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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Re-Os Dating of Galena and Sphalerite from Lead-Zinc Sulfide Deposits in Yunnan Province, SW China显示文摘Dating of lead-zinc deposits is of critical importance for better understanding of ore genesis, but has long been a big challenge due to the lack of suitable minerals that can be unequivocally linked to the ore genesis and that can be used for tradition radiometric methods. This kind of deposits have simple mineralogy dominated by galena and sphalerite commonly associated with calcite and other gangue minerals. Both galena and sphalerite have low and high variable Re concentrations and thus Re-Os dating of these minerals have been less promising. In addition, the recovery of Re is extremely low for galena when conventional method was applied, lending additional difficulty in precisely dating galena. In this study, we investigate the recovery of Re using different media for anion exchange separation and reporte a revised preparation method for Re-Os dating of galena and sphalerite. By using the new protocol, two reliable Re-Os isochron ages of galena and sphalerite from the Fule(20.4±3.2 Ma) and Laochang(308±25 Ma) Pb-Zn deposits in Yunnan Province, SW China, are achieved. | Yingying Liu Liang Qi Jianfeng Gao Lin Ye Zhilong Huang Jiaxi Zhou | 2015 | Journal of Earth Science2015，26，3： | 14 |
| 3 | treatment of swine wastewater in aerobic granular reactors: comparison of different seed granules as factors显示文摘使成粒状过程,药品化学药品性质,污染移动能力和有不同喂废水的氧气的小粒的细菌的社区(合成废水, R1;猪废水, R2 ) ,并且在对待猪废水的长期的操作反应堆的小粒的二种类型的一些参数的变化趋势在这个实验被调查。结果显示有合成废水的氧气的使成粒状在 R1 与猪废水和那完整的使成粒状相比有更快的率, R2 分别地在第 30 天和第 39 白天被到达。然而,尽管 feed 废水也在使成粒状过程期间在生物资源部分和氧气的小粒的细胞外的聚合物质上有明显的效果,这些性质在长期的操作以后在类似的水平留下了。而且,一个类似的增加趋势能也在反应堆,和 organics 的平均特定的移动率以氧气的小粒的氮移动效率被观察,在不变的阶段的氨氮为 R1 是 35.33 mgg 1 VSS 和 51.46 mgg 1 VSS ,并且为 R2 的 35.47 mgg 1 VSS 和 51.72 mgg 1 VSS 分别地。另外,在细菌的差异的移动发生在使成粒状过程,而在氧气的小粒的反应堆的细菌的社区没被种子小粒在长期的操作以后影响。 | Lin LIU Qiyu YOU Valerie GIBSON Xu HUANG Shaohua CHEN Zhilong YE Chaoxiang LIU | 2015 | Frontiers of Environmental Science & Engineering2015，9，6： | 9 |
| 4 | Geological significance of nickeliferous minerals in the Fule Pb–Zn deposit, Yunnan Province, China显示文摘The Fule Pb–Zn deposit is located in the Sichuan–Yunnan–Guizhou Province, and it is an important and giant low temperature metallogenic domain in China.In our research area, the Pb–Zn deposits are mainly hosted in the Permian Yangxin Formation and are composed of dolostone and limestone. The distance between the ore bodies and the Permian Emeishan basalt ranged from 50 to160 m. In this study, the nickel rich minerals, including vaesite, polydymite and millerite, were reported for the first time in the Fule deposit. These minerals occurred as xenomorphic mineral aggregate and were sporadically distributed in the sphalerite–galena–calcite vein, which is the main ore type in the deposit. Our study indicated that the paragenetic sequence of minerals in the Fule deposit is the following order: polydymite → vaesite→ millerite → sphalerite → galena → tetrahedrite(tennantite).The geological occurrence characteristics of those nickeliferous minerals suggested that the Permian Emeishan basalt is a possible barrier layer of Pb–Zn ore-forming fluid, and it is an important source for the Ni and part of the Cu in the deposit. The Sichuan–Yunnan–Guizhou Pb–Zn mineralization province is a world-class production base of Pb and Zn, in which the Permian Emeishan basalt and Pb–Zn deposits have uniformly spatial distribution, but the relationship of mineralization between them is still under debate. This report provides new evidence forunderstanding the relationship between Pb–Zn mineralization and Permian Emeishan basalt in the Sichuan–Yunnan–Guizhou Pb–Zn mineralization province. | Zhenli Li Lin Ye Yusi Hu Zhilong Huang | 2018 | Acta Geochimica2018，37，5： | 6 |
| 5 | The mixing of multi-source fluids in the Wusihe Zn–Pb ore deposit in Sichuan Province, Southwestern China显示文摘The Sichuan-Yunnan-Guizhou(SYG)metallogenic province of southwest China is one of the most important Zn-Pb ore zones in China,with^200 Mt ZnPb ores at mean grades of 10 wt.%Zn and 5 wt.%Pb.The source and mechanism of the regional Zn-Pb mineralization remain controversial despite many investigations that have been conducted.The Wusihe Zn-Pb deposit is a representative large-scale Zn-Pb deposit in the northern SYG,which mainly occurs in the Dengying Formation and yields Zn-Pb resources of^3.7 Mt.In this paper,Zn and S isotopes,and Fe and Cd contents of sphalerite from the Wusihe deposit were investigated in an attempt to constrain the controls on Zn and S isotopic variations,the potential sources of ore-forming components,and the possible mineralization mechanisms.Both theδ66Zn andδ34S values in sphalerite from the Wusihe deposit increase systematically from the bottom to the top of the strata-bound orebodies.Such spatial evolution inδ66Zn andδ34S values of sphalerite can be attributed to isotopic Rayleigh fractionation during sphalerite precipitation with temperature variations.The strong correlations between the Zn-S isotopic compositions and Fe-Cd concentrations in sphalerite suggest that their variations were dominated by a similar mechanism.However,the Rayleigh fractionation mechanism cannot explain the spatial variations of Fe and Cd concentrations of sphalerite in this deposit.It is noted that the bottom and top sphalerites from the strata-bound orebodies document contrasting Zn and S isotopic compositions which correspond to the Zn and S isotopic characteristics of basement rocks and host rocks,respectively.Therefore,the mixing of two-source fluids with distinct Zn-S isotopic signatures was responsible for the spatial variations of Zn-S isotopic compositions of sphalerite from the Wusihe deposit.The fluids from basement rocks are characterized by relatively lighter Zn(~0.2‰)and S(~5‰)isotopic compositions while the fluids from host rocks are marked by relatively heavier Zn(~0.6‰)and S(~15‰)isotopic compositions. | Hongjie Zhang Haifeng Fan Chaoyi Xiao Hanjie Wen Lin Ye Zhilong Huang Jiaxi Zhou Qingjun Guo | 2019 | Acta Geochimica2019，38，5： | 6 |
| 6 | Growth factor regulatory system:a new system for not truly recognized organisms显示文摘Growth,development,aging,and disease occurrence in organisms,especially animals or Homo sapiens,are regulated by different regulatory systems in vivo.The nervous,endocrine,metabolic,and immune systems are the traditional biological systems essential for the growth,development,and metabolism of the body.These systems maintain a balance and precisely biologically regulate every aspect of life activities under normal circumstances.However,in abnormal situations,owing to endogenous or exogenous attack,these regulatory systems result in dysfunction,subsequently leading to illness or injury(Muggianu et al.,2018).In the classical neuroendocrine regulatory system,Cushing’s syndrome is defined as a series of abnormal clinical symptoms with chronic overproduction of glucocorticoids in the adrenal cortex.Its clinical manifestations are“moon face”and“buffalo hump,”involving blood circulation,bone metabolism,and gonadal function,among others.In addition,severe trauma or burn leads to an imbalanced immune regulatory system,resulting in excessive inflammatory reactions and sepsis.Thus,an independent or cooperative regulation of multiple regulatory systems is critical in maintaining the body’s homeostasis,healthy development,and growth. | Jian Xiao Zhuofeng Lin Hua Qin Zhilong Zheng Fanghua Gong Yanlong Liu Xiaokun Li Xiaobing Fu | 2020 | Science China(Life Sciences)2020，63，3： | 5 |
| 7 | Trace Elements in Sphalerite from the Dadongla Zn-Pb Deposit, Western Hunan-Eastern Guizhou Zn-Pb Metallogenic Belt, South China显示文摘The western Hunan-eastern Guizhou Zn-Pb metallogenic belt is one of the important Zn-Pb mineralization regions in China.The Dadongla deposit,located in the northeast of Guizhou Province,is one of the typical Zn-Pb deposits in the region and has estimated resources more than 12 million metric tons(Mt)with an average grade of 4.11 wt%Zn+Pb.Its orebodies are hosted in the lower Cambrian Aoxi Formation dolomite,occurring as bedded,para-bedded in shape,and in conformity with the wall rock.The ore mineral assemblage is simple,dominated by sphalerite with minor pyrite and galena,and the gangue minerals are composed of dolomite,calcite with minor bitumen and barite.In view of the lack of geological and geochemical researches,the genesis of Zn-Pb ore is still unclear.Laser ablation-inductively coupled plasma mass spectrometry(LA-ICPMS)spot and mapping analyses were used to obtain sphalerite trace element chemistry in the Dadongla Zn-Pb deposit in Guizhou,China,aiming to constrain its ore genesis.The results show that sphalerite is characterized by the enrichment of Cd,Fe,Ge and Hg,corresponding with that of typical MVT deposits.Four zones were identified in the sphalerite crystal from Dadongla from the center to margin according to the color bands.in which the zone in the center,representing the early ore-stage sphalerite,is characterized by enrichment of Cd relatively,while the zone forming at late ore-stage is enriched in Ge and Hg relatively.The finding was controlled by differential leached metals content in ore-forming fluid from its source rock.Notably,critical element Ge trends to be enriched at the late ore-stage and follows a substitution of 2 Zn^2+(?)Ge^4++□(vacancy).Moreover,the calculated ore-forming temperature ranges from 79.9℃to 177.6℃by the empirical formula,which is similar to that of typical Mississippi Valley-type(MVT)deposits.Compared with the features of trace elements in sphalerite from different types of deposits,together with the geology,the Dadongla deposit belongs to an MVT Zn-Pb deposit. | HU Yusi YE Lin WEI Chen LI Zhenli HUANG Zhilong WANG Haoyu | 2020 | Acta Geologica Sinica(English Edition)2020，94，6： | 3 |
| 8 | Genesis of the Maoping carbonate-hosted Pb–Zn deposit,northeastern Yunnan Province,China:evidences from geology and C–O–S–Pb isotopes显示文摘The Maoping Pb-Zn deposit(~3 Mt Pb+Zn reserves with grades of 12-30 wt%)is one of the largest Pb-Zn deposits in the Sichuan-Yunnan-Guizhou(SYG)metallogenic province,which has contributed a tremendous amount of lead and zinc resources for China.To obtain a further understanding of the sources of ore-forming materials and ore genesis of the deposit,S-Pb isotopes of sulfides and C-O isotopes of ore-stage calcites were systematically collected from representative orebodies at different elevations with a Finnigan MAT-253 mass spectrometer.The calcites separated from the sulfides of the NoⅠand NoⅡorebodies shared identical b13 CPDB values(-5.3 to-0.8‰)andδ18OSMOW values(+14.5 to+21.8‰)with those of the calcites in the SYG region,suggesting that CO2 in regional ore-forming fluids possibly had a homologous C-O source that originated from a ternary mixture of the dissolution of marine carbonate rocks,degassing process of the Emeishan mantle plume,and dehydroxylation of sedimentary organic matter.The No.Ⅰ-1 and No.Ⅰ-2 orebody was hosted in the same strata,but the sulfur source of No.Ⅰ-1 orebody(+13.1 to+19.0‰)with equilibrated sulfur fractionation(δ34Sspbaierite-<δ34Sgalena)and No.Ⅰ-2 orebody(+18.0 to+21.8‰)with sulfur equilibrium fractionation(δ34Sspnaierite>δ34-Sgalena)were different.They were derived from the allopatry thermochemical sulfate reduction(TSR)of overlying Carboniferous sulfates in the ore-hosting strata and local TSR of sulfates in the ore-bearing Upper Devonian Zaige Formation,respectively.The narrow and uniform Pb isotopic ratios of single galena grains collected from sulfides with 206Pb/204Pb of 18.713-18.759,207Pb/204Pb of 15.772-15.776 and 208Pb/204Pb of39.383-39.467 indicate a well-mixed metal source(s)that consist of Proterozoic Kunyang and Huili Group basement rocks and Devonian to Middle Permian ore-hosting sedimentary rocks.Besides,the late Permian Emeishan basalts are difficult to contribute metals for regional Pb-Zn mineralization despite a closely spatial relationship with the distribution of the Pb-Zn deposit.This is supported by Pb isotopic ratios plotting above the average upper crustal Pb evolution curves and staying far away from that of the agecorrected Emeishan basalts.Hence,taking into account of the similarities in tectonic setting,ore-hosting rock,ore assemblage,wall rock alteration,ore-controlling structure,and ore-forming materials and the differences in relationship with regional magmatism,fluid inclusion characteristic and ore grade between the Maoping deposit and typical MVT Pb-Zn deposit,the ore genesis of the Maoping deposit should be an MVT like Pb-Zn deposit. | Yufan He Tao Wu Zhilong Huang Lin Ye Ping Deng Zhenzhong Xiang | 2020 | Acta Geochimica2020，39，5： | 3 |
| 9 | Co-strengthening contribution of δ′and T_1 precipitates in Al-Li alloys 2090 and 2090+Ce显示文摘The microstructure of dislocation in two kinds of aluminum-lithium alloys 2090 and 2090 + Ce was observed by means of TEM technology. The contributions of δ′ and T1 precipitates to strength were separately calculated by using the results of quantitative metallography and analysis of micro-deformation behavior; the co-strengthening effect of δ′ and T1 precipitates was studied. The results show that the adding relationship of co-strengthening of δ′ and T1 is in accordance with q = 1.4 form at the near peak-aged condition, i.e., 11.4 1.4 1.4?τ p = ?τ δ’ + ? τT; but the adding relationship is approximately a linear relation (q = 1) at the under-aged condition and becomes the parabola form when over-aged (q = 2). The adding rela-tionship of co-strengthening contribution of δ′ and T1 is obviously dependent on aging time. | ZHAO Zhilong LIU Lin CHEN Zheng | 2006 | Rare Metals2006，25，3： | 3 |
| 10 | Research Progress of the Mineralization of Carbonate-Hosted Pb-Zn Deposits in the Sichuan-Yunnan-Guizhou Pb-Zn Metallogenic Province, Southwest China显示文摘The Sichuan-Yunnan-Guizhou(SYG)Pb-Zn metallogenic province in the western Yangtze Block,is a key component of the low-temperature metallogenic domain in South China.In this area,more than 400 Pb-Zn deposits have been discovered,and the total proven reserves are up to 260 million tons with lead and zinc grade reaching 10%,even up to 30%.Another | ZHOU Jiaxi HUANG Zhilong YE Lin BAO Zhiwei LIU Yun XIA Yong | 2015 | Acta Geologica Sinica(English Edition)2015，89，1： | 3 |
| 11 | A method forthe catalytic reduction of graphene oxide at temperatures be-low 150°C显示文摘 | Li Junfeng Lin Hong Yang Zhilong | 2011 | Carbon2011，49，： | 1 |
| 12 | Genesis of fahlore in the Tianbaoshan lead–zinc deposit, Sichuan Province, China: a scanning electron microscopy–energy dispersive spectroscopy study显示文摘The Tianbaoshan deposit, located in the southwestern part of the Yangtze Block, is a representative Pb–Zn deposit in the Sichuan–Yunnan–Guizhou Pb–Zn metallogenic province. The Pb–Zn orebodies are hosted in the upper Sinian Dengying Formation dolostone. The predominant minerals are sphalerite, galena, pyrite, chalcopyrite, quartz, and calcite with minor arsenopyrite,fahlore, and dolomite. The deposit is characterized by relatively strong Cu mineralization. However, the relationship between Pb–Zn and Cu mineralization is unknown. We analyzed the mineralogy and composition of fahlore, chalcopyrite, arsenopyrite, sphalerite, and galena using scanning electron microscopy–energy dispersive spectroscopy, with the aim of providing new evidence for the genesis of the Pb–Zn–(Cu) ore. The results show that the Cu ore in the deposit is dominated by chalcopyrite and fahlore, both of which formed before or during the Pb–Zn ore-forming stage. The fahlore showed dramatic compositional variation and was characterized by negative correlations between Ag and Cu, and between As and Sb,suggesting substitution of Ag for Cu, and that As and Sb substitute in the same site in the fahlore lattice. Based on backscattered electron images and composition, the fahlorewas divided into two types. Type I fahlore crystallized early and is characterized by enrichment of Cu and depletion in Ag and Sb. Type II fahlore formed after Type I, and is rich in Ag and poor in Cu and As. Moreover,galena and fahlore are the host minerals of Ag. The variation of valence state with As host mineral—from fahlore to arsenopyrite—indicates the metallogenic environment changed from relatively oxidizing to reducing with a high p H. In the light of Gibbs energies of reciprocal reactions and isotherms for cation exchange, the composition of the fahlore implies its ore-forming temperature was lower than220 °C, corresponding with typical Mississippi Valley-type(MVT) deposits. Based on the geologic character and geochemical data of this deposit, we suggest that the Tianbaoshan deposit belongs to the MVT deposit category. | Yusi Hu Lin Ye Zhenli Li Zhilong Huang Jiawei Zhang | 2018 | Acta Geochimica2018，37，6： | 1 |
| 13 | Simultaneous and systematic analysis of cellular and viral gene expression during Enterovirus 71-induced host shutoff显示文摘Dear Editor, Enteroviruses, including poliovirus, enterovirus 71 (EV71), enterovirus 68, coxsackievirus A16, cause millions of infections every year. The infection can lead to serious human diseases and is a significant public health problem. Among them, EV71 is an emerging pathogen that causes severe hand, foot and mouth disease (HFMD) and neurological disease, especially in young children. Currently, there is no effective treatment to EV71-caused diseases, partially blaming to a lack of understanding EV71 replication mechanism (Solomon et al., 2010). As a member of Picornaviri-dae, EV71 infection induces a rapid induction of host shutoff, which is marked by the inhibition of cellular protein synthesis (Holland, 1963). In the meantime, viral protein synthesis takes over the cellular translational machinery. It is believed that the cellular protein synthesis shutoff benefits viral replication by relocating cellular resources and facilitating viral escape from host cell immune responses (Cao et al., 2017). Both transcription and translation inhibition have been suggested to contribute to the host protein synthesis shutoff during picornavirus infection (Holland, 1963;Belsham, 2009). However, the relative role of transcription and translation inhibition in virus-induced host shutoff is yet elusive. | Yongquan Lin Yan Wang Hui Li Yuhang Chen Wentao Qiao Zhi Xie Juan Tan Zhilong Yang | 2019 | Protein & Cell2019，10，1： | 1 |
| 14 | Alignment and Permeability of Al-7Si Alloy Directional Solidification with the Application of a Pulsed Magnetic Field显示文摘 | Zhilong Zhao Tian Qi Peng Hu Haiguo Ren Lin Liu | 2012 | Materials and Manufacturing Processes2012，，5： | 1 |
| 15 | Managing urban nutrient biogeochemistry for sustainable urbanization显示文摘 | Tao Lin Valerie Gibson Shenghui Cui Chang-Ping Yu Shaohua Chen Zhilong Ye Yong-Guan Zhu | 2014 | Environmental Pollution2014，，： | 1 |
| 16 | Profiling the Bisecting N-acetylglucosamine Modification in Amniotic Membrane via Mass Spectrometry显示文摘Bisecting N-acetylglucosamine(GlcNAc),a GlcNAc linked to the coreβ-mannose residue via aβ1,4 linkage,is a special type of N-glycosylation that has been reported to be involved in various biological processes,such as cell adhesion and fetal development.This N-glycan structure is abundant in human trophoblasts,which is postulated to be resistant to natural killer cellmediated cytotoxicity,enabling a mother to nourish a fetus without rejection.In this study,we hypothesized that the human amniotic membrane,which serves as the last barrier for the fetus,may also express bisected-type glycans.To test this hypothesis,glycomic analysis of the human amniotic membrane was performed,and bisected N-glycans were detected.Furthermore,our proteomic data,which have been previously employed to explore human missing proteins,were analyzed and the presence of bisecting GlcNAc-modified peptides was confirmed.A total of 41glycoproteins with 43 glycopeptides were found to possess a bisecting GlcNAc,and 25 of these glycoproteins were reported to exhibit this type of modification for the first time.These results provide insights into the potential roles of bisecting GlcNAc modification in the human amniotic membrane,and can be beneficial to functional studies on glycoproteins with bisecting GlcNAc modifications and functional studies on immune suppression in human placenta. | Qiushi Chen Yuanliang Zhang Keren Zhang Jie Liu Huozhen Pan Xinran Wang Siqi Li Dandan Hu Zhilong Lin Yun Zhao Guixue Hou Feng Guan Hong Li Siqi Liu Yan Ren | 2022 | Genomics, Proteomics & Bioinformatics2022，20，4： | 0 |
| 17 | Underground space use of urban built-up areas in the central city of Nanjing:Insight based on a dynamic population distribution显示文摘With the expansion of cities and the emergence of various urban problems,urban underground space has been developed as a solution.In China’s urban transition context,there is a need for the development of underground space in urban built-up areas.In this casestudy of the central city of Nanjing,we used spatial analysis and statistical methods to characterize the underground space use of urban built-up areas from a dynamic spatiotemporal perspective.We first analyzed the relationship between the population distribution and the underground space use of the central city of Nanjing based on a Baidu heat map,which can reflect the real-time population distribution,and then,we explored the spatiotemporal characteristics and spatial structure of the underground space use in urban built-up areas.The analysis results provide a reference for planning to improve and optimize the layout of underground space in the central city of Nanjing and,more generally,for the stock-type planning of underground space in urban built-up areas. | Yulu Chen Zhilong Chen Dongjun Guo Ziwei Zhao Tong Lin Chenhao Zhang | 2022 | Underground Space2022，7，5： | 0 |
| 18 | Cell-penetrating riboflavin conjugate for antitumor photodynamic therapy显示文摘Riboflavin(RF,vitamin B2)is an essential vitamin and has been considered as a promising natural photosensitizer for photodynamic therapy(PDT).However,further exploration of RF in antitumor application was limited by its poor cellular uptake.In this study,using cell-penetrating peptides Arg8,(Cha-Arg)3 and small molecule triphenylphosphine(TPP)as delivery compounds,three RF conjugates were prepared to increase the accumulation of RF in cells,termed as Arg8-RF,(Cha-Arg)3-RF and TPP-RF,respectively.Compared with TPP-RF and Arg8-RF,(Cha-Arg)3-RF exhibited better cell internalization and stronger cytotoxicity against HeLa cells upon exposure to blue light.Further researches proved that(Cha-Arg)3-RF generated reactive oxygen species(ROS)under irradiation,which could indiscriminately destroy endogenous proteins and mitochondria,ultimately inducing cell death.This work provides a new approach to explore RF as a natural photosensitizer for antitumor photodynamic therapy. | Chunlei Wu Yanyan Li Zhehong Cheng Pengxin Wang Zhilong Ma Ke Liu Yulian Cheng Yimin Zhou Xian Lin Ximing Shao Yong Yang Hongchang Li Lijing Fang | 2022 | Chinese Chemical Letters2022，33，9： | 0 |
| 19 | Predicting adsorption ability of adsorbents at arbitrary sites for pollutants using deep transfer learning显示文摘Accurately evaluating the adsorption ability of adsorbents for heavy metal ions(HMIs)and organic pollutants in water is critical for the design and preparation of emerging highly efficient adsorbents.However,predicting adsorption capabilities of adsorbents at arbitrary sites is challenging,with currently unavailable measuring technology for active sites and the corresponding activities.Here,we present an efficient artificial intelligence(AI)approach to predict the adsorption ability of adsorbents at arbitrary sites,as a case study of three HMIs(Pb(Ⅱ),Hg(Ⅱ),and Cd(Ⅱ))adsorbed on the surface of a representative two-dimensional graphitic-C_(3)N_(4).We apply the deep neural network and transfer learning to predict the adsorption capabilities of three HMIs at arbitrary sites,with the predicted results of Cd(Ⅱ)>Hg(Ⅱ)>Pb(Ⅱ)and the root-mean-squared errors less than 0.1 eV.The proposed AI method has the same prediction accuracy as the ab initio DFT calculation,but is millions of times faster than the DFT to predict adsorption abilities at arbitrary sites and only requires one-tenth of datasets compared to training from scratch.We further verify the adsorption capacity of g-C_(3)N_(4) towards HMIs experimentally and obtain results consistent with the AI prediction.It indicates that the presented approach is capable of evaluating the adsorption ability of adsorbents efficiently,and can be further extended to other interdisciplines and industries for the adsorption of harmful elements in aqueous solution. | Zhilong Wang Haikuo Zhang Jiahao Ren Xirong Lin Tianli Han Jinyun Liu Jinjin Li | 2021 | npj Computational Materials2021，，1： | 0 |
| 20 | Observation of low thermal expansion behavior and weak thermal anisotropy in M_(3)A_(2)C phases显示文摘M_(3)A_(2)X phases,named 321 phases,are an atypical series of MAX phases featuring in the MA-triangular-prism bilayers,with the A=As/P,exhibiting excellent elastic properties.This work systematically studies the thermal expansion properties of 321 phases.We found their average linear thermal expansion coefficients(TECs),α_(L)=5-6μK^(–1),are the lowest among the reported values of MAX phases.The lowest average TEC was found in Nb_(3)As_(2)C(αa=4.46(4)μK^(–1),αc=5.09(4)μK–1,αL=5.09(4)μK–1).The average TEC and anisotropy factor(αc/αa)of Nb_(3)As_(2)C and Nb_(3)P_(2)C were lower than the ones of the corresponding 211 phases.The best isotropy performance was found in Nb_(3)P_(2)C (αc/αa=1.11).Moreover,our first-principles calculations demonstrate that the weaker chemical bonding between Nb-As/P than Nb-C induces thermal expansion in M_(3)A_(2)X phases.Furthermore,a relatively weaker anharmonic effect in 321 phases than in the 211 phases was revealed by the as-calculated average Grüneisen parameters,which account for the lower TECs in 321 phases.The low TECs and enhanced thermal isotropy make 321 phases outstanding among MAX phases,which could be sound candidates for varying-temperature structural-functional components. | Hongxiang Chen Zhilong Zhang Jun Deng Zhijie Lin Chunfu Hong Shixuan Du Pinqiang Dai | 2023 | Journal of Materials Science & Technology2023，，23： | 0 |
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