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| 1 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 2 | A critical epitope in CD147 facilitates memory CD4^(+) T-cell hyper-activation in rheumatoid arthritis显示文摘The abnormal activation of CD4^(+)CD45RO+memory T(Tm)cells plays an important role in the pathogenesis of rheumatoid arthritis(RA).Previous studies have shown that CD147 participates in T-cell activation.However,it remains unclear whether CD147 is involved in abnormal Tm-cell activation in RA patients.In this study,we demonstrated that CD147 was predominantly upregulated in Tm cells derived from RA patients.The anti-CD147 mAb 5A12 specifically inhibited Tm-cell activation and proliferation and further restrained osteoclastogenesis.Using a structural–functional approach,we depicted the interface between 5A12 and CD147.This allowed us to identify two critical residues,Lys63 and Asp65,as potential targets for RA treatment,as the double mutation K63A/D65A inhibited Tm-cell activation,mimicking the neutralization by 5A12.This study provides not only a theoretical basis for a“CD147-Tm/Osteoclast-RA chain”for the potential prevention and treatment of RA or other T-cell-mediated autoimmune diseases but also a new target for related drug design and development. | Na Guo Sheng Ye Kui Zhang Xiaoling Yu Hongyong Cui Xiangmin Yang Peng lin Minghua Lv Jinlin Miao Yang Zhang Qing Han Rongguang Zhang Zhinan Chen Ping Zhu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 3 | Data-driven containment control of discrete-time multi-agent systems via value iteration显示文摘Dear editor,We consider a containment control problem for a linear discrete-time(DT)multi-agent system via reinforcement learning.Containment control(CC)of multi-agent networks has received extensive attention in the control community in recent years[1–4]. | Zhinan PENG Jiangping HU Bijoy Kumar GHOSH | 2020 | Science China(Information Sciences)2020，63，8： | 1 |
| 4 | Recent advances in the research and development of human defensins显示文摘 | Haiqin Chen Zhinan Xu Li Peng Xiangming Fang Xiufei Yin Naizheng Xu Peilin Cen | 2005 | Peptides2005，，4： | 1 |
| 5 | Gut microbiota have blood types as human显示文摘ABO blood group system was firstly recognized by Landsteiner in 1900[1].Since then,the antigens of the ABO system (A,B and H determinants,respectively)have been shown to encompass complex carbohydrate structures [2].A and B antigen were synthesized by the sequential action of glycosyltransferases,with A and B glycosyltransferases catalyzing the addition of N-acetylgalactosamine and D-galactose to precursor H antigen,respectively. Group O individuals lack such transferase enzymes and consequently continue to express the basic H structure only [3,4].It is determined that approximate 2million ABH glycan antigen sites are presented on each red blood cell [5].Additionally,the ABH antigens are widely expressed in other human ceils and tissues,including the sensory neurons,epithelium,the vascular endothelium and platelets [6]. | Qizheng Wu Hui Zhong Yafei Zhai Yanjiong Jia Zhinan Yin Min Chen Hengwen Yang Peng George Wang | 2018 | Science Bulletin2018，63，20： | 0 |
| 6 | Inhibition of MALT1 paracaspase activity improves lesion recovery following spinal cord injury显示文摘Spinal cord injury(SCI) is a devastating traumatic injury that causes persistent, severe motor and sensory dysfunction. Immune responses are involved in functional recovery after SCI. Mucosa-associated lymphoid tissue lymphoma translocation 1(MALT1) has been shown to regulate the survival and differentiation of immune cells and to play a critical role in many diseases, but its function in lesion recovery after SCI remains unclear. In this paper, we generated KI(knock in) mice with a point mutation(C472 G) in the active center of MALT1 and found that the KI mice exhibited improved functional recovery after SCI.Fewer macrophages were recruited to the injury site in KI mice and these macrophages differentiated into anti-inflammatory macrophages. Moreover, macrophages from KI mice exhibited reduced phosphorylation of p65, which in turn resulted in decreased SOCS3 expression and increased pSTAT6 levels.Similar results were obtained upon inhibition of MALT1 paracaspase with the small molecule inhibitor‘‘MI-2' or the more specific inhibitor ‘‘MLT-827'. In patients with SCI, peripheral blood mononuclear cells(PBMC) displayed increased MALT1 paracaspase. Human macrophages showed reduced proinflammatory and increased anti-inflammatory characteristics following the inhibition of MALT1 paracaspase. These findings suggest that inhibition of MALT1 paracaspase activity in the clinic may improve lesion recovery in subjects with SCI. | Hua Zhang Guodong Sun Xiaowei Li Zhen Fu Chengbin Guo Guangchao Cao Baocheng Wang Qian Wang Shuxian Yang Dehai Li Xichun Xia Peng Li Jing Zhu Wei Zhou Liangyan Zheng Jingxia Li Lei Zhang Jianlei Hao Libing Zhou Frederic Bornancin Zhizhong Li Zhinan Yin Yunfei Gao | 2019 | Science Bulletin2019，64，16： | 0 |
| 7 | Distributed multi-agent temporal-difference learning with full neighbor information显示文摘This paper presents a novel distributed multi-agent temporal-difference learning framework for value function approximation,which alows agents using all the neighbor information instead of the information from only one neighbor.With full neighbor information,the proposed framework(1)has a faster convergence rate,and(2)is more robust compared to the state of-the art approaches.Then we propose a distributed multi-agent discounted temporal dfferene algorithm and a distributed muli-agent average cost temporal diference leaming algorithm based on th framework.Moreover,the two proposed algorthms'theoretical convergence proofs are provided.Numerical simulation resuts show that our proposed algorihms are superior to the gossip-based algorithm in convergence speed,robustness to noise and time-varying network topology. | Zhinan Peng Jiangping Hu Rui Luo Bijoy K.Ghosh | 2020 | Control Theory and Technology2020，18，4： | 0 |
| 8 | Optimal containment control of continuous-time multi-agent systems with unknown disturbances using data-driven approach显示文摘Dear editor,Containment control problems of multi-agent systems(MASs)have attracted considerable attention in recent years owing to their widespread use in applications pertaining to spacecraft control,sensor networks,power systems,and mobile robots. | Zhinan PENG Jiefu ZHANG Jiangping HU Rui HUANG Bijoy Kumar GHOSH | 2020 | Science China(Information Sciences)2020，63，10： | 0 |
| 9 | The role of AFAP1-AS1 in mitotic catastrophe and metastasis of triple-negative breast cancer cells by activating the PLK1 signaling pathway显示文摘Triple-negative breast cancer(TNBC)is characterized by fast growth,high metastasis,high invasion,and a lack of therapeutic targets.Mitosis and metastasis of TNBC cells are two important biological behaviors in TNBC malignant progression.It is well known that the long noncoding RNA AFAP1-AS1 plays a crucial role in various tumors,but whether AFAP1-AS1 is involved in the mitosis of TNBC cells remains unknown.In this study,we investigated the functional mechanism of AFAP1-AS1 in targeting Polo-like Kinase 1(PLK1)activation and participating in mitosis of TNBC cells.We detected the expression of AFAP1-AS1 in the TNBC patient cohort and primary cells by in situ hybridization(ISH),northern blot,fluorescent in situ hybridization(FISH)and cell nucleus/cytoplasm RNA fraction isolation.High AFAP1-AS1 expression was negatively correlated with overall survival(OS),disease-free survival(DFS),metastasis-free survival(MFS)and recurrence-free survival(RFS)in TNBC patients.We explored the function of AFAP1-AS1 by transwell,apoptosis,immunofluorescence(IF)and patient-derived xenograft(PDX)models in vitro and in vivo.We found that AFAP1-AS1 promoted TNBC primary cell survival by inhibiting mitotic catastrophe and increased TNBC primary cell growth,migration and invasion.Mechanistically,AFAP1-AS1 activated phosphorylation of the mitosis-associated kinase PLK1 protein.Elevated levels of AFAP1-AS1 in TNBC primary cells increased PLK1 pathway downstream gene expression,such as CDC25C,CDK1,BUB1 and TTK.More importantly,AFAP1-AS1 increased lung metastases in a mouse metastasis model.Taken together,AFAP1-AS1 functions as an oncogene that activates the PLK1 signaling pathway.AFAP1-AS1 could be used as a potential prognostic marker and therapeutic target for TNBC. | SHUIZHONG CEN XIAOJIE PENG JIANWEN DENG HAIYUN JIN ZHINAN DENG XIAOHUA LIN DI ZHU MING JIN YANWEN ZHU PUSHENG ZHANG YUNFENG LUO HONGYAN HUANG | 2023 | Oncology Research2023，31，3： | 0 |
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