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| 1 | Ecotoxicological effects of waterborne PFOS exposure on swimming performance and energy expenditure in juvenile goldfish (Carassius auratus)显示文摘The potential risks of perfluorooctane sulfonate (PFOS) are of increasing ecological concern. Swimming performance is linked to the fitness and health of fish. However, the impacts of PFOS on swimming performance remain largely unknown. We investigated the ecotoxicological effects of acute exposure to PFOS on the swimming performance and energy expenditure of juvenile goldfish (Carassius auratus). The fish were exposed to a range of PFOS concentrations (0, 0.5, 2, 8 and 32 mg/L) for 48 hr. The spontaneous swimming activity, fast-start swimming performance, critical swimming speed (Ucrit) and active metabolic rate (AMR) of the goldfish were examined after exposure to PFOS. PFOS exposure resulted in remarkable effects on spontaneous activity. Motion distance was reduced, and the proportion of motionless time increased with increasing concentrations of PFOS. However, no significant alterations in the fast-start performance-related kinematic parameters, such as latency time, maximum linear velocity, maximum linear acceleration or escape distance during the first 120 msec after stimulus, were observed after PFOS exposure. Unexpectedly, although PFOS exposure had marked influences on the swimming oxygen consumption rates and AMR of goldfish, the U crit of the goldfish was not significantly affected by PFOS. This may result in a noteworthy increase in the energetic cost of transport. The overall results indicate that, in contrast to spontaneous activity, underlying swimming capabilities are maintained in goldfish after short-term exposure to PFOS, but energy expenditure during the process of swimming is dramatically aggravated. | Jigang Xia Shijian Fu Zhendong Cao Jianglan Peng Jing Peng Tingting Dai Lili Cheng | 2013 | Journal of Environmental Sciences2013，25，8： | 4 |
| 2 | Strength softening models of soil and its application in rainfall-induced landslide simulation显示文摘In this study, strength softening models are developed for exploring rainfall-induced landslide mechanism based on Mohr-Coulomb strength theory with both saturation degree and temporal evolution into consideration. According to the ratio of two time scales available, the model can be classified into three categories, i.e., instant softening model, delay softening model, and coupling softening model. Corresponding evolution functions are specified to represent these kinds of softening processes and then applied to simulate landslide of homogeneous slopes triggered by rainfall, therefrom, useful conclusions can be drawn in the end. | Zhendong Fu Jiachun Li | 2013 | Theoretical & Applied Mechanics Letters2013，3，4： | 3 |
| 3 | Resistance to powdery mildew in the pea cultivar Xucai 1 is conferred by the gene er1显示文摘Powdery mildew, caused by Erysiphe pisi D.C., is a major constraint to pea production worldwide. The pea cultivar Xucai 1 has shown high resistance to E. pisi under greenhouse and field conditions. The objectives of this study were to identify and characterize genes conferring resistance to powdery mildew in Xucai 1. Three crosses, Qizhen 76 × Xucai 1,Bawan 6 × Xucai 1, and Xucai 1 × Bawan 6, were made to generate populations for genetic analysis. The resistance to E. pisi and segregation ratios in the F_1, F_2, and F_(2:3)populations suggested a single recessive gene conferring the resistance of Xucai 1. Bulked segregant analysis was used to map the resistance gene using two F2 populations. The resistance gene was close to markers AD60 and c5 DNAmet on linkage group VI with genetic distances of9.9 c M and 15.4 c M in the Xucai 1 × Bawan 6 F_2 population and 8.7 c M and 8.1 c M in the Qizhen 76 × Xucai 1 F_2 population, respectively, suggesting that the resistance gene was an er1 allele. This hypothesis was confirmed by comparison of the c DNA sequences of the Ps MLO1 gene between the parents and the Ps MLO1 wild type. Three distinct types of transcripts in Xucai 1, characterized by a 129-bp deletion and 155- and 220-bp insertions,were detected, consistent with the structure of the er1-2 allele. We concluded that resistance in Xucai 1 was conferred by er1-2 and that its linked markers will be useful in pea breeding programs. | Suli Sun Zhongyi Wang Haining Fu Canxing Duan Xiaoming Wang Zhendong Zhu | 2015 | The Crop Journal2015，3，6： | 2 |
| 4 | Soliton and bound-state soliton mode-locked fiber laser based on a MoS_2/fluorine mica Langmuir–Blodgett film saturable absorber显示文摘In this article, we report on an experimentally generated soliton and bound-state soliton passively mode-locked erbium-doped fiber laser by incorporating a saturable absorber(SA) made of MoS2∕fluorine mica(FM) that was fabricated with the Langmuir–Blodgett(LB) method. The FM substrate is 20 μm thick and easy to bend or cut,like a polymer. However, it has a higher damage threshold and a better thermal dissipation than polymers.In addition, the LB method can be used to fabricate a thin film with good uniformity. In this study, the modulation depth, saturable intensity, and unsaturated loss of the SA are measured as 5.9%, 57.69 MW∕cm2, and13.4%, respectively. Based on the SA, a soliton mode-locked laser is achieved. The pulse duration, repetition rate, and signal-to-noise ratio are 581 fs, 15.67 MHz, and 65 dB, respectively. By adjusting the polarization controller and pump power, we obtain a bound-state soliton mode-locked pulse. The temporal interval between the two solitons forming the bound-state pulse is 2.7 ps. The repetition rate of the bound-state pulses is proportional to the pump power. The maximum repetition rate is 517 MHz, corresponding to the 33 rd harmonic of the fundamental repetition rate. The results indicate that the MoS2∕FM LB film absorber is a promising photonic device in ultrafast fiber lasers. | RUIDONG Lü YONGGANG WANG JIANG WANG WEI REN LU LI SICONG LIU ZHENDONG CHEN YONGFANG LI HONGYING WANG FUXING FU | 2019 | Photonics Research2019，7，4： | 2 |
| 5 | Coupling multiscale finite element method for consolidation analysis of heterogeneous saturated porous media显示文摘 | ZHANG Hongwu FU Zhendong WU Jingkai | 2009 | Adv Water Resour2009，32，2： | 1 |
| 6 | Extended multiscale finite element method for elasto-plastic analysis of 2D periodic lattice truss materials显示文摘 | ZHANG Hongwu WU Jingkai FU Zhendong | 2010 | Comput Mech2010，45，6： | 1 |
| 7 | Analysis of the effect of medical insurance on cancer inpatients: A 10-year retrospective study on a large hospital in Northeast China显示文摘Objective The aim of the study was to analyze hospital costs for cancer inpatients availing different methods of payment and the influencing factors, to provide inputs to improve the medical insurance payment policy. Methods We analyzed the information related to length of hospital stay, hospitalization cost, and self-pay cost, collected from one large-scale, Grade A, Class Three hospital in Shenyang, China, during 2004–2013.Results The number of cancer inpatients with different payment types(medical insurance group and non-medical insurance group) presented a rising trend. Further, the ratio of medical insurance inpatients increased rapidly(from 22.2% to 48.7%); however, this group was still a minority. The length of hospital stay became shorter(21 d vs. 17 d; P = 0.000) while the gap got narrower; the hospitalized expense showed an upward trend and the difference was remarkable($24048.6 ± $4376.28 vs. $20544.36 ± $4057.01; P = 0.000). Conclusion Along with normalization of cancer therapy, the influence of payment on treatment has been getting weak, the policy has impact on controlling hospitalization cost, lightening burden of cancer patient, as well as allocating medical resources in a reasonable way, becoming an important defray pattern of hospitalization cost. | Zhendong Zheng Lu Wang Quanwei Fu Tao Han Xiaodong Xie | 2015 | Oncology and Translational Medicine2015，1，6： | 1 |
| 8 | Switching the coordination geometry to enhance erbium(Ⅲ)single-molecule magnets显示文摘Two erbium(Ⅲ)complexes[ErCl(OAr^(Ad))_(3)][Na(THF)_(6)](1)and Er(OAr^(Ad))_(3)(2)are successfully prepared by using one variety of'hard'base ligand with large steric hindrance.The coordination geometry around the Er(Ⅲ)site changes from distorted tetrahedral to flat trigonal pyramid geometry in different solvent environment due to the removal of the coordinated chloride.Such an alternation significantly enhances the single-molecule magnet(SMM)behavior and makes the field-induced effective energy barrier(Ueff)arrive at 43(1)cm-1for the latter.Together with theoretical calculations,this study shows that strong equatorial ligand field and high local symmetry are critical to suppress the quantum tunneling of the magnetization(QTM)and achieve high-performance erbium(Ⅲ)based SMMs. | Qian-Cheng Luo Ning Ge Yuan-Qi Zhai Tengbo Wang Lin Sun Qi Sun Fanni Li Zhendong Fu Yan-Zhen Zheng | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
| 9 | The finding of natural GaN crystals in sediments from the East Pacific Ocean显示文摘The first finding of natural GaN crystals is reported in sediments from the East Pacific. They are identified by multiple micro-beam techniques such as TEM, EDS and EELS. Detailed examinations show that these GaN crystals are euhedral and authigenic, and belong to the hexagonal system (space group P63mc) with cell parameters: a = b = 0.3186 nm, c = 0.5178 nm. Structure data fit closely with those of the synthetic GaN crystals obtained from high-temperature and high-pressure experi- ments. Moreover, the nearly perfect euhedral form of the sample excludes the possible synthetic origin of the GaN crystals as artifacts with long transport. The sampling localities are located between the Clarion and Clipperton Fracture Zone in the East Pacific where ongoing hydrothermal activities, deformation, and volcanic eruptions are very intensive. It is sug- gested that the natural GaN crystals may form at relatively high-temperature and high-pressure condi- tions in geologic environments that have been af- fected by intense hydrothermal activities. | CHEN Jing SHI Xuefa ZHANG Haiping LUE Huahua FU Zhendong | 2006 | Chinese Science Bulletin2006，51，9： | 0 |
| 10 | Effect of Cl doping amount on the microstructure,photovoltaic properties and ferroelectric properties of Bi-based lead-free perovskite显示文摘Organic-inorganic hybrid perovskites with 3D perovskite structure have gained much attention as light harvesting materials in thinfilm photovoltaics.This is because of their outstanding light-absorption characteristics,charge-transport dynamics and their simple processability using lab-scale solution and vapor phase deposition techniques.However,the inherent instability and lead toxicity of lead-based PSCs are the major problems at present.Recent studies have shown that the(CH_(3)NH_(3)T_(3)Bi_(2)I_(9)(MBI)0D bismuth-based compound can be used as an optical absorption layer in solar cells.In this paper,the(CH_(3)NH_(3)T_(3)Bi_(2)I_(9)was doped with Cland a series of(CH_(3)NH_(3)T_(3)Bi_(2)I_(9-x)Cl_(x)films were prepared.The effects of different doping amounts on the microstructure,photovoltaic properties and ferroelectric properties were systematically investigated.Scanning electron microscope(SEM)and Atomic force microscope(AFM)analysis showed that with the increase of doping content,the density of the films increased and the roughness decreased.The photoelectric conversion efficiency of(CH_(3)NH_(3)T_(3)Bi_(2)I_(9-x)Cl_(x)raises with the increase of doping content.For example,the photoelectric conversion efficiency of(C_(H)3NH_(3)T_(3)Bi_(2)I_(3)Cl_(6)is 0.473%.We find that the leakage current descends into the increase in doping content,which may be due to the increase in the film density and the decrease of porosity.These research results have a positive effect on the development of Bi-based lead-free perovskite. | Shilong Zhang Ruicheng Xu Zhendong Li Qianwei Zhang Li Cheng Zhenhua Wang Chunlin Fu | 2019 | Journal of Advanced Dielectrics2019，9，2： | 0 |
| 11 | Synthesis of FER Zeolite Using 4-(Aminomethyl)pyridine as Structure-directing Agent显示文摘This paper describes the synthesis of FER zeolite using commercially available 4-(aminomethyl)pyridine as organic structure-directing agent(OSDA). FER zeolites were prepared in mixtures with SiO2/Al2O3 molar ratios in a narrow range and the resultant products possessed a typical flake-shaped morphology. The crystallization of FER zeolite was tracked in order to better understand the formation mechanism and the products obtained at different crystallization time were systematically characterized using multiple techniques. It showed that a majority of Si atoms and nearly all the Al atoms transformed into the solid phase during the hydrothermal synthesis. The rearrangement of inorganic species gave rise to zeolitic 5-membered rings(5-MRs) and 6-membered rings(6-MRs). Consequently, FER zeolite crystals were formed by the consumption of amorphous bulky gel/solid matrix. Tracking the synthesis process of FER can help. | LIANG Jun FU Wenhua LIU Chuang LI Xiangcheng WANG Yu MA Duozheng LI Yuekun WANG Zhendong YANG Weimin | 2022 | Chemical Research in Chinese Universities2022，38，1： | 0 |
| 12 | Neutron Scattering Study on 3d-4f Cyclic Molecular Magnet显示文摘{Fe8Y8}and{Fe8Dy8}are recently discovered 3d-4f cyclic molecular magnets.In order toreveal their complicated magnetic structure,we have finished the macroscopic magnetic property characterizations.Further study will be carried out to fully understand their magnetic ground state and spin dynamics by means of neutron scattering methods. | FU Zhendong HAO Lijie SUN Kai | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 13 | DNA repair-and nucleotide metabolism-related genes exhibit differential CHG methylation patterns in natural and synthetic polyploids (Brassica napus L.)显示文摘Polyploidization plays a crucial role in the evolution of angiosperm species.Almost all newly formed polyploids encounter genetic or epigenetic instabilities.However,the molecular mechanisms contributing to genomic instability in synthetic polyploids have not been clearly elucidated.Here,we performed a comprehensive transcriptomic and methylomic analysis of natural and synthetic polyploid rapeseeds(Brassica napus).Our results showed that the CHG methylation levels of synthetic rapeseed in different genomic contexts(genes,transposon regions,and repeat regions)were signi fi cantly lower than those of natural rapeseed.The total number and length of CHG-DMRs between natural and synthetic polyploids were much greater than those of CG-DMRs and CHH-DMRs,and the genes overlapping with these CHG-DMRs were signi fi cantly enriched in DNA damage repair and nucleotide metabolism pathways.These results indicated that CHG methylation may be more sensitive than CG and CHH methylation in regulating the stability of the polyploid genome of B.napus.In addition,many genes involved in DNA damage repair,nucleotide metabolism,and cell cycle control were significantly differentially expressed between natural and synthetic rapeseeds.Our results highlight that the genes related to DNA repair and nucleotide metabolism display differential CHG methylation patterns between natural and synthetic polyploids and reveal the potential connection between the genomic instability of polyploid plants with DNA methylation defects and dysregulation of the DNA repair system.In addition,it was found that the maintenance of CHG methylation in B.napus might be partially regulated by MET1.Our study provides novel insights into the establishment and evolution of polyploid plants and offers a potentialidea for improving the genomic stability of newly formed Brassica polyploids. | Liqin Yin Zhendong Zhu Liangjun Huang Xuan Luo Yun Li Chaowen Xiao Jin Yang Jisheng Wang Qiong Zou Lanrong Tao Zeming Kang Rong Tang Maolin Wang Shaohong Fu | 2021 | Horticulture Research2021，8，1： | 0 |
| 14 | Geological evaluation for the carbon dioxide geological utilization and storage(CGUS)site:A review显示文摘Carbon dioxide(CO_(2))geological utilization and storage(CGUS)is the key link of CO_(2)capture,utilization,and storage(CCUS).The accurate characterization of the geological body structure is a vital prerequisite of CGUS.This paper gives a review of the multi-scale three-dimensional geological structure characterization and site selection of CO_(2)storage.It shows that there is a lack of systematic and high-precision methods for transparency characterization of multi-scale three-dimensional engineering geological structure and hydrogeological structure of a CO_(2)storage site.There is no clear understanding of the fracture evolution and gas-liquid migration process of multi-scale geological body structure under the disturbance of CO_(2)injection.There is a lack of sufficient quantitative methods for the dynamic evaluation of CO_(2)geological storage potential.The geological suitability evaluation method for site selection of CO_(2)storage is rough and has poor applicability,which is difficult to satisfy the urgent needs of CGUS site selection in the whole process of CO_(2)sequestration industrialization in the future.Thus,it is required to conduct studies on the transparency characterization of geological body structure and intelligent site selection for CO_(2)storage,which is of great importance for CGUS engineering practice. | Shengwen QI Bowen ZHENG Zan WANG Haijun ZHAO Zhendong CUI Tianming HUANG Songfeng GUO Lei FU Pingchuan DONG | 2023 | Science China Earth Sciences2023，66，9： | 0 |
| 15 | Identification of Germline Mutations in East‑Asian Young Never‑Smokers with Lung Adenocarcinoma by Whole‑Exome Sequencing显示文摘Recently,an increasing number of young never-smokers are diagnosed with lung cancer.The aim of this study is to investigate the genetic predisposition of lung cancer in these patients and discover candidate pathogenic variants for lung adenocarcinoma in young never-smokers.Peripheral blood was collected from 123 never-smoking east-Asian patients diagnosed with lung adenocarcinoma before the age of 40.Whole-exome sequencing(WES)was conducted on genomic DNA extracted from peripheral blood cells.As a result,3,481 single nucleotide variants were identified.By bioinformatical tools and the published gene list associated with genetic predisposition of cancer,pathogenic variants were detected in ten germline genes:ATR,FANCD2,FANCE,GATA2,HFE,MSH2,PDGFRA,PMS2,SDHB,and WAS.Patients with pathogenic variants were more likely to occur in females(9/10,90.0%)and have stage IV lung adenocarcinoma(4/10,40%).Furthermore,germline muta-tions in 17 genes(ASB18,B3GALT5,CLEC4F,COL6A6,CYP4B1,C6orf132,EXO1,GATA4,HCK,KCP,NPHP4,PIGX,PPIL2,PPP1R3G,RRBP1,SALL4,and TTC28),which occurred in at least two patients,displayed potentially pathogenic effects.Gene ontology analysis further showed that these genes with germline mutations were mainly located in nucleo-plasm and associated with DNA repair-related biological processes.The study provides spectrum of pathogenic variants and functional explanation for genetic predisposition of lung adenocarcinoma in young never-smokers,which sheds a light on prevention and early diagnosis of lung cancer. | Fangqiu Fu Xiaoting Tao Zhonglin Jiang Zhendong Gao Yue Zhao Yuan Li Hong Hu Libing Shen Yihua Sun Yang Zhang | 2023 | Phenomics2023，3，2： | 0 |
| 16 | A soybean NAC homolog contributes to resistance to Phytophthora sojae mediated by dirigent proteins显示文摘Phytophthora sojae infection severely impairs soybean production. We previously identified a dirigent protein, Gm DRR1(Glycine max Disease Resistant Response 1), that increases soybean resistance to P.sojae. However, the molecular basis of Gm DRR1 function remained largely uncharacterized. In the present study, analysis of Gm DRR1-RNAi, Gm DRR1-overexpressing, and CRISPR/Cas9-derived Gmdrr1 mutant lines revealed that Gm DRR1 expression significantly restricted P. sojae growth. Combining coimmunoprecipitation with liquid chromatography–tandem mass spectrometry revealed a Gm DRR1-interacting protein, Gm DRR2, which is homologous to Gm DRR1. An E-coniferyl alcohol coupling assay indicated that Gm DRR1 promotes the synthesis of(+)-pinoresinol, which helps to protect plants from P. sojae. The Gm NAC1(Glyma.05 G025500) transcription factor bound to the Gm DRR1 promoter both in vitro and in vivo to upregulate Gm DRR1 expression. Soybean resistance to P. sojae was increased by overexpression of Gm NAC1. Our findings suggest a novel signaling pathway involving a NAC transcription factor that mediates soybean resistance to P. sojae. Specifically, Gm NAC1 directly induces Gm DRR1 expression to increase resistance of soybean plants to P. sojae. | Guolong Yu Jianan Zou Jinhui Wang Rongsheng Zhu Zhaoming Qi Hongwei Jiang Zhenbang Hu Mingliang Yang Ying Zhao Xiaoxia Wu Chunyan Liu Candong Li Xue Yang Zhendong Zhu Qingshan Chen Yongfu Fu Dawei Xin | 2022 | The Crop Journal2022，10，2： | 0 |
| 17 | Prognostic role of C-reactive protein to albumin ratio in lung cancer:An updated systematic review and meta-analysis显示文摘Background: C-reactive protein to albumin ratio(CRP/Alb ratio,CAR)has been suggested as a potential prognostic biomarker in lung cancer.This updated systematic review and meta-analysis aimed to assess the association between CAR and lung cancer prognosis in current literature.Methods: A systematic search of databases was conducted to identify relevant studies published up to April 2023.Pooled hazard ratios(HRs)and 95%confidence intervals(CIs)were calculated to assess the association between CAR and overall survival(OS)and progression-free survival(PFS)and recurrence-free survival(RF)in lung cancer patients.Results: This meta-analysis includes 16 studies with a total of 5337 patients,indicating a significant association between higher CAR and poorer OS,PFS,and RFS in lung cancer patients,with a pooled HR of 1.78(95%CI=1.60-1.99),1.57(95%CI=1.36-1.80),and 1.97(95%CI=1.40-2.77),respectively.Conclusions: This updated meta-analysis provides evidence for the potential prognostic role of CAR in lung cancer,suggesting its utility as an effective and noninvasive biomarker for identifying high-risk patients and informing treatment decisions in a cost-effective manner.However,further large-scale studies will be necessary to establish the optimal cut-off value for CAR in lung cancer and confirm the present findings. | Zhendong Lu Siyun Fu Wei Li Xiang Gao Jinghui Wang | 2024 | Chronic Diseases and Translational Medicine2024，10，1： | 0 |
| 18 | Development of Cold Neutron Inelastic Scattering Spectrometer显示文摘2017is the last year for the construction of cold neutron inelastic scattering spectrometers.The cold polarized neutron triple-axis spectrometer and the multi-axis crystal spectrometer included in this project have entered the installation and acceptance phase.The whole mechanical assembly,the software development,and the debugging of automatic control on the cold neu- | HAO Lijie MA Xiaobai QIN Jianfei FU Zhendong LI Yuqing SUN Kai CHEN Dongfeng | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
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