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| 1 | Multicenter study of endoscopic preoperative biliary drainage for malignant distal biliary obstruction显示文摘AIM: To determine the optimal method of endoscopic preoperative biliary drainage for malignant distal biliary obstruction.METHODS: Multicenter retrospective study was conducted in patients who underwent plastic stent(PS) or nasobiliary catheter(NBC) placement for resectable malignant distal biliary obstruction followed by surgery between January 2010 and March 2012. Procedurerelated adverse events, stent/catheter dysfunction(occlusion or migration of PS/NBC, developmentof cholangitis, or other conditions that required repeat endoscopic biliary intervention), and jaundice resolution(bilirubin level < 3.0 mg/d L) were evaluated. Cumulative incidence of jaundice resolution and dysfunction of PS/NBC were estimated using competing risk analysis. Patient characteristics and preoperative biliary drainage were also evaluated for association with the time to jaundice resolution and PS/NBC dysfunction using competing risk regression analysis.RESULTS: In total, 419 patients were included in the study(PS, 253 and NBC, 166). Primary cancers included pancreatic cancer in 194 patients(46%), bile duct cancer in 172(41%), gallbladder cancer in three(1%), and ampullary cancer in 50(12%). The median serum total bilirubin was 7.8 mg/d L and 324 patients(77%) had ≥ 3.0 mg/d L. During the median time to surgery of 29 d [interquartile range(IQR), 30-39 d]. PS/NBC dysfunction rate was 35% for PS and 18% for NBC [Subdistribution hazard ratio(SHR) = 4.76; 95%CI: 2.44-10.0, P < 0.001]; the pig-tailed tip was a risk factor for PS dysfunction. Jaundice resolution was achieved in 85% of patients and did not depend on the drainage method(PS or NBC).CONCLUSION: PS has insufficient patency for preoperative biliary drainage. Given the drawbacks of external drainage via NBC, an alternative method of internal drainage should be explored. | Naoki Sasahira Tsuyoshi Hamada Osamu Togawa Ryuichi Yamamoto Tomohisa Iwai Kiichi Tamada Yoshiaki Kawaguchi Kenji Shimura Takero Koike Yu Yoshida Kazuya Sugimori Shomei Ryozawa Toshiharu Kakimoto Ko Nishikawa Katsuya Kitamura Tsunao Imamura Masafumi Mizuide Nobuo Toda Iruru Maetani Yuji Sakai Takao Itoi Masatsugu Nagahama Yousuke Nakai Hiroyuki Isayama | 2016 | World Journal of Gastroenterology2016，22，14： | 18 |
| 2 | Pancreatic duct drainage using EUS-guided rendezvous technique for stenotic pancreaticojejunostomy显示文摘The patient was a 30-year-old female who had undergone excision of the extrahepatic bile duct and Rouxen-Y hepaticojejunostomy for congenital biliary dilatation at the age of 7.Thereafter,she suffered from recurrent acute pancreatitis due to pancreaticobiliary maljunction and received subtotal stomach-preserving pancreaticoduodenectomy.She developed a pancreatic fistula and an intra-abdominal abscess after the operation.These complications were improved by percutaneous abscess drainage and antibiotic therapy.How ever,upper abdominal discomfort and the elevation of serum pancreatic enzymes persisted due to stenosis from the pancreaticojejunostomy.Because we could not accomplish dilation of the stenosis by endoscopic retrograde cholangiopancreatography,we tried an endoscopic ultrasonography(EUS) guided rendezvous technique for pancreatic duct drainage.After transgastric puncture of the pancreatic duct using an EUS-fine needle aspiration needle,the guidewire was inserted into the pancreatic duct and finally reached to the jejunum through the stenotic anastomosis.We changed the echoendoscope to an oblique-viewing endoscope,then grasped the guidewire and withdrew it through the scope.The stenosis of the pancreaticojejunostomy was dilated up to 4 mm,and a pancreatic stent was put in place.Though the pancreatic stent was removed after three months,the patient remained symptomfree.Pancreatic duct drainage using an EUS-guided rendezvous technique was useful for the treatment of a stenotic pancreaticojejunostomy after pancreaticoduodenectomy. | Tetsuya Takikawa Atsushi Kanno Atsushi Masamune Shin Hamada Eriko Nakano Shin Miura Hiroyuki Ariga Jun Unno Kiyoshi Kume Kazuhiro Kikuta Morihisa Hirota Hiroshi Yoshida Yu Katayose Michiaki Unno Tooru Shimosegawa | 2013 | World Journal of Gastroenterology2013，19，31： | 3 |
| 3 | Reactive ion etching of poly(vinylidene fluoride-trifluoroethylene) copolymer for flexible piezoelectric devices显示文摘A microfabrication process for poly(vinylidene fluoride-trifluoroethylene)(P(VDF-TrFE)) based flexible piezoelectric devices is proposed using heat controlled spin coating and reactive ion etching(RIE) techniques.Dry etching of P(VDF-TrFE) in CF 4 +O2 plasma is found to be more effective than that using SF 6 +O2 or Ar+O2 feed gas with the same radiofrequency power and pressure conditions.A maximum etching rate of 400 nm/min is obtained using the CF 4 +O2 plasma with an oxygen concentration of 60% at an antenna power of 200 W and a platen power of 20 W.The oxygen atoms and fluorine atoms are found to be responsible for the chemical etching process.Microstructuring of P(VDF-TrFE) with a feature size of 10 m is achieved and the patterned films show a high remanent polarization of 63.6mC/m 2. | JIANG YongGang SHIONO Syohei HAMADA Hiroyuki FUJITA Takayuki ZHANG DeYuan MAENAKA Kazusuke | 2013 | Chinese Science Bulletin2013，58，18： | 2 |
| 4 | A standardized technique for safe pancreaticojejunostomy:Pair-Watch suturing technique显示文摘AIM:To prevent pancreatic leakage after pancreaticoje-junostomy,we designed a new standardized technique that we term the 'Pair-Watch suturing technique'.METHODS:Before anastomosis,we imagine the faces of a pair of watches on the jejunal hole and pancreatic duct.The first stitch was put between 9 o'clock of the pancreatic side and 3 o'clock of the jejunal side,and a total of 7 stitches were put on the posterior wall,followed by the 5 stitches on the anterior wall.Using this technique,twelve stitches can be sutured on the first layer anastomosis regardless of the caliber of the pancreatic duct.In all cases the amylase activity of the drain were measured.A postoperative pancreatic fistula was diagnosed using postoperative pancreatic fistula grading.RESULTS:From March 2007 to July 2008,29 consecutive cases underwent pancreaticojejunostomy using this technique.Pathologic examination results showed pancreatic carcinoma(n=14),intraductal papillary-mucinous neoplasm(n=10),intraductal papillary-mucinous carcinoma(n=1),carcinoma of ampulla of Vater(n=1),carcinoma of extrahepatic bile duct(n=1),metastasis of renal cell carcinoma(n=1),and duodenal carcinoma(n=1).Pancreaticojejunal anastomoses using this technique were all watertight during the surgical procedure.The mean diameter of main pancreatic duct was 3.4 mm(range 2-7 mm).Three patients were recognized as having an amylase level greater than 3 times the serum amylase level,but all of them were diagnosed as grade A postoperative pancreatic fistula grading and required no treatment.None of the cases developed complications such as hemorrhage,abdominal abscess,and pulmonary infection.There was no postoperative mortality.CONCLUSION:Our technique is less complicated than other methods and very secure,providing reliable anastomosis for any size of pancreatic duct. | Yoshinori Azumi Shuji Isaji Hiroyuki Kato Yuu Nobuoka Naohisa Kuriyama Masashi Kishiwada Takashi Hamada Shugo Mizuno Masanobu Usui Hiroyuki Sakurai Masami Tabata | 2010 | World Journal of Gastrointestinal Surgery2010，2，8： | 2 |
| 5 | 玻璃纤维/大麻纤维增强聚丙烯混杂复合材料的力学性能和断裂特征(英文)显示文摘目前在土木工程,建筑,汽车等领域里使用的复合材料中,玻璃纤维是用量最大的增强材料。由于保护地球环境的呼声日趋高涨,天然纤维被期待着代替源于石油而且再利用困难的玻璃纤维,成为绿色复合材料的必要材料之一。本文通过注射成型工艺制作了玻璃短纤维,大麻短纤维以及混杂型纤维增强复合材料,并在拉伸实验中应用两种不同频率的声发射技术检测了拉伸断裂特性。实验发现,随着大麻纤维的加入和混杂复合材料绿色度的增加,复合材料的拉伸弹性模量随之线性增大,而拉伸强度基本保持不变。当大麻纤维的含量超过20wt%的时候,拉伸强度开始降低。在不同频率的声发射实验中,混杂型复合材料的声发射事件的产生都比单一纤维增强型复合材料要来的晚,也就是说,纤维的混杂有助于推迟微裂纹的产生。 | Tomoko OHTA Tohru MORII Hiroyuki HAMADA | 2009 | 材料工程2009，37，S2： | 2 |
| 6 | Mechanical Properties of Carbon Epoxy Prepreg Insert Phenolic Resin Injection Moldings显示文摘This study focuses on the insert-injection molding process. The thermoset composite inserts in this study were carbon fiber/epoxy (CF/Epoxy) prepreg sheets. The injected molded part was glass fiber contained phenolic resin (GF/PF). The CF/Epoxy was placed in the mold cavity prior to injecting GF/PF onto the inserted injection molded CF/Epoxy specimens. The role of adhesion between the inserted part and injected resin on the mechanical properties was evaluated by 3 point bending and impact tests. In addition, the effect of prepreg orientation on the mechanical properties of the prepreg inserted-injection molding system was investigated. It was found that the prepreg with unidirectional orientation significantly improved flexural and impact strength of the inserted injection molding composites, providing better support and resistance to bending and impact loading. The main failure modes of the specimens were structural and adhesive failure. | PINPATHOMRAT Badin KEIGO Nishitani THUMSORN Supaphom Narongchai O-Charoen Yuqiu YANG HAMADA Hiroyuki | 2019 | 纤维复合材料2019，36，2： | 2 |
| 7 | Simulation of the Interphase of Insert Injection Moldings显示文摘In this work, the generalizing of the finite element method (FEM) of thermoplastic prepreg insert injection molding composites was investigated. The specimens were prepared using glass fiber/polyamidc 6 (GF/PA6) inserted prepreg, and their characteristics were investigated and compared under ANSYS workbench program. The prediction of the bending initial fracture point under analytical tensile testing with interlayer on prepreg insert moldings was focused. It was found that the bending initial fracture point was applied to predict by matching the shear stress. There was obtained from analytical tensile testing and bending analysis. Therefore, it can be obtained the optimum of the clastic modulus ratio on the injection part/interlayer/insert part by using FEM via ANSYS workbench. | Keigo Nishitani Badin Pinpathomrat Narongchai O-Charoen Yuqiu Yang Hiroyuki Hamada | 2019 | 纤维复合材料2019，36，2： | 2 |
| 8 | Short- and long-term outcomes of endoscopic papillary large balloon dilation with or without sphincterotomy for removal of large bile duct stones显示文摘 | Hirofumi Kogure Takeshi Tsujino Hiroyuki Isayama Naminatsu Takahara Rie Uchino Tsuyoshi Hamada Koji Miyabayashi Suguru Mizuno Dai Mohri Yoko Yashima Kazumichi Kawakubo Takashi Sasaki Natsuyo Yamamoto Yousuke Nakai Kenji Hirano Naoki Sasahira Minoru Tada K | 2013 | Scandinavian Journal of Gastroenterology2013，，1： | 1 |
| 9 | IGF and myostatin pathways are respectively induced during the earlier and the later stages of skeletal muscle hypertrophy induced by clenbuterol, a β <sub>2</sub>‐adrenergic agonist显示文摘 | Tokuhisa Abo Ryo‐hei Iida Syuhei Kaneko Takeo Suga Hiroyuki Yamada Yoshiki Hamada Akira Yamane | 2012 | Cell Biochem Funct2012，，8： | 1 |
| 10 | Film insert molding as a novel weld-line inhibition and strengthening technique 显示文摘 | Yewwer Leong Toshikazu Umemura Hiroyuki hamada | 2008 | Polymer Engineering and Science2008，48，： | 1 |
| 11 | Upregulation of epidermal growth factor receptor 4 in oral leukoplakia显示文摘In the present study, we investigate the expression profile of the epidermal growth factor receptor family, which comprises EGFR/ ErbB 1, HER2/ErbB2, HER3/ErbB3 and HER4/ErbB4 in oral leukoplakia (LP), The expression of four epidermal growth factor receptor (EGFR) family genes and their ligands were measured in LP tissues from 14 patients and compared with levels in 10 patients with oral lichen planus (OLP) and normal oral mucosa (NOM) from 14 healthy donors by real-time polymerase chain reaction (PCR) and immunohistochemistry. Synchronous mRNA coexpression of ErbB1, ErbB2, ErbB3 and ErbB4 was detected in LP lesions. Out of the receptors, only ErbB4 mRNA and protein was more highly expressed in LP compared with NOM tissues. These were strongly expressed by epithelial keratinocytes in LP lesions, as shown by immunohistochemistry. Regarding the ligands, the mRNA of Neuregulin2 and 4 were more highly expressed in OLP compared with NOM tissues. Therefore, enhanced ErbB4 on the keratinocytes and synchronous modulation of EGFR family genes may contribute to the pathogenesis and carcinogenesis of LP. | Hiroshi Kobayashi Kenichi Kumagai Akito Gotoh Takanori Eguchi Hiroyuki Yamada Yoshiki Hamada Satsuki Suzuki Ryuji Suzuki | 2013 | International Journal of Oral Science2013，5，1： | 1 |
| 12 | Management of the late effects of disconnected pancreatic duct syndrome: A case report显示文摘BACKGROUND There have been few reports about the late effects of disconnected pancreatic duct syndrome(DPDS). Although few reports have described the recurrence interval of pancreatitis, it might be rare for recurrence to occur more than 5 years later.Herein, we describe a case of recurrence in an 81-year-old man after the treatment of walled-off necrosis(WON) with pancreatic transection 7 years ago.CASE SUMMARY An 81-year-old man visited our hospital with chief complaints of fever and abdominal pain 7 years after the onset of WON due to severe necrotic pancreatitis. His medical history included an abdominal aortic aneurysm(AAA),hypertension, dyslipidemia, and chronic kidney disease. Computed tomography(CT) scan showed that the pancreatic fluid collection(PFC) had spread to the aorta with inflammation surrounding it, and CT findings suggested that bleeding occurred from the vasodilation due to splenic vein occlusion. First, we attempted to perform transpapillary drainage because of venous dilation around the residual stomach and the PFC. However, pancreatic duct drainage failed because of complete main pancreatic duct disruption. Second, we performed endoscopic ultrasound-guided drainage. After transmural drainage, the inflammation improved and stenting for the AAA was performed successfully. The inflammation was resolved, and he has been free from infection for more than 2 years after the procedure.CONCLUSION This case highlights the importance of continued follow-up of patients for recurrence after the treatment of WON with pancreatic transection. | Reiko Yamada Yuhei Umeda Yasunori Shiono Hiroaki Okuse Naoki Kuroda Junya Tsuboi Hiroyuki Inoue Yasuhiko Hamada Kyosuke Tanaka Noriyuki Horiki Yoshiyuki Takei | 2019 | World Journal of Clinical Cases2019，7，9： | 1 |
| 13 | Development of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) after pancreaticoduodenectomy: proposal of a postoperative NAFLD scoring system显示文摘 | Hiroyuki Kato Shuji Isaji Yoshinori Azumi Masashi Kishiwada Takashi Hamada Shugo Mizuno Masanobu Usui Hiroyuki Sakurai Masami Tabata | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，3： | 1 |
| 14 | Physiological Functions of Pten in Mouse Tissues显示文摘 | Hiroyuki Kishimoto Koichi Hamada Mary Saunders | 2003 | Cell Structure and Function2003，28，7： | 1 |
| 15 | Effect of CF/GF fiber hybrid on impact properties of multi-axial warp knitted fabric composite materials 显示文摘 | TOMOHIKO Sugie ASAMI Nakai HIROYUKI Hamada | 2009 | Composites: Part A2009，40，12： | 1 |
| 16 | Effect of surface treatment and weave structure on model interlaminar fracture behavior of glass woven fabric composites显示文摘 | Hiroyuki Hamada Masaya Kotaki Yasunobu Hirai | 1995 | Proceedings of ICCM - 101995，，5： | 1 |
| 17 | Fabrication Mechanical Properties of Unidirectional Jute/PP Composites Using Jute Yarns by Film Stacking Method显示文摘 | Omar A. Khondker Umaru S. Ishiaku Asami Nakai Hiroyuki Hamada | 2005 | Journal of Polymers and the Environment2005，，2： | 1 |
| 18 | Energy Absorption Characteristics of Crash Worthy Structural Composite Materials显示文摘 | Ramakrishna S. Hamada Hiroyuki | 1998 | Key Engineering Materials1998，，141： | 1 |
| 19 | Fabrication Mechanical Properties of Unidirectional Jute/PP Composites Using Jute Yarns by Film Stacking Method显示文摘 | Omar A. Khondker Umaru S. Ishiaku Asami Nakai Hiroyuki Hamada | 2005 | Journal of Polymers and the Environment2005，，2： | 1 |
| 20 | Recent progress and limitations of chemotherapy for pancreatic and biliary tract cancers显示文摘Gemcitabine chemotherapy has been the standard for advanced pancreatic cancer for more than a decade.New oral fluoropyrimidines such as S-1 and capecitabine are other key drugs.Gemcitabine plus erlotinib was the only combination therapy that significantly prolonged survival,although the effect was minimal.Little or no improvement in survival with recent moleculartargeted drugs might be attributed to the very high incidence of K-ras gene mutation in pancreatic cancer.Recently,the non-gemcitabine-based-regimen of FOLFIRINOX showed significantly greater overall survival compared with gemcitabine for the first time.For biliary tract cancer,gemcitabine plus cisplatin combination chemotherapy has been proved to significantly prolong survival and will become the standard therapy.Further improvement in survival is expected by the addition of cetuximab. | Minoru Tada Yousuke Nakai Takashi Sasaki Tsuyoshi Hamada Rie Nagano Dai Mohri Koji Miyabayashi Keisuke Yamamoto Hirofumi Kogure Kazumichi Kawakubo Yukiko Ito Natsuyo Yamamoto Naoki Sasahira Kenji Hirano Hideaki Ijichi Keishuke Tateishi Hiroyuki Isayama Masao Omata Kazuhiko Koike | 2011 | World Journal of Clinical Oncology2011，2，3： | 1 |
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