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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | The biogeochemistry,stable isotope geochemistry,and microbial community structure of a temperate intertidal mudflat: an integrated study 显示文摘 | MICHAEL E BRITTA H ENRIQUE LB | 2000 | Continental Shelf Research2000，20，： | 1 |
| 3 | Vitamin D Deficiency and Risk of Cardiovascular Disease显示文摘 | Thomas JW Michael JP Sarah LB | 2008 | Circulation2008，117，： | 1 |
| 4 | Route an method of delivery of DNA vaccine influence immune responses in mice and non-human primates显示文摘 | Michael JM Cynthia LB Robert AG | 1999 | Molecular Medicine1999，，5： | 1 |
| 5 | Arsenic drinking water exposure and urinary excretion among adults in the Yaqui Valley,Sonora,Mexico显示文摘 | Maria MM Michael JK Jefferey LB | 2004 | Environ Res2004，96，： | 1 |
| 6 | Cyclin A1 expression in leukemia and normal hematopoietic cells显示文摘 | RONG Y TSUYOSHI N MICHAEL LB | 1999 | Blood1999，93，6： | 1 |
| 7 | Evolution of the Ratio of Strontium 87 to Strontium 86 in Seawater from Cretaceous to Present 显示文摘 | Hess J Michael LB Jean G S | 1986 | Science1986，231，： | 1 |
| 8 | Distal femoral allograft for mas sive proximal femoral deficiency显示文摘 | Robert LB Michael WW Paul M | 2000 | Acta Orthop Scand2000，71，1： | 1 |
| 9 | A phase ii trial of surgery with perioperative ingn 201 (ad5 cmv-p53 ) gene therapy followed by chemoradiotherapy for advanced, reseetable squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx and larynx : report of the southwest oneology group 显示文摘 | George HY James M Michael LB | 2009 | Arch Otolaryngol Head Neck Surg2009，135，9： | 1 |
| 10 | Warfarin in the prevention of stroke associated with nonrheumatic atrial fibrillation显示文摘 | Michael DE Samuel LB | 1992 | N Engl J Med1992，327，： | 1 |
| 11 | Effect of seeing tobacco use in fil ms on trying s rooking among adolescents: cross sectional study显示文摘 | James DS Michael LB Medeline AD | 2001 | BMJ2001，323，： | 1 |
| 12 | Patellar resufacing in total knee arthroplasty显示文摘 | Robert LB Alexander JB Michael ww | 2001 | J Bone Joint Surg2001，83，： | 1 |
| 13 | Patellar resuffacing in total knee arthroplasty显示文摘 | Robert LB Alexander JB Michael WW | 2001 | J Bone Joint Surg2001，83，： | 1 |
| 14 | Patellar resurfacing in total kneearthroplasty 显示文摘 | Robert LB Alexander JB Michael WW | 2001 | J Bone Joint Surg2001，83，： | 1 |
| 15 | Effect of seeing tobaccouse in films on trying smoking among adolescents:cross sectionalstudy显示文摘 | James DS Michael LB Madeline AD | 2001 | BMJ2001，323，： | 1 |
| 16 | Acceleration tensile of strength incisions treated with EGF and TGF-β显示文摘 | Gregory LB Luke JC Michael White | 1988 | Ann Surg1988，208，： | 1 |
| 17 | Immunohistochemical profiles of claudin-3 in primary and metastatic prostatic adenocarcinoma 显示文摘 | Tanner LB Uma RC Michael JB | 2011 | Diagnostic Pathology2011，6，12： | 1 |
| 18 | Mechanisms of air way remode- ling : air way smooth muscle 显示文摘 | Judith LB Michael R Lee J | 2001 | Am J RespirCritCareMed2001，164，： | 1 |
| 19 | Patellar resuffacing in total knee arthroplasly显示文摘 | Roberl LB Alexander JB Michael WW | 2001 | J Bone Joint Surg2001，83，： | 1 |
| 20 | Arsenic drinking water exposure and urinary excretion among adults in the Yaqui Valley, Sonora, Mexieo显示文摘 | Maria MM Michael JK Jefferey LB | 2004 | Environ Res2004，96，： | 1 |
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