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| 1 | Chronology and geochemistry of the volcanic rocks in Woruo Mountain region,Northern Qiangtang depression:Implications to the Late Triassic volcanic-sedimentary events显示文摘A suite of sedimentary-volcaniclastic rocks intercalated with the volcanic rocks unconformably overlies the Triassic Xiaochaka Formation in the Woruo Mountain region, Qiangtang Basin, northern Tibet. The vitric tuff from the base of these strata gives a SHRIMP zircon U-Pb age of 216 ± 4.5 Ma, which represents the age of the Late Triassic volcanic-sedimentary events in the Woruo Mountain region, and is consistent with that of the formation of the volcanic rocks from the Nadi Kangri Formation in the Nadigangri-Shishui River zone. There is a striking similarity in geochemical signatures of the volcanic rocks from the Woruo Mountain region and its adjacent Nadigangri-Shishui River zone, indicating that all the volcanic rocks from the Qiangtang region might have the same magmatic source and similar tectonic setting during the Late Triassic. The proper recognition of the Late Triassic large-scale volcanic eruption and volcanic-sedimentary events has important implications for the interpretation of the Late Triassic biotic extinction, climatic changes and regressive events in the eastern Tethyan domain, as well as the understanding of the initiation and nature, and sedimentary features of the Qiangtang Basin during the Late Triassic-Jurassic. | WANG Jian FU XiuGen CHEN WenXi WANG ZhengJiang TAN FuWen CHEN Ming ZHUO JieWen | 2008 | Science China Earth Sciences2008，51，2： | 21 |
| 2 | 0.04 degree-per-hour MEMS disk resonator gyroscope with high-quality factor (510 k) and long decaying time constant(74.9 s)显示文摘The disk resonator gyroscope is an attractive candidate for high-performance MEMS gyroscopes.This gyroscope consists of a sensor and readout electronics,and the characteristics of the sensor directly determine the performance.For the sensor,a high-quality factor and long decaying time constant are the most important characteristics required to achieve high performance.We report a disk resonator gyroscope with a measured quality factor of 510 k and decaying time constant of 74.9 s,which is a record for MEMS silicon disk resonator gyroscopes,to the best of our knowledge.To improve the quality factor of the DRG,the quality factor improvement mechanism is first analyzed,and based on this mechanism two stiffness-mass decoupled methods,i.e.,spoke length distribution optimization and lumped mass configuration design,are proposed and demonstrated.A disk resonator gyroscope prototype is fabricated based on these design strategies,and the sensor itself shows an angle random walk as low as 0.001°/√h,demonstrating true potential to achieve navigation-grade performance.The gyroscope with readout electronics shows an angle random walk of 0.01°/√h and a bias instability of 0.04°/h at room temperature without compensation,revealing that the performance of the gyroscope is severely limited by the readout electronics,which should be further improved.We expect that the quality factor improvement methods can be used in the design of other MEMS gyroscopes and that the newly designed DRG can be further improved to achieve navigation-grade performances for high-end industrial,transportation,aerospace,and automotive applications. | Qingsong Li Dingbang Xiao Xin Zhou Yi Xu Ming Zhuo Zhanqiang Hou Kaixuan He Yongmeng Zhang Xuezhong Wu | 2018 | Microsystems & Nanoengineering2018，4，1： | 16 |
| 3 | Landscape of DILI-related adverse drug reaction in China Mainland显示文摘Drug-induced liver injury(DILI)is a type of bizarre adverse drug reaction(ADR)damaging liver(L-ADR)which may lead to substantial hospitalizations and mortality.Due to the general low incidence,detection of L-ADR remains an unsolved public health challenge.Therefore,we used the data of 6.673 million of ADR reports from January 1st,2012 to December 31st,2016 in China National ADR Monitoring System to establish a new database of L-ADR reports for future investigation.Results showed that totally 114,357 ADR reports were retrieved by keywords searching of liver-related injuries from the original heterogeneous system.By cleaning and standardizing the data fields by the dictionary of synonyms and English translation,we resulted 94,593 ADR records reported to liver injury and then created a new database ready for computer mining.The reporting status of L-ADR showed a persistent 1.62-fold change over the past five years.The national population-adjusted reporting numbers of L-ADR manifested an upward trend with age increasing and more evident in men.The annual reporting rate of L-ADR in age group over 80 years old strikingly exceeded the annual DILI incidence rate in general population,despite known underreporting situation in spontaneous ADR reporting system.The percentage of herbal and traditional medicines(H/TM)L-ADR reports in the whole number was 4.5%,while 80.60%of the H/TM reports were new findings.There was great geographical disparity of reported agents,i.e.more cardiovascular and antineoplastic agents were reported in higher socio-demographic index(SDI)regions and more antimicrobials,especially antitubercular agents,were reported in lower SDI regions.In conclusion,this study presented a large-scale,unbiased,unified,and computer-minable L-ADR database for further investigation.Age-,sex-and SDI-related risks of L-ADR incidence warrant to emphasize the precise pharmacovigilance policies within China or other regions in the world. | Jiabo Wang Haibo Song Feilin Ge Peng Xiong Jing Jing Tingting He Yuming Guo Zhuo Shi Chao Zhou Zixin Han Yanzhong Han Ming Niu Zhaofang Bai Guangbin Luo Chuanyong Shen Xiaohe Xiao | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 12 |
| 4 | UPLC/ESI-QTOF-MS-based metabolomics survey on the toxicity of triptolide and detoxication of licorice显示文摘Triptolide(TP) from Tripterygium wilfordii has been demonstrated to possess anti-inflammatory, immunosuppressive, and anticancer activities. TP is specially used for the treatment of awkward rheumatoid arthritis, but its clinical application is confined by intense side effects. It is reported that licorice can obviously reduce the toxicity of TP, but the detailed mechanisms involved have not been comprehensively investigated. The current study aimed to explore metabolomics characteristics of the toxic reaction induced by TP and the intervention effect of licorice water extraction(LWE) against such toxicity. Obtained urine samples from control, TP and TP + LWE treated rats were analyzed by UPLC/ESI-QTOF-MS. The metabolic profiles of the control and the TP group were well differentiated by the principal component analysis and orthogonal partial least squares-discriminant analysis. The toxicity of TP was demonstrated to be evolving along with the exposure time of TP. Eight potential biomarkers related to TP toxicity were successfully identified in urine samples. Furthermore, LWE treatment could attenuate the change in six of the eight identified biomarkers. Functional pathway analysis revealed that the alterations in these metabolites were associated with tryptophan, pantothenic acid, and porphyrin metabolism. Therefore, it was concluded that LWE demonstrated interventional effects on TP toxicity through regulation of tryptophan, pantothenic acid, and porphyrin metabolism pathways, which provided novel insights into the possible mechanisms of TP toxicity as well as the potential therapeutic effects of LWE against such toxicity. | WANG Zhuo LIU Jian-Qun XU Jin-Di ZHU He KONG Ming ZHANG Guo-Hua DUAN Su-Min LI Xiu-Yang LI Guang-Fu LIU Li-Fang LI Song-Lin | 2017 | Chinese Journal of Natural Medicines2017，15，6： | 9 |
| 5 | Analysis of genetic architecture and favorable allele usage of agronomic traits in a large collection of Chinese rice accessions显示文摘Genotyping and phenotyping large natural populations provide opportunities for population genomic analysis and genome-wide association studies(GWAS). Several rice populations have been re-sequenced in the past decade;however, many major Chinese rice cultivars were not included in these studies. Here, we report large-scale genomic and phenotypic datasets for a collection mainly comprised of 1,275 rice accessions of widely planted cultivars and parental hybrid rice lines from China. The population was divided into three indica/Xian and three japonica/Geng phylogenetic subgroups that correlate strongly with their geographic or breeding origins. We acquired a total of 146 phenotypic datasets for 29 agronomic traits under multi-environments for different subpopulations. With GWAS, we identified a total of 143 significant association loci, including three newly identified candidate genes or alleles that control heading date or amylose content. Our genotypic analysis of agronomically important genes in the population revealed that many favorable alleles are underused in elite accessions, suggesting they may be used to provide improvements in future breeding efforts. Our study provides useful resources for rice genetics research and breeding. | Xiuxiu Li Zhuo Chen Guomin Zhang Hongwei Lu Peng Qin Ming Qi Ying Yu Bingke Jiao Xianfeng Zhao Qiang Gao Hao Wang Yunyu Wu Juntao Ma Liyan Zhang Yongli Wang Lingwei Deng Shanguo Yao Zhukuang Cheng Diqiu Yu Lihuang Zhu Yongbiao Xue Chengcai Chu Aihong Li Shigui Li Chengzhi Liang | 2020 | Science China(Life Sciences)2020，63，11： | 8 |
| 6 | Inhibition of miR-144-3p exacerbates non-small cell lung cancer progression by targeting CEP55显示文摘Increasing evidence has indicated that microRNA dysregulation is closely related to the occurrence and development of cancers.Herein,we investigated the relationship between miR-144-3p&CEP55 expression.We then evaluated the association between miR-144-3p&CEP55 expression,&proliferation,invasion&apoptosis of non-small cell lung cancer[NSCLC]cells.Real-time quantitative PCR results revealed that CEP55 was over-expressed whereas miR-144-3p was underexpressed in NSCLC tissues.CCK-8 assay,wound healing assay,&flow cytometry further revealed that overexpression of miR-144-3p significantly inhibited proliferation&migration,but promoted apoptosis of A549 cells.Conversely,inhibition of miR-144-3p promoted proliferation. | Ming Li Yannan Liu Xinglin Jiang Yuanxin Hang Haiying Wang Hang Liu Zhuo Chen Yubo Xiao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 7 |
| 7 | Dexmedetomidine Attenuates High Glucose-induced HK-2 Epithelial-mesenchymal Transition by Inhibiting AKT and ERK显示文摘Objective To explore the protective effects of dexmedetomidine(Dex)against high glucose-induced epithelial-mesenchymal transition in HK-2 cells and relevant mechanisms.Methods HK-2 cells were exposed to either glucose or glucose+Dex for 6 h.The production of ROS,morphology of HK-2 cells,and cell cycle were detected.Moreover,the expression of AKT,p-AKT,ERK,pERK,PI3 K,E-Cadherin,Claudin-1,andα-SMA were determined and compared between HK-2 cells exposed to glucose and those exposed to both glucose and Dex with or without PI3 K/AKT pathway inhibitor LY294002 and ERK pathway inhibitor U0126.Results Compared with HK-2 cells exposed to high level of glucose,the HK-2 cells exposed to both high level of glucose and Dex showed:(1)lower level of ROS production;(2)cell morphology was complete;(3)more cells in G1 phase;(4)lower expression of p-AKT,p-ERK andα-SMA,higher expression of ECadherin and Claudin-1.PI3 K/AKT inhibitor LY294002 and ERK inhibitor U0126 decreased the expression of p-AKT,p-ERK andα-SMA,and increased the expression of E-Cadherin and Claudin-1.Conclusion Dex can attenuate high glucose-induced HK-2 epithelial-mesenchymal transition by inhibiting AKT and ERK. | PAN Qi Zheng LI Kai YANG Zhuo Dong GAO Ming SHI Jia Hong REN Shu Ping ZHAO Guo Qing | 2020 | Biomedical and Environmental Sciences2020，33，5： | 7 |
| 8 | Coating of Al_2O_3 on layered Li(Mn_(1/3)Ni_(1/3)Co_(1/3))O_2 using CO_2 as green precipitant and their improved electrochemical performance for lithium ion batteries显示文摘Li(Mn1/3Ni1/3Co1/3)O2 cathode materials were fabricated by a hydroxide precursor method.Al2O3 was coated on the surface of the Li(Mn1/3Ni1/3CO1/3)O2 through a simple and effective one-step electrostatic self-assembly method.In the coating process,a NaHCO3-H2CO3 buffer was formed spontaneously when CO2 was introduced into the NaAlO2 solution.Compared with bare Li(Mn1/3Ni1/3Co1/3)O2, the surface-modified samples exhibited better cycling performance,rate capability and rate capability retention.The Al2O3-coated Li(Mn1/3Ni1/3Co1/3)O2 electrodes delivered a discharge capacity of about 115 mAh·g-1 at 2A·g-1,but only 84 mAh·g-1 for the bare one.The capacity retention of the Al2O3-coated Li(Mn1/3Ni1/3Co1/3)O2 was 90.7%after 50 cycles,about 30%higher than that of the pristine one. | Yingqiang Wu Linhai Zhuo Jun Ming Yancun Yu Fengyu Zhao | 2013 | Journal of Energy Chemistry2013，22，3： | 6 |
| 9 | Genetic analysis and fine mapping of an enclosed panicle mutant esp2 in rice (Oryza sativa L.)显示文摘The phenomenon of panicle enclosure in rice is mainly caused by the shortening of uppermost internode.Elucidating the molecular mechanism of panicle enclosure will be helpful for solving the problem of panicle enclosure in male sterile lines and creating new germplasms in rice.We acquired a monogenic recessive enclosed panicle mutant,named as esp2 (enclosed shorter panicle 2),from the tissue culture progeny of indica rice cultivar Minghui-86.In the mutant,panicles were entirely enclosed by flag leaf sheaths and the uppermost internode was almost completely degenerated,but the other internodes did not have obvious changes in length.Genetic analysis indicated that the mutant phenotype was controlled by a recessive gene,which could be steadily inherited and was not affected by genetic background.Apparently,ESP2 is a key gene for the development of uppermost internode in rice.Using an F 2 population of a cross between esp2 and a japonica rice cultivar Xiushui-13 as well as SSR and InDel markers,we fine mapped ESP2 to a 14-kb region on the end of the short arm of chromosome 1.According to the rice genome sequence annotation,only one intact gene exists in this region,namely,a putative phosphatidylserine synthase gene.Sequencing analysis on the mutant and the wild type indicated that this gene was inserted by a 5287-bp retrotransposon sequence.Hence,we took this gene as a candidate of ESP2.The results of this study will facilitate the cloning and functional analysis of ESP2 gene. | GUAN HuaZhong DUAN YuanLin LIU HuaQing CHEN ZhiWei ZHUO Ming ZHUANG LiJun QI WenMing PAN RunSen MAO DaMei ZHOU YuanChang WANG Feng WU WeiRen | 2011 | Chinese Science Bulletin2011，56，14： | 6 |
| 10 | Novel miniature mobile cardiac catheterization laboratory for critical cardiovascular disease following natural disasters: a feasibility study显示文摘 | HAN Ya-ling LIANG Zhuo YAO Tian-ming SUN Jing-yang LIANG Ming HUO Yu WANG Geng, WANG Xiao-zeng LIANG Yan-chun MENG Wei-hong | 2012 | Chinese Medical Journal2012，，6： | 5 |
| 11 | Simvastatin combined with nifedipine enhances endothelial cell protection by inhibiting ROS generation and activating Akt phosphorylation显示文摘 | Xiao-niao CHEN Jun XU Zhe FENG Ming FAN Jing-yao HAN Zhuo YANG | 2010 | Acta Pharmacologica Sinica2010，31，7： | 4 |
| 12 | Algorithm of ratio rules'Optimizations显示文摘 | ZHUO Ming WANG Li-zhen ZHOU Li-hua | 2001 | Computer Science2001，，： | 2 |
| 13 | Genetic Analysis and Mapping of an Enclosed Panicle Mutant Locus esp1 in Rice (Oryza sativa L.)显示文摘A mutant was isolated from the M2 of 60Co-γ ray mutagenized male-fertility restorer line Zao-R974 in rice. The mutant showed pleiotropic phenotypes including dwarfism, delayed heading time, short and partially enclosed panicles, short uppermost internode, decreased grain and secondary branch numbers per panicle, and partially degenerated spikelets. The mutant was named as esp1 (enclosed shorter panicle 1). Genetic analysis indicated that the mutant phenotype was controlled by a recessive locus. Spraying exogenous GA3 did not rescue the panicle enclosure. Using an F2 and a BC1 population of the cross between esp1 and a japonica cultivar Nipponbare, we mapped the ESP1 locus to a region of ~260 kb on chromosome 11. This result provides a basis for further map-based cloning of the ESP1 locus. | DUAN Yuan-lin GUAN Hua-zhong ZHUO Ming CHEN Zhi-wei LI Wen-tao PAN Run-sen MAO Da-mei ZHOU Yuan-chang WU Wei-ren | 2012 | Journal of Integrative Agriculture2012，11，12： | 2 |
| 14 | Awareness intervention for Beijing neurologists regarding secondary prevention of cerebral infarction/transient ischemia Cross-sectional investigation显示文摘BACKGROUND: Stroke prevention guidelines should be made available to neurologists for clinical application to aid in uniformity, timing, preciseness, and acceptance of disease. OBJECTIVE: To investigate the awareness of neurologists in some Beijing hospitals of intervention in secondary prevention of cerebral infarction/transient ischemia. DESIGN: Cross-sectional study. SETTING: Beijing Tiantan Hospital, Beijing Anzhen Hospital, General Hospital of Beijing Military Area, Command of Chinese PLA, Beijing Chuiyangliu Hospital, Beijing 6th Hospital, Beijing Hepingli Hospital, and Beijing Daxing District Hospital. PARTICIPANTS: A total of 28 (associate) chief physicians, 58 attending physicians, and 54 resident physicians who engaged in clinical treatment of cerebrovascular diseases were selected from 8 hospitals in Beijing from March to April 2007. All physicians provided informed consent. METHODS: Self-made closed questionnaires were provided for data collection, consisting of 16 questions that were single choice or multiple choice. Specifically, questions 1-7 focused on awareness of blood pressure regulation in different patients and first choice of decompression drug; questions 8-12 focused on awareness of lipid regulation; and questions 13-16 focused on awareness of anti-blood platelet drugs applied in secondary prevention. The scores ranged from 0-100 points, and each question was worth 6.25 points. The scores positively correlated with the awareness rate. To test leveling real-time, the survey lasted for a maximum of 20 minutes. One questionnaire was independently finished by each subject in the survey. MAIN OUTCOME MEASURES: Awareness intervention among neurologists during secondary prevention of cerebral infarction/transient ischemia and questionnaire scores. RESULTS: 140 subjects were included in the final analysis. ① The awareness rate among neurologists for intervention during secondary prevention of cerebral infarction/transient ischemia ranged from 0.7-57.9%, the scores ranged between 0-56 points, and the mean score was 26 points. ② Scores of resident physicians were 0-56 points with a mean score of 26 points; attending physicians scored 6-50 points, with a mean score of 26 points; and chief physicians scored 6-50 points, with a mean score of 23 points. There were no significant differences among the various physicians (F = 0.771, t = 0.465, P > 0.05). CONCLUSION: Awareness among neurologists of intervention during secondary prevention of cerebral infarction/transient ischemia is not ideal. However, there was no significant difference between professional titles. | Ruihua Ma Chunxue Wang Xianwei Wang Yuhui Zhang Yongjun Wang Yilong Wang Xingquan Zhao Jingjing Li Ying Lu Mingjie Xu Zhuo Zhang Li Wang Weiwei Zhang Lang Lin Jiping Tan Yao Li Ming Wei Hongtao Li | 2008 | Neural Regeneration Research2008，3，3： | 2 |
| 15 | Computer simulation model for spherical particle filled composite materials 显示文摘 | Chen Zhuo Huang Zhixiong Zhang Ming Shl Minxian Qin Yah Mei Qilin | 2011 | Key Eng Mater2011，47，： | 1 |
| 16 | The effect of smoking on the risk of gallbladder cancer: a meta-analysis of observational studies显示文摘 | Ding Wenbin Chen Zhuo Ming Zhibing Zhou Chen Yuan Ruifan Jin Jie Qian Cheng Ge Zhenming | 2013 | European Journal of Gastroenterology & Hepatology2013，，3： | 1 |
| 17 | Association of miRNA-492 rs2289030 G>C and miRNA-938rs2505901 T>C Gene Polymorphisms with Biliary Atresia Susceptibility显示文摘Biliary atresia(BA)is one of the most common and enigmatic forms of neonatal cholestasis and is characterized by inflammation and obstruction of extrahepatic bile ducts resulting in biliary cirrhosis,which occurs in 1 in 8,000 to 1 in 18,000 live births.Revealing of the mechanisms underlying BA is crucial for early diagnosis,intervention,and better prognosis.The etiology of BA remains unclear,and currently,noncoding and epigenetic factors,rather than classic genetic alterations,are assumed to be responsible for genetic predisposition to BA. | SU Liang TIAN Yan FU Ming ZHANG Rui Zhong OU Xiu Fei XIA Hui Min LI Rui Zhuo | 2021 | Biomedical and Environmental Sciences2021，34，7： | 1 |
| 18 | Genomic Characterization of a Streptococcus suis Serotype 2 Isolated from a Human Patient显示文摘Streptococcus suis(S. suis) is a Gram-positive zoonotic pathogen. S. suis infection in humans commonly causes meningitis, septicemia, arthritis,and streptococcal toxic shock-like syndrome(STSLS). S. suis has 29 serotypes, of which S. suis serotype 2(SS2) has the highest clinical isolation rate and strongest pathogenicity and causes most S. suis human infections.About 1,000 different sequence types(STs)were identified in S.suis based on multilocus sequence typing(MLST).Among these,STs,ST1,and ST7 belong to serotype 2 and are the major hazards of S.suis.in 1998 and 2005,two cases of SS2 human infection outbreak were reported in Jiangsu and Sichuan,China,causing 14 deaths and 38 deaths,respectively. | GUO Geng Lin GAO Hua Sheng WANG Zhuo Hao TAN Zhong Ming HAN Ming Xiao CHEN Qi DU Hong ZHANG Wei ZHANG Hai Fang | 2022 | Biomedical and Environmental Sciences2022，35，8： | 1 |
| 19 | Effects of estrogen and tibolone on bladder histology and estrogen receptors in rats显示文摘背景雌激素缺乏在尿生殖的道以内引起衰退变化,并且与尿症状被联系。这研究的目的是在雌激素受体的膀胱组织学,和变化上调查雌激素和 tibolone 的效果并且(嗯并且) 在 detrusor muscle.Methods 的蛋白质表示四十只雌老鼠被分开成四组十各个。他们收到了假冒的操作(假冒) ,卵巢切除术(Ovx ) ,加雌激素代替(Ovx+E ) 的卵巢切除术,或加 tibolone 治疗(Ovx+T ) 的卵巢切除术。在 12 个星期以后,每只老鼠是 anesthetized,膀胱被移开。膀胱的极端结构,骨胶原纤维(CF ) 到光滑的肌肉(SM ) 比率并且嗯子类型被学习。统计分析用变化 test.Results Ovx 的单程的分析被执行在膀胱导致了重要退化极端结构;然而,雌激素和 tibolone 颠倒了那些变化。Ovx 增加了 CF/SM 比率,雌激素和 tibolone 导致了增加。二雌激素受体(ERs ) 在膀胱 detrusor 被表示,与嗯主要子类型。Ovx 导致了起来规定嗯并且下面规定嗯。与雌激素和 tibolone 治疗,嗯显示出重要增加但是嗯显示出的不重要的差别与 Ovx.Conclusions 雌激素相比,缺乏败坏膀胱极端结构和组织学。增补雌激素能改进可能由于骨胶原增生的抑制并且增加 SM 密度的膀胱功能。嗯在调停有一个重要角色在膀胱的雌激素功能。Tibolone 有一个温和雌激素的行动并且在某种程度上在膀胱功能和结构上有效果。 | YANG Xin LI Ya-zhen MAO Zhuo GU Pei SHANG Ming | 2009 | Chinese Medical Journal2009，，4： | 1 |
| 20 | Study on the preparation of novel functional poly(dioxanone) and for the controlled release of protein 显示文摘 | Ming Xia Li Ren Xi Zhuo Fan Qi Qu | 2003 | Reactive and Functional Polymers2003，55，： | 1 |
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