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| 1 | 基于正交试验设计的滑动摩擦性能研究显示文摘以正交试验方法设计销盘摩擦副滑动摩擦磨损的试验方案,在MMW-1A多功能立式摩擦磨损试验机上研究载荷、速度、时间对摩擦因数的影响。通过极差分析和方差分析得到上述因素对摩擦因数影响的权重次序,结果表明载荷对摩擦因数具有最显著影响。建立销盘摩擦副的几何模型,运用有限元分析软件ANSYS仿真分析载荷变化对接触应力的影响,结果表明,接触界面的压力分布不均匀,呈现中间小、边缘大的态势;接触应力数值大小随载荷变化而改变,但应力分布形态不受其影响。 | 张向伟 金晓怡 周正珠 Yuyi Lin | 2015 | 润滑与密封2015，40，4： | 8 |
| 2 | A novel inhibitor of N^(6)-methyladenosine demethylase FTO induces m RNA methylation and shows anti-cancer activities显示文摘N^(6)-methyladenosine(m^(6)A)modification is critical for m RNA splicing,nuclear export,stability and translation.Fat mass and obesity-associated protein(FTO),the first identified m^(6)A demethylase,is critical for cancer progression.Herein,we developed small-molecule inhibitors of FTO by virtual screening,structural optimization,and bioassay.As a result,two FTO inhibitors namely 18077 and 18097 were identified,which can selectively inhibit demethylase activity of FTO.Specifically,18097 bound to the active site of FTO and then inhibited cell cycle process and migration of cancer cells.In addition,18097 reprogrammed the epi-transcriptome of breast cancer cells,particularly for genes related to P53 pathway.18097 increased the abundance of m^(6)A modification of suppressor of cytokine signaling1(SOCS1)m RNA,which recruited IGF2 BP1 to increase m RNA stability of SOCS1 and subsequently activated the P53 signaling pathway.Further,18097 suppressed cellular lipogenesis via downregulation of peroxisome proliferator-activated receptor gamma(PPARγ),CCAAT/enhancer-binding protein alpha(C/EBPa),and C/EBPβ.Animal studies confirmed that 18097 can significantly suppress in vivo growth and lung colonization of breast cancer cells.Collectively,we identified that FTO can work as a potential drug target and the small-molecule inhibitor 18097 can serve as a potential agent against breast cancer. | Guoyou Xie Xu-Nian Wu Yuyi Ling Yalan Rui Deyan Wu Jiawang Zhou Jiexin Li Shuibin Lin Qin Peng Zigang Li Hongsheng Wang Hai-Bin Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 3 | Potential and its effects on compac-tion of biomass fuel logs 显示文摘 | Lin Yuyi Mao Shanfu | 2001 | Biomass and Bioenergy2001，，20： | 1 |
| 4 | Potential and its effect on compaction of biomass fuel logs显示文摘 | Lin Yuyi Mao Shanfu | 2001 | Biomass and Bioenergy2001，20，： | 1 |
| 5 | Potential and its effect on compaction of biomass fuel logs显示文摘 | Lin Yuyi Mao Shanfu | 2001 | Biomass and Bioenergy2001，，20： | 1 |
| 6 | Phosphorothioate modification of the TLR9 ligand CpG ODN inhibits poly(I:C)-induced apoptosis of hepatocellular carcinoma by entry blockade显示文摘 | Yuyi Zhang Ang Lin Qiangjun Sui Cai Zhang Zhigang Tian Jian Zhang | 2014 | Cancer Letters2014，，1： | 1 |
| 7 | Biodegradation of bensulfuron-methyl and its effect on bacterial community in paddy soils显示文摘 | LIN Xiaoyan YANG Yuyi ZHAO Yuhua | 2012 | Ecotoxicology2012，21，5： | 1 |
| 8 | No tillage outperforms conventional tillage under arid conditions and following fertilization显示文摘Reduced tillage practices present a tool that could sustainably intensify agriculture.The existing literature,however,lacks a consensus on how and when reduced tillage practices should get implemented.We reanalyzed here an extensive dataset comparing how regular tillage practices(i.e.,conventional tillage)impacted yield of eight crops compared to stopping tillage altogether(i.e.,no-tillage practice).We observed that aridity and fertilization favored no tillage over conventional tillage whereas conventional tillage performed better under high fertility settings.We further show that the responses are consistent across the crops.Our reanalysis complements the original and fills a gap in the literature questioning the conditions under which reducing tillage presents a viable alternative to common tillage practices. | Stavros D.Veresoglou Junjiang Chen Xuheng Du Qi Fu QingLiu Geng Chenyan Huang Xilin Huang Nan Hu Yiming Hun Guolin C.Li Zhiman Lin Zhiyu Ma Yuyi Ou Shuo Qi Haitian Qin Yingbo Qiu Xibin Sun Ye Tao YiLing Tian Jie Wang Lingxiao Wu Ziwei Wu Siqi Xie Ao Yang Dan Yang Chen Zeng Ying Zeng RuJie Zhang | 2023 | Soil Ecology Letters2023，5，1： | 1 |
| 9 | Potential and its effect on compaction of biomass fuel logs 显示文摘 | Lin Yuyi Mao Shanfu | 2001 | Biomass and Bioenergy2001，20，： | 1 |
| 10 | Research on the theory and application of adsorbed natural gas used in new energy vehicles: A review显示文摘天然气,其主要成分是甲烷,为世界范围的精力供应的生长被认为一种有说服力的选择。吸附的天然气(ANG ) ,最有希望的甲烷存储方法,是在过去的二十年的学习的一个活跃领域。ANG 组成一个安全、便宜的方法当在实质地低的压力(3.5-4.0 MPa ) 工作时,在可接受的精力密度存储甲烷为天然气车辆,允许一致的店坦克。这个工作服务考察在 ANG 车辆上在吸附物,吸附理论, ANG 一致坦克,和相关技术上在科学文学报导的最先进的发展。专利文学也被寻找了并且讨论。在说明 ANG 技术的成就和问题的评论目的 -- 基于的车辆,以及预报发展趋势和关键问题这些技术被决定。 | Zhengwei NIE Yuyi LIN Xiaoyi JIN | 2016 | Frontiers of Mechanical Engineering2016，11，3： | 0 |
| 11 | Modified R-CODOX-M/IVAC chemotherapy regimens in Chinese patients with untreated sporadic Burkitt lymphoma显示文摘Objective:To characterize modified R-CODOX-M/IVAC-based chemotherapy to lower the severe adverse events in Chinese adult patients with sporadic Burkitt lymphoma.Methods:We enrolled a retrospective cohort including 123 adult patients with untreated sporadic Burkitt lymphoma from August 2008 to September 2019 at Sun Yat-sen University Cancer Center.We studied a dose-modified and long-course R-CODOX-M/IVAC regimen utilizing a low dose of 1.0 g/m2/cycle cyclophosphamide,2 g/m2/cycle methotrexate,4,500 mg/m2/cycle ifosfamide,and 4.0 g/m2/cycle cytarabine.Forty-nine patients with low risk disease underwent 4–6 cycles of dose-modified R-CODOX-M-based chemotherapy.Seventy-four patients with high risk disease underwent 6–8 cycles of dose-modified alternating R-CODOX-M/IVAC regimens.Results:The objective remission was 87.0%.The event-free survival rate and overall survival at 3 years were 81.2%and 92.1%,respectively.Major grade 3–4 adverse events included leukopenia(91.9%),anemia(58.5%),thrombocytopenia(73.2%),and febrile neutropenia(48.8%).A total of 26.0%and 37.4%of patients received red blood cell and platelet transfusions,respectively.We observed 4 cases(3.3%)of septic shock after chemotherapy.Two treatment-related deaths occurred from severe infection.Conclusions:The modified R-CODOX-M/IVAC chemotherapy regimen was effective for sporadic Burkitt lymphoma in the Chinese population,with a lower toxicity than standard regimens. | Meiting Chen Zhao Wang Xiaojie Fang Yuyi Yao Quanguang Ren Zegeng Chen Ying Tian Fei Pan Xiaoqian Li Zhiming Li Qingqing Cai He Huang Tongyu Lin | 2021 | Cancer Biology & Medicine2021，18，3： | 0 |
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