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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Clinical features and outcomes of 210 patients with idiopathic pulmonary fibrosis显示文摘 | Cai Miaotian Zhu Min Ban Chengjun Su Jin Ye Qiao Liu Yan Zhao Wen Wang Chen Dai Huaping | 2014 | Chinese Medical Journal2014，，10： | 8 |
| 3 | Clinicopathological analysis of metaplastic meningioma: report of 15 cases in Huashan Hospital显示文摘Objective: Metaplastic meningioma is a rare subtype of benign meningiomas, classified as WHO grade I with well prognosis. Here we presented our experiences on 15 cases of metaplastic meningioma, to investigate the clinicopathological features, therapies and prognosis of these cases. Methods: 15 patients underwent surgical treatment for intracranial metaplastic meningioma between 2001 and 2010 at Neurosurgery Department of Huashan Hospital, Shanghai, China. The clinical data, radiological manifestation, treatment strategy, pathological findings and prognosis of all patients were analyzed retrospectively. Results: Among the 15 cases (10 males and 5 females), the age ranged from 22 to 74 years old (the mean age was 50.67-year old). The clinical manifestations include headache, dizziness, seizure attack, vision decrease, and weakness of bilateral lower limbs. All the patients received surgical treatment, combined with radiotherapy in some cases. In the follow-up period, recurrence occurred in 2 cases, of which 1 patient died of other system complications. Conclusions: Metaplastic meningiomas are characterized by focal or widespread mesenchymal differentiation with formation of bone, cartilage, fat, and xanthomatous tissue elements. Surgical removal is the optimal therapy, and the overall prognosis is well. But recurrence may occur in some cases, thus radiotherapy is necessary for such kind of patients. | Hailiang Tang Huaping Sun Hong Chen Ye Gong Ying Mao Qing Xie Liqian Xie Mingzhe Zheng Daijun Wang Hongda Zhu Xiaoming Che Ping Zhong Kang Zheng Shiqi Li Weimin Bao Jianhong Zhu Xuanchun Wang Xiaoyuan Feng Xiancheng Chen Liangfu Zhou | 2013 | Chinese Journal of Cancer Research2013，25，1： | 6 |
| 4 | Transition metal carbides in electrocatalytic oxygen evolution reaction显示文摘Oxygen evolution reaction(OER) is admitted to an important half reaction in water splitting for sustainable hydrogen production.The sluggish four-electron process is known to be the bottleneck for enhancing the efficiency of OER.In this regard,tremendous efforts have been devoted to developing effective catalysts for OER.In addition to Ir-or Ru-based oxides taken as the benchmark,transition metal carbides have attracted ever-increasing interest due to the high activity and stability as low-cost OER electrocatalysts.In this review,the transition metal carbides for water oxidation electrocatalysis concerning design strategies and synthesis are briefly summarized.Some typical applications for various carbides are also highlighted.Besides,the development trends and outlook are also discussed. | Huaping Wang Sheng Zhu Jiwei Deng Wenchao Zhang Yuezhan Feng Jianmin Ma | 2021 | Chinese Chemical Letters2021，32，1： | 5 |
| 5 | Ore-forming and Exploration Models of the Baguamiao Gold Deposit,Shaanxi Province显示文摘The Baguamiao superlarge gold deposit in Shaanxi Province is one of the typical cases in China that are hosted by sedimentary rocks. Explorers and researchers have discussed the gold mineralization enrichment conditions by studying sulphur, oxygen, carbon, silicon stable isotopes and mineralizing fluid features of the Baguamiao gold deposit and proposed a hydrothermal sedimentation-magmatic reconstructing gold mineralization model featuring multi-sources of ore-forming materials and multistage mineralizations. In addition, prospecting for 'Baguamiao-type' gold deposits was started in the Fengtai Basin and a great number of important prospecting targets such as Tonglinggou, Simaoling, Guoansi and Dachaigou were discovered. | GUO Jian LIU Ping ZHANG Wanye ZHU Huaping ZHU Hongzhou | 2000 | Acta Geologica Sinica(English Edition)2000，74，3： | 4 |
| 6 | H.sinensis mycelium inhibits epithelial–mesenchymal transition by inactivating the midkine pathway in pulmonary fibrosis显示文摘The medical fungus Hirsutella sinensis has been used as a Chinese folk health supplement because of its immunomodulatory properties.Our previous studies established the antifibrotic action of Hirsutella sinensis mycelium(HSM)in the lung.The epithelial–mesenchymal transition(EMT)is involved in the pathogenesis of idiopathic pulmonary fibrosis.The present study investigates the role of HSM in mediating EMT during the development of pulmonary fibrosis.HSM significantly inhibits bleomycin(BLM)-induced pulmonary fibrosis by blocking the EMT.In addition,the expression levels of midkine are increased in the lungs of the BLM-induced group.Further analysis of the results indicates that the mRNA level of midkine correlated positively with EMT.HSM markedly abrogates the transforming growth factorβ-induced EMT-like phenotype and behavior in vitro.The activation of midkine related signaling pathway is ameliorated following HSM treatment,whereas this extract also caused an effective attenuation of the induction of EMT(caused by midkine overexpression)in vitro.Results further confirm that oral medication of HSM disrupted the midkine pathway in vivo.Overall,findings suggest that the midkine pathway and the regulation of the EMT may be considered novel candidate therapeutic targets for the antifibrotic effects caused by HSM. | Li Lu Haiyan Zhu Hailin Wang Huaping Liang Yayi Hou Huan Dou | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 7 | The relationship between matrix metalloproteinases-9 and CD15s antigen in angiogenesis of gastric carcinoma显示文摘调查在矩阵 metalloproteinases-9 (MMP-9 ) 和 sialyl 之间的关系的目的在胃的癌的侵略和转移的路易斯十世(CD15s ) 抗原。在胃的癌的 47 种情况中的 CD105, MMP-9 和 CD15s 的方法表示经历的激进的外科被 SP 免疫评估用各自的单音的同种细胞的抗体的组织化学的染色。与 CD105 标记的微容器密度(MVD ) 被检测。在 MVD 和 MMP-9 之间的关联, CD15s 统计上也被分析。结果在 MMP-9 和 CD15s 的 MVD 积极表示组独自在 MMP-9 或 CD15s 积极表示比那显著地更高级组,和它在 MMP-9 和 CD15s 否定表示组也是比那显著地高级的。结论 MMP-9 是侵略的一个标记, CD15s 是在胃的癌的转移的一个标记。MMP-9 和 CD15s 的联合察觉为诊断有某些临床的意义,处理并且为胃的 caner 估计预后。 | Peizhong Shang Xiaowu Li Xiqin Zhu Jianjun Miao Guohong Jia Huaping Gu | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，3： | 3 |
| 8 | Intraoperative ultrasound assistance in resection of intracranial meningiomas显示文摘Objective: Intracranial meningiomas, especially those located at anterior and middle skull base, are difficult to be completely resected due to their complicated anatomy structures and adjacent vessels. It's essential to locate the tumor and its vessels precisely during operation to reduce the risk of neurological deficits. The purpose of this study was to evaluate intraoperative ultrasonography in displaying intracranial meningioma and its surrounding arteries, and evaluate its potential to improve surgical precision and minimize surgical trauma. Methods: Between December 2011 and January 2013, 20 patients with anterior and middle skull base meningioma underwent surgery with the assistance of intraoperative ultrasonography in the Neurosurgery Department of Shanghai Huashan Hospital. There were 7 male and 13 female patients, aged from 31 to 66 years old. Their sonographic features were analyzed and the advantages of intraoperative ultrasonography were discussed. Results: The border of the meningioma and its adjacent vessels could be exhibited on intraoperative ultrasonography. The sonographic visualization allowed the neurosurgeon to choose an appropriate approach before the operation. In addition, intraoperative ultrasonography could inform neurosurgeons about the location of the tumor, its relation to the surrounding arteries during the operation, thus these essential arteries could be protected carefully. Conclusions: Intraoperative ultrasonography is a useful intraoperative technique. When appropriately applied to assist surgical procedures for intracranial meningioma, it could offer very important intraoperative information (such as the tumor supplying vessels) that helps to improve surgical resection and therefore might reduce the postoperative morbidity. | Hailiang Tang Huaping Sun Liqian Xie Qisheng Tang Ye Gong Ying Mao Qing Xie Mingzhe Zheng Daijun Wang Hongda Zhu Jianhong Zhu Xiaoyuan Feng Zhenwei Yao Xiancheng Chen Liangfu Zhou | 2013 | Chinese Journal of Cancer Research2013，25，3： | 3 |
| 9 | Petrogenesis of Kejie Granite in the Northern Changning-Menglian Zone, Western Yunnan: Constraints from Zircon U-Pb Geochronology, Geochemistry and Hf Isotope显示文摘The Kejie pluton is located in the north of the Changning-Menglian suture zone. The rock types are mainly biotite-granite. Zircon LA-ICP-MS U-Pb dating indicates that the Kejie pluton emplaced at about 80–77 Ma, Late Cretaceous. The Kejie pluton samples are characterized by high SiO2(71.68%–72.47%), K2O(4.73%–5.54%), total alkali(K2O + Na2O = 8.21%–8.53%), K2O/Na2O ratios(1.36–1.94) and low P2O5(0.13%–0.17%), with A/CNK of 1.025–1.055; enriched in U, Th, and K, depleted in Ba, Nb, Sr, Ti, P and Eu. They are highly fractionated, slightly peraluminous I-type granite. The two samples of the Kejie pluton give a large variation of εHf(t) values(-5.04 to 1.96) and Hf isotope crustal model ages of 1.16–1.5 Ga. Zircon Hf isotopes and zircon saturation temperatures of whole-rock(801°C–823°C) show that the mantle-derived materials maybe have played a vital role in the generation of the Kejie pluton. The Kejie pluton was most likely generated in a setting associated with the eastward subduction of the neo-Tethys ocean, where intrusion of mantle wedge basaltic magmas in the crust caused the anatexis of the latter, forming hybrid melts, which subsequently experienced high-degree fractional crystallization. | NIE Fei DONG Guochen MO Xuanxue WANG Xia FAN Wenyu DONG Meiling ZHU Huaping | 2014 | Acta Geologica Sinica(English Edition)2014，88，3： | 3 |
| 10 | Highly-rough surface carbon nanofibers film as an effective interlayer for lithium–sulfur batteries显示文摘Lithium–sulfur(Li–S)battery with a new configuration is demonstrated by inserting a flexible nitrogen-doping carbon nanofiber(N-CNFs)interlayer between the sulfur cathode and the separator.The N-CNFs film with high surface roughness and surface area is fabricated by electrospinning and a subsequent calcination process.The N-CNFs film interlayer not only effectively traps the shuttling migration of polysulfides but also gives the whole battery reliable electronic conductivity,which can effectively enhance the electrochemical performance of Li–S batteries.Finally,Li–S batteries with long cycling stability of 785 mAh/g after 200 cycles and good rate capability of 573 mAh/g at 5 C are achieved. | Hongfan Zhu Mo Sha Huaping Zhao Yuting Nie Xuhui Sun Yong Lei | 2020 | Journal of Semiconductors2020，41，9： | 3 |
| 11 | Analysis on Dynamic Characteristics in Time Domain of Slider with Ultra Thin Spacing显示文摘With increasing recording density in computer hard disks,the flying height of the magnetic head becomes 10 nm or less.The numerical method of the control equations needs to be optimized consistently with the decrease of the flying height.The iterative process is usually divergent with traditional methods which cannot ensure the accuracy of the analysis results and the stability of numerical calculations.Firstly,a new scheme is presented to solve the ultra-thin lubricating control equations in this paper.The equilibrium equation is obtained by taking the Couette flow terms and time term as dominating terms in iterative process.Moreover,the weighting flow factor is introduced for the abrupt change of film thickness in order to reduce calculated deviation.Secondly,the rules for variation of flying pose of the magnetic head with time are obtained by the time domain analysis.The results show that the magnetic head can recover to the equilibrium position after being slightly influenced by outside disturbance.And the dynamic lubrication properties of the head suffer heavily from the vibrations in the height direction and fluctuation in the pitch direction.Finally,the analysis of the sine roughness-passing capacity of the head indicates that the head can surpass small sine waves and the equilibrium position can be retrieved after a period of decaying oscillation.The proposed research ensures the accuracy and stability of the numerical calculation of the control equations,and the dynamic characteristics and flying stability of a magnetic head is studied systematically.It can also be the theoretical basis for the analysis of the flight characteristics of the slider. | YAO Huaping HUANG Ping CHEN Yangzhi ZHU Lixue | 2012 | Chinese Journal of Mechanical Engineering2012，25，3： | 2 |
| 12 | Preparation of BST ferroelectric thin film by pulsed laser ablation for dielectric bolometers显示文摘 | Xu Huaping Zhu Hong Hashimoto K | 2000 | Vacuum2000，59，23： | 1 |
| 13 | Bronsted acidic ionic liquid 1-methylimidazolium tetrafluoroborate: a green catalyst and recyelable medium for estefifieation 显示文摘 | ZHU Huaping YANG Fan TANG Jie | 2003 | Green Chemistry2003，5，1： | 1 |
| 14 | Brnsted acidic ionic liquid 1-methylimidazolium tetrafluoroborate:a green catalyst and recyclable medium for esterification显示文摘 | Yang Fan Tang Jie | 2003 | Green Chemistry2003，5，： | 1 |
| 15 | Robust Estimation for Poisson Integer-Valued GARCH Models Using a New Hybrid Loss显示文摘The Poisson integer-valued GARCH model is a popular tool in modeling time series of counts.The commonly used maximum likelihood estimator is strongly influenced by outliers,so there is a need to develop a robust M-estimator for this model.This paper has three aims.First,the authors propose a new loss function,which is a hybrid of the tri-weight loss for relatively small errors and the exponential squared loss for relatively large ones.Second,Mallows’quasi-likelihood estimator(MQLE)is proposed as an M-estimator and its existence,uniqueness,consistency and asymptotic normality are established.In addition,a data-adaptive algorithm for computing MQLE is given based on a datadriven selection of tuning parameters in the loss function.Third,simulation studies and analysis of a real example are conducted to illustrate the performance of the new estimator,and a comparison with existing estimators is made. | LI Qi CHEN Huaping ZHU Fukang | 2021 | Journal of Systems Science & Complexity2021，34，4： | 1 |
| 16 | Multi walled carbon nanotubes as solid phase extraction adsorbents for de- termination of atrazine and its principal metabolites in water and soil samples by gas chromatography-mass spectrometry 显示文摘 | Min Guang Wang Shuo Zhu Huaping | 2008 | Science of the Total Environmenb2008，396，1： | 1 |
| 17 | Multi-walled carbon nanotubes as solid-phase extrac- tion adsorbents for determination of atrazine and its principal metabolites in water and soil samples by gas chromatography-mass spectrometry 显示文摘 | M1N Guang WANG Shuo ZHU Huaping | 2008 | Science of the Total Environment2008，396，1： | 1 |
| 18 | Electroencephalogram evidence for mirror neuron activity during the observation of drawn hand motion显示文摘The present study used electroencephalography to examine mu rhythm suppression (a putative index of human mirror neuron system activation) at frontal sites (F3, Fz and F4), central sites (C3, Cz and C4), parietal sites (P3, Pz and P4) and occipital sites (O1 and O2), while subjects observed real hand motion (real hand motion condition) and illustrative depictions of hand motion (drawn hand motion condition). Experimental data revealed that mu rhythm suppression was exhibited in the mirror neuron system when subjects observed both real and drawn hand motion. Moreover, the mu rhythm recorded at the F3, Fz, F4, and Pz poles was significantly suppressed while observing both stimulus types, but no obvious mu suppression occurred at the O1, O2 and O3 poles. These results suggest that the observation of drawings of human hand actions can activate the human mirror neuron system. This evidence supports the hypothesis that the mirror neuron system may be involved in intransitively abstract action understanding. | Huaping Zhu Yaoru Sun Wenya Duan | 2011 | Neural Regeneration Research2011，6，18： | 1 |
| 19 | Bronsted acidic ionic liquid I - methylimidazolium tetrafluoroborate: a green catalyst and recyclable medium for esterification 显示文摘 | ZHU HUAPING YANG FAN TANG JIE | 2003 | Green Chemistry2003，5，： | 1 |
| 20 | A New Deramp-NECS Imaging Algorithm for Missile-Borne Hybrid SAR显示文摘 | XU Huaping ZHU Yadi KANG Changhui ZHOU Yinqing | 2011 | Chinese Journal of Electronics2011，20，4： | 1 |
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