|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Whether Syndrome Differentiation Affects Treatment Result:Study Protocol of MaZiRenWan(麻子仁丸)for Functional Constipation in A Randomized Controlled Trial显示文摘Background: Syndrome is one of the most important concepts in Chinese medicine(CM) theory. However, it was not well accounted in most of randomized controlled trials(RCTs). Objective: To determine whether CM syndrome differentiation affects the treatment results, functional constipation(FC) was selected as a target disease, and MaZiRenWan(麻子仁丸, MZRW), a classic CM formula commonly used for constipation with excessive heat syndrome, was selected for study. Methods: It is an 18-week prospective double-blinded, doubledummy RCT, including 2-week run-in, 8-week treatment and 8-week post treatment follow-up. A total of 120 FC patients diagnosed as excessive heat syndrome will be recruited from the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine and the Baokang Affiliated Hospital of Tianjin University of Traditional Chinese Medicine. Patients will be randomly allocated into fixed MZRW(f_MZRW) granule group, modified MZRW(m_MZRW) granule group or bisacodyl group. For m_MZRW group, no more than two herbal granules can be added according to the syndrome differentiation for individual participants. The primary end point is the mean of complete spontaneous bowel movements(CSBMs) per week during the treatment period. Secondary end points include mean of CSBMs per week during follow-up, stool form, global symptom improvement, constipation and constipation-related symptoms assessment, CM syndrome change, and reported adverse events. Discussion: This trial is designed to evaluate the effectiveness of these three interventions for FC patients with the CM syndrome of excessive heat, and to determine the change of CM syndrome and the progress of disease during the treatment course. The results are important to explore whether syndrome differentiation is important for the therapeutic effect of a formula on a disease. | CHENG Chung-wah ZHANG Li ZHAO Chen ZHONG Linda LD SHI Li-jie DAI Liang ZHENG Rui CHEN Jing LI Ge ZHAI Jing-bo KUN Wai LU Ai-ping SHANG Hong-cai BIAN Zhao-xiang | 2019 | Chinese Journal of Integrative Medicine2019，25，3： | 3 |
| 2 | Effects of DAPT and Atohl overexpression on hair cell production and hair bundle orientation in cultured Organ of Corti from neonatal rats显示文摘 | Zhao LD Guo WW Lin C | 2011 | PLoS ONE2011，6，23： | 1 |
| 3 | Influence of Pb Doping on the Electrical Transport Properties of Bi Cu Se O显示文摘 | Pan L Berardan D Zhao LD | 2013 | Applied Physics Letters2013，102，02： | 1 |
| 4 | Remarkable Enhancement in Thermoelectric Performance of Bi Cu Se O by Cu Deficiencies显示文摘 | Liu Y Zhao LD Liu YC | 2011 | Journal of the American Chemical Society2011，133，20： | 1 |
| 5 | Effects ofDAPT andAtohl overexpression on hair cell production and hair bundle orientation in cultured Organ of Corti from neonatal rats显示文摘 | Zhao LD Guo WW Lin C | 2011 | PLoS One2011，6，23： | 1 |
| 6 | Aberrant CD200CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity显示文摘 | Li Y Zhao LD Tong LS | 2012 | Arthritis Res Ther2012，14，： | 1 |
| 7 | PKC-induced ERK1/2 interactions and downstream effectors in ovine cerebral arteries显示文摘 | Zhao Y Zhang L Longo LD | 2005 | Am J Physiol Regul Integr Comp Physio2005，289，： | 1 |
| 8 | Neuroprotective effect of Buyang Huanwu decoction against focal cerebral ischemia reperfusion injury in rats - time window and mechanism显示文摘 | Zhao LD Wang JH Jin GR | 2012 | J Ethnopharmac ol2012，140，2： | 1 |
| 9 | Curcumin combined with ox- aliplatin effectively suppress colorectal carcinoma in vivo through inducing apoptosis 显示文摘 | Guo LD Sben YQ Zhao XH | 2015 | Phytother Res2015，29，3： | 1 |
| 10 | Aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contr- ibutes to abnormal T-cell responsiveness and dendritic cell activity显示文摘 | Li Y Zhao LD Tong LS | 2012 | Arthritis Res Ther2012，14，3： | 1 |
| 11 | NE-induced contraction, alphal-adrenergic receptors,and Ins( 1、4、5)P3 responses in cerebral arteries显示文摘 | Veno N Zhao Y | 1996 | Am J Physiol1996，270，32： | 1 |
| 12 | Nortradiographic axial spondyloarth- ritis: early ankylosing spondylitis显示文摘 | Zhao LD Zhao Y Zhang X | 2013 | Chinese Journal of Internal Medi- cine2013，52，11： | 1 |
| 13 | Ultrasonic- assisted extraction of epimedin C from fresh leaves of Epimedium and extraction mechanism显示文摘 | Zhang HF Yang XH Zhao LD | 2009 | Innovative Food Science and Emerging Technologies2009，，10： | 1 |
| 14 | Factors affecting the sensitivity of EGFR-TKI treatment in advanced non-smaU cell lung cancer显示文摘 | Zhao LD Li JL Wang Y | 2011 | Zhonghua Zhong Liu Za Zhi2011，33，3： | 1 |
| 15 | Differential expression of caprineβ -defensins in digestive and respiratory tissues显示文摘 | Zhao CQ Nguyen T Liu LD | 1999 | Infect Immun1999，67，： | 1 |
| 16 | High-performance Nanostructured Thermoelectric Materials显示文摘 | Li JF Liu WS Zhao LD | 2010 | Npg Asia Materials2010，2，4： | 1 |
| 17 | The Panoscopic Approach to High Performance Thermoelectrics显示文摘 | Zhao LD Dravid VP Kanatzidis MG | 2014 | Energy&Environmental Science2014，7，1： | 1 |
| 18 | Neonatal rhesus monkey is a potential animal model for studying pathogenesis of EV71 infection显示文摘 | Liu LD Zhao HL Zhang Y | | 0，，01： | 1 |
| 19 | Crustal structure of the central Tibet as derived from project INDEPTH wide-angle seismic data 显示文摘 | Zhao W Mechie J Brown LD Guo J Haines S Hearn T | 2001 | Geophys J Int2001，145，： | 1 |
| 20 | Are CD4CD25Foxp3 cells in un-treated new-onset lupus patients regulatory Tcells 显示文摘 | Yang HX Zhang W Zhao LD | 2009 | Arthritis ResTher2009，11，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员