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| 1 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 2 | Facile construction of carbon dots via acid catalytic hydrothermal method and their application for target imaging of cancer cells显示文摘为了解决高温度或长反应的问题,在碳点(CD ) 的热水的合成预定,一个新奇方法基于支持的碳化由盐酸催化作用在现在的工作被开发的酸。催化的碳点的酸(ACD ) 在 200 虪箳椰嬑郢 G | Zhenggang Wang Boshi Fu Siwei Zou Bo Duan Chunyu Chang Bai Yang Xiang Zhou Lina Zhang | 2016 | Nano Research2016，9，1： | 8 |
| 3 | Effect of N fertilization rate on soil alkalihydrolyzable N, subtending leaf N concentration,fiber yield, and quality of cotton显示文摘Soil alkali-hydrolyzable nitrogen, which is sensitive to N fertilization rate, is one of the indicators of soil nitrogen supplying capacity. Two field experiments were conducted in Dongtai(120°19″ E, 32°52″ N), Jiangsu, China in 2009 and Dafeng(120°28″ E, 33°12″ N), Jiangsu province, China in 2010. Six nitrogen rates(0, 150, 300, 375, 450, and 600 kg ha^(-1)) were used to study the effect of N fertilization rate on soil alkali-hydrolyzable nitrogen content(SAHNC), subtending leaf nitrogen concentration(SLNC), yield, and fiber quality. In both Dongtai and Dafeng experiment station, the highest yield(1709 kg ha^(-1)), best quality(fiber length 30.6 mm, fiber strength 31.6 c N tex^(-1), micronaire 4.82), and highest N agronomic efficiency(2.03 kg kg^(-1)) were achieved at the nitrogen fertilization rate of 375 kg ha^(-1). The dynamics of SAHNC and SLNC could be simulated with a cubic and an exponential function,respectively. The changes in SAHNC were consistent with the changes in SLNC. Optimal average rate(0.276 mg day^(-1)) and duration(51.8 days) of SAHNC rapid decline were similar to the values obtained at the nitrogen rate of 375 kg ha^(-1)at which cotton showed highest fiber yield, quality, and N agronomic efficiency. Thus, the levels and strategies of nitrogen fertilization can affect SAHNC dynamics. The N fertilization rate that optimizes soil alkali-hydrolyzable nitrogen content would optimize the subtending leaf nitrogen concentration and thereby increase the yield and quality of the cotton fiber. | Binglin Chen Hongkun Yang Weichao Song Chunyu Liu Jiao Xu Wenqing Zhao Zhiguo Zhou | 2016 | The Crop Journal2016，4，4： | 8 |
| 4 | Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection显示文摘Missense mutations in Leucine-Rich Repeat Kinase 2(LRRK2)cause the majority of familial and some sporadic forms of Parkinson’s disease(PD).The hyperactivity of LRRK2 kinase induced by the pathogenic mutations underlies neurotoxicity,promoting the development of LRRK2 kinase inhibitors as therapeutics.Many potent and specific small-molecule LRRK2 inhibitors have been reported with promise.However,nearly all inhibitors are ATP competitive—some with unwanted side effects and unclear clinical outcome—alternative types of LRRK2 inhibitors are lacking.Herein we identify 5′-deoxyadenosylcobalamin(AdoCbl),a physiological form of the essential micronutrient vitamin B12 as a mixed-type allosteric inhibitor of LRRK2 kinase activity.Multiple assays show that AdoCbl directly binds LRRK2,leading to the alterations of protein conformation and ATP binding in LRRK2.STD-NMR analysis of a LRRK2 homologous kinase reveals the contact sites in AdoCbl that interface with the kinase domain.Furthermore,we provide evidence that AdoCbl modulates LRRK2 activity through disrupting LRRK2 dimerization.Treatment with AdoCbl inhibits LRRK2 kinase activity in cultured cells and brain tissue,and prevents neurotoxicity in cultured primary rodent neurons as well as in transgenic C.elegans and D.melanogaster expressing LRRK2 disease variants.Finally,AdoCbl alleviates deficits in dopamine release sustainability caused by LRRK2 disease variants in mouse models.Our study uncovers vitamin B12 as a novel class of LRRK2 kinase modulator with a distinct mechanism,which can be harnessed to develop new LRRK2-based PD therapeutics in the future. | Adam Schaffner Xianting Li Yacob Gomez-Llorente Emmanouela Leandrou Anna Memou Nicolina Clemente Chen Yao Farinaz Afsari Lianteng Zhi Nina Pan Keita Morohashi Xiaoluan Hua Ming-Ming Zhou Chunyu Wang Hui Zhang Shu G.Chen Christopher J.Elliott Hardy Rideout Iban Ubarretxena-Belandia Zhenyu Yue | 2019 | Cell Research2019，29，4： | 7 |
| 5 | Longitudinal,transverse,density-of-states,and conductivity masses of electrons in(001),(101) and(111) biaxiallystrained-Si and strained-Si_(1-x)Ge_x显示文摘In this study,the electron effective masses,including longitudinal,transverse,density-of-states and conductivity effective masses,have been systematically investigated in(001),(101) and(111) biaxially strained Si and Si1-xGex.It is found that the effect of strain on the longitudinal and transverse masses can be neglected,that the density-of-states masses in(001) and(110) biaxially strained Si and Si1-xGex materials decrease significantly with increasing Ge fraction(x),and that the conductivity masses along typical orientations in(001) and(110) strained Si and Si1-xGex.are obviously different from those in relaxed Si.The quantitative results obtained from this work may provide valuable theoretical references to understanding strained materials physics and studying conduction channel design related to stress and orientations in the strained devices. | SONG JianJun YANG Chao ZHANG HeMing HU HuiYong ZHOU ChunYu WANG Bin | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，11： | 5 |
| 6 | Space-confined growth of monolayer ReSe2 under a graphene layer on Au foils显示文摘Vertical heterostructures based on two-dimensional(2D)materials have attracted widespread interest for their numerous applications in electronic and optoelectronic devices.Herein,we report the direct construct!on of an abnormal graphene/ReSe2 stack on Au foils by a two-step chemical vapor deposition(CVD)strategy.During the second growth stage,mono layer ReSe2 is found to prefere ntially evolve at the irUerface between the first-grown graphene layer and the Au substrate.The unusual stacking behavior is unraveled by in-situ'cutting open'the upper graphene from the defects to expose the lower ReSe2 using scanning tunneling microscopy(STM).From combination of these results with density functional theory calculations,the domain boundaries and edge sites of graphene are proposed to be adsorption sites for Re and Se precursors,further facilitating the growth of ReSe2 at the van der Waals gap of graphene/Au.This work hereby offers an intriguing strategy for obtaining vertical 2D heterostructures featured with an ultra-clean interface and a designed stacking geometry. | Chunyu Xie Shaolong Jiang Xiaolong Zou Yuanwei Sun Liyun Zhao Min Hong Shulin Chen Yahuan Huan Jianping Shi Xiebo Zhou Zhepeng Zhang Pengfei Yang Yuping Shi Porun Liu Qing Zhang Peng Gao Yanfeng Zhang | 2019 | Nano Research2019，12，1： | 4 |
| 7 | ENPP1/PC-1 Gene K121Q Polymorphism Is Associated with Obesity in European Adult Populations: Evidence from A Meta-Analysis Involving 24 324 Subjects显示文摘Objective Findings from the previous studies have suggested a relationship between ectonucleotide pyrophosphatase /phosphodiesterase 1 (ENPP‐1) or plasma cell membrane glycoprotein 1 (PC‐1) gene single nucleotide polymorphism (K121Q, rs1044498) and genetic susceptibility to obesity. However, such relationship is not reproduced by some currently available studies. In this context, the present study is aimed to quantitatively analyze the association of K121Q variant with obesity in all published case‐control studies in European adult populations. Methods Published literature from PubMed, EMBASE, and ISI web of science databases were retrieved. The studies evaluating the association of ENPP1/PC1 gene K121Q polymorphism with obesity were included, in which sufficient data were presented to calculate the odds ratio (OR) with 95% confidence intervals (CIs). Results Ten case‐control studies meeting the inclusion criteria identified a total of 24,324 subjects including 11,372 obese and 12,952 control subjects. The meta‐analysis results showed a statistically significant association of K121Q with obesity [OR (95%CI): 1.25 (1.04‐1.52) P=0.021] under a recessive model of inheritance (QQ vs. KK+KQ) without heterogeneity or publication bias. Conclusions The results from the present study have indicated that ENPP1/PC1 Q121 variant may increase the risk of obesity and that more well‐designed studies based on a larger population will be required to further evaluate the role of ENPP1/PC1 gene K121Q polymorphism in obesity and other related metabolic syndromes. | WANG RuoQi ZHOU DongHao XI Bo GE XiuShan ZHU Ping WANG Bo ZHOU MingAi HUANG YuBei LIU JunTing YU Yang WANG ChunYu | 2011 | Biomedical and Environmental Sciences2011，24，2： | 4 |
| 8 | Classification of Northeast China Cold Vortex Activity Paths in Early Summer Based on K-means Clustering and Their Climate Impact显示文摘The classification of the Northeast China Cold Vortex(NCCV)activity paths is an important way to analyze its characteristics in detail.Based on the daily precipitation data of the northeastern China(NEC)region,and the atmospheric circulation field and temperature field data of ERA-Interim for every six hours,the NCCV processes during the early summer(June)seasons from 1979 to 2018 were objectively identified.Then,the NCCV processes were classified using a machine learning method(k-means)according to the characteristic parameters of the activity path information.The rationality of the classification results was verified from two aspects,as follows:(1)the atmospheric circulation configuration of the NCCV on various paths;and(2)its influences on the climate conditions in the NEC.The obtained results showed that the activity paths of the NCCV could be divided into four types according to such characteristics as the generation origin,movement direction,and movement velocity of the NCCV.These included the generation-eastward movement type in the east of the Mongolia Plateau(eastward movement type or type A);generation-southeast longdistance movement type in the upstream of the Lena River(southeast long-distance movement type or type B);generationeastward less-movement type near Lake Baikal(eastward less-movement type or type C);and the generation-southward less-movement type in eastern Siberia(southward less-movement type or type D).There were obvious differences observed in the atmospheric circulation configuration and the climate impact of the NCCV on the four above-mentioned types of paths,which indicated that the classification results were reasonable. | Yihe FANG Haishan CHEN Yi LIN Chunyu ZHAO Yitong LIN Fang ZHOU | 2021 | Advances in Atmospheric Sciences2021，38，3： | 4 |
| 9 | Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair显示文摘There are intense interests in discovering pro regenerative medicine leads that can promote cardiac differentiation and regeneration,as well as repair damaged heart tissues.We have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart development and regeneration with minimal adverse effects.Two related compounds with novel structures,named as Cardiomogen 1 and 2(CDMG1 and CDMG2),were identified for their capacity to promote myocardial hyperplasia through expansion of the cardiac progenitor cell population.We find that Cardiomogen acts as a Wnt inhibitor by targeting p-catenin and reducing Tcf/Lef-mediated transcription in cultured cells.CDMG treatment of amputated zebrafish hearts reduces nuclear p-catenin in injured heart tissue,increases cardiomyocyte(CM)proliferation,and expedites wound healing,thus accelerating cardiac muscle regeneration.Importantly,Cardiomogen can alleviate the functional deterioration of mammalian hearts after myocardial infarction.Injured hearts exposed to CDMG1 display increased newly formed CMs and reduced fibrotic scar tissue,which are in part attributable to the^-catenin reduction.Our findings indicate Cardiomogen as a Wnt inhibitor in enhancing injury-induced CM proliferation and heart regeneration,highlighting the values of embryo-based small molecule screens in discovery of effective and safe medicine leads. | Shuying Xie Wenbin Fu Guangju Yu Xueli Hu Kaa Seng Lai Xiangwen Peng Yating Zhou Xuejiao Zhu Ptamen Christov Leah Sawyer Terri T.Ni Gary A.Sulikowski Zhongzhou Yang Ethan Lee Chunyu Zeng Wei E.Wang Tao P.Zhong | 2020 | Journal of Molecular Cell Biology2020，12，1： | 4 |
| 10 | Agricultural Risk Factors Influence Microbial Ecology in Honghu Lake显示文摘Agricultural activities, including stock-farming, planting industry, and fish aquaculture,can affect the physicochemical and biological characters of freshwater lakes. However, the effects of pollution producing by agricultural activities on microbial ecosystem of lakes remain unclear.Hence, in this work, we selected Honghu Lake as a typical lake that is influenced by agriculture activities. We collected water and sediment samples from 18 sites, which span a wide range of areas from impacted and less-impacted areas. We performed a geospatial analysis on the composition of microbial communities associated with physicochemical properties and antibiotic pollution of samples. The co-occurrence networks of water and sediment were also built and analyzed. Our results showed that the microbial communities of impacted and less-impacted samples of water were largely driven by the concentrations of TN, TP, NO_3^--N, and NO_2^--N, while those of sediment were affected by the concentrations of Sed-OM and Sed-TN. Antibiotics have also played important roles in shaping these microbial communities: the concentrations of oxytetracycline and tetracycline clearly reflected the variance in taxonomic diversity and predicted functional diversity between impacted and less-impacted sites in water and sediment samples, respectively. Furthermore, for samples from both water and sediment, large differences of network topology structures between impacted and less-impacted were also observed. Our results provide compelling evidence that the microbial community can be used as a sentinel of eutrophication and antibiotics pollution risk associated with agricultural activity; and that proper monitoring of this environment is vital to maintain a sustainable environment in Honghu Lake. | Maozhen Han Melissa Dsouza Chunyu Zhou Hongjun Li Junqian Zhang Chaoyun Chen Qi Yao Chaofang Zhong Hao Zhou Jack A Gilbert Zhi Wang Kang Ning | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 3 |
| 11 | Neuroprotective role of edaravone and the effects of endoplasmic reticulum stress in an adult rat model of focal cerebral ischemia/reperfusion显示文摘BACKGROUND: Endoplasmic reticulum (ER) stress impairs ER functions and leads to the accumulation of unfolded or misfolded proteins in the ER lumen. ER stress-induced cell death plays an important role in cerebral ischemia. Edaravon (3-methyl-1-phenyl-2-pyrazolin-5-one) is a potent and novel scavenger of free radicals that inhibit delayed neuronal death, as demonstrated by in vitro and animal studies. However, its effect on ER stress and induced neuronal apoptosis in a rat model of brief middle cerebral artery occlusion remains unclear. OBJECTIVE: To explore the effects of edaravone on the expression of ER stress-related factors and neuronal apoptosis, based on the hypothesis that edaravone influences ER stress in a rat model of cerebral ischemia/reperfusion. DESIGN, TIME AND SETTING: A randomized, controlled, animal study was performed at the Laboratory of Department of Neurology, Xiangya Hospital and the Department of Laboratory Animals, Xiangya Medical College, Central South University in China from June 2005 to May 2006. MATERIALS: Edaravone was purchased from Simcere Pharmaceutical Group, China. METHODS: A total of 216 adult, male, Sprague Dawley rats were randomly assigned to sham-surgery, model and edaravone groups, with 72 rats in each group. Brief middle cerebral artery occlusion was established in the model and edaravone groups. In addition, the edaravone group rats were injected with 3 mg/kg edaravone through the tail vein. MAIN OUTCOME MEASURES: RNA-dependent protein kinase-like endoplasmic reticulum eukaryotic translation initiation factor 2α kinase (PERK) and C/EBP homology protein (CHOP) mRNA expression in the ischemic parietal cortex was determined by reverse transcription- polymerase chain reaction; phosphorylated PERK and CHOP protein expression was detected by immunohistochemistry; neuronal apoptosis was detected by TdT-mediated-dUTP nick end labeling. RESULTS: Neurological deficit scores were significantly reduced in the edaravone group compared to the model group at 12, 24, and 72 hours following reperfusion (P < 0.05). In addition, PERK and CHOP mRNA as well as phosphorylated PERK and CHOP protein expression were significantly reduced in the edaravone group compared to the model group at 1, 3, and 6 hours following reperfusion (P < 0.05, P < 0.01). CHOP mRNA expression was decreased in the edaravone group compared to the model group at 3, 6, 12, and 24 hours following reperfusion (P < 0.01), while CHOP protein expression was less than the model group at 6, 12, and 24 hours following reperfusion (P < 0.05). CONCLUSION: Edaravone treatment resulted in decreased PERK and CHOP expression following ischemia/reperfusion, as well as reduced neuronal apoptosis. Edaravone exhibited a neuroprotective role by inhibiting endoplasmic reticulum stress. | Xiangmin Shen Liming Tan Yunhai Liu Hainan Zhang Chunyu Wang Qidong Yang QingHuang Lin Zhou Zhenyu Tang | 2010 | Neural Regeneration Research2010，5，3： | 2 |
| 12 | Clustering Aggregation by Probability Accumulation显示文摘 | Wang Xi Yang Chunyu Zhou Jie | 2009 | Pattern Recognition2009，42，5： | 1 |
| 13 | Clustering aggregation by probability accumulation显示文摘 | Wang Xi Yang Chunyu Zhou Jie | 2009 | Pattern Recognition2009，42，5： | 1 |
| 14 | Artificial photosynthesis bringing new vigor into plastic wastes显示文摘The accumulation of plastic wastes in landfills and the environment threatens our environment and public health,while leading to the loss of potential carbon resources.The urgent necessary lies in developing an energy-saving and environmentally benign approach to upgrade plastic into value-added chemicals.Artificial photosynthesis holds the ability to realize plastic upcycling by using endless solar energy under mild conditions,but remains in the initial stage for plastic upgrading.In this review,we aim to look critically at the photocatalytic conversion of plastic wastes from the perspective of resource reutilization.To begin with,we present the emerging conversion routes for plastic wastes and highlight the advantages of artificial photosynthesis for processing plastic wastes.By parsing photocatalytic plastic conversion process,we demonstrate the currently available routes for processing plastic,including plastic photodegradation,tandem decomposition of plastic and CO_(2) reduction,selective plastic oxidation,as well as photoreforming of plastic.This review concludes with a personal perspective for potential advances and emerging challenges in photocatalytic plastic conversion. | Sailei Kang Tao Sun Yingxin Ma Mengmeng Du Mingfu Gong Chunyu Zhou Yang Chai Bocheng Qiu | 2023 | SmartMat2023，4，4： | 1 |
| 15 | Angiotensin II AT2 receptor decreases AT1 receptor expression and function via nitric oxide/cGMP/Sp1 in renal proximal tubule cells from Wistar–Kyoto rats显示文摘 | Jian Yang Caiyu Chen Hongmei Ren Yu Han Duofen He Lin Zhou Ulrich Hopfer Pedro A. Jose Chunyu Zeng | 2012 | Journal of Hypertension2012，，6： | 1 |
| 16 | Clustering aggregation by probability accumulation显示文摘 | Wang Xi Yang Chunyu Zhou Jie | 2009 | Pattem Recognition2009，42，5： | 1 |
| 17 | Carbon paper modified by hydrothermal ammoniated treatment for vanadium redox battery显示文摘 | Zhangxing He Anqun Su Chao Gao Zhi Zhou Chunyue Pan Suqin Liu | 2013 | Ionics2013，，7： | 1 |
| 18 | Fingerprint recognition by combi- ning global structure and local cues显示文摘 | Gu Jinwei Zhou Jie Yang Chunyu | 2006 | IEEE Trans on Image Pro- cessing2006，15，7： | 1 |
| 19 | Diffraction optics calibrator: design and construction显示文摘 | Wenrui Cai Ping Zhou Chunyu Zhao | 2013 | Opt Eng2013，52，12： | 1 |
| 20 | Association of immunoglobulin G4-related disease with a family history of malignancy:A retrospective study of 168 cases显示文摘Objective:Immunoglobulin G4-related disease(IgG4-RD)is a systemic immune-mediated fibroinflammatory condition.Previous studies have indicated relationships between malignancy and autoimmunity.This retrospective cohort study aimed to determine IgG4-RD incidence and clinical features in patients with a family history of malignancy.Methods:To analyze the relationship between IgG4-RD and family history of malignancy,we reviewed IgG4-RD patients with a family history of malignancy diagnosed in various departments in West China Hospital,Sichuan University from December 2012 to September 2019.Clinical data and laboratory features were compared between IgG4-RD patients with and without a family history of malignancy.Results:Among 168 enrolled patients with IgG4-RD,22(13.1%)had a family history of malignancy.The most frequently involved system in family members with malignancy was the digestive system(38.5%).Among patients with a family history of malignancy,the most frequently involved organs in IgG4-RD were the pancreas(31.9%)and lymph nodes(31.9%).Age at symptom onset was older in IgG4-RD patients with a family history of malignancy than in patients without a family history of malignancy(50–59 years:36.3%vs.16.4%,p=0.0393).Hemoglobin(p=0.0172)and albumin(p=0.0247)levels were higher and globulin(p=0.0232)levels were lower in patients with a family history of malignancy.Conclusions:Our findings suggest that a family history of malignancy may be associated with IgG4-RD development.We hypothesize that genetic susceptibility may be involved in the pathogenesis of IgG4-RD. | Diping Hu Yanhong Li Yu Zhou Yubin Luo Lu Cheng Chunyu Tan Qiuping Zhang Yi Zhao Yi Liu | 2021 | Rheumatology & Autoimmunity2021，1，2： | 1 |
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