasticity.Zn^(2+) metabolism has been shown to contribute to the regenerative sprouting of hippocampal mossy fibers. Furthermore,zinc transporter-3(ZnT3) is responsible for Zn^(2+) transport in the hippocampal mossy fiber pathway. OBJECTIVE:To investigate the effects of long-term recurrent neonatal seizures on learning, memory formation and hippocampal ZnT3 expression in rats. DESIGN,TIME AND SETTING:Based on molecular biological research and behavioral examination, a randomized,controlled,animal experiment was performed at the Laboratory Animal Center, Peking University Health Science Center,between October 2004 and July 2005. MATERIALS:Flurothyl was purchased from Aldrich Chemical Co.,USA.ZnT3 mRNA in situ hybridization kits were provided by Tianjin Haoyang Biological Manufacture Co.,Ltd.,China.Morris water maze was produced by Shanghai Jiliang Science and Technology Co.,Ltd.,China. METHODS:Sixty,6-day old,Wistar rats were randomly divided into three groups:single seizure(n =21),recurrent seizure(n=21,one seizure daily for 6 consecutive days),and control(n=18). Seizures were induced by flurothyl gas inhalation,in the single seizure and recurrent seizure groups. MAIN OUTCOME MEASURES:At postnatal days 12,46 and 90,rat hippocampal ZnT3 mRNA expression was detected by RT-PCR;at postnatal days 46 and 90,ZnT3 mRNA expression was determined by in situ hybridization;and at postnatal days 41-46 and 85-90,rat spatial learning and memory formation were examined by the Morris water maze test. RESULTS:RT-PCR results revealed that at postnatal day 12,ZnT3 expression was significantly greater in the recurrent seizure group than in the control and single seizure groups,and at day 46,it was also significantly greater in the recurrent seizure group compared with the control group(P<0.05).In situ hybridization results showed that at postnatal day 46,the recurrent seizure group exhibited increased hippocampal ZnT3 expression over the control and single seizure groups(P<0.05).Morris water maze test results displayed that,in the first place navigation test at postnatal day 44,and the second test at days 87-88,the recurrent seizure group exhibited significantly higher value of average escape latency compared with the control group(P<0.05).In the two spatial probe tests,the search strategies were significantly inferior in the recurrent seizure group than in the control and single seizure groups(P<0.05). CONCLUSION:Neonatal concurrent seizures produce long-term damaging effects on hippocampal ZnT3 expression and cognitive function,while both of which have no parallel correlation. | Hong Ni Yuwu Jiang Luyang Tao Zhenghong Qin Xiru Wu | 2009 | Neural Regeneration Research2009，4，8： | 0 |
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