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| 1 | The effect of beta-elemene on alpha-tubulin polymerization in human hepatoma HepG2 cells显示文摘Objective:To investigate the impact of beta-elemene injection on the growth and alpha-tubule of human hepatocarcinoma HepG2 cells.Methods:Cell proliferation was assessed by MTT assay.Cell cycle distribution was detected by flow cytometry(FCM).The mRNA expression of alpha-tubulin was measured by RT-PCR.Western blot analysis was used to determine protein expression of alpha-tubulin and the polymerization of tubulin.Results:Beta-elemene injection inhibited HepG2 cells proliferation in a dose-and time-dependent manner;FCM analysis indicated beta-elemene injection induced cell cycle arrested at S phase.RT-PCR and westernblot analysis showed that beta-elemene injection down-regulated alpha-tublin at both mRNA and protein levels,presenting a dose-dependent manner.Moreover,beta-elemene injection reduced the polymerization of microtubules in a dose-dependent manner.Conclusions:Beta-elemene injection can inhibit the proliferation of hepatoma HepG2 cells and induce cell apoptosis,the mechanism might be partly related to the down-regulation of alpha-tubulin and inhibition of microtubular polymerization. | Jielin Zhang Yuqiu Mao Li Hou Xiaonan Cui | 2013 | Chinese Journal of Cancer Research2013，25，6： | 17 |
| 2 | Acupuncture preconditioning protects hippocampal neurons from transient ischemia/reperfusion injury显示文摘The present study established a model of brain ischemia in aged rats using four-vessel occlusion.We observed hippocampal CA1 neuronal apoptosis and apoptosis-mediated protease caspase-3 expression following preconditioning of electroacupuncture at Baihui(GV 20).Our results showed that the number of hippocampal CA1 normal neurons was decreased,and degenerated neurons were increased 12 hours to 3 days following cerebral ischemia/reperfusion.The number of hippocampal CA1 apoptotic neurons and caspase-3-positive neurons in rats with cerebral ischemia/reperfusion injury was significantly decreased following acupuncture preconditioning.Acupuncture preconditioning protects aged rats against ischemia/reperfusion injury by regulating caspase-3 protein expression. | Mingshan Wang Haipeng Zhou Fei Shi Shilong Ma Yanlin Bi Yuqiu Liu Hong Liu Haiou Li | 2011 | Neural Regeneration Research2011，6，15： | 12 |
| 3 | Genomic Features and Regulatory Roles of Intermediate-Sized Non-Coding RNAs in Arabidopsis显示文摘在染色体宽的技术的最近的进展与各种各样的尺寸 ineukaryotes 允许几千非编码的 RNA 的鉴定,其中一些进一步被显示了在许多生物进程服务重要函数。然而在 modelplant Arabidopsis,新奇中介大小的 ncRNAs (im-ncRNAs )(50 ~ 300 nt ) 很限制了信息。由与深定序的技术使用修改隔离 strategycombined,我们全球性在 Arabidopsis 识别了 838 im-ncRNAs。多于一半(58%) 是新 ncRNA 种类,主要进化分叉。有趣地,与 5-UTR-derived 小说 im-ncRNAs 注解了 protein-codinggenes 趋于高度被表示。为 intergenic im-ncRNAs,他们比得上在幼苗的 mRNAs 的平均 abundanceswere,而是子集,在开始衰老的展出显著地更低的表示离开。进一步, intergenic im-ncRNAs 被调整由类似基因并且编码蛋白质的基因的到那些的 epigenetic 机制,和 someshowed 发展地调整了表示模式。基因屏蔽显示出的大规模颠倒 down-regulationof 很多 im-ncRNAs 在 vivo 导致了明显的分子的变化或反常发展显型,在植物生长和开发显示 im-ncRNAs 的功能的重要性。一起,我们的结果证明 thatnovel Arabidopsis im-ncRNAs 发展地被调整,功能的部件在 transcriptome.Key 词发现了: | Yuqiu Wang Xuncheng Wang Wei Deng Xiuduo Fan Ting-Ting Liu Guangming He Runsheng Chen William Terzaghi Danmeng Zhu Xing Wang Deng | 2014 | Molecular Plant2014，7，3： | 9 |
| 4 | A new orthogonality relationship for orthotropic thin plate theory and its variational principle显示文摘The thought how dual vectors are constructed in a new orthogonality relationship for theory of elasticity is generalized into orthotropic thin plate bending problems by using the analogy theory between plane elasticity problems and plate bending problems. Dual differential equations are directly obtained by using a mixed variables method. A dual differential matrix to be derived possesses a peculiarity of which principal diagonal sub-matrixes are zero matrixes. Two independently and symmetrically orthogonality sub-relationships are discovered. By using the integral form for elastic bending theory of orthotropic thin plate the orthogonality relationship is demonstrated. By selecting felicitous dual vectors a new orthogonality relationship for theory of elasticity can be generalized into elastic bending theory of orthotropic thin plate. By using the integral form a variational principle which is relative to differential form and a whole function expression are proposed. | LUO Jianhui 1 , LONG Yuqiu 2 & LIU Guangdong 1 1. College of Civil Engineering, Hunan University, Changsha 410082, China 2. Department of Civil Engineering, Tsinghua University, Beijing 100084, China | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，3： | 8 |
| 5 | Identification of unconditional and conditional QTL for oil, protein and starch content in maize显示文摘Oil, protein and starch are key chemical components of maize kernels. A population of 245 recombinant inbred lines(RILs) derived from a cross between a high-oil inbred line, By804, and a regular inbred line, B73, was used to dissect the genetic interrelationships among oil, starch and protein content at the individual QTL level by unconditional and conditional QTL mapping. Combined phenotypic data over two years with a genetic linkage map constructed using 236 markers, nine, five and eight unconditional QTL were detected for oil, protein and starch content, respectively. Some QTL for oil, protein and starch content were clustered in the same genomic regions and the direction of their effects was consistent with the sign of their correlation. In conditional QTL mapping, 37(29/8) unconditional QTL were not detected or showed reduced effects, four QTL demonstrated similar effects under unconditional and conditional QTL mapping, and 17 additional QTL were identified by conditional QTL mapping. These results imply that there is a strong genetic relationship among oil, protein and starch content in maize kernels. The information generated in the present investigation could be helpful in marker-assisted breeding for maize varieties with desirable kernel quality traits. | Yuqiu Guo Xiaohong Yang Subhash Chander Jianbing Yan Jun Zhang Tongming Song Jiansheng Li | 2013 | The Crop Journal2013，1，1： | 7 |
| 6 | Application of the quadrilateral area coordinate method:a new element for laminated composite plate bending problems显示文摘最近,一些新四边的有限元素被四边的区域坐标(QAC ) 方法成功地开发。与用 isoparametric 坐标的那些传统的模型相比,这些新模型对网孔失真不太敏感。在这篇论文,一新基于排水量, 4 节点 20-DOF (5-DOF 每节点) 四边的弯曲元素基于一阶砍为任意的把压成薄片的合成盘子的分析的变丑理论被介绍。它的弯曲部分基于元素 AC-MQ4,高效的 Mindlin-Reissner 板元素由 QAC 方法提出了的最近开发和概括一致条件方法;并且它的在里面飞机排水量地被双线性的形状功能在 isoparametric 坐标插入内推。而且,混合 processing 以后过程,被作者第一建议,再被采用改进压力答案,为特别横向砍压力。产生元素,作为 AC-MQ4-LC 表示了,在所有线性静态、动态的数字例子展出优秀性能。它再证明 QAC 方法,概括一致条件方法,和混合 processing 以后过程是为开发简单、有效、可靠的有限元素模型的有效工具。 | Song Cen Xiangrong Fu Yuqiu Long Hongguang Li Zhenhan Yao | 2007 | Acta Mechanica Sinica2007，23，5： | 6 |
| 7 | Cognitive-behavioural therapy for personal recovery of patients with schizophrenia:A systematic review and meta-analysis显示文摘Background To date, cognitive-behavioural therapy (CBT) trials have primarily focused on clinical recovery;however, personal recovery is actually the fundamental aspect of the recovery process. The aim of this study was to summarise and synthesise the existing evidence regarding the effectiveness of CBT for personal recovery In patients with schizophrenia. Aim This study aimed to determine the effectiveness of CBT for personal recovery in patients with schizophrenia. Methods A systematic search of the literature in PsycINFO, PubMed, Cochrane (CENTRAL), Embase and Web of Science (SCI) was conducted to identify randomised controlled trials reporting the impact of CBT interventions on personal recovery in patients with schizophrenia. The estimated effect sizes of the main study outcomes were calculated to estimate the magnitude of the treatment effects of CBT on personal recovery. We also evaluated the CBT’s effect size at the end-of-treatment and long-term (follow-up) changes in some aspects of personal recovery. Results Twenty-five studies were included in the analysis. The effect of CBT on personal recovery was 2.27 (95% CI 0.10 to 4.45;I^2=0%;p=0.04) at post-treatment and the long-term effect size was 2.62 (95% CI 0.51 to 4.47;I^2=0%;p=0.02). During the post-treatment period, the pooled effect size of CBT was 0.01 (95% CI -0.12 to 0.15;I^2=33.0%;p>0.05) for quality of life (QoL), 0.643 (95% CI 0.056 to 1.130;I^2=30.8%;p<0.01) for psychological health-related QoL,-1.77 (95% CI -3.29 to -0.25;I^2=40%;p=0.02) for hopelessness and 1.85 (95% CI 0.69 to 3.01;I^2=41%;p<0.01) for self-esteem. We also summarised the effects of CBT on QoL (subscale scores not included in the evaluation of the pooled effect size), self-confidence and connectedness, and all results corresponded to positive effects. However, there was insufficient evidence regarding the long-term effects of CBT on personal recovery. Conclusions CBT is an effective therapy with meaningful clinical effect sizes on personal recovery and some aspects of personal recovery of schizophrenia after treatment. However, the effect is relatively immediate and rapidly decreases as time progresses. Therefore, in the future, more studies should focus on the mechanism of CBT for personal recovery and the factors that influence the long-term effects of CBT. | Weiliang Wang Yuqiu Zhou Nannan Chai Dongwei Liu | 2019 | General Psychiatry2019，32，4： | 4 |
| 8 | High-resolution X-ray flash radiography of Ti characteristic lines with multilayer Kirkpatrick–Baez microscope at the Shenguang-ⅡUpdate laser facility显示文摘High-resolution X-ray flash radiography of Ti characteristic lines with a multilayer Kirkpatrick-Baez microscope was developed on the Shenguang-Ⅱ(SG-Ⅱ)Update laser facility.The microscope uses an optimized multilayer design of Co/C and W/C stacks to obtain a high reflection efficiency of the Ti characteristic lines while meeting the precise alignment requirement at the Cu Kα line.The alignment method based on dual simulated balls was proposed herein,which simultaneously realizes an accurate indication of the center field of view and the backlighter position.The optical design,multilayer coatings,and alignment method of the microscope and the experimental result of Ti flash radiography of the Au-coned CH shell target on the SG-Ⅱ Update are described. | Shengzhen Yi Feng Zhang Qiushi Huang Lai Wei Yuqiu Gu Zhanshan Wang | 2021 | High Power Laser Science and Engineering2021，9，3： | 3 |
| 9 | Group inverses for some 2 × 2 block matrices over rings显示文摘我们首先考虑块矩阵 \ 的组逆(\left ({\begin { 数组 }{*{ 20 }{ c }} A&B \\ 0 &C \end { 数组 }}\right )\) 在一枚弱有限的戒指上。然后,我们为存在和块矩阵\的组逆的代表学习足够、必要的条件( \left ({ \begin {数组}{*{ 20 }{ c }} A&B \\ C&D \end {数组}} \right )\)在一枚戒指上与在下列下面的统一 1 分别地调节:(i) B = C, D = 0, B # 并且(B A )# 两个都存在;(ii ) B 是可颠倒的并且 m = n;(iii )# 并且(D CA # B )# 两个都存在, A 和 D 是 m 栠灹牥牧灡 ? 的 C = CAA #,?? ?? | Chongguang CAO Yingchun WANG Yuqiu SHENG | 2016 | Frontiers of Mathematics in China2016，11，3： | 3 |
| 10 | Photocatalytic degradation of methyl orange using ZnO/TiO_(2) composites显示文摘ZnO/TiO_(2)composites were synthesized by using the solvothermal method and ultrasonic precipitation followed by heat treatment in order to investigate their photocatalytic degradation of methyl orange(MO)in aqueous suspension under UV irradiation.The composition and surface structure of the catalyst were characterized by X-ray diffraction(XRD),field emission scanning electron microscope(FE-SEM),and transmission electron microscopy(TEM).The degradation efficiencies of MO at various pH values were obtained.The highest degradation efficiencies were obtained before 30 min and after 60 min at pH 11.0 and pH 2.0,respectively.A sample analysis was conducted using liquid chromatography coupled with electrospray ionization ion-trap mass spectrometry.Six intermediates were found during the photocatalytic degradation process of quinonoid MO.The degradation pathway of quinonoid MO was also proposed. | Ming GE Changsheng GUO Xingwang ZHU Lili MA Zhenan HAN Wei HU Yuqiu WANG | 2009 | Frontiers of Environmental Science & Engineering2009，3，3： | 3 |
| 11 | Water-trapping and drag-reduction effects of fish Ctenopharyngodon idellus scales and their simulations显示文摘In the last decades, surface drag reduction has been re-emphasized because of its practical values in engineering applications,including vehicles, aircrafts, ships, and fuel pipelines. The bionic study of drag reduction has been attracting scholars' attentions. Here, it was determined that the delicate microstructures on the scales of the fish Ctenopharyngodon idellus exhibit remarkable drag-reduction effect. In addition, the underlying drag-reduction mechanism was carefully investigated. First,exceptional morphologies and structures of the scales were observed and measured using a scanning electron microscope and3-dimensional(3D) microscope. Then, based on the acquired data, optimized 3D models were created. Next, the mechanism of the water-trapping effect of these structures was analyzed through numerical simulations and theoretical calculations. It was determined that there are many microcrescent units with certain distributions on its surface. In fact, these crescents are effective in generating the 'water-trapping' effect and forming a fluid-lubrication film, thus reducing the skin friction drag effectively.Contrasting to a smooth surface, the dynamics finite-element analysis indicated that the maximum drag-reduction rate of a bionic surface is 3.014% at 0.66 m/s flow rate. This study can be used as a reference for an in-depth analysis on the bionic drag reduction of boats, underwater vehicles, and so forth. | WU LiYan JIAO ZhiBin SONG YuQiu REN WenTao NIU ShiChao HAN ZhiWu | 2017 | Science China(Technological Sciences)2017，60，7： | 3 |
| 12 | Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders in mice显示文摘Both immunosuppressants and antibiotics (ABX) are indispensable for transplant patients. However, the former increases the risk of new-onset diabetes, whereas the latter impacts intestinal microbiota (IM). It is still unclear whether and how the interaction between immunosuppressants and ABX alters the IM and thus leads to glucose metabolism disorders. This study examined the alterations of glucose and lipid metabolism and IM in mice exposed to tacrolimus (TAC) with or without ABX. We found that ABX further aggravated TAC-induced glucose tolerance and increased insulin secretion. Combined treatment resulted in exacerbated lipid accumulation in the liver. TAC-altered microbial community was further amplified by ABX administration, as characterized by reductions in phylum Firmicutes, family Lachnospiraceae, and genus Copyococcus. Analyses based on the metagenomic profiles revealed that ABX augmented the effect of TAC on microbial metabolic function mostly related to lipid metabolism. The altered components of gut microbiome and predicted microbial functional profiles showed significant correlation with hepatic lipid accumulation and glucose disorders. In conclusion, ABX aggravated the effect of TAC on the microbiome and its metabolic capacities, which might contribute to hepatic lipid accumulation and glucose disorders. These findings suggest that the ABX-altered microbiome can amplify the diabetogenic effect of TAC and could be a novel therapeutic target for patients. | Yuqiu Han Xiangyang Jiang Qi Ling Li Wu Pin Wu Ruiqi Tang Xiaowei Xu Meifang Yang Lijiang Zhang Weiwei Zhu Baohong Wang Lanjuan Li | 2019 | Frontiers of Medicine2019，13，4： | 3 |
| 13 | The neural mechanisms of pain-related affect and memory显示文摘疼痛经验包括一感觉歧视并且一感情的部件。感情方面的尺寸指感觉的不愉快或厌恶。在疼痛的感觉尺寸的学习上的分子、细胞、全身的层次经过四十年被改变了的 genetic' 的大进步。然而,“考虑仅仅疼痛的感觉特征,并且忽略它的激发性、感情方面的性质,是看仅仅这个问题的部分不甚至那的最重要的部分”。诊所观察的一根线显示有长期的疼痛的病人自己比疼痛受不了更多感情方面的骚乱。显然,到疼痛的生理的唤起和亢奋的警戒引起否定影响例如焦虑,发怒,担心,厌恶,甚至自杀的趋势,内在的感情方面的状态接着提高疼痛感觉。今天,越来越多的注意在位于疼痛的感情方面的尺寸下面的机制上对学习被给予了。以便深一 and 扩展我们疼痛的性质的理解,这评论在神经解剖学,神经生理学,和房间生物化学关于疼痛的感情方面的部件从我们的实验室总结主要进步和最近的调查结果。 | ZHANG Yuqiu | 2006 | Progress in Natural Science:Materials International2006，16，4： | 3 |
| 14 | Effect of river plume on phytoplankton community structure in Zhujiang River estuary显示文摘To examine the phytoplankton assemblages and the effect of diluted waters on them,a research cruise was conducted from July 19 to August 7,2015 in the Zhujiang(Pearl)River estuary in the northern South China Sea(21°N–23.5°N,111°E–117°E).Samples were collected from 65 stations including one for time-series sampling.A total of 212 phytoplankton taxa were identified from 61 genera belonging to 4 phyla.Among them,122 species identified from 42 genera of Bacillariophyta and 83 species from 15 genera of Pyrrophyta.Chain-forming diatoms dominated the phytoplankton community where Pseudonitzschia delicatissima,Guinardia striata,Thalassionema nitzschioides,and P.pungens comprised about 52%of the total abundance.However,higher cell abundances concentrated on both sides of the estuary,because of low salinity and high nutrients brought by diluted water.In addition,Canonical Correspondence Analysis revealed that salinity and dissolved inorganic nitrogen shaped the species composition in the study area.Furthermore,the Jaccard similarity index showed prevailing high similarity in the distribution of species in low-salinity diluted waters,and the Bray-Curtis similarity depicted distinguished grouping for phytoplankton assemblages along the salinity gradient.However,phytoplankton diel vertical cycles showed maximum abundance occurred at 2:00 am,which was mainly contributed by benthic phytoplankton species Pseudo-nitzschia spp.and T.nitzschioides. | Qi ZHONG Bing XUE Md Abu NOMAN Yuqiu WEI Haijiao LIU Hongbin LIU Liping ZHENG Hongmei JING Jun SUN | 2021 | Journal of Oceanology and Limnology2021，39，2： | 2 |
| 15 | Effects of typhoon Roke and Haitang on phytoplankton community structure in northeastern South China sea显示文摘The influence of typhoon and Kuroshio intrusion process on the natural phytoplankton assemblages in the northeastern South China Sea(neSCS)was examined during a cruise in summer 2017.One hundred ninety-six seawater samples were collected and analyzed in the neSCS.In total,299 species were identified belonging to 82 genera,mostly dominated by Bacillariophyta(159),followed by Dinophyta(132),Cyanophyta(4)and Chrysophyta(4).Among all,Thalassionema nitzschioides,Thalassionema frauenfeldii,Thalassiosira minima,in Bacillariophyta,Prorocentrum lenticulatum,Prorocentrum compressum in Dinophyta,and Trichodesmium thiebautii,in the Cyanophyta were the most dominated species,respectively.Correlation analysis shows compared with other groups Bacillariophyta was mostly influenced by silicate,whereas,Dinophyta and Cyanophyta showed significant correlation with temperature,salinity,phosphate,and nitrate.After the typhoon,the higher abundance of Dinophyta was observed,whereas it was lower in case of Bacillariophyta and Cyanophyta,shows typhoon“Roke“and”Haitang”had a significant influence on the phytoplankton assemblages,which could be manifested by the variations of total phytoplankton abundance in the surface water of neSCS.Overall,our present study provides the latest in-depth information about how the environmental factors influencing the phytoplankton density and diversity in the neSCS during summer. | Yingjie Mao Jun Sun Congcong Guo Yuqiu Wei Xingzhou Wang Shuang Yang Chao Wu | 2019 | Ecosystem Health and Sustainability2019，5，1： | 2 |
| 16 | Mechanical Properties of Carbon Epoxy Prepreg Insert Phenolic Resin Injection Moldings显示文摘This study focuses on the insert-injection molding process. The thermoset composite inserts in this study were carbon fiber/epoxy (CF/Epoxy) prepreg sheets. The injected molded part was glass fiber contained phenolic resin (GF/PF). The CF/Epoxy was placed in the mold cavity prior to injecting GF/PF onto the inserted injection molded CF/Epoxy specimens. The role of adhesion between the inserted part and injected resin on the mechanical properties was evaluated by 3 point bending and impact tests. In addition, the effect of prepreg orientation on the mechanical properties of the prepreg inserted-injection molding system was investigated. It was found that the prepreg with unidirectional orientation significantly improved flexural and impact strength of the inserted injection molding composites, providing better support and resistance to bending and impact loading. The main failure modes of the specimens were structural and adhesive failure. | PINPATHOMRAT Badin KEIGO Nishitani THUMSORN Supaphom Narongchai O-Charoen Yuqiu YANG HAMADA Hiroyuki | 2019 | 纤维复合材料2019，36，2： | 2 |
| 17 | Simulation of the Interphase of Insert Injection Moldings显示文摘In this work, the generalizing of the finite element method (FEM) of thermoplastic prepreg insert injection molding composites was investigated. The specimens were prepared using glass fiber/polyamidc 6 (GF/PA6) inserted prepreg, and their characteristics were investigated and compared under ANSYS workbench program. The prediction of the bending initial fracture point under analytical tensile testing with interlayer on prepreg insert moldings was focused. It was found that the bending initial fracture point was applied to predict by matching the shear stress. There was obtained from analytical tensile testing and bending analysis. Therefore, it can be obtained the optimum of the clastic modulus ratio on the injection part/interlayer/insert part by using FEM via ANSYS workbench. | Keigo Nishitani Badin Pinpathomrat Narongchai O-Charoen Yuqiu Yang Hiroyuki Hamada | 2019 | 纤维复合材料2019，36，2： | 2 |
| 18 | Application of the ReNuMa model in the Sha He river watershed: Tools for watershed environmental management显示文摘 | Jian Sha Min Liu Dong Wang Dennis P. Swaney Yuqiu Wang | 2013 | Journal of Environmental Management2013，，： | 2 |
| 19 | High-quality MeV protons from laser interaction with umbrellalike cavity target显示文摘 | Ma Yanyun Sheng Zhengming Gu Yuqiu | 2009 | Phys Plasmas2009，16，03： | 1 |
| 20 | Occurrence of endocrine-disrupting compounds in reclaimed water from Tianjin, China显示文摘 | Yuqiu Wang Wei Hu Zhonghong Cao Xueqi Fu Tan Zhu | 2005 | Analytical and Bioanalytical Chemistry2005，，5： | 1 |
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