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| 1 | The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice显示文摘Hepatic ischemia/reperfusion injury(HIRI) is a serious complication that occurs following shock and/or liver surgery. Gut microbiota and their metabolites are key upstream modulators of development of liver injury. Herein, we investigated the potential contribution of gut microbes to HIRI.Ischemia/reperfusion surgery was performed to establish a murine model of HIRI. 16 S r RNA gene sequencing and metabolomics were used for microbial analysis. Transcriptomics and proteomics analysis were employed to study the host cell responses. Our results establish HIRI was significantly increased when surgery occurred in the evening(ZT12, 20:00) when compared with the morning(ZT0, 08:00);however, antibiotic pretreatment reduced this diurnal variation. The abundance of a microbial metabolite3,4-dihydroxyphenylpropionic acid was significantly higher in ZT0 when compared with ZT12 in the gut and this compound significantly protected mice against HIRI. Furthermore, 3,4-dihydroxyphenylpropionic acid suppressed the macrophage pro-inflammatory response in vivo and in vitro. This metabolite inhibits histone deacetylase activity by reducing its phosphorylation. Histone deacetylase inhibition suppressed macrophage pro-inflammatory activation and diminished the diurnal variation of HIRI. Our findings revealed a novel protective microbial metabolite against HIRI in mice. The potential underlying mechanism was at least in part, via 3,4-dihydroxyphenylpropionic acid-dependent immune regulation and histone deacetylase(HDAC) inhibition in macrophages. | Rui Li Li Xie Lei Li Xiaojiao Chen Tong Yao Yuanxin Tian Qingping Li Kai Wang Chenyang Huang Cui Li Yifan Li Hongwei Zhou Neil Kaplowitz Yong Jiang Peng Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 2 | Carbon-based derivatives from metal-organic frameworks as cathode hosts for Li–S batteries显示文摘Lithium-sulfur batteries(Li–S batteries) are promising candidates for the next generation high-energy rechargeable Li batteries due to their high theoretical specific capacity(1672 m Ahg-1) and energy density(2500 Wh kg-1). The commercialization of Li–S batteries is impeded by several key challenges at cathode side, e.g. the insulating nature of sulfur and discharged products(Li2S 2 and Li2S), the solubility of long-chain polysulfides and volume variation of sulfur cathode upon cycling. Recently, the carbonbased derivatives from metal-organic frameworks(MOFs) has emerged talent in their utilization as cathode hosts for Li–S batteries. They are not only highly conductive and porous to enable the acceleration of Li +/e-transfer and accommodation of volumetric expansion of sulfur cathode during cycling, but also enriched by controllable chemical active sites to enable the adsorption of polysulfides and promotion of their conversion reaction kinetics. In this review, based on the types of MOFs(e.g. ZIF-8, ZIF-67, Prussian blue, Al-MOF, MOF-5, Cu-MOF, Ni-MOF), the synthetic methods, formation process and morphology, structural superiority of MOFs-derived carbon frameworks along with their electrochemical performance as cathode host in Li–S batteries are summarized and discussed. | Qingping Wu Xuejun Zhou Jun Xu Fahai Cao Chilin Li | 2019 | Journal of Energy Chemistry2019，28，11： | 7 |
| 3 | Transcriptomic analyses identify albino-associated genes of a novel albino tea germplasm ‘Huabai 1’显示文摘Albinism in shoots of tea plants is a common phenotypic expression which gives the tea infusion a pleasant umami taste.A novel natural albino mutant tea germplasm containing high amino acids content was found and named as‘Huabai 1’.‘Huabai 1’has white jade tender shoots under low temperature and turns green with increased temperature.In order to understand the molecular mechanism of color change in leaf of‘Huabai 1’,transcriptome analysis was performed to identify albino-associated differentially expressed genes(DEGs).A total of 483 DEGs were identified from white shoots of‘Huabai 1’compared to its green shoots.There were 15 DEGs identified to be involved in phenylpropanoid biosynthesis,which account for the majority of characterized DEGs.The metabolites related to phenylpropanoid biosynthesis revealed similar expression pattern of DEGs.Furthermore,metabolic pathways such as ubiquonone,tyrosine,and flavonoid biosynthesis associated with phenylpropanoid biosynthesis could also contribute to the color change in‘Huabai 1’tender shoots.Protein–protein interaction analysis revealed a hub protein NEDD8(CSA009575)which interacted with many regulated genes in spliceosome,nitrogen metabolism,phenylpropanoid biosynthesis,and other pathways.In conclusion,the findings in this study indicate that the color change of‘Huabai 1’tender shoots is a combined effect of phenylpropanoid biosynthesis pathway and other metabolic pathways including flavonoid biosynthesis in tea plants.Chlorophyll biosynthesis-related genes LHCII and SGR may also play some roles in color change of‘Huabai 1’. | Qingping Ma Huan Li Zhongwei Zou Emmanuel Arkorful Qianru Lv Qiongqiong Zhou Xuan Chen Kang Sun Xinghui Li | 2018 | Horticulture Research2018，5，1： | 7 |
| 4 | Evaluation of seed production in a first-generation seed orchard of Chinese pine (Pinus tabuliformis)显示文摘We evaluated seed production in a first-generation orchard of Chinese pine(Pinus tabuliformis) during the crucial transition period from first generation to advanced generations.Clones varied significantly in all traits related to seed production.Repeatability of these traits ranged from 0 to 0.96.Seed production per ramet(SPPR),seed producing index(SPI),the number of relative female strobili(RFS),the number of scales,and the number of ineffective scales had comparatively high repeatability at 0.86,0.87,0.89,0.96,and 0.91,respectively.Correlation analysis showed that SPPR was greatly influenced by RFS and by the number of full seeds per cone.Finally,we showed that SPI was the best predictor of the seed-producing ability of clones.Our findings will assist seed orchard managers in effectively predicting and improving seed production of Chinese pine seed orchards. | Huwei Yuan Shihui Niu Xianqing Zhou Qingping Du Yue Li Wei Li | 2016 | Journal of Forestry Research2016，27，5： | 4 |
| 5 | Free-volume evolution of glassy Zr_(65)Al_(7.5)Ni_(10)Cu_(17.5) during inhomogeneous deformation显示文摘Free-volume evolutions of the as-cast and pre-annealed Zr65Al7.5Ni10Cu17.5 metallic glasses during cold-rolling were investigated using differential scanning calorimetry. As deformation degree increases, free volume in the glasses always increases first and then saturates above a critical strain, while the structure remains completely amorphous. The glass with less initial free volume possesses a higher increase rate of free-volume content during deformation, and as a result the free-volume contents of all the glasses approach each other at higher strains. Coalescence of free volume in shear bands into nanovoids is proposed to be responsible for the saturation of free-volume content at high strains. | LIU HuiBin LI JinFut CAO QingPing ZHOU YaoHe | 2007 | Chinese Science Bulletin2007，52，24： | 4 |
| 6 | Microstructure of Cu_(60)Zr_(20)Ti_(20) bulk metallic glass rolled at different strain rates显示文摘The structural evolution of Cu60Zr20Ti20 bulk metallic glass during rolling at different strain rates and cryogenic temperature was investigated by X-ray diffraction (XRD),differential scanning calorimetry (DSC) and high-resolution transmission electron microscopy (HRTEM). It is revealed that the deformation-induced transformation is strongly dependent on the strain rate. At the lowest experimental strain rate of 1.0×10-4 s-1,no phase transformation occurs until the highest deformation degree reaches 95%. In a strain rate range of 5.0×10-4-5.0×10-2 s-1,phase separation oc-curs in a high deformation degree. As the strain rate reaches 5.0×10-1 s-1,phase separation and nanocrystallization concur. The critical deformation degree for oc-currence of phase transformation decreases with the strain rate increasing. | LI JinFu,CAO QingPing & ZHOU YaoHe State Key Laboratory of Metal Matrix Composites,School of Materials Science and Engineering,Shanghai Jiao Tong University,Shanghai 200030,China | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，4： | 3 |
| 7 | Alteration of P2X3 expression in dorsal root ganglia after sciatic nerve ligation显示文摘BACKGROUND:The expressions of P2X3 receptor in dorsal root ganglia(DRG)after different peripheral nerve injuries are diverse.It indicates the different roles of P2X3 in different models-caused neuropathologic pains.OBJECTIVE:To observe the expressions of P2X3 in corresponding DRG after sciatic nerve ligation in rats.DESIGN:Controlled observation experiment.SETTING:Department of Morphology,Hunan Traditional Chinese Medical College;Department of Human Anatomy and Neurobiology,Xiangya Medical College,Central South University.MATERIALS:Thirty-five healthy adult SD rats of clean grade an d either gender,weighing(200±20)g,were involved.According to the random digits table,the involved rats were randomized into 3 groups:normal group(n =5),sham-operated group(n =5)and experimental group(n =25).The experimental group were subdivided into 3,7,14,21,28 days groups according to different surviving time after operation,5 rats at each time point.Polyclonal rabbit anti-P2X3 antibody(ABCAM company);biotinylated goat anti-rabbit IgG(Zhongshanjingqiao Biotechnical Co.,Ltd.,Beijing);Motic fluorescence microscope(Motic,Germany).METHODS:The experiments were carried out in the Department of Human Anatomy and Neurobiology,Xiangya Medical College,Central South University from June to December 2006.① Rats of experimental group were created into models by ligation of right sciatic nerve according to the method of Seltzer et al.Left sciatic nerve was used as self-control.As for rats in the sham-operated group,ligation of sciatic nerve was omitted,but other procedures were the same as those in the experimental group.Rats of normal group were untouched.② Rats of the normal group and sham-operated group survived for 14 days separately,and those of experimental group survived for corresponding time.After being deeply anesthetized by intraperitoneal injection of over-dose sodium pentobarbital,the rats of experimental group were transcardially perfused.L4-6 corresponding DRG connected to sciatic nerve were taken for preparing transverse sections serially.③P2X3 expression in L4-6 DRG was detected by immunohistochemistry,immunofluorescence and image analysis techniques.MAIN OUTCOME MEASURES:P2X3 expression in L4-6 DRG of rats in each group.RESULTS:Thirty-five SD rats were involved in the final analysis.① P2X3 expression in DRG:In normal DRG of rats,there were abundant P2X3 immuno-positive small-and medium-sized primary sensory neurons,especially the small ones,which mostly received the input from C fibers.There were only a few large neurons expressing P2X3.The immuno-positive products mostly were located in the cytoplasm and processes.The expression of P2X3 had a slight but significant decrease in ipsilateral L4-6 DRG 3 days after sciatic nerve ligation,and a decreasing tendency was observed with the elongation of time.At 28 days,the expression had not returned to base line,and still maintained at a low level.② P2X3 immuno-positive gray scale in DRG:P2X3 immuno-positive gray scale in ipsilateral side L4-6 DRG was 117.74±2.38,129.12± 4.86,133.56±3.79,148.75±6.90 and 150.49±5.15,respectively at 3,7,14,21 and 28 days after sciatic nerve ligation,which was significantly higher than that in the normal group and sham-operated group(105.11±3.52,104.22±5.41,F =78.861,P < 0.05),also significantly higher than that in the contralateral side(105.53±5.85,108.54±3.70,104.07±4.16,106.55±2.02,106.29±5.19,t =3.48-13.95,P < 0.05);There were no significant differences when comparing sham-operated group or contralateral side at each time point with normal group(P > 0.05)CONCLUSION:P2X3 is significantly down regulated in L4-6 DRG after sciatic nerve ligation.It may exert certain effects in neuropathic pain. | Guoxing Zhou Lesi Xie Qiben Wang Qingping Yu Xiaofu Liu Qiumei Liu Wei Peng Zhicheng Zeng | 2007 | Neural Regeneration Research2007，2，4： | 3 |
| 8 | The Response of Vegetation Biomass to Soil Properties along Degradation Gradients of Alpine Meadow at Zoige Plateau显示文摘Alpine grassland of the Tibetan Plateau has undergone severe degradation, even desertification. However, several questions remain to be answered, especially the response mechanisms of vegetation biomass to soil properties. In this study, an experiment on degradation gradients was conducted in an alpine meadow at the Zoige Plateau in 2017. Both vegetation characteristics and soil properties were observed during the peak season of plant growth. The classification and regression tree model(CART) and structural equation modelling(SEM) were applied to screen the main factors that govern the vegetation dynamics and explore the interaction of these screened factors. Both aboveground biomass(AGB) and belowground biomass(BGB) experienced a remarkable decrease along the degradation gradients. All soil properties experienced significant variations along the degradation gradients at the 0.05 significance level. Soil physical and chemical properties explained 54.78% of the variation in vegetation biomass along the degradation gradients. AGB was mainly influenced by soil water content(SWC), soil bulk density(SBD), soil organic carbon(SOC), soil total nitrogen(STN), and pH. Soil available nitrogen(SAN), SOC and p H, had significant influence on BGB. Most soil properties had positive effects on AGB and BGB, while SBD and p H had a slightly negative effect on AGB and BGB. The correlations of SWC with AGB and BGB were relatively less significant than those of other soil properties. Our results highlighted that the soil properties played important roles in regulating vegetation dynamics along the degradation gradients and that SWC is not the main factor limiting plant growth in the humid Zoige region. Our results can provide guidance for the restoration and improvement of degraded alpine grasslands on the Tibetan Plateau. | LIU Miao ZHANG Zhenchao SUN Jian XU Ming MA Baibing TIJJANI Sadiy Baba CHEN You-jun ZHOU Qingping | 2020 | Chinese Geographical Science2020，30，3： | 3 |
| 9 | Remote Generation of Quantum Communication Channel with Continuous Variable via Beam Splitters显示文摘 | ZHOU Qingping ZHANG Yanliang ZHOU Fang WANG Xiaobo | 2010 | Chinese Journal of Electronics2010，19，2： | 2 |
| 10 | Development of an immobilization and detection method of Enterobacter sakazakii from powdered infant formula显示文摘 | ZHOU Yanhong WU Qingping XU Xiaoke | 2008 | Food Microbiology2008，25，5： | 1 |
| 11 | Nanofretting behaviors of NiTi shape memory alloy显示文摘 | QIAN Linmao ZHOU Zhongrong SUN Qingping | 2007 | Wear2007，263，： | 1 |
| 12 | Large Curvature Folding Strategies of Butterfly Proboscis显示文摘Due to its real-time control,high folding ratio,and structure self-locking,flexible large curvature self-folding devices have broad application prospects,such as foldable human implants,flexible electronics,and flexible robots.Driven by this background,flexible large curvature folding butterfly(Polyura eudamippus)proboscises were studied in this work.The folding ratio of the proboscises was about 15.The curvature of coiled proboscises ranged from about 150 m_1 to 880 m The external and internal structures of the proboscises were studied by different methods.Three main strategies for large-curvature folding of proboscises were identified:a gradual decrease in thickness,a lower elastic modulus,and(most importantly)large numbers of regular corrugated cracks arranged on the surface.These corrugated cracks can effectively accommodate the coiled strain and provide space for the large curvature folding of proboscises.Finally,a 4D printed coiled sample with corrugated cracks was fabricated to mimic the proboscises stretching process.Large-curvature folding strategies,based on these proboscises,provide insights for the biomimetic design of artificial highly folded components. | Daobing Chen Honglie Song Qingping Liu Jie Gan Yang Liu Keyu Che' Chong Wang Shifeng Wen Yan Zhou Chunze Yan Junqiu Zhang Yusheng Shi Zhiwu Han | 2020 | Journal of Bionic Engineering2020，17，6： | 1 |
| 13 | 5 forecasting based on ensemble empirical mode decomposition and a general regression neural network 显示文摘 | Zhou Qingping Jiang Haiyan Wang Jianzhou A hybrid model for PM2 | 2014 | Science of the Total Environment2014，496，： | 1 |
| 14 | al Development of an immobilization and detection method of Enterobaeter sakazakii from pow- dered infant formula显示文摘 | Yanhong Zhou Qingping Wu Xiaoke Xu et | 2008 | Food Mierobiol2008，25，5： | 1 |
| 15 | Extraction, characterization and antioxidant activities of polysaccharides from E. corneum gigeriae galli显示文摘 | Qingping Xiong Xia Li Ruizhen Zhou Hairong Hao Songlin Li Yi Jing Chun Zhu Qinghua Zhang Yingying Shi | 2014 | Carbohydrate Polymers2014，，： | 1 |
| 16 | Abnormal expression of matrix metalloproteinase-9 (MMP9)correlates with clinical course in Chinese patients with endometrialcancer显示文摘 | Fang Yu Qingping Jiang Ying Zhou Zhen Yang Xiaoli Yu Hao Wang Zhen Liu Lijing Wang Weiyi Fang Suiqun Guo | 2012 | Disease Markers2012，，5： | 1 |
| 17 | Creep-Fatigue Interaction in an Fe-25Ni-15Cr Based Alloy显示文摘The interaction between high temperature creep and low cycle fatigue in an Fe-25Ni-15Cr basedalloy GH132 has been studied under three different loading schedules: (a) continuous cycliccreep, (b) prior creep followed by fatigue, and (c) prior fatigue followed by creep. It is found thatthe interaction appears nearly linear for all the three schedules. The behaviour of interactionin GH132 alloy is different from that previously observed in a GH30 alloy (Nimonic 75 type),in which although the interaction at schedules (a) and (c) was linear, a pronounced negativeinteraction occurred at the schedule (b), i.e., prior creep followed by fatigue. This differenceis found to be associated with the difference in the evolution of microstructure. In the GH132alloy, no cell structure is formed during the tests. while in the GH30 alloy, cell structure is welldeveloped during prior creep, which impedes the motion of dislocations during sequential fatigue,resulting in a negative interaction between creep and fatigue. | Zhu, Huiwen Zhou, Hao Wang, Xiang Tian, Maosheng Kong, Qingping
| 1999 | Journal of Materials Science & Technology1999，15，1： | 0 |
| 18 | Quantum Dot Nanobeads-Labelled Lateral Flow Immunoassay Strip for Rapid and Sensitive Detection of Salmonella Typhimurium Based on Strand Displacement Loop-Mediated Isothermal Amplification显示文摘Rapid,sensitive,point-of-care detection of pathogenic bacteria is important for food safety.In this study,we developed a novel quantum dot nanobeads-labelled lateral flow immunoassay strip(QBs-labelled LFIAS)combined with strand displacement loop-mediated isothermal amplification(SD-LAMP)for quantitative Salmonella Typhimurium(ST)detection.Quantum dot nanobeads(QBs)served as fluorescence reporters,providing good detection efficiency.The customizable strand displacement(SD)probe was used in LAMP to improve the specificity of the method and prevent by-product capture.Detection was based on a sandwich immunoassay.A fluorescence strip reader measured the fluorescence intensity(FI)of the test(T)line and control(C)line.The linear detection range of the strip was 10^(2)–10^(8) colony forming units(CFU)·mL^(-1).The visual limit of detection was 10^(3) CFU·mL^(-1),indicating that the system was ten-fold more sensitive than AuNPs-labelled test strips.ST specificity was analyzed in accordance with agarose gel outputs of polymerase chain reaction(PCR)and SD-LAMP.We detected ST in foods with an acceptable recovery of 85%–110%.The method is rapid,simple,almost equipment-free,and suitable for bacterial detection in foods and for clinical diagnosis. | Yuting Shang Shuzhen Cai Qinghua Ye Qingping Wu Yanna Shao Xiaoying Qu Xinran Xiang Baoqing Zhou Yu Ding Moutong Chen Liang Xue Honghui Zhu Jumei Zhang | 2022 | Engineering2022，，12： | 0 |
| 19 | Fundamental characteristics of gas hydrate-bearing sediments in the Shenhu area, South China Sea显示文摘The basic physical properties of marine natural gas hydrate deposits are important to the understanding of seabed growth conditions, occurrence regularity, and occurrence environment of natural gas hydrates. A comprehensive analysis of the core samples of drilling pressure-holding hydrate deposits at a depth of 1310 m in the Shenhu area of the South China Sea was conducted. The experimental results indicate that the particle size in the hydrate sediment samples are mainly distributed in the range from 7.81 µm to 21.72 µm, and the average particle size decreases as the depth of the burial increases. The X-ray CT analytical images and surface characteristics SEM scan images suggest that the sediment is mostly silty clay. There are a large number of bioplastics in the sediment, and the crack inside the core may be areas of hydrate formation. | Xin LYU Qingping LI Yang GE Junlong ZHU Shouwei ZHOU Qiang FU | 2021 | Frontiers in Energy2021，15，2： | 0 |
| 20 | Black-phosphorus-based junctions and their optoelectronic device applications显示文摘Black phosphorus(BP)has attracted significant attention owing to its unique structure and preeminent photoelectric properties,which can be utilized to create novel junctions.Based on different BP-based junctions,versatile optoelectronic devices have been fabricated and investigated in recent years,providing a fertile library for the characteristics of BP-based junctions and their optoelectronic applications.This review summarizes diverse BP-based junctions and their optoelectronic device applications.We firstly introduce the structure and properties of BP.Then,we emphatically describe the formation,properties,and optoelectronic device applications of the BP-based junctions including heterojunctions of BP and other two-dimensional(2D)semiconductors,BP p–n homojunctions,and BP/metal Schottky junctions.Finally,the challenge and prospect of the development and application of BP-based junctions are discussed.This timely review gives a snapshot of recent research breakthroughs in BP-based junctions and optoelectronic devices based on them,which is expected to provide a comprehensive vision for the potential of BP in the optoelectronic field. | Kunchan Wang Zhuoyang He Xinyue Li Ke Xu Qingping Zhou Xiaowo Ye Teng Zhang Shenghao Jiang Yanming Zhang Bei Hu Changxin Chen | 2023 | Nano Research2023，16，1： | 0 |
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