|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 2 | Porous surfur-doped hard carbon for excellent potassium storage显示文摘Hard carbon is promising anode for potassium-ion batteries(PIBs),however,the poor rate capability hinders its development as potential anode.To address this question,we design a sulfur-doped porous hard carbon(S-HC)for PIBs through the combination of structural design and composition adjustment.The as-designed S-HC exhibits a long cycling life with^191 mAh/g after 300 cycles at 1 A/g,and an excellent rate capability with^100 mAh/g at 5 A/g,which was attributed to its structural characteristics and compositions.The S-HC demonstrates to be promising anode in the future. | Xuan Xie Shihan Qi Daxiong Wu Huaping Wang Fang Li Xiaoxin Peng Jinfeng Cai Jiaojiao Liang Jianmin Ma | 2020 | Chinese Chemical Letters2020，31，1： | 4 |
| 3 | H.sinensis mycelium inhibits epithelial–mesenchymal transition by inactivating the midkine pathway in pulmonary fibrosis显示文摘The medical fungus Hirsutella sinensis has been used as a Chinese folk health supplement because of its immunomodulatory properties.Our previous studies established the antifibrotic action of Hirsutella sinensis mycelium(HSM)in the lung.The epithelial–mesenchymal transition(EMT)is involved in the pathogenesis of idiopathic pulmonary fibrosis.The present study investigates the role of HSM in mediating EMT during the development of pulmonary fibrosis.HSM significantly inhibits bleomycin(BLM)-induced pulmonary fibrosis by blocking the EMT.In addition,the expression levels of midkine are increased in the lungs of the BLM-induced group.Further analysis of the results indicates that the mRNA level of midkine correlated positively with EMT.HSM markedly abrogates the transforming growth factorβ-induced EMT-like phenotype and behavior in vitro.The activation of midkine related signaling pathway is ameliorated following HSM treatment,whereas this extract also caused an effective attenuation of the induction of EMT(caused by midkine overexpression)in vitro.Results further confirm that oral medication of HSM disrupted the midkine pathway in vivo.Overall,findings suggest that the midkine pathway and the regulation of the EMT may be considered novel candidate therapeutic targets for the antifibrotic effects caused by HSM. | Li Lu Haiyan Zhu Hailin Wang Huaping Liang Yayi Hou Huan Dou | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 4 | Spatial evolution of friction of a textured wafer surface显示文摘Mechanical failure of integrated circuits and micro-electro-mechanical systems(MEMS)demands new understanding of friction in small devices.In present research,we demonstrated an in situ approach to measure sliding friction of a patterned surface composing multi-materials and structures.The effects of materials and surface morphology on friction and electrical contact resistance were investigated.The material transfer at the interface of dissimilar materials was found to play dominating roles in friction.The current work provides important insights from the fundamentals of friction that benefit the design of new micro-devices. | Huaping XIAO Ke WANG Grant FOX Michel BELIN Julien FONTAINE Hong LIANG | 2013 | Friction2013，1，1： | 3 |
| 5 | Interferometric Phase Statistics and Estimation Accuracy of Strong Scatterer for InSAR显示文摘 | XU Huaping LI Shuang FENG Liang | 2012 | Chinese Journal of Electronics2012，21，4： | 3 |
| 6 | Ferrocene-modified Fe3O4@SiO 2magnetic nanoparticles as building blocks for construction of reagentless enzyme-based biosensors显示文摘 | Qiu Jianding Peng Huaping Liang Ruping | 2007 | Electrochemistry Communications2007，9，11： | 1 |
| 7 | Ferrocene-Modified Fe3O4@SiO2 Magnetic Nanoparticles as Building Blocks for Construction of Reagentless Enzyme-Based Biosensors显示文摘 | Qiu Jianding Peng Huaping Liang Ruping | 2007 | Electrochem Commun2007，9，： | 1 |
| 8 | Ferrocenemodified Fe304 @ Si02 : Magnetic nanoparticles as building blocks for construetion of reagentless enzyme-based biosensors显示文摘 | Qiu Iianding Peng Huaping Liang Ruping | 2007 | Eletrochem Commun2007，9，1： | 1 |
| 9 | Compo- sition and variability of essential oils of Platycladus orientalis grow- ing in China 显示文摘 | LEI Huaping WANG Yonggang LIANG Fengyin | 2010 | Biochemical Systematics and Ecology2010，38，5： | 1 |
| 10 | Simplified Receiver Design for STBC Binary Continuous Phase Modulation 显示文摘 | XIAN Liang PUNNOOSE R LIU Huaping | 2008 | IEEE Transactions on Wireless Communications2008，7，2： | 1 |
| 11 | Simplified Receiver Design for STBC Binary Continuous Phase Modulation 显示文摘 | Liang Xian Punnoose Ratish Liu Huaping | 2008 | IEEE Transactions on Wireless Communication2008，7，2： | 1 |
| 12 | Facile preparation of novel core-shell enzyme-Au-polydopa mine- Fe3O4 magnetic bionanoparticles for glucose sensor显示文摘 | PENG Huaping LIANG Ruping ZHANG Li | 2013 | Biosensors and Bioelectronics2013，42，： | 1 |
| 13 | Assessment of plasma 12(S)-Hydroxyeicosatetraenoic acid as a biomarker to predict mortality in adults with severe trauma显示文摘To the Editor Identification upon admission of a group of patients with severe traumatic injury presenting with a higher risk of death is crucial in designing personalized treatment strategies[1].However,there are as yet limited biomarkers for the prediction of mortality in patients with traumatic injury.12(S)-Hydroxyeicosatetraenoic acid(12(S)-HETE),as a classic metabolite of arachidonic acid,was suggested to be a potential biomarker in brain injury[2]or subarachnoid hemorrhage[3]. | Liping Yang Qian Cheng Qi Huang Huaping Liang Yan Luo | 2020 | Burns & Trauma2020，8，1： | 0 |
| 14 | Hierarchical Sb-Ni nanoarrays as robust binder-free anodes for high-performance sodium-ion half and full cells显示文摘A novel hierarchical electrode material for Na-ion batteries composed of Sbnanoplates on Ni nanorod arrays is developed to tackle the issues of the rapidcapacity fading and poor rate capability of Sb-based materials. The three-dimensional (3D) Sb-Ni nanoarrays as anodes exhibit the synergistic effects ofthe two-dimensional nanoplates and the open and conductive array structureas well as strong structural integrity. Further, their capacitive behavior isconfirmed through a kinetics analysis, which shows that their excellent Na-storageperformance is attributable to their unique nanostructure. When used asbinder-free sodium-ion battery (SIB) anodes, the nanoarrays exhibit a highcapacity retention rate (more than 80% over 200 cycles) at a current density of0.5 A.g-1 and excellent rate capacity (up to 20 A·g^-1), with their capacity being580 mAh-g-1. Moreover, a P2-Na2/3Nil/3Mn2/302//3D Sb-Ni nanoarrays full celldelivers a highly reversible capacity of 579.8 mAh.g-1 over 200 cycles and an energydensity as high as 100 Wh-kg^-1 This design strategy for ensuring fast and stableNa storage may work with other electrode materials as well. | Liying Liang Yang Xu Liaoyong Wen Yueliang Li Min Zhou Chengliang Wang Huaping Zhao Ute Kaiser Yong Lei | 2017 | Nano Research2017，10，9： | 0 |
| 15 | Study on Influence of Crack on the Blade Status Using FBGs显示文摘自从传感器被旋转在易燃、爆炸、强壮的磁性的环境影响,为旋转部分的地位察觉是困难的。基于察觉到技术的纤维布拉格栅栏,这份报纸学习快克的尺寸在片影响的转子片的自然频率和变丑的影响。测试结果证明设备和片的速度使颤动频率激动是二个主要因素或变丑和片的颤动频率。随裂缝深度的增加,当片的刺激自然频率被减少时,片变丑被增加;以低旋转速度,变丑被片的旋转速度主要引起。相反,颤动片本身以高速度贡献变丑。在全速旋转的过程期间,片变丑上的旋转速度的影响几乎仍然是片变丑上的自然颤动的一样,和影响随旋转速度的增加被增加。 | Gang XU Lei LIANG Jianzhi LI Huaping MEI Hongli LI Yijun LIU | 2018 | Photonic Sensors2018，8，1： | 0 |
| 16 | 肿瘤再生细胞通过犬尿氨酸转移以及芳香烃受体激活诱导CD8^+T细胞表达PD-1显示文摘文章简介肿瘤免疫治疗是当前肿瘤研究的热点领域之一,通过利用免疫细胞、免疫分子直接或间接杀伤肿瘤细胞,以控制或清除肿瘤,被认为是人类战胜癌症的希望所在。肿瘤免疫治疗主要依赖活化的T细胞杀伤肿瘤细胞. | 刘玉英 梁晓雨 董文茜 Yi Fang Jiadi Lv Tianzhen Zhang Roland Fiskesund Jing Xie Jinyan Liu Xiaonan Yin Xun Jin Degao Chen Ke Tang Jingwei Ma Huafeng Zhang Jing Yu Jun Yan Huaping Liang Siqi Mo Feiran Cheng Yabo Zhou Haizeng Zhang Jing Wang Jingnan Li Yang Chen Bing Cui Zhuo-Wei Hu Xuetao Cao F. Xiao-Feng Qin 黄波 | 2019 | 科学新闻2019，0，2： | 0 |
| 17 | Immune-related DNA methylation signature associated with APLN expression predicts prognostic of hepatocellular carcinoma显示文摘TIME,Immunity,Prognosis,BioinformaticsThis study used transcriptome and epigenetic data to predict the prognosis of immune-related genes(IRGs)Apelin(APLN)in patients with hepatocellular carcinoma(HCC).The TCGA database has gene expression and clinical data for HCC.And DNA methylation 450 k data for HCC was download from the University of California Santa Cruz(UCSC)Xena browser.Performing clinical and prognostic analysis of APLN expression,results show that APLN is highly expressed in tumor samples.And it has an increasing trend with the development of clinical stage and T stage.To explore the prognostic role of APLN,the Immune-related DNA methylation(DNAm)sites associated with APLN analyzed by bioinformatics.Univariate COX screened the methylation sites that are related to both APLN and survival.The risk score related to methylation site signature was determined according to their least absolute shrinkage and selection operator(LASSO)coefficients.Then the patients were divided into high-risk groups and low-risk groups.Significant differences in overall survival(OS)were found in the training cohort.Nomogram shows that APLN or methylation signature can effectively predict the prognosis of HCC patients.In summary,APLN may be a diagnostic and prognostic marker for HCC. | FEIFEI TIAN HUAN HU DI WANG HUAN DING QINGJIA CHI HUAPING LIANG WENLI ZENG | 2022 | BIOCELL2022，46，10： | 0 |
| 18 | The Logic of Self-Justification of China’s Anti-Epidemic Effectiveness显示文摘The COVID-19 outbreak in 2020 is a syndrome of economic,social and governance crises.It is not only a test of the medical and health system of a country or a region,but also a test of the emergency management system and the comprehensive governance capacity.Based on the complexity of epidemic prevention and control,no single factor can explain and respond to the'exceptional status'of epidemic prevention and control.Only by applying the'Theory of History Resultant Force',establishing systematic thinking,and comprehensively reviewing and analyzing can we comprehensively and objectively clarify its pros and cons.Having taken advantage of the party’s leadership,the nationwide system,and the Socialism with Chinese characteristics with a broad mass base and strong material support,China has achieved obvious results in a relatively short period of time in the process of epidemic prevention and control.It provides other countries or regions with Chinese experience,and Chinese wisdom for anti-epidemic efforts. | Liang Huaping Lu Weiming | 2020 | 学术界2020，，5： | 0 |
| 19 | Elite,transformable haploid inducers in maize显示文摘The introduction of alleles into commercial crop breeding pipelines is both time consuming and costly.Two technologies that are disrupting traditional breeding processes are doubled haploid(DH)breeding and genome editing(GE).Recently,these techniques were combined into a GE trait delivery system called HI-Edit(Haploid Inducer-Edit).In HI-Edit,the pollen of a haploid inducer line is reprogrammed to deliver GE traits to any variety,obviating recurrent selection.For HI-Edit to operate at scale,an efficient transformable HI line is needed,but most maize varieties are recalcitrant to transformation,and haploid inducers are especially difficult to transform given their aberrant reproductive behaviors.Leveraging marker assisted selection and a three-tiered testing scheme,we report the development of new Iodent and Stiff Stalk maize germplasm that are transformable,have high haploid induction rates,and exhibit a robust,genetically-dominant anthocyanin native trait that may be used for rapid haploid identification.We show that transformation of these elite‘‘HI-Edit”lines is enhanced using the BABYBOOM and WUSCHEL morphogenetic factors.Finally,we evaluate the HI-Edit performance of one of the lines against both Stiff Stalk and non-Stiff Stalk testers.The strategy and results of this study should facilitate the development of commercially scalable HI-Edit systems in diverse crops. | Brent Delzer Dawei Liang David Szwerdszarf Isadora Rodriguez Gonzalo Mardones Sivamani Elumalai Francine Johnson Samson Nalapalli Rachel Egger Erin Burch Kerry Meier Juan Wei Xiujuan Zhang Huaping Gui Huaibing Jin Huan Guo Kun Yu Yubo Liu Becky Breitinger Ana Poets Jason Nichols Wan Shi David Skibbe Qiudeng Que Timothy Kelliher | 2024 | The Crop Journal2024，12，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员