|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Nipah virus infection in dogs,Malaysia,1999显示文摘 | James NM Asiah NMA Michel LB | 2009 | Emerg Infect Dis2009，15，6： | 1 |
| 3 | Automated Ribotyping Using Different Enzymes To Improve Discrimination of Listeria monocytogenes Isolates, with a particular focus on serotype 4b strains显示文摘 | Alessandra DC James LB Timothy liD | 2001 | J Clin Microbial2001，39，8： | 1 |
| 4 | Mutational analysis of the,DNA binding, dimerization, an d transcriptional activation do-mains of MEF2C显示文摘 | Molkentin JD Brian LB James FM | 1996 | Mol Cell Biol1996，16，6： | 1 |
| 5 | Prospectively gated transverse coronary CT angiography versus retrospectively gated helical technique:improved image quality and reduced radiation dose显示文摘 | James PE Elise LB Bruce AU | 2008 | Radiology2008，246，： | 1 |
| 6 | A phase ii trial of surgery with perioperative ingn 201 (ad5 cmv-p53 ) gene therapy followed by chemoradiotherapy for advanced, reseetable squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx and larynx : report of the southwest oneology group 显示文摘 | George HY James M Michael LB | 2009 | Arch Otolaryngol Head Neck Surg2009，135，9： | 1 |
| 7 | Prospectively Gated Trans- verse Coronary CT Angiography versus Retrospectively Gated He- lical Technique: Improved Image Quality and Reduced Radiation Dose显示文摘 | James PE Elise LB Bruce AU | 2008 | Radiology2008，246，： | 1 |
| 8 | Fluid and solid mechanical implications of vascular stenting 显示文摘 | James E Moore JR Joel LB | 2002 | Ann Biomed Eng2002，30，： | 1 |
| 9 | Helical Biphaslc Contrast enhanced CT of the liver: Technique, Indications, Interpretation, and Pitfalls显示文摘 | James H Oliver III Richard LB | 1996 | Radology1996，，201： | 1 |
| 10 | Effect of seeing tobacco use in fil ms on trying s rooking among adolescents: cross sectional study显示文摘 | James DS Michael LB Medeline AD | 2001 | BMJ2001，323，： | 1 |
| 11 | Leiomyosarcoma of the esophagus: radiographic findings in 10 patients显示文摘 | Marc SL James LB | 1996 | AJR1996，167，： | 1 |
| 12 | Prospectively gated transverse coronary CT angiography versus retrospectively gated helical technique: Improved image quality and reduced radiation dose显示文摘 | James PE Elise LB Bruce AU | 2008 | Radiology2008，246，： | 1 |
| 13 | Systemic treatment of gastric cancer显示文摘 | Dickson James LB Cunningham D | 2004 | European Journal of Gastroenterology & Hepatology2004，16，3： | 1 |
| 14 | Burden of dis- ease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates 显示文摘 | Katherine LB Lara JW James PW | 2009 | Lancet2009，374，： | 1 |
| 15 | Popliteal artery disease:diagnosis and treatment显示文摘 | Wright LB Matchett WJ Crtz CP James CA Culp WC Eidt JF | | 0，，： | 1 |
| 16 | Treatment planning evaluation of non-coplanar techniques for conformal radiotherapy of the prostate显示文摘 | James LB Anthony JH David PD | 2005 | Radiother Oncol2005，75，3： | 1 |
| 17 | Parental symptoms ofposttraumaticstress following a child's diagnosis of autismspectrum disorder: a pilot study 显示文摘 | Casey LB Zanksas S James N | 2012 | Res Autism Spect Dis2012，，6： | 1 |
| 18 | Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates 显示文摘 | Katherine LB Lara JW James PW | 2009 | Lancet2009，374，9693： | 1 |
| 19 | Technique for arthroscopic re placement of severely damaged rotator cuff using 'Graft Jacket'allograft显示文摘 | Stephen JS james LB | 2007 | Oper fech Sports Med2007，15，1： | 1 |
| 20 | Dose advanced cirrhosis with portosystemic shunting affect the value of CT arterial orthography in the evaluation of the liver 显示文摘 | James HO Richard LB Cerald DD | 1995 | AJR1995，164，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员