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| 1 | Advances in the early diagnosis of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most prevalent cancers globally.In contrast to the declining death rates observed for all other common cancers such as breast,lung,and prostate cancers,the death rates for HCC continue to increase by^2e3%per year because HCC is frequently diagnosed late and there is no curative therapy for an advanced HCC.The early diagnosis of HCC is truly a big challenge.Over the past years,the early diagnosis of HCC has relied on surveillance with ultrasonography(US)and serological assessments of alpha-fetoprotein(AFP).However,the specificity and sensitivity of US/AFP is not satisfactory enough to detect early onset HCC.Recent technological advancements offer hope for early HCC diagnosis.Herein,we review the progress made in HCC diagnostics,with a focus on emerging imaging techniques and biomarkers for early disease diagnosis. | Weiyi Wang Chao Wei | 2020 | Genes & Diseases2020，7，3： | 42 |
| 2 | The cytokine network involved in the host immune response to periodontitis显示文摘Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue in the periodontal region.Although dysbiosis of the local microbial community initiates local inflammation,over-activation of the host immune response directly activates osteoclastic activity and alveolar bone loss.Many studies have reported on the cytokine network involved in periodontitis and its crucial and pleiotropic effect on the recruitment of specific immunocytes,control of pathobionts and induction or suppression of osteoclastic activity.Nonetheless,particularities in the stimulation of pathogens in the oral cavity that lead to the specific and complex periodontal cytokine network are far from clarified.Thus,in this review,we begin with an up-to-date aetiological hypothesis of periodontal disease and summarize the roles of cytokines in the host immune response.In addition,we also summarize the latest cytokine-related therapeutic measures for periodontal disease. | Weiyi Pan Qingxuan Wang Qianming Chen | 2019 | International Journal of Oral Science2019，11，4： | 31 |
| 3 | Natural Variation in CCD4 Promoter Underpins Species-Specific Evolution of Red Coloration in Citrus Peel显示文摘Carotenoids and apocarotenoids act as phytohormones and volatile precursors that influence plant development and confer aesthetic and nutritional value critical to consumer preference.Citrus fruits display considerable natural variation in carotenoid and apocarotenoid pigments.In this study,using an integrated genetic approach we revealed that a 5;c/s-regulatory change at CCD4b encoding CAROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural variation in C3 0 apocarotenoids responsible for red coloration of citrus peel.Functional analyses demonstrated that in addition the known role in synthesizing 3-citraurin,CCD4b is also responsible for the production of another important C3 0 apocarotenoid pigment,p-citraurinene.Furthermore,analyses of the CCD4b promoter and transcripts from various citrus germplasm accessions established a tight correlation between the presence of a putative 5'c/s-regulatory enhancer within an MITE transposon and the enhanced allelic expression of CCD4b in C3 0 apocarotenoid-rich red-peeled accessions.Phylogenetic analysis provided further evidence that functional diversification of CCD4b and naturally occurring variation of the CCD4b promoter resulted in the stepwise evolution of red peels in mandarins and their hybrids.Taken together,our findings provide new insights into the genetic and evolutionary basis of apocarotenoid diversity in plants,and would facilitate breeding efforts that aim to improve the nutritional and aesthetic value of citrus and perhaps other fruit crops. | Xiongjie Zheng Kaijie Zhu Quan Sun Weiyi Zhang Xia Wang Hongbo Cao Meilian Tan Zongzhou Xie Yunliu Zeng Junli Ye Lijun Chai Qiang Xu Zhiyong Pan Shunyuan Xiao Paul D.Fraser Xiuxin Deng | 2019 | Molecular Plant2019，12，9： | 18 |
| 4 | Efficacy of Atorvastatin combined with adipose-derived mesenchymal stem cell transplantation on cardiac function in rats with acute myocardial infarction显示文摘间充质的干细胞(MSC ) 广泛地被申请了在尖锐心肌的梗塞(AMI ) 以后的 cardiomyocytes 损失的恢复。然而,在 ischemic 心疾病的 MSC 的最佳的治疗学的功效被他们的差的幸存和低区分的率妨碍了。因此, MSC 幸存的改进和区分的率被保证并且为在 AMI 的 MSC 的功效批评。在这份报纸,从腹股沟的胖纸巾作为脂肪质导出被称为间充质的干细胞(ASC ) 的老鼠孤立的 MSC,和 ASC 的第四个段落被文化 co 在一个 transwell 系统与 cardiomyocytes 预先指定作为 co-ASCs 称为。十四天以后, GATA-4 (一个抄写因素) 和心脏的 troponin -- 我被细胞的 immunofluorescence 检测。Atorvastatin (Ator 组) 或车辆(控制组) 在老鼠在 AMI 生产以后为开始的 24 h 被管理。十四天以后,煽动性的参数和心脏的功能被评估。另外的幸存老鼠与 1 普物敭 ? 潴戠 ? 的一个总数被注射 ? 楤敲瑣琠牡敧 ? 敧敮漠 ? 業??? 祢攠桮湡散 ? 牧敥 ? 汦潵敲 ' 諟?牰瑯楥? 敲潰瑲牥攠灸牥浩湥吗? | Anping Cai Dongdan Zheng Yugang Dong Ruofeng Qiu Yuli Huang Yuanbin Song Zhigao Jiang Shaoqi Rao Xinxue Liao Jian Kuang Gang Dai Weiyi Mai | 2011 | Acta Biochimica et Biophysica Sinica2011，43，11： | 16 |
| 5 | A Truncated SVD-Based ARIMA Model for Multiple QoS Prediction in Mobile Edge Computing显示文摘In the mobile edge computing environments,Quality of Service(QoS)prediction plays a crucial role in web service recommendation.Because of distinct features of mobile edge computing,i.e.,the mobility of users and incomplete historical QoS data,traditional QoS prediction approaches may obtain less accurate results in the mobile edge computing environments.In this paper,we treat the historical QoS values at different time slots as a temporal sequence of QoS matrices.By incorporating the compressed matrices extracted from QoS matrices through truncated Singular Value Decomposition(SVD)with the classical ARIMA model,we extend the ARIMA model to predict multiple QoS values simultaneously and efficiently.Experimental results show that our proposed approach outperforms the other state-of-the-art approaches in accuracy and efficiency. | Chao Yan Yankun Zhang Weiyi Zhong Can Zhang Baogui Xin | 2022 | Tsinghua Science and Technology2022，27，2： | 9 |
| 6 | Preparation and characterization of capric-palmitic-stearic acid ternary eutectic mixture/expanded vermiculite composites as form-stabilized thermal energy storage materials显示文摘In this study, a composite of form-stable phase change materials(FSPCMs) were prepared by the incorporation of a eutectic mixture of capric–palmitic–stearic acid(CA–PA–SA) into expanded vermiculite(EV)via vacuum impregnation. In the composites, CA–PA–SA was utilized as a thermal energy storage material,and EV served as the supporting material. X-ray diffraction and Fourier transform infrared spectroscopy results demonstrated that CA–PA–SA and EV in the composites only undergo physical combination, not a chemical reaction. Scanning electron microscopy images indicated that CA–PA–SA is sufficiently absorbed in the expanded vermiculite porous network. According to differential scanning calorimetry results, the70 wt% CA–PA–SA/EV sample melts at 19.3℃ with a latent heat of 117.6 J/g and solidifies at 17.1℃ with a latent heat of 118.3 J/g. Thermal cycling measurements indicated that FSPCMs exhibit adequate stability even after being subjected to 200 melting–freezing cycles. Furthermore, the thermal conductivity of the composites increased by approximately 49.58% with the addition of 5 wt% of Cu powder. Hence,CA–PA–SA/EV FSPCMs are effective latent heat thermal energy storage building materials. | Weiyi Zhang Xiaoguang Zhang Zhaohui Huang Zhaoyu Yin Ruilong Wen Yaoting Huang Xiaowen Wu Xin Min | 2018 | Journal of Materials Science & Technology2018，34，2： | 8 |
| 7 | Expression of IL-1α, IL-6, TGF-β, FasL and ZNF265 During Sertoli Cell Infection by Ureaplasma Urealyticum显示文摘 | Rongping Li Yebin Xi Xiuzhi Liu Guangjie Chen Baoguo Wang Lihua Jiang Weiyi Li | 2009 | Cellular & Molecular Immunology2009，6，3： | 8 |
| 8 | Effect of Exogenous Ghrelin on Cell Differentiation Antigen 40 Expression in Endothelial Cells显示文摘Ghrelin 是为生长荷尔蒙促泌素受体(GHSR ) 用作自然配体的大脑勇气肽。它也在心血管的系统富有地存在。以便在动脉粥样硬化的发展评估 ghrelin 的可能的角色,房间区别抗原 40 的表示(CD40 ) 上的 ghrelin 的效果被学习。人的脐的静脉 endothelial 房间(HUVEC ) line-ECV 304 与 ghrelin 的不同集中被预先对待, des 酰 ghrelin 或[d-Lys ]-GHRP-6 (一个 ghrelin 受体对手) ,然后与肿瘤坏死 factor-alpha (TNF-alpha ) 和干扰素鲸鱼群妈(TFN-gamma ) 导致了。CD40 的 mRNA 层次被反向的抄写聚合酶链反应分析,并且在房间的 CD40 蛋白质的表情被流动 cytometry (FCM ) 并且西方的弄污测量。结果证明外长的 ghrelin 能显著地禁止 TNF-alpha/IFN-gamma 在以一种集中依赖者方式的 HUVEC 房间的导致的 CD40 表示。当与 ghrelin 的 1000 ng/ml 对待时,在房间的 CD40 的 mRNA 水平被约77%减少,但是当与 ghrelin 的 1000 ng/ml 和 1000 ng/ml 对待时[ d-Lys ]-GHRP-6,在房间的 CD40 的 mRNA 水平被减少由仅仅42%,建议那[ d-Lys ] -GHRP-6 能在这些房间抵抗 ghrelin 的禁止的效果。然而, CD40 表示没被 des 酰 ghrelin 在 1000 ng/ml 禁止。在 FCM 并且进一步的西方的弄污检测的蛋白质表示分析的结果证实了这些结果。我们的结果在心血管的系统建议了那, ghrelin 不仅有反煽动性的效果,而且有重要免疫可以通过 GHSR-1a 受体被调停的规章的效果。 | Min ZHANG Fang YUAN Hui CHEN Xingbiao QIU Weiyi FANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，12： | 8 |
| 9 | Inhibition of proliferation and apoptosis of vascular smooth muscle cells by ghrelin显示文摘在动脉粥样硬化的发展评估 ghrelin 的可能的角色,它肿瘤上的效果脉管的光滑的肌肉房间(VSMC ) 的坏死因素(TNF )-α-induced 增长和 apoptosis 被调查。老鼠 VSMC 是有 ghrelin 的不同集中然后与 TNF-α 的 pretreated。VSMC 增长被 3-(4,5-dimethylthiazol-2-yl ) 测量 -2,5-diphenyl tetrazolium 溴化物试金和流动 cytometry 方法。Apoptosis 用 propidium 碘化物和 Annexin-V 标记方法被检测。外长的 ghrelin (10-1000 ng/ml ) 显著地以一种集中依赖者方式禁止了 VSMC 的 TNF-α-induced 增长。有 1000 ng/ml ghrelin 的处理在禁止 VSMC 增长率和增殖的房间的表示是很有效的原子抗原。然而,有 des 酰 ghrelin 的处理影响了既不增长也不 PCNA 表示。相反, VSMC 的 TNF-α-induced apoptosis 被 ghrelin 和 des 酰 ghrelin 在集中依赖者礼貌禁止,与为在 1000 ng/ml 的两混合物观察的最大的抑制。总起来说,我们的结果建议 ghrelin 禁止了老鼠 VSMC 的增长和 apoptosis。而且,以前的效果被生长荷尔蒙促泌素受体类型 la 受体可能调停,当后者效果可以通过另外的受体被调停时。 | Min Zhang Fang Yuan Hua Liu Hui Chen Xingbiao Qiu Weiyi Fang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，9： | 8 |
| 10 | CONNECTION BETWEEN THE ORDER OF FRACTIONAL CALCULUS AND FRACTIONAL DIMENSIONS OF A TYPE OF FRACTAL FUNCTIONS显示文摘The linear relationship between fractal dimensions of a type of generalized Weierstrass functions and the order of their fractional calculus has been proved.The graphs and numerical results given here further indicate the corresponding relationship. | Yongshun Liang Weiyi Su | 2007 | Analysis in Theory and Applications2007，23，4： | 7 |
| 11 | Synergistic antibacterial activity of physical-chemical multi-mechanism by TiO2 nanorod arrays for safe biofilm eradication on implant显示文摘Treatment of implant-associated infection is becoming more challenging,especially when bacterial biofilms form on the surface of the implants.Developing multi-mechanism antibacterial methods to combat bacterial biofilm infections by the synergistic effects are superior to those based on single modality due to avoiding the adverse effects arising from the latter.In this work,TiO2 nanorod arrays in combination with irradiation with 808 nearinfrared(NIR)light are proven to eradicate single specie biofilms by combining photothermal therapy,photodynamic therapy,and physical killing of bacteria.The TiO2 nanorod arrays possess efficient photothermal conversion ability and produce a small amount of reactive oxygen species(ROS).Physiologically,the combined actions of hyperthermia,ROS,and puncturing by nanorods give rise to excellent antibacterial properties on titanium requiring irradiation for only 15 min as demonstrated by our experiments conducted in vitro and in vivo.More importantly,bone biofilm infection is successfully treated efficiently by the synergistic antibacterial effects and at the same time,the TiO2 nanorod arrays improve the new bone formation around implants.In this protocol,besides the biocompatible TiO2 nanorod arrays,an extra photosensitizer is not needed and no other ions would be released.Our findings reveal a rapid bacteria-killing method based on the multiple synergetic antibacterial modalities with high biosafety that can be implemented in vivo and obviate the need for a second operation.The concept and antibacterial system described here have large clinical potential in orthopedic and dental applications. | Xiangyu Zhang Guannan Zhang Maozhou Chai Xiaohong Yao Weiyi Chen Paul KChu | 2021 | Bioactive Materials2021，6，1： | 7 |
| 12 | The effects of Haversian fluid pressure and harmonic axial loading on the poroelastic behaviors of a single osteon显示文摘In order to well understand the mechanism of the mechanotransduction in bone,we propose a new model of transverse isotropic and poroelastic osteon cylinder considering Haversian fluid pressure.The analytical pore pressure and velocity solutions are obtained to examine the fluid transport behavior and pressure distribution in a loaded osteon on two different exterior surface cases.Case I is stress free and fully permeable and case II is impermeable.The following are the results obtained.(i) The Haversian fluid may not be ignored because it can enlarge the whole osteonal fluid pressure field,and it bears the external loads together with the solid skeleton.(ii) The increase of both axial strain amplitude and frequency can result in the increase of fluid pressure and velocity amplitudes,while in case II,the frequency has little effect on the fluid pressure amplitude.(iii) Under the same loading conditions,the pressure amplitude in case II is larger than that in case I,while the velocity amplitude is smaller than that in case I.This model permits the linking of the external loads to the osteonal fluid pressure and velocity,which may be a stimulus to the mechanotransduction of bone remodeling signals. | WU XiaoGang CHEN WeiYi GAO ZhiPeng GUO HongMei WANG LiLi | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，9： | 7 |
| 13 | Reduction and characterization of bioaerosols in a wastewater treatment station via ventilation显示文摘Bioaerosols from wastewater treatment processes are a significant subgroup of atmospheric aerosols. In the present study,airborne microorganisms generated from a wastewater treatment station(WWTS) that uses an oxidation ditch process were diminished by ventilation.Conventional sampling and detection methods combined with cloning/sequencing techniques were applied to determine the groups,concentrations,size distributions,and species diversity of airborne microorganisms before and after ventilation. There were 3021 ± 537 CFU/m3 of airborne bacteria and 926 ± 132 CFU/m3 of airborne fungi present in the WWTS bioaerosol.Results showed that the ventilation reduced airborne microorganisms significantly compared to the air in the WWTS. Over 60% of airborne bacteria and airborne fungi could be reduced after4 hr of air exchange. The highest removal(92.1% for airborne bacteria and 89.1% for fungi) was achieved for 0.65–1.1 μm sized particles. The bioaerosol particles over 4.7 μm were also reduced effectively. Large particles tended to be lost by gravitational settling and small particles were generally carried away,which led to the relatively easy reduction of bioaerosol particles0.65–1.1 μm and over 4.7 μm in size. An obvious variation occurred in the structure of the bacterial communities when ventilation was applied to control the airborne microorganisms in enclosed spaces. | Xuesong Guo Pianpian Wu Wenjie Ding Weiyi Zhang Lin Li | 2014 | Journal of Environmental Sciences2014，26，8： | 6 |
| 14 | Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9显示文摘In this study,we present novel molecular mechanisms by which FOXO1 functions as a tumor suppressor to prevent the pathogenesis of nasopharyngeal carcinoma(NPC).First,we observed that FOXO1 not only controlled tumor stemness and metastasis,but also sensitized NPC cells to cisplatin(DDP)in vitro and in vivo.Mechanistic studies demonstrated that FOXO1-induced miR-200b expression through the GSK3β/β-catenin/TCF4 network-mediated stimulation of ZEB1,which reduced tumor stemness and the epithelial–mesenchymal transition(EMT)signal.Furthermore,we observed FOXO1 interaction with MYH9 and suppression of MYH9 expression by modulating the PI3K/AKT/c-Myc/P53/miR-133a-3p pathway.Decreased MYH9 expression not only reduced its interactions with GSK3β,but also attenuated TRAF6 expression,which then decreased the ubiquitin-mediated degradation of GSK3βprotein.Increased GSK3βexpression stimulated theβ-catenin/TCF4/ZEB1/miR-200b network,which increased the downstream tumor stemness and EMT signals.Subsequently,we observed that chemically synthesized cinobufotalin(CB)strongly increased FOXO1-induced DDP chemosensitivity by reducing MYH9 expression,and the reduction in MYH9 modulated GSK3β/β-catenin and its downstream tumor stemness and EMT signal in NPC.In clinical samples,the combination of low FOXO1 expression and high MYH9 expression indicated the worst overall survival rates.Our studies demonstrated that CB potently induced FOXO1-mediated DDP sensitivity by antagonizing its binding partner MYH9 to modulate tumor stemness in NPC. | YongHao Li Xiong Liu Xian Lin Menyang Zhao Yanyi Xiao Chen Liu Zixi Liang Zelong Lin Renhui Yi Zibo Tang Jiahao Liu Xin Li Qingping Jiang Libo Li Yinyin Xie Zhen Liu Weiyi Fang | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 6 |
| 15 | Size-controlled MoS2 nanodots supported on reduced graphene oxide for hydrogen evolution reaction and sodium-ion batteries显示文摘转变金属 dichalcogenide nanodots (ND ) 收到了可观的兴趣。我们由在 oleylamine 把铝 pentachloride 和 L 半胱氨酸用作先锋为瞬间 2 ND 报导一条灵巧的自底向上的合成线路。有从 2.2 ~ 5.3 nm 的狭窄的尺寸分布的 ND 的合成,被控制反应时间定制。因为它的涂层特征, oleyalmine 导致 ND 的一致性和 monodispersity。而且, ND 综合了有大特定的表面区域提供活跃地点。Graphene 拥有突出的电导率。联合二材料的优点,因为 2D, 0D/2D 材料展出优异电气化学的性能为离子吸附,精力存储,和变换的可渗透的隧道。同样准备的瞬间 2/rGO (~ 2.2 nm ) 显示出 220 mAhroscopy 分析的一个稳定的能力。与另外的报导金属 oxide/CN composites 比较,有 TiO 2 nanoparticles 的 ultrathin CN-NSs 层的强壮的相互作用制止他们的重新叠,哪个导致 234.0 m 2 的一个大特定的表面区域吗? | Weiyi Sun Pan Li Xue Liu Jiajia Shi Hongming Sun Zhanliang Tao Fujun Li Jun Chen | 2017 | Nano Research2017，10，7： | 6 |
| 16 | CALCULUS ON FRACTALS BASED UPON LOCAL FIELDS─In memory of Founding Editor Professor M.T.Cheng with great respect and deep sorrow显示文摘The main contents in this note are: 1. introduction; 2. locally compact groups and local fields; 3. calculus on fractals based upon local fields; 4. fractional calculus and fractals; 5. fractal function spaces and PDE on fractals. | Su Weiyi(Department of Mathematics Nanjing University Nanjing, 210093 P. R. C e-mail: suqiu@nju. edu. cn) | 2000 | Analysis in Theory and Applications2000，16，1： | 6 |
| 17 | Fabrication of ultrafine ZnFe2O4 nanoparticles for efficient photocatalytic reduction CO2 under visible light illumination显示文摘A one-pot, solvent-thermal process was used to create the ultrafine ZnFe_2O_4 nanoparticles photocatalyst.During the solvent-thermal process, the in situ self-forming NaCl not only served as a 'cage' to confine the ion diffusion, but also acted as a microreactor for nanocrystallite growth. An average particle size of ~10 nm and a high-specific surface area of~112.9 m^2/g were observed for the ultrafine ZnFe_2O_4 nanoparticles Owing to the synergistic effect of ultrafine particle size, the full utilization of the visible light region and high conduction band(CB) position, ultrafine ZnFe_2O_4 photocatalyst displayed an efficient photocatalytic CO_2 reduction under visible light illumination. Besides, the ultrafine ZnFe_2 O_4 photocatalyst showed high production selectivity for CH_3CHO and C_2H_5OH generation in aqueous CO_2/NaHCO_3 solution. This work may provide a new idea for the synthesis of new high-efficiency photocatalysts. | Jun xiao Weiyi Yang Shuang Gao Caixia Sun Qi Li | 2018 | Journal of Materials Science & Technology2018，34，12： | 6 |
| 18 | PROPAGATION BEHAVIORS OF SHEAR HORIZONTAL WAVES IN PIEZOELECTRIC-PIEZOMAGNETIC PERIODICALLY LAYERED STRUCTURES显示文摘This paper investigates shear horizontal(SH) waves propagating in a periodically layered structure that consists of piezoelectric(PE) layers perfectly bonded with piezomagnetic(PM) layers alternately.The explicit dispersion relations are derived for the two cases when the propagation directions of SH waves are normal to the interface and parallel to the interface,respectively.The asymptotic expressions for dispersion relations are also given when the wave number is extremely small.Numerical results for stop band effect and phase velocity are presented for a periodic system of alternating BaTiO3 and Terfenol-D layers.The influence of volume fraction on stop band effect and dispersion behaviors is discussed and revealed. | Jinxi Liu Weiyi Wei Daining Fang | 2010 | Acta Mechanica Solida Sinica2010，23，1： | 5 |
| 19 | Phosphine production in anaerobic wastewater treatment under tetracycline antibiotic pressure显示文摘The influence of tetracycline(TC) antibiotics on phosphine(PH_3) production in the anaerobic wastewater treatment was studied. A lab-scale anaerobic baffled reactor with three compartments was employed to simulate this process. The reactor was operated in a TC-absence wastewater and 250 μg/L TC-presence wastewater for three months after a start-up period,respectively. The responses of p H, oxidation–reduction potential(ORP), chemical oxygen demand(COD), total phosphorus(TP), enzymes activity(dehydrogenase and acid phosphatase),and microbial community were investigated to reveal the effect of TC on PH_3 production.Results suggested that the dehydrogenase(DH) activity, acid phosphatase(ACP) activity and COD have positive relationship with PH_3 production, while p H, ORP level and the TP in liquid phase have negative relationship with PH_3 production. With prolonged TC exposure, decrease in p H and increase in DH activity are beneficial to PH_3 production, while decrease in COD and ACP activity are not the limiting factors for PH_3 production. | Meiqing Lu Xiaojun Niu Weiyi Chen Zhu Liang Sheng You Xiaohong Gu | 2018 | Journal of Environmental Sciences2018，30，7： | 5 |
| 20 | Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in osteosarcoma显示文摘Osteosarcoma is the most common primary bone sarcoma that mostly occurs in young adults. The causes of osteosarcoma are heterogeneous and still not fully understood. Identification of novel, important oncogenic factors in osteosarcoma and development of better, effective therapeutic approaches are in urgent need for better treatment of osteosarcoma patients. In this study, we uncovered that the oncogene MYC is significantly upregulated in metastastic osteosarcoma samples. In addition, high MYC expression is associated with poor survival of osteosarcoma patients. Analysis of MYC targets in osteosarcoma revealed that most of the osteosarcoma super enhancer genes are bound by MYC. Treatment of osteosarcoma cells with super enhancer inhibitors THZ1 and JQ1 effectively suppresses the proliferation, migration, and invasion of osteosarcoma cells. Mechanistically,THZ1 treatment suppresses a large group of super enhancer containing MYC target genes including CDK6 and TGFB2. These findings revealed that the MYC-driven super enhancer signaling is crucial for the osteosarcoma tumorigenesis and targeting the MYC/super enhancer axis represents as a promising therapeutic strategy for treatment of osteosarcoma patients. | Demeng Chen Zhiqiang Zhao Zixin Huang Du-Chu Chen Xin-Xing Zhu Yi-Ze Wang Ya-Wei Yan Shaojun Tang Subha Madhavan Weiyi Ni Zhan-peng Huang Wen Li Weidong Ji Huangxuan Shen Shuibin Lin Yi-Zhou Jiang | 2018 | Bone Research2018，6，2： | 5 |
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