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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds显示文摘最近,我们报导了一条化学途径从老鼠成纤维细胞产生 pluripotent 干细胞。然而,是否化学上导致了 pluripotent 干细胞(CiPSCs ) ,能从要示威的另外的房间类型遗体被导出。用系跟踪,这里,我们首先从成纤维细胞验证 CiPSCs 的产生。下次,我们证明从外胚层的神经干细胞(NSC ) 和从内胚叶的小肠的上皮的房间(IEC ) 能是化学上 reprogrammed 进 pluripotent 干细胞。CiPSCs 源于 NSC 和 IEC 类似于老鼠处于增长率,全球基因表示侧面, epigenetic 地位,自强和区别能力的胚胎的干细胞,和 germline 传播才能。有趣地, pluripotency 基因 Sall4 从不同房间类型,和一样的核心在化学 reprogramming 过程在起始的阶段被表示小分子为 reprogramming 被要求,在从这些多样的房间类型位于化学 reprogramming 下面的分子的机制建议保存。我们的分析也证明这些小分子的使用应该被调整从不同房间类型满足 reprogramming 的要求。一起,这些调查结果证明那条完整的化学 reprogramming 途径能在不同织物起源的房间被使用并且建议化学 reprogramming 是有要延长到更起始的类型的潜力的有希望的策略。 | Junqing Ye Jian Ge Xu Zhang Lin Cheng Zhengyuan Zhang Shan He Yuping Wang Hua Lin Weifeng Yang Junfang Liu Yang Zhao Hongkui Deng | 2016 | Cell Research2016，26，1： | 19 |
| 3 | Hollow TiO2-x porous microspheres composed of wellcrystalline nanocrystals for high-performance lithiumion batteries显示文摘 | Chun Wang Faxing Wang Yujuan Zhao Yuhui Li Qin Yue Yupu Liu Yong Liu Ahmed A. Elzatahry Abdullah Al-Enizi Yuping Wu Yonghui Deng Dongyuan Zhao | 2016 | Nano Research2016，9，1： | 8 |
| 4 | The R2R3-MYB transcription factor GhMYB1a regulates flavonol and anthocyanin accumulation in Gerbera hybrida显示文摘Anthocyanins and flavonols have vital roles in flower coloration,plant development,and defense.Because anthocyanins and flavonols share the same subcellular localization and common biosynthetic substrates,these pathways may compete for substrates.However,the mechanism regulating this potential competition remains unclear.Here,we identified GhMYB1a,an R2R3-MYB transcription factor involved in the regulation of anthocyanin and flavonol accumulation in gerbera(Gerbera hybrida).GhMYB1a shares high sequence similarity with that of other characterized regulators of flavonol biosynthesis.In addition,GhMYB1a is also phylogenetically grouped with these proteins.The overexpression of GhMYB1a in gerbera and tobacco(Nicotiana tabacum)resulted in decreased anthocyanin accumulation and increased accumulation of flavonols by upregulating the structural genes involved in flavonol biosynthesis.We further found that GhMYB1a functions as a homodimer instead of interacting with basic helix-loop-helix cofactors.These results suggest that GhMYB1a is involved in regulating the anthocyanin and flavonol metabolic pathways through precise regulation of gene expression.The functional characterization of GhMYB1a provides insight into the biosynthesis and regulation of flavonols and anthocyanins. | Chunmei Zhong Yi Tang Bin Pang Xukun Li Yuping Yang Jing Deng Chengyong Feng Lingfei Li Guiping Ren Yaqin Wang Jianzong Peng Shulan Sun Shan Liang Xiaojing Wang | 2020 | Horticulture Research2020，7，1： | 7 |
| 5 | A wireless, implantable optoelectrochemical probe for optogenetic stimulation and dopamine detection显示文摘Physical and chemical technologies have been continuously progressing advances in neuroscience research.The development of research tools for closed-loop control and monitoring neural activities in behaving animals is highly desirable.In this paper,we introduce a wirelessly operated,miniaturized microprobe system for optical interrogation and neurochemical sensing in the deep brain.Via epitaxial liftoff and transfer printing,microscale light-emitting diodes(micro-LEDs)as light sources and poly(3,4-ethylenedioxythiophene)polystyrene sulfonate(PEDOT:PSS)-coated diamond films as electrochemical sensors are vertically assembled to form implantable optoelectrochemical probes for real-time optogenetic stimulation and dopamine detection capabilities.A customized,lightweight circuit module is employed for untethered,remote signal control,and data acquisition.After the probe is injected into the ventral tegmental area(VTA)of freely behaving mice,in vivo experiments clearly demonstrate the utilities of the multifunctional optoelectrochemical microprobe system for optogenetic interference of place preferences and detection of dopamine release.The presented options for material and device integrations provide a practical route to simultaneous optical control and electrochemical sensing of complex nervous systems. | Changbo Liu Yu Zhao Xue Cai Yang Xie Taoyi Wang Dali Cheng Lizhu Li Rongfeng Li Yuping Deng He Ding Guoqing Lv Guanlei Zhao Lei Liu Guisheng Zou Meixin Feng Qian Sun Lan Yin Xing Sheng | 2020 | Microsystems & Nanoengineering2020，6，1： | 3 |
| 6 | Immunotherapy with Autologous, Human Dendritic Cells Transfected with Carcinoembryonic Antigen mRNA显示文摘 | Michael A. Morse Smita K. Nair Paul J. Mosca Amy C. Hobeika Timothy M. Clay Yuping Deng David Boczkowski Alan Proia Donna Neidzwiecki Pierre-A. Clavien# Herbert I. Hurwitz Jeffrey Schlom Eli Gilboa H. Kim Lyerly | 2003 | Cancer Investigation2003，，3： | 2 |
| 7 | Hierarchically mesoporous carbon spheres coated with a single atomic Fe-N-C layer for balancing activity and mass transfer in fuel cells显示文摘Novel cost-effective fuel cells have become more attractive due to the demands for rare and expensive platinum-group metal(PGM)catalysts for mitigating the sluggish kinetics of the oxygen reduction reaction(ORR).The high-cost PGM catalyst in fuel cells can be replaced by earth-abundant transition-metalbased catalysts,that is,an Fe-N-C catalyst,which is considered one of the most promising alternatives.However,the performance of the Fe-N-C catalyst is hindered by the low catalytic activity and poor stability,which is caused by insufficient active sites and the lack of optimization of the triple-phase interface for mass transportation.Herein,a novel Fe–N–C catalyst consisting of mono-dispersed hierarchically mesoporous carbon sphere cores and single Fe atom-dispersed functional shells are presented.The synergistic effect between highly dispersed Fe-active sites and well-organized porous structures yields the combination of high ORR activity and high mass transfer performance.The half-wave potential of the catalyst in 0.1M H_(2)SO_(4) is 0.82 V versus reversible hydrogen electrode,and the peak power density is 812 mW·cm^(−2) in H_(2)–O_(2) fuel cells.Furthermore,it shows superior methanol tolerance,which is almost immune to methanol poisoning and generates up to 162 mW·cm^(−2) power density in direct methanol fuel cells. | Chengyong Shu Qiang Tan Chengwei Deng Wei Du Zhuofan Gan Yan Liu Chao Fan Hui Jin Wei Tang Xiao-dong Yang Xiaohua Yang Yuping Wu | 2022 | Carbon Energy2022，4，1： | 2 |
| 8 | Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood显示文摘 | Yu Jing Elias Shaheen Richard R. Drake Nianyong Chen Stefan Gravenstein Yuping Deng | 2009 | Human Immunology2009，，： | 1 |
| 9 | A facile and controllable one-pot synthesis approach to amino-functionalized hollow silica nanoparticles with accessible ordered mesoporous shells显示文摘The development of a practical synthetic method to functionalize hollow mesoporous silica with organic groups is of current intere st for selective adsorption and ene rgy storage applications.Herein,a facile and controllable one-pot approach for the synthesis of monodisperse amino-functionalized hollow mesoporous silica nanoparticles is presented.A novel solid-to-hollow structural transformation procedure of the silica nanoparticles is presented.The structural transformation is easily designed,as obse rved through transmission electro n microscopy,by tailo ring the HCl and N-lauroylsarcosine sodium molar ratio and the water content in the sol-gel.Ordered and radially oriented in situ aminofunctionalized mesochannels were successfully introduced into the shells of the hollow silica nanoparticles.A formation mechanism for the hollow mesoporous silica materials is discussed. | Shaoxin Deng Cheng-Xing Cui Lu Liu Lingyao Duan Jichao Wang Yuping Zhang Lingbo Qu | 2021 | Chinese Chemical Letters2021，32，3： | 1 |
| 10 | Segmentation of M-FISHimages for improved classification of chromosomes with an adaptive fuzzy C-means clustering algorithm显示文摘 | Cao Hongbao Deng Hongwen Wang Yuping | 2012 | IEEE Trans on Fuzzy Sys- tems2012，20，1： | 1 |
| 11 | A Fragment Substitution in Promoter of MS92/PTC1 Causes Male Sterility in Rice显示文摘Persistent tapetal cell1(PTC1) plays a curial role in pollen development, and is thought to function as a transcriptional activator in rice. However, the molecular mechanism of PTC1 in regulating pollen development and its cis-elements are not well understood. We identified a novel weak male sterility mutant(ms92) which exhibited expanded tapetum and shrink pollen grains. Map-based cloning and allelic analysis suggested that the male sterility of ms92 was caused by a DNA fragment substitution in the promoter of PTC1. The decreased expression of MS92/PTC1 in ms92 and cis-element analysis indicated that the substituted sequence contained several potential binding cis-element of negative feedback. MS92/PTC1 was specifically expressed in tapetum and microspores at the young microspore stage, and its protein was localized in nucleus. We further found that MS92/PTC1 functions as a transcription activator by recognizing H3K4me3. Transcriptomic analysis revealed that a number of genes involved in tapetum degeneration and pollen wall formation were down-regulated in ms92, which are the potential targets of MS92/PTC1. The substitution fragment in MS92/PTC1 promoter was essential for pollen development, and we provided a novel mutant for further identifying the cis-elements in promoter and the molecular network of MS92/PTC1. | Qin Peng Deng Luchang Chen Weilan Huang Juan Fan Shijun Tu Bin Tan Jun Yuan Hua Wang Yuping Ma Bingtian Li Shigui | 2020 | Rice science2020，27，5： | 1 |
| 12 | Extracellular high mobility group box chromosomal protein 1 promotesdrug resistance by increasing the expression of P?glycoprotein expression in gastricadenocarcinoma cells显示文摘 | Yuping Yin Wei Li Meizhou Deng Peng Zhang Qian Shen Guobing Wang Kaixiong Tao | 2014 | Molecular Medicine Reports2014，，4： | 1 |
| 13 | Effects of Powder Ridge Cultivation on Growth and Yield of Hunan Cassava显示文摘[Objective] The aim was to explore a suitable cultivation approach for cassava in Hunan province. [Method] With SC9(Southern China 9) as test materials, the test included four treatment methods, as follows: control group by traditional cultivation with crops uncovered(CK), treatment 1 by traditional cultivation with mulch coverage, treatment 2 by powder ridge cultivation with crops uncovered, and treatment 3 by powder ridge cultivation with mulch coverage. Water and fertilizer managements were kept the same. [Result] Compared with traditional cultivation(CK), the treatment by powder ridge cultivation with mulch coverage performed better. Specifically, yield per unit area reached 44 790 kg/hm2, increasing by 86.38%(20 760 kg/hm2) than that of control; starch content grew by 17.24%. The cultivation method considerably improved cassava yield and quality. [Conclusion] Powder ridge cultivation with mulch coverage is a cultivation approach suitable for cassava in Hunan province. | Yong SONG Xuan LIN Jinhui YANG Yuping DENG Xingyao XIONG | 2014 | Agricultural Science & Technology2014，15，3： | 1 |
| 14 | FLOW CHARACTERISTICS OF WALLFLOW DIESEL PARTICULATE FILTER SYSTEM WITH REVERSE PULSE AIR REGENERATION显示文摘To simulate steady airflows inside of wall-flow diesel paniculate filters (DPF) with differentreverse blowing pipes collocation, a mathematical model of the flow in a DPF is established by anequivalent continuum approach. The experimental results agree well with the theoretical values calcu-lated from the model. Simulation shows that the velocity and the pressure distribution of the filters inthe regenerative process are key factors to the filter’s regeneration. How to decrease themal-distribution of the flow in the filter and how to achieve the better regenerative performance at theleast cost of air consumption in the regenerative process are the ultimate goals of the study. Calculationand experiments show that the goals can be realized through adjusting the angle of two reverse blowingpipes and their relative location suitably. | Yao Chunde Shao Yuping Zhang Chunrun Zi XinYun Jiang Dahai Deng Chenglin | 2005 | Chinese Journal of Mechanical Engineering2005，18，3： | 1 |
| 15 | DSP-based implementation of matrix converter显示文摘 | Deng Yisheng Sun Yuping Huang Lipei | 2002 | IEEE Tencon2002，，2： | 1 |
| 16 | Effect of Valsartan in the treatment of mild and moderate primary hypertension clinical curative effect observation of 显示文摘 | Deng Yuping | 2009 | Grassroots medical forum2009，13，12： | 1 |
| 17 | Molecular characterization and phylogenetic analysis of the reticuloendotheliosis virus isolated from wild birds in Northeast China显示文摘 | Lili Jiang Xiaole Qi Yulong Gao Yuping Hua Kai Li Xiaoyun Deng Qi Wang Lizhou Zhang Hongliang Chai Yuming Chen Chunhong Yin Honglei Gao Liting Qin Yongqiang Wang Yue Qu Qiang Chen Zhaobin Fan Xiaomei Wang | 2013 | Veterinary Microbiology (-)2013，，1： | 1 |
| 18 | Experimental investigation on oil-gas separator of air-conditioning systems显示文摘The oil-return system plays an important role in the variable refrigerant flow (VRP) systems because it ensures the reliable operation of the VRF systems. The oil-gas separator is the most essential component of the oil- return system, and the separation efficiency of the separator directly influences the performance of the VRF systems. Therefore, in this paper, a test rig was built to measure the oil discharge ratio of the compressor and the separation efficiency of the oil-gas separator. A sound velocity transducer was used to measure the oil mass concentration instantaneously, because the sound velocity was changed with the mass ratio of oil to refrigerant. The separation efficiency of the separator could be obtained by comparing the mass fraction of oil to refrigerant before and after the separator was connected to the system. | Dianbo XIN Shuliang HUANG Song YIN Yuping DENG Wenqiang ZHANG | 2019 | Frontiers in Energy2019，13，2： | 1 |
| 19 | Inwardly rectifying potassium channel 5.1:Structure,function,and possible roles in diseases显示文摘Inwardly rectifying potassium(Kir)channels make it easier for K^(+)to enter into a cell and subsequently regulate cellular biological functions.Kir5.1(encoded by KCNJ16)alone can form a homotetramer and can form heterotetramers with Kir4.1(encoded by KCNJ10)or Kir4.2(encoded by KCNJ15).In most cases,homomeric Kir5.1 is non-functional,while hetero-meric Kir5.1 on the cell membrane contributes to the inward flow of K^(+)ions,which can be regulated by intracellular pH and a variety of signaling mechanisms.In the form of a heterotetramer,Kir5.1 regulates Kir4.1/4.2 activity and is involved in the maintenance of nephron function.Actually,homomeric Kir5.1 may also play a very important role in diseases,including in the ventilatory response to hypoxia and hypercapnia,hearing impairment,cardio-vascular disease and cancer.With an increase in the number of studies into the roles of Kir channels,researchers are paying more attention to the pathophysiological functions of Kir5.1.This minireview provides an overview regarding these Kir5.1 roles. | Junhui Zhang Jian Han Lingfei Li Qiong Zhang Yanhai Feng Youzhao Jiang Fang Deng Yuping Zhang Qinan Wu Bing Chen Jiongyu Hu | 2021 | Genes & Diseases2021，8，3： | 0 |
| 20 | Eight Zhes Decoction ameliorates the lipid dysfunction of nonalcoholic fatty liver disease using integrated lipidomics, network pharmacology and pharmacokinetics显示文摘Nonalcoholic fatty liver disease(NAFLD)has developed into the most common chronic liver disease and can lead to liver cancer.Our laboratory previously developed a novel prescription for NAFLD,“Eight Zhes Decoction”(EZD),which has shown good curative effects in clinical practice.However,the pharmacodynamic material basis and mechanism have not yet been revealed.A strategy integrating lipidomics,network pharmacology and pharmacokinetics was used to reveal the active components and mechanisms of EZD against NAFLD.The histopathological results showed that EZD attenuated the degrees of collagen deposition and steatosis in the livers of nonalcoholic steatofibrosis model mice.Furthermore,glycerophospholipid metabolism,arachidonic acid metabolism,glycerolipid metabolism and linoleic acid metabolism with phospholipase A2 group IVA(PLA2G4A)and cytochrome P450 as the core targets and 12,13-cis-epoxyoctadecenoic acid,12(S)-hydroxyeicosatetraenoic acid,leukotriene B4,prostaglandin E2,phosphatidylcholines(PCs)and triacylglycerols(TGs)as the main lipids were found to be involved in the treatment of NAFLD by EZD.Importantly,naringenin,artemetin,canadine,and bicuculline were identified as the active ingredients of EZD against NAFLD;in particular,naringenin reduces PC consumption by inhibiting the expression of PLA2G4A and thus promotes sufficient synthesis of very-low-density lipoprotein to transport excess TGs in the liver.This research provides valuable data and theoretical support for the application of EZD against NAFLD. | Yuping Zhou Ze Dai Kaili Deng Yubin Wang Jiamin Ying Donghui Chu Jinyue Zhou Chunlan Tang | 2023 | Journal of Pharmaceutical Analysis2023，13，9： | 0 |
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