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| 1 | A metabonomic investigation on the biochemical perturbation in liver failure patients caused by hepatitis b virus显示文摘 | Yu, K Sheng, GP Sheng, JF Chen, YM Xu, W Liu, XL Cao, HC Qu, HB Cheng, YY Li, LJ | 2007 | 中国生物学文摘2007，21，11： | 25 |
| 2 | Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3显示文摘AIM: To investigate the inhibitory role and the underlying mechanisms of sorafenib on signal transducer and activator of transcription 3 (STAT3) activity in hepatocellular carcinoma (HCC).METHODS: Human and rat HCC cell lines were treated with sorafenib. Proliferation and STAT3 dephosphorylation were assessed. Potential molecular mechanisms of STAT3 pathway inhibition by sorafenib were evaluated. In vivo antitumor action and STAT3 inhibition were investigated in an immunocompetent orthotopic rat HCC model.RESULTS: Sorafenib decreased STAT3 phosphorylationat the tyrosine and serine residues (Y705 and S727), but did not affect Janus kinase 2 (JAK2) and phosphatase shatterproof 2 (SHP2), which is associated with growth inhibition in HCC cells. Dephosphorylation of S727 was associated with attenuated extracellular signal-regulated kinase (ERK) phosphorylation, similar to the effects of a mitogen-activated protein kinase (MEK) inhibitor U0126, suggesting that sorafenib induced S727 dephosphorylation by inhibiting MEK/ERK signaling. Meanwhile, sorafenib could also inhibit Akt phosphorylation, and both the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and Akt knockdown resulted in Y705 dephosphorylation, indicating that Y705 dephosphorylation by sorafenib was mediated by inhibiting the PI3K/Akt pathway. Finally, in the rat HCC model, sorafenib signifi cantly inhibited STAT3 activity, reducing tumor growth and metastasis.CONCLUSION: Sorafenib inhibits growth and metastasis of HCC in part by blocking the MEK/ERK/STAT3 and PI3K/Akt/STAT3 signaling pathways, but independent of JAK2 and SHP2 activation. | Fang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian ZhouFang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian Zhou, Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai 200032, China Author contributions: Gu FM, Li QL and Gao Q contributed equally to this work Gu FM and Li QL performed the experi- ments and interpretation of the data and statistical analysis Zhou J and Gao Q contributed to the conception and design of the study Gu FM, Gao Q, Li QL and Zhou J wrote the manuscript Jiang JH, Huang XY, Pan JF and Fan J made substantial contri- bution to the design and conception of the study and interpreta- tion of data all authors read and approved the f inal manuscript. | 2011 | World Journal of Gastroenterology2011，17，34： | 18 |
| 3 | Aminoglycoside-induced and non-syndromic hearing loss is associated with the G7444A mutation in the mitochondrial COI/tRNA (Ser(UCN)) genes in two Chinese families显示文摘 | Zhu Y Qian YP Tang XW Wang JD Yang L Liao ZS Li RH Ji JZ Li ZY Chen JF Choo DI Lu JX Guan MX | 2006 | 中国生物学文摘2006，20，4： | 16 |
| 4 | Anatomic structural study of cerebellopontine angle via endoscope显示文摘在颅骨底依靠寻找内视镜的技术的可能的解剖基础的背景最低限度地侵略的外科是争论的。这研究的目的是在 cerebellopontine 角度区域观察在主要的血容器和神经之间的空间关系并且为侧面、以后的颅骨底提供解剖基础经由内视镜的 retrosigmoid 锁眼 approach.Methods 的最低限度地侵略的外科这研究在三十个弄干的成年颅骨上被进行测量空间关系在之中出现以后的头部的窝的多骨的标记,并且为 retrosigmoid 锁眼 ap 定位最适当的钻区域在直径与 2.0 厘米在这个点上集中的一个洞对在 cerebellopontine 角度暴露相关结构合适。 Retrosigmoid 锁眼途径罐头减少小脑上的压力并且有效地暴露相关结构它包括面部神经, vestibulocochlear 神经,三叉的神经,舌与喉的神经,迷走神经神经,附件神经,舌下神经神经,前面的劣等的小脑的动脉,以后的劣等的小脑的动脉和迷宫的动脉,内诊镜 retrosigmoid 途径上的准确地点能避免在最低限度地侵略的外科期间拖小脑的 etc.Conclusions 。retrosigmoid 锁眼途径的申请将扩大内视镜的技术的申请。 | XIA Yin LI Xi-ping HAN De-min ZHENG Jun LONG Hai-shan SHI Jin-feng Department of Otolaryngology,Beijing Tongren Hospital,Capital Medical University Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University),Ministry of Education,Beijing 100730,China (Xia Y,Li XP,Han DM,Zheng J,Long HS and Shi JF) | 2007 | Chinese Medical Journal2007，，20： | 7 |
| 5 | On abiogenic natural gas显示文摘NATURAL gases usually refer to the inflammable gases dominated by methane from the angle of research on energy gases. Three genetic types of natural gases can be recognized according to the process of methane generation: (ⅰ) biogenic (bacterial) gas, mainly the gas formed by the decomposition of organic matter in sediments under the action of anaerobic bacteria; (ⅱ) thermogenic gas, mainly the gas formed by the degradation of organic matter in sediments under the action of certain temperature and pressure; (ⅲ) abiogenic gas, mainly the | Wang, XB Li, CY Chen, JF Xia, XY Guo, ZQ Xie, HS | 1997 | Chinese Science Bulletin1997，42，16： | 5 |
| 6 | Discovery of virus pathogen from soft-shelled turtle Trionyx sinesis显示文摘THE soft-shelled turtle Trionyx sinesis, because of its nutritional and medicinal values, | Zhang, QY Li, ZQ Jiang, YL Liang, SC Gui, JF | 1997 | Chinese Science Bulletin1997，42，6： | 3 |
| 7 | Guide to em'ly surgical management of lip hemangiomas based on our experience of 214 cases显示文摘 | Li WY Chaudh O Reinisch JF | 2011 | Plast Recon- str Surg2011，128，5： | 1 |
| 8 | A new locus for autosomal dominant high myopia maps to 4q22-q27 between IMS1578 and D4S1612 显示文摘 | Zhang Q Guo X Xiao X Jia X Li S Hejtmancik JF | 2005 | Mol Vis2005，11，： | 1 |
| 9 | A novel pathogen-binding gClqR homolog, FcgClqR,in the Chinese white shrimp, Fenneropenaeus chinensis 显示文摘 | Li XC Du ZQ Lan JF | 2012 | Dev Comp lmmunol2012，36，1： | 1 |
| 10 | Combination of diane-35 andmetformin to treat early endometrial carcinoma in PCOSwomen with insulin resistance显示文摘 | Li X Guo YR Lin JF | 2014 | J Cancer2014，5，3： | 1 |
| 11 | Chemotherapy- and radiotherapy- induced intestinal damage is regulated by intestinal trefoil factor显示文摘 | Beck PL Wong JF Li Y | 2004 | Gastroenterology2004，126，3： | 1 |
| 12 | Esti- mation of cancer cases and deaths at- tributable to infection in China显示文摘 | Xiang W Shi JF Li P | 2011 | Cancer Causes Control2011，22，8： | 1 |
| 13 | Signaling pathways governing osteo-blast proliferation differentiation and function显示文摘 | Chau JF Leong WF Li B | 2009 | Histol His-topathol2009，24，12： | 1 |
| 14 | Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2显示文摘 | Zhao Y Ransom JF Li A | 2007 | Cell2007，129，2： | 1 |
| 15 | Antibody specific to thioredoxin re- ductase as a new biomarker for serodiagnosis of invasive aspergillosis in non-neutropenic patients 显示文摘 | Shi LN Li FQ Lu JF | 2012 | Clin Chimica Acta2012，413，910： | 1 |
| 16 | Scavenger receptor B2 is a cellular receptor for enterovirus 71显示文摘 | Yamayoshi S YamashitaY Li JF | | 0，，07： | 1 |
| 17 | ERalpha positively regulated DNMT1 expression by binding to the gene promoter region in human breast cancer MCF-7 cells显示文摘 | Shi JF Li XJ Si XX | 2012 | Biochem Biophys Res Commun2012，427，1： | 1 |
| 18 | Inhibition of T-cell expansion caused by inducible eostimulator/B7h costimulatian blockade in direct alloreeognition pathway 显示文摘 | Du JF Li QY Ji XQ | 2011 | Transplant Proc2011，43，10： | 1 |
| 19 | Age-related differences in insulin-like growth factor-1 receptor signaling regulates Akt/F0X03aand ERK/Fos pathways in vascular smooth muscle cells 显示文摘 | Li M Chiu JF Gagne J | 2008 | JCell Physiol2008，217，2： | 1 |
| 20 | Analysis of microsatellites in major crops assessed by computational and experimental approaches显示文摘 | Gao LF Tang JF Li HW | 2003 | Molecular Breeding2003，12，3： | 1 |
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