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| 1 | Targeting glutamine metabolism in PIK3CA mutant colorectal cancers显示文摘We recently reported that PIK3CA mutant colorectal cancers(CRCs)are addicted to glutamine through up-regulation of glutamate pyruvate transaminase 2(GPT2).A GPT2 inhibitor suppresses in vivo growth of PIK3CA mutant,but not wild-type,CRCs.This study indicates that targeting glutamine may be an effective approach to treat CRCs with PIK3CA mutations. | Xiujing Feng Yujun Hao Zhenghe Wang | 2016 | Genes & Diseases2016，3，4： | 4 |
| 2 | Mutations in TP53, ZNF750, and RB1 typify ocular sebaceous carcinoma显示文摘Sebaceous carcinoma (SC) of the eyelid is a rare but aggressive malignancy, accounting for 3%—5% of eyelid malignancies in the United States, and up to 35% in Asian populations (Deprez and Uffer, 2009;Xu et al., 2018;Yu et al., 2018). It is frequently mistaken for benign conditions or less aggressive malignancies such as basal cell carcinoma (Muqit et al., 2013), and the effects of delay in diagnosis can be devastating to patients. Aggressive surgical resection is the primary treatment of these tumors and often invoIves orbital exenteration with significant morbidity to patients, and these tumors frequently recur, with local recurrence rate as high as 18%. Importantly, this disease has a high metastatic potential, and there are very limited data guiding systemic treatment options;ultimately 6%—18% of patients diagnosed with SC of the eyelid succumb to metastatic disease (Zurcher et al., 1998;Shields et al., 2004). | Yongyang Bao J. Eva Selfridge Janet Wang Yiqing Zhao Junqi Cui Kishore Guda Zhenghe Wang Yanbo Zhu | 2019 | Journal of Genetics and Genomics2019，46，6： | 4 |
| 3 | Physics issues in diffraction limited storage ring design显示文摘Diffraction limited electron storage ring is considered a promising candidate for future light sources,whose main characteristics are higher brilliance,better transverse coherence and better stability.The challenge of diffraction limited storage ring design is how to achieve the ultra low beam emittance with acceptable nonlinear performance.Effective linear and nonlinear parameter optimization methods based on Artificial Intelligence were developed for the storage ring physical design.As an example of application,partial physical design of HALS(Hefei Advanced Light Source),which is a diffraction limited VUV and soft X-ray light source,was introduced.Severe emittance growth due to the Intra Beam Scattering effect,which is the main obstacle to achieve ultra low emittance,was estimated quantitatively and possible cures were discussed.It is inspiring that better performance of diffraction limited storage ring can be achieved in principle with careful parameter optimization. | FAN Wei BAI ZhengHe GAO WeiWei FENG GuangYao LI WeiMin WANG Lin HE DuoHui | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，5： | 2 |
| 4 | Regulation of protein stability of DNA methyltransferase 1 by post-translational modifications显示文摘DNA methylation 是保证正确基因表示并且维持基因 stability.DNA methyltransferase 的重要 epigenetic 机制(DNMT1 ) 1 是在复制期间维持 DNA methylation 的主要的酶。Dysregulation ofDNMT1 在许多疾病被含有。DNMT1 蛋白质稳定性经由各种各样的 translational 以后修正被调整,例如 acetylation 和 ubiquitination,而且通过 proteinprotein 相互作用。这些机制保证 DNMT1 在房间周期并且在正确 genomic loci 的正确时间期间是 properlyactivated,以及响应适当 extracellularcues。这些规章的机制的进一步的理解可以帮助为人的疾病设计新奇治疗学的途径。 | Anthony Scott Jing Song Rob Ewing Zhenghe Wang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，3： | 2 |
| 5 | Synthesis,Conductivity and Photosensitivity of 2-D Conjugated Polymers of Metal-porphyrazine with Sulfur Bridges显示文摘Theporphyrazines(Pzs),i.e.tetraazaporphyrins(TAPs),andphthalocyanines(Pcs)andtheirpoly-mershavebeenreportedinmanypapers[1~13]... | Peng Zhenghe,\ Chen Xiaogui,\ Wang Zhengping,\ Wei Yihai,\ Qin Zibin College of Chemistry,Wuhan University, Wuhan 430072,China | 1998 | Wuhan University Journal of Natural Sciences1998，3，3： | 2 |
| 6 | Fundamental study of an ambient temperature ferrite process in the treatment of acid mine drainage显示文摘 | Wang Weixing Xu Zhenghe Finch J | 1996 | Environmental Science & Technolo- gy1996，30，8： | 1 |
| 7 | Synthesis of LiNi 1/3 Co 1/3 Mn 1/3 O 2 as a cathode material for lithium battery by the rheological phase method显示文摘 | Haibo Ren Yourong Wang Daocong Li Lihua Ren Zhenghe Peng Yunhong Zhou | 2008 | Journal of Power Sources2008，，1： | 1 |
| 8 | A facile and sensitive method of quantifying glutaminase binding to its ninhibitor CB-839 in tissues显示文摘Many cancer types reprogram their metabolism to become addicted to glutamine.One of the critical enzymes in the utilization of glutamine in these cells is glutaminase.CB-839(telaglenastat)is a drug that targets glutaminase that is currently being evaluated in many clinical trials for efficacy in various cancer types that are known to be driven by glutamine metabolism.Despite its use,there are limited assays available for testing the pharmacodynamic on-target effects of CB-839 on the limited,small-volume patient samples that are obtained in early-phase clinical trials.Thus,we developed an assay based on the cellular thermal shift assay technique using AlphalLlSA technology to show that CB-839 specifically engages glutaminase in colon cancer cell lines in vitro and in minute quantities of mouse xenograft tumors.Notably,we show that this assay detects CB-839 binding to glutaminase in platelets of patients collected while receiving CB-839 on a clinical trial.This assay may be used to study the pharmacodynamic profile of CB-839 in very small tissue samples obtained from patients on a clinical trial and may be useful infuture studies designed to screen other in hibitors of glutaminase. | Yicheng Chen Yiqing Zhao David L.Bajor Zhenghe Wang J.Eva Selfridge | 2020 | Journal of Genetics and Genomics2020，47，7： | 1 |
| 9 | A water-free metal organic deposition method for YBa2Cu3O7?δ thin film fabrication显示文摘 | Rongxia Huang Feng Feng Wei Wu Yunran Xue Yanyi Zhang Kai Shi Timing Qu Yongjie Zhao Xiaohao Wang Xiaowen Zhang Zhenghe Han | 2013 | Superconductor Science and Technology2013，，： | 1 |
| 10 | Effect of OH^- on fluorescence properties in 1.5-1.6 μm for Er:Yb:YCOB crystal显示文摘FTIR absorption spectra indicate that H^+can easily enter the crystal structure and form OH^-centers in Er:Yb:YCOB and O-H bonds prefer to lie in the a-c plane.Within our current studied concentration level,crystal samples with higher OH-abso rption coefficie nts demonstrate stro nger fluo rescence intensity and longer fluorescence lifetime at 1535 nm.As the stretching vibration energy of OH-group approximately corresponds to the energy gap between the 4 I11/2 and 4 I13/2 levels of Er^3+,and thus,OH^-ions can shorten the fluorescence lifetime of Er^3+-4I11/2 level by the phonon-assisted cross-relaxation process between the Er^3+and OH-ions.Our curre nt results confirm that a certain conte nt of OH ions can enhance the ene rgy transfer process from Yb^3+to Er^3+and subsequently promote fluorescence output in 1.5-1.6μm. | Degao Zhong Chen Hu Shakir Ullah Hui Xu Jianhong Li Fei You Dongjuan Wang Shijia Sun Weijin Kong Jie Tang Zhenghe Yu Bing Teng | 2019 | Journal of Rare Earths2019，37，9： | 0 |
| 11 | Effect of Culture Parameters on the Growth of Sparassis crispa Mycelium显示文摘The effect of carbon and nitrogen sources, pH, temperature and substrate water content on the growth and vigor of Sparassis crispa mycelium was evaluated. Mycelial growth rates were highest when rice starch served as the carbon source and when peptone, yeast extract or soybean meal were adopted as the nitrogen source. The optimum pH and substrate water content values were 5.25 and 62.5% respectively. Mycelial growth was optimal at 20.2 ℃ and inhibited at 35 ℃, and temperatures of 40 ℃ and above killed the fungus. | WANG Jiancheng YING Zhenghe YU Yingrui LI Kaiben | 2007 | 食用菌学报2007，14，3： | 0 |
| 12 | PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain显示文摘How PD-L1 expression is regulated in cancer is poorly understood.Here,we report that the ATP-binding activity of ERBB3 pseudokinase regulates PD-L1 gene expression in colorectal cancers(CRCs).ERBB3 is one of the four members of the EGF receptor family,all with protein tyrosine kinase domains.ERBB3 is a pseudokinase with a high binding affin-ity to ATP.We showed that ERBB3 ATP-binding inactivation mutant reduces tumorigenicity in genetically engineered mouse models and impairs xenograft tumor growth of CRC cell lines.The ERBB3 ATP-binding mutant cells dramatically reduce IFN-g-induced PD-L1 expres-sion.Mechanistically,ERBB3 regulates IFN-g-induced PD-L1 expression through the IRS1-PI3K-PDK1-RSK-CREB signaling axis.CREB is the transcription factor that regulates PD-L1 gene expression in CRC cells.Knockin of a tumor-derived ERBB3 mutation located in the ki-nase domain sensitizes mouse colon cancers to anti-PD1 antibody therapy,suggesting that ERBB3 mutations could be predictive biomarkers for tumors amenable to immune check-point therapy. | Yamu Li Zhonghua Liu Yiqing Zhao Jie Yang Tsan Sam Xiao Ronald A.Conlon Zhenghe Wang | 2023 | Genes & Diseases2023，10，4： | 0 |
| 13 | Identification of Yeast Factors Involved in the Replication of Mungbean Yellow Mosaic India Virus Using Yeast Temperature-Sensitive Mutants显示文摘Dear Editor,The geminiviruses are small single-stranded plant DNA viruses belonging to the family Geminiviridae,which cause serious diseases in many economically important crops world-wide.Geminiviruses typically infect the differentiated leaf cells or vascular tissues,and multiply progeny DNA in the nucleus of infected cells.Geminiviruses encoding replication initiator protein(Rep)is essential for viral genome replication,but Rep does not possess DNA polymerase activity and relies heavily on host DNA replication machine for replication(Hanley-Bowdoin et al.2000). | Fangfang Li Xiongbiao Xu Zhenghe Li Yaqin Wang Xueping Zhou | 2020 | Virologica Sinica2020，35，1： | 0 |
| 14 | High-Q collective Mie resonances in monocrystalline silicon nanoantenna arrays for the visible light显示文摘Dielectric optical antennas have emerged as a promising nanophotonic architecture for manipulating the propagation and localization of light.However,the optically induced Mie resonances in an isolated nanoantenna are normally with broad spectra and poor��-factors,limiting their performances in sensing,lasing,and nonlinear optics.Here,we dramatically enhance the��-factors of Mie resonances in silicon(Si)nanoparticles across the optical band by arranging the nanoparticles in a periodic lattice.We select monocrystalline Si with negligible material losses and develop a unique method to fabricate nanoparticle arrays on a quartz substrate.By extinction dispersion measurements and electromagnetic analysis,we can identify three types of collective Mie resonances with��-factors∼500 in the same nanocylinder arrays,including surface lattice resonances,bound states in the continuum,and quasi-guided modes.Our work paves the way for fundamental research in strong light-matter interactions and the design of highly efficient light-emitting metasurfaces. | Zhenghe Zhang Pengbo Liu Wanli Lu Ping Bai Bingchang Zhang Zefeng Chen Stefan A.Maier Jaime Gómez Rivas Shaojun Wang Xiaofeng Li | 2023 | Fundamental Research2023，3，5： | 0 |
| 15 | Support vector regression constraint to remove fault shadows-A case study of an oil field in the pearl river estuary basin,South China Sea显示文摘The main reservoirs in different fields in the YP oil region of the eastern Pearl River Estuary Basin are all fault-locked reservoirs.A large amount of seismic data in this area has fault-influenced distortion imaging zones,which poses a challenge to the tectonic evaluation of the area.Traditional solutions to fault shadows generally use reacquisition of multi-directional seismic data or targeted processing for fault imaging,which involves the acquisition of high cost and long processing cycle.In this paper,we propose to quantitatively depict the shadow zone range of faults using 3D stratigraphic dip attributes,and then combine it with the lateral distribution of marine stratigraphy features in the YP oil region,we introduced a support vector regression algorithm to calculate a high-precision nonlinear tectonic trend surface in the area.Under the constraint of this trend surface,we completed the prediction of distortion area structure of the fault shadow zone.The theoretical model test calculations and the production application of an oil field in the YP oil region show that the method has a great potential for application. | Xiaojiang Yang Xiaotao Wen Yahui Wang Zhenghe Yan Kai Hou | 2021 | Earthquake Research Advances2021，1，S01： | 0 |
| 16 | The Post-exposure Effects of Spinosad and Plant Allelochemicals on Biological Characteristics of Helicoverpa armigera(Lepidoptera: Noctuvidae)显示文摘In order to define the combined effects of spinosad and plant allelochemicals on Helicoverpa armigera(Lepidoptera:Noctuvidae), the research fed them on artificial diets with different doses of spinosad, gossypol, quercetin and tannicacid, and the changes of pupal and imaginal biological characteristics were observed and recorded. The results showed that spinosad at sublethal concentrations decreased pupation ratio and pupal weight, prolonged prepupal and pupal periods, and decreased emergence ratio, fecundity and longevity of adults. Combined with plant allelochemicals, spinosad significantly prolonged pupal period and shorten adult longevity. Other life-cycle parameters such as pupation ratio, pupal weights, emergence ratio, eggs laid per female and hatch ratio did not change significantly. The results clearly indicated that plant allelochemicals did not change spinosad efficiency on H. armigera, but the combination of spinosad and plant allelochemicals might affect pest population dynamics significantly by changing its development. | Xuexiang REN Zhenghe YE Xianyan SU Dong WANG Shanmin CHENG Zhongchen FAN | 2016 | Agricultural Science & Technology2016，17，2： | 0 |
| 17 | Research highlights from ACACR members显示文摘Dr.Chuan He at The University of Chicago and his collaborator at the ShanghaiTech University found that N6-methyladenosine(m6A)facilitates hippocampus-dependent learning and memory through YTHDF1,a m6A binding protein that enhances protein synthesis in a neuronal-stimulusdependent manner.http://gffzz58fe80aa75a24977s6p60n9056nvb60on.ffgz.tsg.suse.edu.cn/articles/s41586-018-0666-1. | Zhenghe John Wang | 2018 | Genes & Diseases2018，5，4： | 0 |
| 18 | Recent Advances of Deep Learning in Geological Hazard Forecasting显示文摘Geological hazard is an adverse geological condition that can cause loss of life and property.Accurate prediction and analysis of geological hazards is an important and challenging task.In the past decade,there has been a great expansion of geohazard detection data and advancement in data-driven simulation techniques.In particular,great efforts have been made in applying deep learning to predict geohazards.To understand the recent progress in this field,this paper provides an overview of the commonly used data sources and deep neural networks in the prediction of a variety of geological hazards. | Jiaqi Wang Pengfei Sun Leilei Chen Jianfeng Yang Zhenghe Liu Haojie Lian | 2023 | Computer Modeling in Engineering & Sciences2023，，11： | 0 |
| 19 | Plant virology in the 21st century in China:Recent advances and future directions显示文摘Plant viruses are a group of intracellular pathogens that persistently threaten global food security.Significant advances in plant virology have been achieved by Chinese scientists over the last 20 years,including basic research and technologies for preventing and controlling plant viral diseases.Here,we review these milestones and advances,including the identification of new crop-infecting viruses,dissection of pathogenic mechanisms of multiple viruses,examination of multilayered interactions among viruses,their host plants,and virus-transmitting arthropod vectors,and in-depth interrogation of plantencoded resistance and susceptibility determinants.Notably,various plant virus-based vectors have also been successfully developed for gene function studies and target gene expression in plants.We also recommend future plant virology studies in China. | Jianguo Wu Yongliang Zhang Fangfang Li Xiaoming Zhang Jian Ye Taiyun Wei Zhenghe Li Xiaorong Tao Feng Cui Xianbing Wang Lili Zhang Fei Yan Shifang Li Yule Liu Dawei Li Xueping Zhou Yi Li | 2024 | Journal of Integrative Plant Biology2024，66，3： | 0 |
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