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| 1 | Would integrated Western and traditional Chinese medicine have more benefits for stroke rehabilitation? A systematic review and meta-analysis显示文摘Background Stroke is a major cause of death or long-term disability worldwide.Many patients with stroke receive integrative therapy consisting of Western medicine(WM)and routine rehabilitation in conjunction with Chinese medicine(CM),such as acupuncture and Chinese herbal medicine.However,there is no available evidence on the effectiveness of the combined use of WM and CM interventions in stroke rehabilitation.Aims The purpose of this meta-analysis is to evaluate the results of all individual studies to assess the combined use of CM and WM in stroke rehabilitation compared with WM only.Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed.MEDLINE,EMBASE,Cochrane and China National Knowledge Infrastructure(CNKI)were searched.The included outcomes were dependency,motor function,depression and swallowing function.Subgroup analysis was performed,and publication bias was assessed using funnel plots.Summary of review 58 studies and 6339 patients were included in the meta-analysis.Subgroup analysis revealed that combined therapy comprising both acupuncture and WM had a superior effect on improving dependency and swallowing function compared with standard WM therapy alone.Potential superiority of combined therapy comprising CM and WM in improving depression compared with standard WM therapy was also found.Conclusions Our results indicate that the combined use of CM and WM could be more efficacious in stroke rehabilitation compared with the use of WM therapy alone.However,most studies were short in duration(2 to 4 weeks)and prone to different types of biases,which prevents making any conclusion regarding the long-term effects and raises concerns regarding true efficacy in context of high likelihood of Hawthorn bias.So,more randomised controlled trials with more rigorous design and longer duration of treatment and follow-up need to be conducted to compare WM alone versus WM and CM combined. | Linda LD Zhong Ya Zheng Alexander Y Lau Norman Wong Liang Yao Xingyao Wu Tengteng Shao Zhenxing Lu Huijuan Li Chun Sum Yuen Jianwen Guo Suzanne Lo Janita Chau Kam Wa Chan Bacon Fung Leung Ng Zhaoxiang Bian Edwin Chau-leung Yu | 2022 | Stroke & Vascular Neurology2022，7，1： | 7 |
| 2 | Detection and taxonomicplacement of endophytic fungi within frond tissues ofLivistona chinensis based on rDNA sequences显示文摘 | Guo LD Hyde KD Liew ECY | 2001 | MolecularPhylogenetics and Evolution2001，20，1： | 1 |
| 3 | Molecular identificationof white morphotype starins of endophytic fungi from Pinustabulaeformis显示文摘 | Guo LD Huang GR Wang Y | 2003 | Mycological Research2003，107，6： | 1 |
| 4 | Effects of DAPT and Atohl overexpression on hair cell production and hair bundle orientation in cultured Organ of Corti from neonatal rats显示文摘 | Zhao LD Guo WW Lin C | 2011 | PLoS ONE2011，6，23： | 1 |
| 5 | Arbuscular mycorrhizal fungi in non-grazed, restored and over-grazed grassland in the Inner Mongolia steppe显示文摘 | Su YY Guo LD | 2007 | Mycorrhiza2007，17，8： | 1 |
| 6 | Endophytic fungal diversity: review oftraditional and molecular techniques显示文摘 | Sun X Guo LD | 2012 | Mycology2012，，3： | 1 |
| 7 | Effects ofDAPT andAtohl overexpression on hair cell production and hair bundle orientation in cultured Organ of Corti from neonatal rats显示文摘 | Zhao LD Guo WW Lin C | 2011 | PLoS One2011，6，23： | 1 |
| 8 | A comparative study of arbuscular mycorrhizal fungi in forest, grassland and cropland in the Tibetan Plateau, China显示文摘 | Gao QM Guo LD | 2010 | Mycology: An International Journal on Fungal Biology2010，1，3： | 1 |
| 9 | A strategy to control transmission of Schistosomajaponicum in China显示文摘 | Wang LD Chen HG Guo JG | 2009 | N Engl J Med2009，360，2： | 1 |
| 10 | Arbuscular mycorrhizal fungi associated with common pteridophytes in Dujiangyan, southwest China显示文摘 | Zhang Y Guo LD Liu RJ | 2004 | Mycorrhiza2004，14，1： | 1 |
| 11 | A strategy to control transmission of schistosoma iaponicum in China 显示文摘 | Wang LD Chen HG Guo JG | 2009 | The New England Journal of Medicine2009，360，2： | 1 |
| 12 | Survey of arbuscular mycorrhizal fungi in deforested and natural forest land in the subtropical region of Dujiangyan, southwest China显示文摘 | Zhang Y Guo LD Liu RJ | 2004 | Plant and Soil2004，261，12： | 1 |
| 13 | A strategy to control transmis-sion of Schistosoma japonicum in China显示文摘 | Wang LD Chen HG Guo JG | 2009 | N Engl J Med2009，360，2： | 1 |
| 14 | Chinas new strategy to block Schistosoma japonicum transmission: experiences and impact beyond schistosomiasis 显示文摘 | Wang LD Guo JG Wu XH | 2009 | Trop Med Int Health2009，14，12： | 1 |
| 15 | A strategy to control trans mission of Schistosoma japonicurn in China显示文摘 | Wang LD Chen HG Guo JG | 2009 | N Engl J Med2009，360，2： | 1 |
| 16 | A strategy to control transmission of Schistosomajaponicum in China 显示文摘 | Wang LD Chen HG Guo JG | 2009 | N EnglJ M ed2009，360，2： | 1 |
| 17 | Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population显示文摘 | Wang LD Guo RF Fan ZM | 2005 | Dis Esophagus2005，18，3： | 1 |
| 18 | A strategy to control transmission of Schistosomajaponicum in China显示文摘 | Wang LD Chen HG Guo JG | | 0，，02： | 1 |
| 19 | China's new strategy to block Schistosoma japonicum transmission:experiences and impact beyond schistosomiasis显示文摘 | Wang LD Guo JG Wu XH | | 0，，12： | 1 |
| 20 | A strategy to control transmission of Schistosoma japonicum in China显示文摘 | Wang LD Chen HG Guo JG | 2009 | N Engl J Med2009，360，2： | 1 |
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