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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Differential effects of sustained inflation in recruitment maneuvers on alveolar epithelial and lung endothelial injury显示文摘 | James A Danny FM Jorge A | 2005 | Crit Care Med2005，33，1： | 1 |
| 3 | Mutational analysis of the,DNA binding, dimerization, an d transcriptional activation do-mains of MEF2C显示文摘 | Molkentin JD Brian LB James FM | 1996 | Mol Cell Biol1996，16，6： | 1 |
| 4 | Transgenes display stable patterns of expression in apple fruit and mendelian segregation in the progeny 显示文摘 | James DJ Passey AJ Baker SA Wilson FM | 1996 | Biotechnology1996，14，6： | 1 |
| 5 | Genetics of vascular cogni-tive impairment the opportunity and the challenges显示文摘 | Gabrille GL James FM Donald TS | | 0，，01： | 1 |
| 6 | Single - point GPS positioning accuracy using precise gps data 显示文摘 | Gao Y and James FM | 1997 | The Australian Surveyor1997，42，4： | 1 |
| 7 | 'Cocktail' approaches and strategies in drug development:valuable tool or flawed science显示文摘 | Zhou HH Zeen T James FM | 2004 | J Clin Pharmacol2004，44，： | 1 |
| 8 | An evaluation of vasopressor therapy for maternal hypotension during spinal anesthesia显示文摘 | JAMES FM Ⅲ GREISS FC JR KEMP RA | 1970 | Anesthesiology1970，33，： | 1 |
| 9 | An evaluation of vasopressor therapy for maternal hypotension during spinal anesthesia显示文摘 | James FM Greiss FC Kemp RA | 1970 | Anesthesiology1970，33，1： | 1 |
| 10 | Acute mesentericis chemia 显示文摘 | James FM Bruce LG | 1997 | Surg Clin North Am1997，77，： | 1 |
| 11 | Differential effect of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury显示文摘 | James AF Danny FM Jorge A | 2005 | Crit Care Med2005，33，1： | 1 |
| 12 | Differential effect of sustained inflation recruitment maneuvers on alveolar epit he- lial and lung endothelial injury显示文摘 | James AF Danny FM Jorge A | 2005 | Crit Care Med2005，33，18： | 1 |
| 13 | Cough suppression by lidoeaine显示文摘 | Poulton TJ James FM | 1979 | Anesthesiology1979，50，： | 1 |
| 14 | Bone cells and matrices in orthopedic tissue engineering 显示文摘 | James EF Charles NC George FM | 2000 | Orthop Clim North Am2000，31，3： | 1 |
| 15 | Effeects of glucose dialysate on extracelluar matrixproduction by human peritoneal mesothelial cells:the role of TGF-β 显示文摘 | James FM John W Izabella ZA | 2001 | Nephrol DialTransplant2001，16，9： | 1 |
| 16 | Acute mesenteric ischemia显示文摘 | James FM Bruce LG | 1997 | Surg Clin North Am1997，77，： | 1 |
| 17 | A modern look at hypertension and anesthesia显示文摘 | James FM Ra Dyer Rayner BI | 2014 | Southern African Journal of Anaesthesia and Analgesia2014，17，2： | 1 |
| 18 | Bone cells and matrices in orthopedic tissue engineering 显示文摘 | James EF Charles NC George FM | 2000 | Orthopedic Clinics of North America2000，31，： | 1 |
| 19 | Demonstration of neurovascular compression in trigeminal neuralgia with magnetic resonance imaging显示文摘 | Paul R Lawrence T | 1995 | J Neurosurg1995，83，： | 1 |
| 20 | Selenoprotein expression is essential in endothelial cell development and cardiac muscle function显示文摘 | RAJEEV KS JAMES AW GEORGINA FM | 2007 | Nueromuscular Disorders2007，，17： | 1 |
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