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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules显示文摘由病毒的 transduction 的四抄写因素 Oct4, Klf4, Sox2 和 c-Myc 的介绍能导致体的房间的 reprogramming 进导致的 pluripotent 干细胞(iPSCs ) ,但是 iPSCs 的使用被病毒的交货系统的使用妨碍。导致化学药品的 reprogramming 把一条新奇途径提供给没有任何病毒的基于向量的基因修正,产生 iPSCs。尽管,以前的报告证明几个小分子能代替一些 reprogramming 因素至少二个抄写因素, Oct4 和 Klf4,仍然被要求从老鼠产生 iPSCs 胚胎的成纤维细胞。这里,我们识别特定的化学联合,它是足够的面对一个单个抄写因素从胚胎的老鼠和成年成纤维细胞允许 reprogramming, Oct4 在 20 天以内,代替 Sox2, Klf4 和 c-Myc。用这个处理产生的 iPSCs 类似于胚胎的干细胞以全球基因表示介绍的老鼠,在 vitro 并且在 vivo 的 epigenetic 地位和 pluripotency。我们也发现那 8 天 Oct4 正式就职是足够的面对小分子启用导致 Oct4 的 reprogramming,它建议 reprogramming 在开始的 8 天以内被开始并且独立于连续外长的 Oct4 表示。没有基因修正,这些发现将帮助 iPSCs 的未来产生,以及阐明位于 reprogramming 过程下面的分子的机制。 | Yanqin Li Qiang Zhang Xiaolei Yin Weifeng Yang Yuanyuan Du Pingping Hou Jian Ge Chun Liu Weiqi Zhang Xu Zhang Yetao Wu Honggang Li Kang Liu Chen Wu Zhihua Song Yang Zhao Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，1： | 51 |
| 3 | The Reference Genome of Tea Plant and Resequencing of 81 Diverse Accessions Provide Insights into Its Genome Evolution and Adaptation显示文摘Tea plant is an important economic crop,which is used to produce the world's oldest and most widely consumed tea beverages.Here,we present a high-quality reference genome assembly of the tea plant(Camellia sinensis var.sinensis)consisting of 15 pseudo-chromosomes.LTR retrotransposons(LTR-RTs)account for 70.38%of the genome,and we present evidence that LTR-RTS play critical roles in genome size expansion and the transcriptional diversification of tea plant genes through preferential insertion in promoter regions and introns.Genes,particularly those coding for terpene biosynthesis pro-teins,associated with tea aroma and stress resistance were significantly amplified through recent tandem duplications and exist as gene clusters in tea plant genome.Phylogenetic analysis of the sequences of 81 tea plant accessions with diverse origins revealed three well-differentiated tea plant populations,support-ing the proposition for the southwest origin of the Chinese cultivated tea plant and its later spread to western Asia through introduction.Domestication and modern breeding left significant signatures on hundreds of genes in the tea plant genome,particularly those associated with tea quality and stress resis-tance.The genomic sequences of the reported reference and resequenced tea plant accessions provide valuable resources for future functional genomics study and molecular breeding of improved cul-tivars of tea plants. | Enhua Xia Wei Tong Yan Hou Yanlin An Linbo Chen Qiong Wu Yunlong Liu Jie Yu Fangdong Li Ruopei Li Penghui Li Huijuan Zhao Ruoheng Ge Jin Huang Ali Inayat Mallano Yanrui Zhang Shengrui Liu Weiwei Deng Chuankui Song Zhaoliang Zhang Jian Zhao Shu Wei Zhengzhu Zhang Tao Xia Chaoling Wei Xiaochun Wan | 2020 | Molecular Plant2020，13，7： | 51 |
| 4 | The Sunway TaihuLight supercomputer: system and applications显示文摘The Sunway Taihu Light supercomputer is the world's first system with a peak performance greater than 100 PFlops. In this paper, we provide a detailed introduction to the Taihu Light system. In contrast with other existing heterogeneous supercomputers, which include both CPU processors and PCIe-connected many-core accelerators(NVIDIA GPU or Intel Xeon Phi), the computing power of Taihu Light is provided by a homegrown many-core SW26010 CPU that includes both the management processing elements(MPEs)and computing processing elements(CPEs) in one chip. With 260 processing elements in one CPU, a single SW26010 provides a peak performance of over three TFlops. To alleviate the memory bandwidth bottleneck in most applications, each CPE comes with a scratch pad memory, which serves as a user-controlled cache. To support the parallelization of programs on the new many-core architecture, in addition to the basic C/C++and Fortran compilers, the system provides a customized Sunway Open ACC tool that supports the Open ACC2.0 syntax. This paper also reports our preliminary efforts on developing and optimizing applications on the Taihu Light system, focusing on key application domains, such as earth system modeling, ocean surface wave modeling, atomistic simulation, and phase-field simulation. | Haohuan FU Junfeng LIAO Jinzhe YANG Lanning WANG Zhenya SONG Xiaomeng HUANG Chao YANG Wei XUE Fangfang LIU Fangli QIAO Wei ZHAO Xunqiang YIN Chaofeng HOU Chenglong ZHANG Wei GE Jian ZHANG Yangang WANG Chunbo ZHOU Guangwen YANG | 2016 | Science China(Information Sciences)2016，59，7： | 45 |
| 5 | Dihydroartemisinin is an inhibitor of ovarian cancer cell growth显示文摘瞄准:调查 dihydroartemisinin (DHA ) 的反癌症活动,在人的卵巢的癌症房间的一块面板的反疟疾药 artemisinin 的衍生物排队。方法: 房间生长被 MTT 生存能力试金决定。Apoptosis 和房间周期前进被 DNA 破碎胶化电气泳动,流动 cytometry 试金,和 TUNEL 试金评估;蛋白质和 mRNA 表示被西方的弄污和 RT-PCR 试金分析。结果:Artemisininand 它的衍生物包括 artesunate, arteether, artemether, arteannuin,和 DHA,在人的卵巢的癌症细胞的 exhibitanticancer 生长活动。在他们之中, DHA 在禁止房间生长是最有效的。卵巢的癌症房间线是更敏感的(5-10-fold ) 到与正常相比的 DHA 治疗,卵巢的房间排队。在微臼齿的剂量层次的 DHA 展出剂量 -- 在卵巢的癌症房间的 andtime 依赖的 cytotoxicity 排队。而且, DHA 导致了 apoptosis 和 G2cell 周期拘捕,由 Bcl-xL 和 Bcl-2 和 Bax 和 Bad.Conclusion 的增加的减少伴随了:有希望的结果第一次证明 DHA 禁止人的卵巢的癌症房间的生长。房间生长, apoptosis 正式就职,和 G2 拘捕在卵巢的癌症的临床的治疗作为可能的反癌症药为 DHA 的进一步的研究在 vitro 证据提供的卵巢的癌症的选择抑制。 | Yang JIAO Chun-min GE Qing-hui MENG Jian-ping CAO Jian TONG Sai-jun FAN | 2007 | Acta Pharmacologica Sinica2007，28，7： | 39 |
| 6 | Behavioral responses for evaluating the attractiveness of specific tea shoot volatiles to the tea green leafhopper, Empoaca vitis显示文摘 | Dan Mu Lin Cui Jian Ge Meng-Xin Wang Li-Fang Liu Xiao-Ping Yu Qing-He Zhang Bao-Yu Han | 2012 | Insect Science2012，19，2： | 35 |
| 7 | Geochemical characteristics of pore water in shallow sediments from Shenhu area of South China Sea and their significance for gas hydrate occurrence显示文摘The Shenhu area is one of the promise target areas for marine gas hydrate exploration in the northern margin of the South China Sea.Pore water samples were collected from two piston cores (8.75 and 8.52 m) in site HS-A and site HS-B in the Shenhu area,and their major anion and cation contents and trace element contents have been analyzed in this study.Cl- concentrations in pore waters are similar to the seawater value and no systematic change along depth profiles has been found for the Cl- content in both sites.In site HS-A,the SO 2- 4 contents show a limited range in pore waters from 0 to 3 m depths,but a dramatic decrease is documented in depth below 3 m.Other elements such as Ca 2+,Mg 2+ and Sr 2+ show similar variation patterns as the SO 2- 4,i.e.,no variation in 0-3 m,but large decrease in depth below 3 m.In site HS-B,both the SO 4 and Ca 2+,Mg 2+ and Sr 2+ display a decrease pattern along the depth profile,but in 0-3 m the variation is less significant than those in depth below 3 m.In both sites HS-A and HS-B,I contents show a dramatic increase along depth profiles.Calculations show that the SMI depths are very shallow (10 and 11 m) in both sites,and the sulfate flux and I flux are very high.These geochemical characteristics and anomalies at Shenhu are quite similar to those found in other gas hydrate locations in the world,and a genetic link is suggested to be related to the gas hydrate occurrence at depths in the study area.In summary,we suggest that combined geochemical parameters in shallow sediment pore waters are useful indicators to indicate the gas hydrate occurrence at depths. | YANG Tao JIANG ShaoYong GE Lu YANG JingHong WU NengYou ZHANG GuangXue LIU Jian | 2010 | Chinese Science Bulletin2010，55，8： | 30 |
| 8 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 9 | A Mitochondrial Genome Sequence of the Tibetan Antelope(Pantholops hodgsonii)显示文摘To investigate genetic mechanisms of high altitude adaptations of native mammalson the Tibetan Plateau, we compared mitochondrial sequences of the endangeredPantholops hodgsonii with its lowland distant relatives Ovis aries and Capra hir-cus, as well as other mammals. The complete mitochondrial genome of P. hodgsonii(16,498 bp) revealed a similar gene order as of other mammals. Because of tandemduplications, the control region of P. hodgsonii mitochondrial genome is shorterthan those of O. aries and C. hircus, but longer than those of Bos species. Phy-logenetic analysis based on alignments of the entire cytochrome b genes suggestedthat P. hodgsonii is more closely related to O. aries and C. hircus, rather than tospecies of the Antilopinae subfamily. The estimated divergence time between P.hodgsonii and O. aries is about 2.25 million years ago. Further analysis on natu-ral selection indicated that the COXI (cytochrome c oxidase subunit I) gene wasunder positive selection in P. hodgsonii and Bos grunniens. Considering the sameclimates and environments shared by these two mammalian species, we proposedthat the mitochondrial COXI gene is probably relevant for these native mammalsto adapt the high altitude environment unique to the Tibetan Plateau. | Shu-Qing Xu Ying-Zhong Yang Jun Zhou Guo-En Jing Yun-Tian Chen Jun Wang Huan-Ming Yang Jian Wang Jun Wu Xiao-Guang Zheng and Ri-Li Ge | 2005 | Genomics, Proteomics & Bioinformatics2005，3，1： | 22 |
| 10 | Relationship between hs-CRP, proMMP-1, TIMP-1 and coronary plaque morphology: intravascular ultrasound study显示文摘Background Rupture of unstable plaque with subsequent thrombus formation is the common pathophy- siological substrate of the acute coronary syndrome (ACS). It is of potential significance to explore the blood indexes predicting plaque characteristics. Little studies have focused on this field. Therefore we investigated the relationship between hypersensitive C-reactive protein (hs-CRP), pro-matrix metalloproteinase-1 (proMMP-1), tissue inhibitors of matrix metalloproteinase-1 (TIMP-1) and coronary plaque morphology. Methods Intravascular ultrasound (IVUS) examination was done in 152 patients with confirmed coronary heart disease before percutaneous coronary intervention from February 2003 to July 2005. Plasma samples of arterial blood were collected prior to the procedure. The level of hs-CRP, proMMP-1 and TIMP-1 were respectively measured by enzyme-linked immunosorbent assay (ELISA). Results Unstable and ruptured plaque were found more frequently in patients with acute myocardial infarction and unstable angina. External elastic membrane cross-sectional area (EEM CSA), plaque area, lipid pool area and plaque burden were significantly larger in ruptured and unstable plaque group. Positive remolding, thinner fabric-cap, smaller minimal lumen cross-sectional area (MLA), dissection and thrombus were significantly more frequent in ruptured and unstable plaque group. The levels of plasma hs-CRP, proMMP-1 and TIMP-1 were higher in ruptured plaque group. hs-CRP>8.94 mg/L was used to predict ruptured plaque with a ROC curve area of 0.76 [95% confidence interval (CI), 67.0%-85.8%], sensitivity of 71.8%, specificity of 77.0% and accuracy of 69.2% (P<0.01), similarly for proMMP-1>0.12 ng/ml with a ROC curve area of 0.69 [95% CI, 58.2%-80.2%], sensitivity of 69.2%, specificity of 75.2% and accuracy of 66.2% (P<0.01), and TIMP-1>83.45 ng/ml with a ROC curve area of 0.67 [95% CI, 56.2%-78.3%], sensitivity of 66.7%, specificity of 61.9% and accuracy of 66.2% (P<0.01). Conclusion The plaque characteristics correlate with the clinical presentation. The elevation of hs-CRP, proMMP-1 and TIMP-1 are related to the plaque instability and rupture. | ZHANG Xing-wei GE Jun-bo YANG Jian-min GE Lei WANG Ning-fu GAO Yan LI Pei-zhang PAN Hao TONG Guo-xin ZHOU Liang YE Xian-hua XU Jian | 2006 | Chinese Medical Journal2006，，20： | 23 |
| 11 | Molecular network-based analysis of Guizhi- Shaoyao-Zhimu decoction, a TCM herbal formula, for treatment of diabetic peripheral neuropathy显示文摘目的: Guizhi-Shaoyao-Zhimu 煎(GSZ ) ,繁体中文药(TCM ) 草药的公式,被显示出在糖尿病的外部神经病(DPN ) 的治疗有效。在这研究,网络分析被执行译解在 DPN 的处理的 GSZ 的分子的机制。 | Ning ZHAO Jian LI Li LI Xu-yan NIU Miao JIANG Xiao-juan HE Zhao-xiang BIAN Ge ZHANG Ai-ping LU | 2015 | Acta Pharmacologica Sinica2015，36，6： | 21 |
| 12 | Endoscopic submucosal dissection vs endoscopic mucosal resection for colorectal tumors: A meta-analysis显示文摘AIM: To compare the efficacy and safety of endoscopic submucosal dissection(ESD) and endoscopic mucosal resection(EMR) for the treatment of colorectal tumors.METHODS: Databases, such as PubMed, EMBASE, Cochrane Library and Science Citation Index updated to 2013 were searched to include eligible articles. In the meta-analysis, the main outcome measurements were the en bloc resection rate, the histological resection rate and the local recurrence rate. Meanwhile, we also compared the operation time and the incidence of procedure-related complications.RESULTS: Six trials were identified and a total of 1642 lesions were included. The en bloc resection rate was higher and the local recurrence rate was lower in the ESD group compared with the EMR group(OR = 7.94; 95%CI: 3.96-15.91; OR = 0.09; 95%CI: 0.04-0.19). There was no significant difference in histological resection rate(OR = 1.65; 95%CI: 0.29-9.30) and procedure-related complication rate between the two groups(OR = 1.59; 95%CI: 0.92-2.73). The meta-analysis also showed that ESD was more time consuming than EMR.CONCLUSION: Compared with EMR, ESD results in higher en bloc resection rate and lower local recurrence rate for the treatment of colorectal tumors, without increasing the procedure-related complications. | Jing Wang Xiao-Hua Zhang Jian Ge Chong-Mei Yang Ji-Yong Liu Shu-Lei Zhao | 2014 | World Journal of Gastroenterology2014，20，25： | 21 |
| 13 | Heat-shocked tumor cell lysate-pulsed dendritic cells induce effective anti-tumor immune response in vivo显示文摘瞄准:学习震惊热的肿瘤房间是否能提高肿瘤房间的效果在唤起反肿瘤免疫者反应的搏动 lysate 的树枝状的房间(DC ) 在活体内。方法:老鼠无差别的结肠癌房间(CT-26 ) 为 1 h 然后结冰融化在 42 度摄氏被加热。骨头导出髓的 DC 与震惊热的 CT-26 房间溶解产物(HSCT-26 DC ) 搏动了被招募使 syngeneic 免疫天真的 BALB/c 老鼠。肿瘤的细胞毒素的活动在老鼠怒气的特定的细胞毒素的 T 淋巴细胞(CTL ) 被 IFN-enzyme-linked 免疫点(ELISpot ) 和 LDH 版本试金评估。在老鼠结肠癌的 DC 建模的 HSCT-26 导致的免疫 prophylactic 效果与单个 CT-26 房间导致的那些相比肿瘤体积,腹转移和老鼠的生存时间上的搏动 lysate 的 DC (CT-26 DC ) 。结果:对待热的 CT-26 房间显示出更高的 hsp70 蛋白质表情。震惊热的 CT-26 房间溶解产物 pulsing 提高了骨头的 co-stimulatory 和 MHC-II 分子表示导出髓的 DC 以及 interleukin-12 p70 分泌物。HSCT-26 DC 导致的 IFN-gamma secreting CTL 被 CT-26 DC (P=0.002 ) 显著地多于那些导致。以前的 CTL 的特定的细胞毒素的活动在 10:1, 20:1,和 40:1 的连续 E/T 比率比后者 CTL 的家高。尽管他们之间没有统计差别,鼠标结肠癌模型比 CT-26 DC,种痘在肿瘤体积上组织证明种痘组织的 HSCT-26 DC 的肿瘤卷小(24 mm3 对 8 mm3, P=0.480 ) 。与 HSCT-26 DC 使免疫的老鼠的中部的生存时间比与 CT-26 DC 使免疫的那些的长(57 d 对 43 d, P=0.0384 ) 。结论:震惊热的肿瘤房间搏动 lysate 的 DC 能有效地唤起反肿瘤免疫者反应在活体内并且用作一支新奇基于 DC 的肿瘤疫苗。 | Jian Qiu Guo-Wei Li Yan-Fang Sui Hong-Ping Song Shao-Yan Si Wei Ge | 2006 | World Journal of Gastroenterology2006，12，3： | 20 |
| 14 | Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds显示文摘最近,我们报导了一条化学途径从老鼠成纤维细胞产生 pluripotent 干细胞。然而,是否化学上导致了 pluripotent 干细胞(CiPSCs ) ,能从要示威的另外的房间类型遗体被导出。用系跟踪,这里,我们首先从成纤维细胞验证 CiPSCs 的产生。下次,我们证明从外胚层的神经干细胞(NSC ) 和从内胚叶的小肠的上皮的房间(IEC ) 能是化学上 reprogrammed 进 pluripotent 干细胞。CiPSCs 源于 NSC 和 IEC 类似于老鼠处于增长率,全球基因表示侧面, epigenetic 地位,自强和区别能力的胚胎的干细胞,和 germline 传播才能。有趣地, pluripotency 基因 Sall4 从不同房间类型,和一样的核心在化学 reprogramming 过程在起始的阶段被表示小分子为 reprogramming 被要求,在从这些多样的房间类型位于化学 reprogramming 下面的分子的机制建议保存。我们的分析也证明这些小分子的使用应该被调整从不同房间类型满足 reprogramming 的要求。一起,这些调查结果证明那条完整的化学 reprogramming 途径能在不同织物起源的房间被使用并且建议化学 reprogramming 是有要延长到更起始的类型的潜力的有希望的策略。 | Junqing Ye Jian Ge Xu Zhang Lin Cheng Zhengyuan Zhang Shan He Yuping Wang Hua Lin Weifeng Yang Junfang Liu Yang Zhao Hongkui Deng | 2016 | Cell Research2016，26，1： | 19 |
| 15 | Tissue clearing of both hard and soft tissue organs with the PEGASOS method显示文摘织物空地技术由转织物在 3 尺寸(3-D ) 启用不透明的机关和纸巾的可视化透明。当前的组织空地方法被能与每个单个协议被清除的纸巾的有限类型限制,它不可避免地导致了存在在整个身体或身体部分成像以内盲点。包括骨头和牙齿的难纸巾仍然是要清除的最困难的机关。另外,内长的荧光的损失为基于溶剂的空地方法仍然是一颗主要担心。这里,我们发展了聚乙烯乙二醇(木钉) 联系了溶剂系统(PEGASOS ) ,它将近显示了纸巾的所有类型透明、保存的内长的荧光。骨头和牙齿能被转在变清以后将近不可见。PEGASOS 方法转了透明的整个成年老鼠身体,我们对一个成年老鼠头骨头,牙齿,大脑,肌肉,和其它填写了的图象有能力没有盲目区域的纸巾。难织物透明性使我们能重建在 3-D 的未经触动的上颚,牙齿,腿节,或膝关节。另外,我们在长距离上在亚 cellular 分辨率并且到踪迹个人神经原和轴突管理了未经触动的鼠标大脑到图象。我们也通过 vertebrae 直接设想了背面的根中心。最后,我们在长骨头的髓空间以内在 3-D 揭示了神经网络的分发模式。这些结果建议 PEGASOS 方法是为一般生物医学的研究的一个有用工具。 | Dian Jing Shiwen Zhang Wenjing Luo Xiaofei Gao Yi Men Chi Ma Xiaohua Liu Yating Yi Abhijit Bugde Bo O. Zhou Zhihe Zhao Quan Yuan Jian Q. Feng Liang Gao Woo-Ping Ge Hu Zhao | 2018 | Cell Research2018，28，8： | 18 |
| 16 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 17 | Effects of Xinfeng capsule on pulmonary function based on treg-mediated notch pathway in a rat model of adjuvant arthritis显示文摘OBJECTIVE:To observe the impact of xinfeng xapsule(XFC) on pulmonary function in a rat model of adjuvant arthritis(AA) and to investigate the mechanism of action.METHODS:Forty rats were randomly divided into four groups of ten:normal control(NC);model control(MC);tripterygium glycosides tablet(TPT);and xinfeng capsule(XFC).Except for the NC group,AA was induced in all rats by intracutaneous injection of 0.1 mL Freund's complete adjuvant in the right paw on the 19th day.NC and MC groups were given(0.9%) physiological saline.The TPT and XFC groups were given TPT(10 mg/kg) and XFC(1.2 g/kg),respectively.Thirty days after administration,changes in paw edema(E),the arthritis index(AI),pulmonary function,levels of regulatory T-cells(Treg),ultrastructure of lung tissue,and expression of Notch receptors and ligands in lung tissue were observed.RESULTS:In the MC group,E and the AI were increased and pulmonary function significantly decreased;the structure of alveolar type-II cells was damaged;ratios of Treg in peripheral blood were reduced;and expression of Notch receptors such as Notch3 and Notch4 and ligands such as Delta1 in lung tissue were significantly increased whereas expression of Notch1,Jagged1 and Jagged2 were significantly decreased.After intervention with XFC,E and the AI were decreased;pulmonary function was enhanced;the structure of alveolar type-II cells was improved;and expression of Treg,Notch1,Jagged1,Jagged2 was elevated,whereas that of Notch3,Notch4 and Delta1 was reduced.CONCLUSION:XFC can not only inhibit E and the AI and improve joint symptoms,it can also improve pulmonary function and reduce inflammation in lung tissue.These actions could be carried out through increases in the expression of Treg,Notch receptors(Notch1) and ligands(Jagged1,Jagged2),and reductions in the expression of Notch3,Notch4 and Delta1.These phenomena would reduce the deposition of immune complexes and the inflammatory response in lung tissue,thereby improving joint symptoms and pulmonary function. | Lei Wan Jian Liu Chuanbing Huang Yuan Wang Xi Shen Wandong Zhang Guizheng Wang Haixia Fan Yao Ge Ruilian Chen Yunxiang Cao Ruikai Zong Li Lei | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 17 |
| 18 | The Clinical Outcomes of Three Surgical Managements on Primary Angle-closure Glaucoma显示文摘Purpose: To investigate the efficacy of trabeculectomy, phacotrabeculectomy and phaco-emulsification in the management of primary angle closure glaucoma (PACG). Methods: A prospective observational study was performed in 88 chronic PACG patients (97 eyes) who were divided into three groups following defined indications to receive different surgical interventions. The indications and clinical outcomes were evaluated. The mean follow-up was (17.7±4.9) months. Results: Success rate in trabeculectomy, phacotrabeculectomy and phacoemulsification group was 81.08%, 78.57‰ and 81.25‰, respectively. The anterior chamber depth was deeper and the angle was wider postoperatively vs. preoperatively both in phaco-trabeculectomy and phacoemulsification group. No obvious changes were seen in trabeculectomy group. The coefficient of outflow facility of aqueous humor (C values) significantly increased in three groups postoperatively (P < 0.01). No severe intra-operative complications were found and the incidence of postoperative complications was low. Five eyes sustained hypotony 3±1.87 months in trabeculectomy group and 1 eye happened malignant glaucoma in phacotrabeculectomy group. The visual acuity in patients with phacotrabeculectomy plus intraocular lens implantation and those only with phacoemulsification plus intraocular lens implantation were improved 78.57% and 93.74%, respectively. No significant improvement was found in trabeculectomy group (χ2 = 47.10, P < 0.001). Conclusion: Three surgical interventions were beneficial to manage PACG and with co-existing cataract. The indication choosing was suggested according to visual acuity, angle closure circumference, cataract, medication requirements and optic nerve damage. Phacotrabeculectomy was recommended for angle closed ≥180° circumference while phacoemulsification for angle closed < 180°. | Xiulan Zhang Leilei Teng Ang Li Shaolin Du Yunyun Zhu Jian Ge | 2007 | 眼科学报2007，23，2： | 16 |
| 19 | Preliminary study on LGM climate simulation and the diagnosis for East Asia显示文摘LGM climate study is a hot topic in international fields on global changes. Climate simulation in this study applies both common designs of 21 kaBP boundary conditions from the Paleoclimate Modeling Intercomparison Project (PMIP), including insolation, glaciation, sea surface temperature and atmospheric CO2 concentration, and land surface conditions from Eurasia continent by compilation of geological evidence. The simulation outputs are in agreement with climate spatial patterns reconstructed by observation records. Sensitive experiment on land surface conditions shows that changes in vegetation would make significant impacts on temperature and precipitation. Particularly in the Tibetan Plateau, this change would increase in differences of winter and summer temperature, precipitation and P-E. | YU Ge CHEN Xing LIU Jian WANG Sumin | 2001 | Chinese Science Bulletin2001，46，5： | 16 |
| 20 | Comparison of combined phacotrabeculectomy with trabeculectomy only in the treatment of primary angle-closure glaucoma显示文摘 | WANG Mei FANG Min BAI Yu-jing ZHANG Wei-zhong LIN Ming-kai LIU Bing-qian HAO Yuan-tao LING Yun-lan ZHUO Ye-hong GE Jian | 2012 | Chinese Medical Journal2012，，8： | 15 |
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