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| 1 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 2 | The Sound Suppression Characteristics of Wing Feather of Owl (Bubo bubo)显示文摘 | Kun Chen Qingping Liu Genghua Liao Ying Yang Luquan Ren Hongxiu Yang Xin Chen | 2012 | Journal of Bionic Engineering2012，9，2： | 12 |
| 3 | Weighted adaptive filtering algorithm for carrier tracking of deep space signal显示文摘Carrier tracking is laid great emphasis and is the difficulty of signal processing in deep space communication system.For the autonomous radio receiving system in deep space, the tracking of the received signal is automatic when the signal to noise ratio(SNR) is unknown.If the frequency-locked loop(FLL) or the phase-locked loop(PLL) with fixed loop bandwidth, or Kalman filter with fixed noise variance is adopted, the accretion of estimation error and filter divergence may be caused.Therefore, the Kalman filter algorithm with adaptive capability is adopted to suppress filter divergence.Through analyzing the inadequacies of Sage–Husa adaptive filtering algorithm, this paper introduces a weighted adaptive filtering algorithm for autonomous radio.The introduced algorithm may resolve the defect of Sage–Husa adaptive filtering algorithm that the noise covariance matrix is negative definite in filtering process.In addition, the upper diagonal(UD) factorization and innovation adaptive control are used to reduce model estimation errors,suppress filter divergence and improve filtering accuracy.The simulation results indicate that compared with the Sage–Husa adaptive filtering algorithm, this algorithm has better capability to adapt to the loop, convergence performance and tracking accuracy, which contributes to the effective and accurate carrier tracking in low SNR environment, showing a better application prospect. | Song Qingping Liu Rongke | 2015 | Chinese Journal of Aeronautics2015，28，4： | 7 |
| 4 | Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9显示文摘In this study,we present novel molecular mechanisms by which FOXO1 functions as a tumor suppressor to prevent the pathogenesis of nasopharyngeal carcinoma(NPC).First,we observed that FOXO1 not only controlled tumor stemness and metastasis,but also sensitized NPC cells to cisplatin(DDP)in vitro and in vivo.Mechanistic studies demonstrated that FOXO1-induced miR-200b expression through the GSK3β/β-catenin/TCF4 network-mediated stimulation of ZEB1,which reduced tumor stemness and the epithelial–mesenchymal transition(EMT)signal.Furthermore,we observed FOXO1 interaction with MYH9 and suppression of MYH9 expression by modulating the PI3K/AKT/c-Myc/P53/miR-133a-3p pathway.Decreased MYH9 expression not only reduced its interactions with GSK3β,but also attenuated TRAF6 expression,which then decreased the ubiquitin-mediated degradation of GSK3βprotein.Increased GSK3βexpression stimulated theβ-catenin/TCF4/ZEB1/miR-200b network,which increased the downstream tumor stemness and EMT signals.Subsequently,we observed that chemically synthesized cinobufotalin(CB)strongly increased FOXO1-induced DDP chemosensitivity by reducing MYH9 expression,and the reduction in MYH9 modulated GSK3β/β-catenin and its downstream tumor stemness and EMT signal in NPC.In clinical samples,the combination of low FOXO1 expression and high MYH9 expression indicated the worst overall survival rates.Our studies demonstrated that CB potently induced FOXO1-mediated DDP sensitivity by antagonizing its binding partner MYH9 to modulate tumor stemness in NPC. | YongHao Li Xiong Liu Xian Lin Menyang Zhao Yanyi Xiao Chen Liu Zixi Liang Zelong Lin Renhui Yi Zibo Tang Jiahao Liu Xin Li Qingping Jiang Libo Li Yinyin Xie Zhen Liu Weiyi Fang | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 6 |
| 5 | Simultaneously Enhanced Cryogenic Tensile Strength,Ductility and Impact Resistance of Epoxy Resins by Polyethylene Glycol显示文摘Rubbers have been well accepted for modifying brittle epoxies but rubber modified epoxies usually posses lowered tensile strength though enhanced ductility and fracture resistance.In this work,a polyethylene glycol(PEG-4000) is used to modify diglycidyl ether of bisphenol A/methyltetrahydrophthalic anhydride system for enhancing cryogenic tensile strength,ductility and impact resistance.The results display that the cryogenic tensile strength,ductility(failure strain) and fracture resistance(impact strength) are all enhanced for the modified epoxy system at proper PEG contents.The maximum tensile strength(127.8 MPa) at the cryogenic temperature(77 K) with an improvement of 30.1%is observed for the modified system with the 15 wt%PEG content.The ductility and impact resistance at both room temperature and cryogenic temperature are all improved for the modified epoxy system with proper PEG-4000 contents.These observations are explained by the positron annihilation lifetime spectroscopy results and scanning electron microscopy results.Moreover,the glass transition temperature decreases slightly with increasing PEG content. | Qingping Feng Jiaoping Yang Yu Liu Hongmei Xiao Shaoyun Fu | 2014 | Journal of Materials Science & Technology2014，30，1： | 6 |
| 6 | Prevalence of Metabolic Syndrome and Risk Factors Among Chinese Adults:Results from a Population-Based Study—Beijing,China,2017–2018显示文摘Summary What is already known about this topic?Metabolic syndrome(MetS)is one of the most easily available health indicative markers for cardiovascular diseases,and it has become a major public health problem worldwide due to increasing urbanization and aging populations.The prevalence of MetS increased dramatically in China,however,there are no records of MetS defined by the 2017 Chinese Diabetes Society for Beijing by far.What is added by this report?In this study,the data of 24,412 participants aged 18–74 years from a large population-based study in Beijing was collected.The overall prevalence of MetS among Beijing residents was 24.5%.The prevalence was 35.2%in males and 15.4%in females.What are the implications for public health practice?Effective public health strategies should target males,people with older age,lower education,higher body mass index,smokers,those who drink alcohol,those who are unemployed or retired,and those who live in rural areas on MetS prevention and control. | Jufen Liu Qingping Liu Zhiwen Li Jing Du Chao Wang Yanlin Gao Zaihua Wei Jing Wang Yunping Shi Jianting Su Yang Liu Ping Wang Chunyan Xie Gang Li Bing Shao Le Zhang | 2022 | China CDC weekly2022，4，29： | 4 |
| 7 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 8 | A transceiver frequency conversion module based on 3D micropackaging technology显示文摘The idea of Ku-band transceiver frequency conversion module design based on 3D micropackaging technology is proposed. By using the double frequency conversion technology,the dual transceiver circuit from Ku-band to L-band is realized by combining with the local oscillator and the power control circuit to complete functions such as amplification, filtering and gain. In order to achieve the performance optimization and a high level of integration of the Ku-band monolithic microwave integrated circuits(MMIC) operating chip, the 3 D vertical interconnection micro-assembly technology is used. By stacking solder balls on the printed circuit board(PCB), the technology decreases the volume of the original transceiver to a miniaturized module. The module has a good electromagnetic compatibility through special structure designs. This module has the characteristics of miniaturization, low power consumption and high density, which is suitable for popularization in practical application. | LIU Boyuan WANG Qingping WU Weiwei YUAN Naichang | 2020 | Journal of Systems Engineering and Electronics2020，31，5： | 4 |
| 9 | Free-volume evolution of glassy Zr_(65)Al_(7.5)Ni_(10)Cu_(17.5) during inhomogeneous deformation显示文摘Free-volume evolutions of the as-cast and pre-annealed Zr65Al7.5Ni10Cu17.5 metallic glasses during cold-rolling were investigated using differential scanning calorimetry. As deformation degree increases, free volume in the glasses always increases first and then saturates above a critical strain, while the structure remains completely amorphous. The glass with less initial free volume possesses a higher increase rate of free-volume content during deformation, and as a result the free-volume contents of all the glasses approach each other at higher strains. Coalescence of free volume in shear bands into nanovoids is proposed to be responsible for the saturation of free-volume content at high strains. | LIU HuiBin LI JinFut CAO QingPing ZHOU YaoHe | 2007 | Chinese Science Bulletin2007，52，24： | 4 |
| 10 | Alteration of P2X3 expression in dorsal root ganglia after sciatic nerve ligation显示文摘BACKGROUND:The expressions of P2X3 receptor in dorsal root ganglia(DRG)after different peripheral nerve injuries are diverse.It indicates the different roles of P2X3 in different models-caused neuropathologic pains.OBJECTIVE:To observe the expressions of P2X3 in corresponding DRG after sciatic nerve ligation in rats.DESIGN:Controlled observation experiment.SETTING:Department of Morphology,Hunan Traditional Chinese Medical College;Department of Human Anatomy and Neurobiology,Xiangya Medical College,Central South University.MATERIALS:Thirty-five healthy adult SD rats of clean grade an d either gender,weighing(200±20)g,were involved.According to the random digits table,the involved rats were randomized into 3 groups:normal group(n =5),sham-operated group(n =5)and experimental group(n =25).The experimental group were subdivided into 3,7,14,21,28 days groups according to different surviving time after operation,5 rats at each time point.Polyclonal rabbit anti-P2X3 antibody(ABCAM company);biotinylated goat anti-rabbit IgG(Zhongshanjingqiao Biotechnical Co.,Ltd.,Beijing);Motic fluorescence microscope(Motic,Germany).METHODS:The experiments were carried out in the Department of Human Anatomy and Neurobiology,Xiangya Medical College,Central South University from June to December 2006.① Rats of experimental group were created into models by ligation of right sciatic nerve according to the method of Seltzer et al.Left sciatic nerve was used as self-control.As for rats in the sham-operated group,ligation of sciatic nerve was omitted,but other procedures were the same as those in the experimental group.Rats of normal group were untouched.② Rats of the normal group and sham-operated group survived for 14 days separately,and those of experimental group survived for corresponding time.After being deeply anesthetized by intraperitoneal injection of over-dose sodium pentobarbital,the rats of experimental group were transcardially perfused.L4-6 corresponding DRG connected to sciatic nerve were taken for preparing transverse sections serially.③P2X3 expression in L4-6 DRG was detected by immunohistochemistry,immunofluorescence and image analysis techniques.MAIN OUTCOME MEASURES:P2X3 expression in L4-6 DRG of rats in each group.RESULTS:Thirty-five SD rats were involved in the final analysis.① P2X3 expression in DRG:In normal DRG of rats,there were abundant P2X3 immuno-positive small-and medium-sized primary sensory neurons,especially the small ones,which mostly received the input from C fibers.There were only a few large neurons expressing P2X3.The immuno-positive products mostly were located in the cytoplasm and processes.The expression of P2X3 had a slight but significant decrease in ipsilateral L4-6 DRG 3 days after sciatic nerve ligation,and a decreasing tendency was observed with the elongation of time.At 28 days,the expression had not returned to base line,and still maintained at a low level.② P2X3 immuno-positive gray scale in DRG:P2X3 immuno-positive gray scale in ipsilateral side L4-6 DRG was 117.74±2.38,129.12± 4.86,133.56±3.79,148.75±6.90 and 150.49±5.15,respectively at 3,7,14,21 and 28 days after sciatic nerve ligation,which was significantly higher than that in the normal group and sham-operated group(105.11±3.52,104.22±5.41,F =78.861,P < 0.05),also significantly higher than that in the contralateral side(105.53±5.85,108.54±3.70,104.07±4.16,106.55±2.02,106.29±5.19,t =3.48-13.95,P < 0.05);There were no significant differences when comparing sham-operated group or contralateral side at each time point with normal group(P > 0.05)CONCLUSION:P2X3 is significantly down regulated in L4-6 DRG after sciatic nerve ligation.It may exert certain effects in neuropathic pain. | Guoxing Zhou Lesi Xie Qiben Wang Qingping Yu Xiaofu Liu Qiumei Liu Wei Peng Zhicheng Zeng | 2007 | Neural Regeneration Research2007，2，4： | 3 |
| 11 | Histone demethylase KDM2B promotes triple negative breast cancer proliferation by suppressing p 15^INK4B, p 16^INK4A, and p57^KIP2 transcription显示文摘 | Qingping Zheng Hongjia Fan Zhenzhen Meng Lin Yuan Cuicui Liu You Peng Weiwei Zhao Lulu Wang Jing Li Jing Feng | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 3 |
| 12 | The Response of Vegetation Biomass to Soil Properties along Degradation Gradients of Alpine Meadow at Zoige Plateau显示文摘Alpine grassland of the Tibetan Plateau has undergone severe degradation, even desertification. However, several questions remain to be answered, especially the response mechanisms of vegetation biomass to soil properties. In this study, an experiment on degradation gradients was conducted in an alpine meadow at the Zoige Plateau in 2017. Both vegetation characteristics and soil properties were observed during the peak season of plant growth. The classification and regression tree model(CART) and structural equation modelling(SEM) were applied to screen the main factors that govern the vegetation dynamics and explore the interaction of these screened factors. Both aboveground biomass(AGB) and belowground biomass(BGB) experienced a remarkable decrease along the degradation gradients. All soil properties experienced significant variations along the degradation gradients at the 0.05 significance level. Soil physical and chemical properties explained 54.78% of the variation in vegetation biomass along the degradation gradients. AGB was mainly influenced by soil water content(SWC), soil bulk density(SBD), soil organic carbon(SOC), soil total nitrogen(STN), and pH. Soil available nitrogen(SAN), SOC and p H, had significant influence on BGB. Most soil properties had positive effects on AGB and BGB, while SBD and p H had a slightly negative effect on AGB and BGB. The correlations of SWC with AGB and BGB were relatively less significant than those of other soil properties. Our results highlighted that the soil properties played important roles in regulating vegetation dynamics along the degradation gradients and that SWC is not the main factor limiting plant growth in the humid Zoige region. Our results can provide guidance for the restoration and improvement of degraded alpine grasslands on the Tibetan Plateau. | LIU Miao ZHANG Zhenchao SUN Jian XU Ming MA Baibing TIJJANI Sadiy Baba CHEN You-jun ZHOU Qingping | 2020 | Chinese Geographical Science2020，30，3： | 3 |
| 13 | Justice as the Virtue of "No Unacceptable Harm to the Human"显示文摘 | Qingping Liu | 2017 | Fudan Journal of the Humanities and Social Sciences2017，10，2： | 3 |
| 14 | Bilinear approach to N=2 supersymmetric KdV equations显示文摘The N=2 supersymmetric KdV equations are studied within the framework of Hirota bilinear method. For two such equations, namely N=2, a=4 and N=2, a=1 supersymmetric KdV equations, we obtain the corresponding bilinear formulations. Using them, we construct particular solutions for both cases. In particular, a bilinear Bcklund transformation is given for the N=2, a=1 supersymmetric KdV equation. | ZHANG MengXia LIU QingPing SHEN YaLi WU Ke | 2009 | Science China Mathematics2009，52，9： | 2 |
| 15 | 饲料级无机磷酸盐和饲料原料中磷的生物学效价的评定显示文摘磷(P)是日粮中不可缺少的重要营养元素。无论无机还是有机磷,他们的生物学效价都会不同。因此,了解生物学效价的知识和评定方法对选择饲料磷的来源,最大限度地发挥动物和家禽的生产性能,避免粪便过量的磷排泄具有极为重要的意义。本文的目的是对一些评定无机磷酸盐和有机饲料原料磷的生物学效价的常规方法做一介绍,并对他们的物理和化学特性加以描述。 磷是动物所必需的主要矿物元素之一。磷、钙。 | Dirk E.Axe Qingping Liu 陈强 | 2000 | 饲料广角2000，，16： | 2 |
| 16 | The detection of tetrahydrofuran hydrate formation and saturation using magnetic resonance imaging technique显示文摘Tetrahydrofuran(THF) hydrate was formed in bulk as well as in glass beads pack with a mean diameter of 3.0 mm by controlling the temperature under ambient pressure.Images of THF hydrate formation procedure were obtained using the magnetic resonance imaging(MRI) technique.The experiment results showed that MRI is an effective method for the detection of hydrate formation.Saturation of hydrate formed both in bulk and glass beads can be confirmed by intensity integration of MRI images. | Yu Liu Yongchen Song Yongjun Chen Lei Yao Qingping Li | 2010 | Journal of Natural Gas Chemistry2010，19，3： | 2 |
| 17 | 奶酪产品(奇饲粉)的营养价值及其在动物饲料中的应用显示文摘 | Qingping Liu Kevin Halpin Jim Sullivan Richard Bradfield Mike Trotter | 2006 | 中国畜牧杂志2006，42，14： | 2 |
| 18 | Analysis and Research of Web Chinese Retrieval system Based Lunece显示文摘 | Liu chun Guo Qingping | 2009 | Computer society2009，，12： | 1 |
| 19 | A Study on Thermal Self-diagnostic and Self-adaptive Smart Concrete Structures显示文摘 | Sun Mingqing Li Zhuoqiu Liu Qingping | 2000 | Cement and Concrete Research2000，30，12： | 1 |
| 20 | Is Mencius'Doctrine of 'Commiseration' tenable?显示文摘 | | 2001 | Asian Philosophy2001，，2： | 1 |
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