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| 1 | Relationship between testicular volume and testicular function: comparison of the Prader orchidometric and ultrasonographic measurements in patients with infertility显示文摘瞄准:为了评估在阴囊的功能和阴囊的体积之间的关系,由使用 Prader orchidometry 和 ultrasonography (美国) 决定由每个方法显示正常阴囊的功能的批评的阴囊的卷测量了。方法:全部的阴囊的体积(恰好正的左阴囊的体积) 与不孕在 397 个人在 794 个睾丸被测量(吝啬的年龄, 35.6 年) 用 Prader orchidometer 并且也由 ultrasonography。Ultrasonographic 阴囊的体积作为长度×宽度×高度×被计算 0.71。评估卷功能关系,病人们被划分成从在 10 mL 下面由每个方法代表全部的阴囊的体积的 5-mL 增长到 50 mL 或更多的 10 个组。结果:吝啬的全部的阴囊的体积分别地基于 Prader orchidometry 和美国是 36.8 mL 和 26.3 mL。精液体积,精子密度,全部的精子计数,全部的能动精子计数,和浆液 FSH, LH,和睾丸激素都显著地相关,全部的阴囊的体积由任何一个方法测量了。吝啬的精子密度在在有在由 orchidometry 或在由 ultrasonography 的 20 mL 下面的 35 mL 下面的全部的阴囊的体积的病人的 oligozoospermic 范围。吝啬的全部的精子计数由 ultrasonography 在有在由 orchidometry 或不到 20 mL 的 30 mL 下面的全部的阴囊的体积的病人是低于正常的。结论:ultrasonography 或 Prader orchidometry 测量的阴囊的体积与阴囊的功能显著地相关。然而,批评全部的阴囊的体积显示正常或将近正常的阴囊的功能用 ultrasonography 是到用 Prader orchidometer 和 20 mL 的 35 mL 的 30 mL。Prader orchidometry morphometrically 并且机能上地与美国相比过高估计阴囊的体积。 | Hideo Sakamoto Yoshio Ogawa Hideki Yoshida | 2008 | Asian Journal of Andrology2008，10，2： | 25 |
| 2 | SMALL ORGAN SIZE 1 and SMALL ORGAN SIZE 2/DWARF AND LOW-TILLERING Form aComplex to Integrate Auxin and Brassinosteroid Signaling in Rice显示文摘尽管植物生长素和 brassinosteroid (BR ) synergistically 控制各种各样的植物回答,位于 auxin-BR 串音下面的分子的机制很好没被理解。我们以前识别了 SMOS1,一个调整植物生长素的 APETALA2 类型抄写因素,作为小机关的原因的基因缩放 1 (smos1 ) 被各种各样的机关的一种减少的最后的尺寸在米饭描绘的异种。在这研究,我们识别了另一 smos 异种, smos2,哪个表演与 smos1 难区分的显型。SMOS2 与以前报导的矮子和 LOW-TILLERING (DLT ) 相同,它编码涉及 BR 发信号的 GRAS 蛋白质。SMOS1 和 SMOS2/DLT 身体上交往合作地在酵母并且在米饭原子核提高 transcriptional transactivation 活动。一致地, OsPHI-1 的表示, SMOS1 的一个直接目标,当 SMOS1 和 SMOS2/DLT 蛋白质两个都是在米饭房间的现在时,仅仅是 upregulated。一起拿,我们的结果建议 SMOS1 和 SMOS2/DLT 在在米饭表明串音的 auxin-BR 上形成重点建筑群。 | Ko Hirano Hideki Yoshida Koichiro Aya Mayuko Kawamura Makoto Hayashi Tokunori Hobo Karma Sato-lzawa Hidemi Kitano Miyako Ueguchi-Tanaka Makoto Matsuoka | 2017 | Molecular Plant2017，10，4： | 20 |
| 3 | Usefulness of vonoprazan,a potassium ion-competitive acid blocker,for primary eradication of Helicobacter pylori显示文摘AIM To investigate usefulness of triple therapy with vonoprazan,a potassium ion-competitive acid blocker and antibiotics,for Helicobacter pylori(H.pylori) eradication.METHODS The H.pylori eradication rate was examined in 2507 patients(2055 undergoing primary eradication and 452 undergoing secondary eradication,excluding patients with subtotal gastrectomy) at the Japanese Red Cross Kyoto Daiichi Hospital from March 2013 to September 2015.For patients treated from March 2013 to February 2015,a proton pump inhibitor(PPI) was used to reduce acid secretion,while vonoprazan was used after March 2015.The success rates of the 2 regimens(PPI + amoxicillin + clarithromycin/metronidazole,or vonoprazan + amoxicillin + clarithromycin/metronidazole) were compared.RESULTS The success rate of primary H.pylori eradication was significantly higher in the vonoprazan group.When stratified by the underlying disease,a significant increase of the H.pylori eradication rate was observed in patients with chronic gastritis.A significantly lower H.pylori eradication rate was observed in younger patients compared to older patients in the PPI group,but there was no difference according to age in the vonoprazan group.On the otherhand,the success rate of secondary eradication was similar at approximately 90% in both groups.CONCLUSION Vonoprazan is very useful for primary eradication of H.pylori,and may become a first-line acid secretion inhibitor instead of PPIs. | Shinya Yamada Takumi Kawakami Yoshikazu Nakatsugawa Takahiro Suzuki Hideki Fujii Naoya Tomatsuri Hideki Nakamura Hideki Sato Yusuke Okuyama Hiroyuki Kimura Norimasa Yoshida | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 8 |
| 4 | OsIDD2, a zinc finger and INDETERMINATE DOMAIN protein, regulates secondary cell wall formation显示文摘Previously, we found 123 transcription factors(TFs) as candidate regulators of secondary cell wall(SCW)formation in rice by using phylogenetic and co-expression network analyses. Among them, we examined in this work the role of OsIDD_2, a zinc finger and indeterminate domain(IDD) family TF. Its overexpressors showed dwarfism, fragile leaves, and decreased lignin content, which are typical phenotypes of plants defective in SCW formation, whereas its knockout plants showed slightly increased lignin content.The RNA-seq and quantitative reverse transcription polymerase chain reaction analyses confirmed that some lignin biosynthetic genes were downregulated in the OsIDD_2-overexpressing plants, and revealed the same case for other genes involved in cellulose synthesis and sucrose metabolism. The transient expression assay using rice protoplasts revealed that OsIDD_2 negatively regulates the transcription of genes involved in lignin biosynthesis, cinnamyl alcohol dehydrogenase 2 and 3(CAD_2 and 3), and sucrose metabolism, sucrose synthase 5(SUS_5), whereas an Alpha Screen assay, which can detect the interaction between TFs and their target DNA sequences, directly confirmed the interaction between OsIDD_2 and the target sequences located in the promoter regions of CAD_2 and CAD_3. Based on these observations, we conclude that OsIDD_2 is negatively involved in SCW formation and other biological events by downregulating its target genes. | Peng Huang Hideki Yoshida Kenji Yano Shunsuke Kinoshita Kyosuke Kawai Eriko Koketsu Masako Hattori Sayaka Takehara Ji Huang Ko Hirano Reynante Lacsamana Ordonio Makoto Matsuoka Miyako Ueguchi-Tanaka | 2018 | Journal of Integrative Plant Biology2018，60，2： | 3 |
| 5 | Comparison of unenhanced magnetic resonance imaging and ultrasound in detecting very small hepatocellular carcinoma显示文摘BACKGROUND In hepatocellular carcinoma(HCC),detection and treatment prior to growth beyond 2 cm are important as a larger tumor size is more frequently associated with microvascular invasion and/or satellites.In the surveillance of very small HCC nodules(≤2 cm in maximum diameter,Barcelona clinical stage 0),we demonstrated that the tumor markers alpha-fetoprotein and PIVKA-Ⅱare not so useful.Therefore,we must survey with imaging modalities.The superiority of magnetic resonance imaging(MRI)over ultrasound(US)to detect HCC was confirmed in many studies.Although enhanced MRI is now performed to accurately diagnose HCC,in conventional clinical practice for HCC surveillance in liver diseases,unenhanced MRI is widely performed throughout the world.While,MRI has made marked improvements in recent years.AIM To make a comparison of unenhanced MRI and US in detecting very small HCC that was examined in the last ten years in patients in whom MRI and US examinations were performed nearly simultaneously.METHODS In 394 patients with very small HCC nodules,those who underwent MRI and US at nearly the same time(on the same day whenever possible or at least within 14 days of one another)at the first diagnosis of HCC were selected.The detection rate of HCC with unenhanced MRI was investigated and compared with that of unenhanced US.RESULTS The sensitivity of unenhanced MRI for detecting very small HCC was 95.1%(97/102,95%confidence interval:90.9-99.3)and that of unenhanced US was 69.6%(71/102,95%confidence interval:60.7-78.5).The sensitivity of unenhanced MRI for detecting very small HCC was significantly higher than that of unenhanced US(P<0.001).Regarding the location of HCC in the liver in patients in whom detection by US was unsuccessful,S7-8 was identified in 51.7%.CONCLUSION Currently,unenhanced MRI is a very useful tool for the surveillance of very small HCC in conventional clinical follow-up practice. | Kazuo Tarao Akito Nozaki Hirokazu Komatsu Tatsuji Komatsu Masataka Taguri Katsuaki Tanaka Testuo Yoshida Hideki Koyasu Makoto Chuma Kazushi Numata Shin Maeda | 2021 | World Journal of Hepatology2021，13，6： | 3 |
| 6 | 活塞环闭口间隙的设计对机油消耗及漏气量的影响显示文摘为了降低柴油机的机油消耗,一二环闭口间隙的联合设计被得到应用。闭口间隙联合设计的功用在于控制活塞环的轴向运动及调节二环岸间气体压力以达到对机油消耗及漏气量的控制目的。笔者通过降低二环岸间气体压力来达到降低机油消耗的目的,尽管这么做可能引起二环的浮起。同时窜气对机油消耗的影响也有一定的影响。 | 祁中高 hideki Yoshida Masaki Yamada hiroyuki kobayashi | 2011 | 内燃机与配件2011，，12： | 2 |
| 7 | STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury显示文摘AIM To elucidate the role of STAT3 in hepatocarcinogenesis and biliary ductular proliferation following chronic liver injury. METHODS We investigated thioacetamide(TAA)-induced liver injury, compensatory hepatocyte proliferation, and hepatocellular carcinoma(HCC) development in hepatic STAT3-deficient mice. In addition, we evaluated TAAinduced biliary ductular proliferation and analyzed the activation of sex determining region Y-box9(SOX9) and Yes-associated protein(YAP), which regulate the transdifferentiation of hepatocytes to cholangiocytes.RESULTS Both compensatory hepatocyte proliferation and HCC formation were significantly decreased in hepatic STAT3-deficient mice as compared with control mice. STAT3 deficiency resulted in augmentation of hepatic necrosis and fibrosis. On the other hand, biliary ductular proliferation increased in hepatic STAT3-deficient livers as compared with control livers. SOX9 and YAP were upregulated in hepatic STAT3-deficient hepatocytes.CONCLUSION STAT3 may regulate hepatocyte proliferation as well as transdifferentiation into cholangiocytes and serve as a therapeutic target for HCC inhibition and biliary regeneration. | Mitsuhiko Abe Takafumi Yoshida Jun Akiba Yu Ikezono Fumitaka Wada Atsutaka Masuda Takahiko Sakaue Toshimitsu Tanaka Hideki Iwamoto Toru Nakamura Michio Sata Hironori Koga Akihiko Yoshimura Takuji Torimura | 2017 | World Journal of Gastroenterology2017，23，37： | 2 |
| 8 | Effects of aging and persistent prehypertension on arterial stiffening显示文摘 | Hirofumi Tomiyama Hideki Hashimoto Chisa Matsumoto Mari Odaira Masanobu Yoshida Kazuki Shiina Mikio Nagata Akira Yamashina Nobutaka Doba Shigeaki Hinohara | 2011 | Atherosclerosis2011，，1： | 2 |
| 9 | Surgical Strategy for Spinal Metastases显示文摘 | Katsuro Tomita Norio Kawahara Tadayoshi Kobayashi Akira Yoshida Hideki Murakami Tomoyuki Akamaru | 2001 | Spine2001，，3： | 2 |
| 10 | Late-onset severe biliary bleeding after endoscopic pigtail plastic stent insertion显示文摘Here, we report our experience with a case of severe biliary bleeding due to a hepatic arterial pseudoaneurysm that had developed 1 year after endoscopic biliary plastic stent insertion. The patient, a 78-year-old woman, presented with hematemesis and obstructive jaundice. Ruptured hepatic arterial pseudoaneurysm was diagnosed, which was suspected to have been caused by long-term placement of an endoscopic retrograde biliary drainage(ERBD) stent. This episode of biliary bleeding was successfully treated by transarterial embolization(TAE). Pseudoaneurysm leading to hemobilia is a rare but potentially fatal complication in patients with long-term placement of ERBD. TAE is a minimally invasive procedure that offers effective treatment for biliary bleeding. | Muneji Yasuda Hideki Sato Yuki Koyama Tomoki Sakakida Takumi Kawakami Takeshi Nishimura Hideki Fujii Yoshikazu Nakatsugawa Shinya Yamada Naoya Tomatsuri Yusuke Okuyama Hiroyuki Kimura Takaaki Ito Hiroyuki Morishita Norimasa Yoshida | 2017 | World Journal of Gastroenterology2017，23，4： | 2 |
| 11 | Telmisartan, a possible PPAR-δ agonist, reduces TNF-α-stimulated VEGF-C production by inhibiting the p38MAPK/HSP27 pathway in human proximal renal tubular cells显示文摘 | Hideki Kimura Daisuke Mikami Kazuko Kamiyama Hidehiro Sugimoto Kenji Kasuno Naoki Takahashi Haruyoshi Yoshida Masayuki Iwano | 2014 | Biochemical and Biophysical Research Communications2014，，： | 1 |
| 12 | Retroportal Hepaticojejunostomy for Extended Resection of Hilar Bile Ducts显示文摘 | Itaru Endo Mitsutaka Sugita Hideki Masunari Kenichi Yoshida Kazuhisa Takeda Hitoshi Sekido Shinji Togo Hiroshi Shimada | 2008 | Journal of Gastrointestinal Surgery2008，，5： | 1 |
| 13 | Corrigendum to “Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor” [Biochem. Biophys. Res. Commun. 326 (2005) 744–751]显示文摘 | Takatoshi Soga Takahide Ohishi Tetsuo Matsui Tetsu Saito Mitsuyuki Matsumoto Jun Takasaki Shun-ichiro Matsumoto Masazumi Kamohara Hideki Hiyama Shigeru Yoshida Kazuhiro Momose Yoshitaka Ueda Hitoshi Matsushime Masato Kobori Kiyoshi Furuichi | 2005 | Biochemical and Biophysical Research Communications2005，，1： | 1 |
| 14 | Ex Vivo Ultrathin Endoscopy of the Seminal Vesicles显示文摘 | Makoto Shimada Hideki Yoshida | 1996 | The Journal of Urology1996，，： | 1 |
| 15 | Techniques of biliary drainage for acute cholangitis: Tokyo Guidelines显示文摘 | Toshio Tsuyuguchi Tadahiro Takada Yoshifumi Kawarada Yuji Nimura Keita Wada Masato Nagino Toshihiko Mayumi Masahiro Yoshida Fumihiko Miura Atsushi Tanaka Yuichi Yamashita Masahiko Hirota Koichi Hirata Hideki Yasuda Yasutoshi Kimura Steven Strasberg Henry | 2007 | Journal of Hepato-Biliary-Pancreatic Surgery2007，，1： | 1 |
| 16 | Abscess in the inguinal hernial sac after peritonitis surgery: A case report显示文摘In this paper, we report an extremely rare case of an abscess that developed in the inguinal hernial sac after surgery for peritonitis. A 60-year-old man underwent laparoscopic low anterior resection for rectal cancer. One day after this operation, peritoneal drainage and ileostomy were performed for rectal anastomotic leakage. Five days after the second operation, computed tomography revealed an abscess in the left inguinal hernial sac. Subsequently, hernioplasty and resection of the inflamed sac were performed. | Satoshi Ikeda Haruka Takeda Masanori Yoshimitsu Takao Hinoi Makoto Yoshida Daisuke Sumitani Yuji Takakura Yasuo Kawaguchi Manabu Shimomura Masakazu Tokunaga Katsufumi Kawahori Hideki Ohdan Masazumi Okajima | 2009 | World Journal of Gastroenterology2009，15，8： | 1 |
| 17 | Rare occurrence of colorectal cancer metastasis in livers infected with Hepatitis B or C virus显示文摘 | Tohru Utsunomiya Hideki Saitsu Motonori Saku Kohji Yoshida Takashi Matsumata Mitsuo Shimada Keizo Sugimachi | 1999 | The American Journal of Surgery1999，，4： | 1 |
| 18 | A clinical study of 11 cases of combined hepatocellular–cholangiocarcinoma显示文摘 | Yuichi Sanada Shigehiro Shiozaki Hideki Aoki Norihisa Takakura Kazuhiro Yoshida Yoshiyuki Yamaguchi | 2005 | Hepatology Research2005，，3： | 1 |
| 19 | Pitavastatin Reduces Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands in Hypercholesterolemic Humans显示文摘 | Tetsuya Matsumoto Masatoshi Fujita Tatsuya Sawamura Akemi Kakino Yuko Sato Yoshiko Fujita Haruo Matsuda Mamoru Nakanishi Kagehiro Uchida Izuru Nakae Hiroshi Kanda Akira Yoshida Kunihisa Miwa Hideki Hayashi Kenichi Mitsunami Minoru Horie | 2010 | Lipids2010，，4： | 1 |
| 20 | The Impact of Spontaneous Ventilation on Distribution of Lung Aeration in Patients with Acute Respiratory Distress Syndrome: Airway Pressure Release Ventilation Versus Pressure Support Ventilation显示文摘 | Takeshi Yoshida Hiroshi Rinka Arito Kaji Akira Yoshimoto Hideki Arimoto Toshinori Miyaichi Masanori Kan | 2009 | Anesthesia & Analgesia2009，，6： | 1 |
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