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| 1 | Research progress of disinfection and disinfection by-products in China显示文摘Disinfection is an indispensable water treatment process for killing harmful pathogens and protecting human health. However, the disinfection has caused significant public concern due to the formation of toxic disinfection by-products(DBPs). Lots of studies on disinfection and DBPs have been performed in the world since 1974. Although related studies in China started in1980 s, a great progress has been achieved during the last three decades. Therefore, this review summarized the main achievements on disinfection and DPBs studies in China, which included:(1) the occurrence of DBPs in water of China,(2) the identification and detection methods of DBPs,(3) the formation mechanisms of DBPs during disinfection process,(4) the toxicological effects and epidemiological surveys of DBPs,(5) the control and management countermeasures of DBPs in water disinfection, and(6) the challenges and chances of DBPs studies in future. It is expected that this review would provide useful information and reference for optimizing disinfection process, reducing DBPs formation and protecting human health. | Xuefeng Sun Miao Chen Dongbin Wei Yuguo Du | 2019 | Journal of Environmental Sciences2019，31，7： | 18 |
| 2 | The temporal and spatial distribution of ancient rice in China and its implications显示文摘The relics of ancient rice have been regarded as the most important objective evidence of the origina- tion and spread of rice cultivation.Based on the records of 280 rice relics sites and the rice cropping regionalization as well as the distribution map of paddy soils,the current study compiled the temporal and spatial distribution map of ancient rice distribution in China.The map shows that the distribution of ancient rice is spatially extensive and meantime comparatively concentrated,temporarily covering a long and relatively continuous time-span.The rice relics in the Central China double and single rice cropping regions are among the earliest and the most abundant ones,possessing continuity in time sequence.Combined with the discovery of ancient rice and paddy filed relics,soil micromorphology, pollen combination and element geochemistry,it is suggested that Central China was the origin center of rice cultivation in China.Rice had been spread to the rest part of China in three major waves,also to the East Asian part like Korea and Japan.The temporal and spatial distribution of ancient rice reflects the past environmental change,which is also meaningful to the current rice regionalization and plan- ning as well as food security in China. | GONG ZiTong CHEN HongZhao YUAN DaGang ZHAO YuGuo WU YunJin ZHANG GanLin | 2007 | Chinese Science Bulletin2007，52，8： | 11 |
| 3 | Land Use-Related Changes in Soils of Hainan Island During the Past Half Century显示文摘During the past half century, the land utilization of Hainan Island has undergone a rapid development,but in the meanwhile, soil degradation occurs. Analysis on some basic data of the soil series collected frommore than 100 soil profiles at the end of the 1990s and beginning of this century, in combination with dataavailable, showed that soils there suffered significant decline in organic matter, experienced P and K deficiencywith soil K going on losing and undergone acidification with continuing trend. The current situation calls forstrategies to build up Hainan into an important province of sound ecology by restoring forests, to improvefood quality by implementing K supplement projects, to combat soil acidification by ameliorating the soils andgrowing leguminous crops and to ensure health of the people by developing dairy production and increasingthe daily Ca uptake by the people. | GONG ZITONG, ZHANG GANLIN, ZHAO WENJUN, ZHAO YUGUO and CHEN ZHICHENGInstitute of Soil Science, the Chinese Academy of Sciences, Nanjing 210008 (China) | 2003 | Pedosphere2003，13，1： | 9 |
| 4 | Association of cystatin C level and cardiovascular prognosis for patients with preexisting coronary heart disease:a meta-analysis显示文摘The association of circulating levels of cystatin C(CysC)and risk of recurrent cardiovascular events in patients with preexisting coronary heart disease are uncertain.To qualitatively and quantitatively address this issue,we performed a random meta-analysis of results from prospective studies on the topic.We searched electronic and printed sources(up to 16 October 2011)using keywords and retrieved articles for seven prospective studies according to the selection criteria.Data were abstracted and meta-analysis was performed using the random-effects model(RevMan 5.0.23 software).The cohorts involved 4,576 patients with preexisting coronary heart disease(CHD)and normal or mild chronic kidney disease,and follow-up ranged from 5.6 to 40.6 months.Highest versus lowest baseline CysC level was significantly associated with increased risk of cardiovascular events(OR 2.30,95%CI 1.80–2.94),all-cause mortality(OR 5.69,95%CI 3.70–8.74),but not with recurrent MI(OR 1.75,95%CI 0.77–4.00).In heterogeneity testing for studies reporting cardiovascular events and all-cause mortality,no significant heterogeneity was found,and exclusion of any single study did not alter the overall finding.For risk of recurrent MI,significant heterogeneity was found among the five trials(v2=13.16,P=0.01,I2=70%)and exclusion of the Taglieri et al.[12]study from the analysis resulted in a rise in relative risk(OR 2.36,95%CI 1.09–5.15).In conclusion,for patients with established CHD,high baseline level of CysC is associated with increased risk of cardiovascular events and all-cause death during long-term follow-up. | Ruijian Li Panpan Hao Yuguo Chen Yun Zhang | 2014 | Chinese Science Bulletin2014，59，5： | 8 |
| 5 | Acute toxicity formation potential of benzophenone-type UV filters in chlorination disinfection process显示文摘Benzophenones(BPs) are a class of widely used UV filters, which have been frequently detected within multiple environmental matrices. Disinfection is a necessary process in water treatment processes. The transformation behaviors and toxicity changes of 14 BP-type UV filters during chlorination disinfection treatment were investigated in this study. A new index, the acute toxicity formation potential, was proposed to evaluate the toxicity changes and potential risks of BP-type UV filters during chlorination treatment. It was found that 13 of 14 BP-type UV filters exhibited toxicity decreases in the chlorination disinfection process, more or less, while one showed a toxicity increase. The toxicity changes were dependent on substitution effects, such that 2,4-di-hydroxylated or 3-hydroxylated BPs exhibited significant toxicity decreases after chlorination treatment due to the ready cleavage of the aromatic ring. Importantly, the acute toxicity changes could be duplicated in an ambient water matrix. | Qi Liu Zhenbin Chen Dongbin Wei Yuguo Du | 2014 | Journal of Environmental Sciences2014，26，2： | 5 |
| 6 | Different fates of avermectin and artemisinin in China显示文摘The 2015 Nobel Prize in Physiology or Medicine has been awarded to Youyou Tu,William C.Campbell and Satoshiōmura for the discoveries of artemisinin and avermectin.Their efficacy on parasitic disease treatment won the recognition of the whole world once again,revealing the dawning of the second'Golden age'in the development of natural products(http://gffzz090550501bae4aechkpnqxbwno5uv6xub.ffgz.tsg.suse.edu.cn/2u0Rb E).Although artemisinin | Jinsong Chen Jin Miao Mei Liu Xueting Liu Lianqun Bao Yuguo Jiang Deming Wang Qing Zhang Lixin Zhang | 2016 | Science China(Life Sciences)2016，59，6： | 4 |
| 7 | MATRIEX imaging:multiarea two-photon real-time in vivo explorer显示文摘Two-photon laser scanning microscopy has been extensively applied to study in vivo neuronal activity at cellular and subcellular resolutions in mammalian brains.However,the extent of such studies is typically confined to a single functional region of the brain.Here,we demonstrate a novel technique,termed the multiarea two-photon real-time in vivo explorer(MATRIEX),that allows the user to target multiple functional brain regions distributed within a zone of up to 12mm in diameter,each with a field of view(FOV)of ~200μm in diameter,thus performing two-photon Ca2+imaging with single-cell resolution in all of the regions simultaneously.For example,we demonstrate real-time functional imaging of single-neuron activities in the primary visual cortex,primary motor cortex and hippocampal CA1 region of mice in both anesthetized and awake states.A unique advantage of the MATRIEX technique is the configuration of multiple microscopic FOVs that are distributed in three-dimensional space over macroscopic distances(>1 mm)both laterally and axially but that are imaged by a single conventional laser scanning device.In particular,the MATRIEX technique can be effectively implemented as an add-on optical module for an existing conventional single-beam-scanning two-photon microscope without requiring any modification to the microscope itself.Thus,the MATRIEX technique can be readily applied to substantially facilitate the exploration of multiarea neuronal activity in vivo for studies of brain-wide neural circuit function with single-cell resolution. | Mengke Yang Zhenqiao Zhou Jianxiong Zhang Shanshan Jia Tong Li Jiangheng Guan Xiang Liao Bing Leng Jing Lyu Kuan Zhang Min Li Yan Gong Zhiming Zhu Junan Yan Yi Zhou Jian K Liu Zsuzsanna Varga Arthur Konnerth Yuguo Tang Jinsong Gao Xiaowei Chen Hongbo Jia | 2019 | Light(Science & Applications)2019，8，1： | 4 |
| 8 | A synthetical methodology for identifying pr ior ity pollutants in reclaimed water based on meta-analysis显示文摘Wastewater reclamation and reuse is an increasing global project,while the reclamation treatment on wastewater does not completely remove all pollutants in water.The residual pollutants in reclaimed water would cause potential risk on human health and ecosystem safety during the long-term use.It is impossible to analyze and control all pollutants one by one in practice,therefore,identification and control of priority pollutants will be efficient strategy to ensure the safe use of reclaimed water.An integrated three-step methodology for identifying priority pollutants in reclaimed water was proposed in this study.First,a comprehensive literature survey on the occurrence of pollutants in reclaimed water was conducted,and a dataset D PR for pollutants occurrence in reclaimed water was established,containing 1,113 pollutants.Second,611 chemicals that had been recommended as hazardous pollutants for various water bodies in previous literatures were summarized,and a dataset D HP for hazardous pollutants in water was obtained.Third,meta-analysis on these two datasets(D PR and D HP)was performed,a new dataset D HPR for hazardous pollutants in reclaimed water was established,including 265 candidates.Finally,59 substances out of dataset D HPR were identified as priority pollutants for reclaimed water based on their recommendation frequency.It is expected that this synthetical methodology will provide powerful support for scientific evaluating and managing water pollution and ensuring safe use of reclaimed water. | Feipeng Wang Dongbin Wei Miao Chen Shuang Peng Qiaorong Guo Xinyi Zhang Jun Liu Yuguo Du | 2022 | Journal of Environmental Sciences2022，34，2： | 2 |
| 9 | Biosynthesis of pmethoxyphenylacetic acid from p-methoxyphettylacetonitrile by immobilized Bacillus subtilis ZJB-063显示文摘 | CHEN Jing ZHENG Yuguo SHEN Yinchu | 2008 | Process Biochemistry2008，43，9： | 1 |
| 10 | Chinese kang as a domestic heating system in rural northern China-A review显示文摘 | Zhi Zhuang Yuguo Li Bin Chen ct al | 2009 | Energy and Building2009，2009，： | 1 |
| 11 | Natural ventilation in an enclosure induced by a heat source distributed uniformly over a vertical wall显示文摘 | Li Yuguo Mahoney J | 2001 | Building and Environment2001，，： | 1 |
| 12 | Citric acid production from the mash of dried sweet potato with its dregs by Aspergillus niger in an external-loop airlift bioreactor显示文摘 | Zheng Yuguo Wang Zhao Chen Xiaolong | | 0，，： | 1 |
| 13 | Chinese kang as a do- mestic heating system in rural northern China--A review显示文摘 | Zhi Zhuang Yuguo'Li Bin Chen Jiye Guo | 2009 | En- ergy and Buildings2009，，11： | 1 |
| 14 | A meta-analysis of the effects of statins on serum C-reactive protein in Chinese population with coronary heart disease or hyperlipidemia显示文摘There is little doubt that statins reduce cardiovascular events more than what the lipid lowering effect can account for. Additional mechanisms have been postulated including the anti-inflammatory effects manifested by reduced C-reactive protein (CRP). It is not known, however, whether statins can decrease CRP in Chinese population. The aim of this study is to investigate the effects of statins on serum CRP in Chinese patients with coronary heart disease (CHD) or hyperlipidemia. Trials were retrieved through Medline (1980 to May, 2009), bibliographies, and the author’s reference files limited to English-language articles. Data were extracted and meta-analysis was performed. Analysis showed statistically significant reduction in CRP after statin treatment (weighted mean difference [WMD] = -0.73, 95% confidence interval [CI] = [-0.80, -0.66], P < 0.00001) and lower CRP after statin treatment than non-statin routine treatment ([WMD] = -0.52, 95% CI [-0.86, -0.18], P = 0.002). In conclusion, statins significantly reduce serum CRP in Chinese population, which may contribute to statin-induced reduction in the cardiovascular risk in addition to the lipid lowering effect. | HAO PanPan CHEN YuGuo WANG XingLi XU Feng WANG JiaLi ZHANG Yun | 2009 | Chinese Science Bulletin2009，54，23： | 1 |
| 15 | Thermal storage performance analysis on Chinese kangs 显示文摘 | Zhuang Zhi Li Yuguo Chen Bin | 2009 | Energy and Buildings2009，41，4： | 1 |
| 16 | Chinese kang as a domestic heating system in rural northern China--A review 显示文摘 | Zhuang Zhi Li Yuguo Chen Bin | 2009 | Energy and Buildings2009，41，1： | 1 |
| 17 | Commodity chemicals derived from glycerol,an important biorefinery feedstock显示文摘 | Zheng Yuguo Chen Xiaolong Shen Yinchu | 2008 | Chemical Reviews2008，108，： | 1 |
| 18 | Buoyancy-driven displacement natural ventilation in a single-zone building with three-level openings 显示文摘 | Z D CHEN YUGUO LI | 2002 | Building and Environment2002，37，： | 1 |
| 19 | Some examples of solution multiplicity in natural ventilation显示文摘 | Li Yuguo Delsante A Chen Zhengdong | 2001 | Building and Environment2001，36，7： | 1 |
| 20 | Eliminating the original cargos of glioblastoma cell-derived small extracellular vesicles for efficient drug delivery to glioblastoma with improved biosafety显示文摘Tumor derived small extracellular vesicles(TsEVs)display a great potential as efficient nanocarriers for chemotherapy because of their intrinsic targeting ability.However,the inherited risks of their original cargos(like loaded proteins or RNAs)from parent cancer cells in tumor progression severely hinder the practical application.In this study,a saponin-mediated cargo elimination strategy was established and practiced in glioblastoma(GBM)cell-derived small extracellular vesicles(GBM-sEVs).A high eliminating efficacy of the cargo molecules was confirmed by systematic analysis of the original proteins and RNAs in GBM-sEVs.In addition,the inherited functions of GBM-sEVs to promote GBM progression vanished after saponin treatment.Moreover,the results of cellular uptake analysis and in vivo imaging analysis demonstrated that saponin treatment preserved the homotypic targeting ability of GBM-sEVs.Thus,we developed an efficient nanocarrier with improved biosafety for GBM suppression.Furthermore,doxorubicin(DOX)transported by the saponin-treated GBM-sEVs(sa-GBM-sEVs)displayed an effective tumor suppression in both subcutaneous and orthotopic GBM models of mouse.Collectively,this study provides a feasible way to avoid the potential protumoral risks of TsEVs and can advance the clinical application of TsEVs in chemotherapy. | Yuhang Guo Guowen Hu Yuguo Xia HaiYan Li Ji Yuan Juntao Zhang Yu Chen Hua Guo Yunlong Yang Yang Wang Zhifeng Deng | 2022 | Bioactive Materials2022，7，10： | 1 |
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