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| 1 | Association of cystatin C level and cardiovascular prognosis for patients with preexisting coronary heart disease:a meta-analysis显示文摘The association of circulating levels of cystatin C(CysC)and risk of recurrent cardiovascular events in patients with preexisting coronary heart disease are uncertain.To qualitatively and quantitatively address this issue,we performed a random meta-analysis of results from prospective studies on the topic.We searched electronic and printed sources(up to 16 October 2011)using keywords and retrieved articles for seven prospective studies according to the selection criteria.Data were abstracted and meta-analysis was performed using the random-effects model(RevMan 5.0.23 software).The cohorts involved 4,576 patients with preexisting coronary heart disease(CHD)and normal or mild chronic kidney disease,and follow-up ranged from 5.6 to 40.6 months.Highest versus lowest baseline CysC level was significantly associated with increased risk of cardiovascular events(OR 2.30,95%CI 1.80–2.94),all-cause mortality(OR 5.69,95%CI 3.70–8.74),but not with recurrent MI(OR 1.75,95%CI 0.77–4.00).In heterogeneity testing for studies reporting cardiovascular events and all-cause mortality,no significant heterogeneity was found,and exclusion of any single study did not alter the overall finding.For risk of recurrent MI,significant heterogeneity was found among the five trials(v2=13.16,P=0.01,I2=70%)and exclusion of the Taglieri et al.[12]study from the analysis resulted in a rise in relative risk(OR 2.36,95%CI 1.09–5.15).In conclusion,for patients with established CHD,high baseline level of CysC is associated with increased risk of cardiovascular events and all-cause death during long-term follow-up. | Ruijian Li Panpan Hao Yuguo Chen Yun Zhang | 2014 | Chinese Science Bulletin2014，59，5： | 8 |
| 2 | Mendelian randomization studies on atherosclerotic cardiovascular disease: evidence and limitations显示文摘Epidemiological research has revealed a galaxy of biomarkers, such as genes, molecules or traits, which are associated with increased risk of atherosclerotic cardiovascular diseases(ASCVD). However, the etiological basis remains poorly characterized.Mendelian randomization(MR) involves the use of observational genetic data to ascertain the roles of disease-associated risk factors and, in particular, differentiate those reflecting the presence or severity of a disease from those contributing causally to a disease. Over the past decade, MR has evolved into a fruitful approach to clarifying the causal relation of a biomarker with ASCVD and to verifying potential therapeutic targets for ASCVD. In this review, we selected high-quality MR studies on ASCVD, examined the causal relationship of a series of biomarkers with ASCVD, and elucidated the role of MR in validating biomarkers as a therapeutic target by comparing the results from MR studies and randomized clinical trials(RCTs) for the treatment of ASCVD. The good agreement between the results derived by MR and RCTs suggests that MR could be performed as a screening process before novel drug development. However, when designing and interpreting a MR study, the assumptions and limitations inherent in this approach should be taken into account. Novel methodological developments, such as sensitivity analysis, will help to strengthen the validity of MR studies. | Qin Hu Panpan Hao Qiji Liu Mei Dong Yaoqin Gong Cheng Zhang Yun Zhang | 2019 | Science China(Life Sciences)2019，62，6： | 4 |
| 3 | Influence mechanism of boron segregation on the microstructure evolution and hot ductility of super austenitic stainless steel S32654显示文摘Influence mechanism of B segregation on the microstructure evolution and hot ductility of S32654 at850-1250℃was systematically investigated through experimental research and theoretical calculation.The results demonstrated that the segregation of B at grain boundary(GB)played different roles in the microstructure evolution and hot ductility at various temperatures.At 850℃,B segregation inhibited Mo segregation at the GB and enhanced the GB cohesion.At 900-950℃,B segregation restricted the diffusion and segregation of Mo to the GB,inhibiting the precipitation ofσphase.At 1000-1050℃,B segregation accelerated the dislocation accumulation and limited the GB migration,promoting the nucleation and inhibiting the growth of DRX grains.At 1100-1150℃,B has little effect on the DRX due to sufficient energy supply by higher temperature.Under the above beneficial effects of B,the hot ductility of S32654 was improved to varying degrees at 850-1150℃.However,as the temperature increased to1200-1250℃,B segregation decreased the solidus temperature and enhanced the liquefaction cracking tendency,resulting in a deterioration of the hot ductility. | Jiangtao Yu Shucai Zhang Huabing Li Zhouhua Jiang Hao Feng Panpan Xu Peide Han | 2022 | Journal of Materials Science & Technology2022，，17： | 2 |
| 4 | Tunable Dynamic Black Phosphorus/Insulator/Si Heterojunction Direct-Current Generator Based on the Hot Electron Transport显示文摘Static heterojunction-based electronic devices have been widely applied because carrier dynamic processes between semiconductors can be designed through band gap engineering.Herein,we demonstrate a tunable direct-current generator based on the dynamic heterojunction,whose mechanism is based on breaking the symmetry of drift and diffusion currents and rebounding hot carrier transport in dynamic heterojunctions.Furthermore,the output voltage can be delicately adjusted and enhanced with the interface energy level engineering of inserting dielectric layers.Under the ultrahigh interface electric field,hot electrons will still transfer across the interface through the tunneling and hopping effect.In particular,the intrinsic anisotropy of black phosphorus arising from the lattice structure produces extraordinary electronic,transport,and mechanical properties exploited in our dynamic heterojunction generator.Herein,the voltage of 6.1 V,current density of 124.0 A/m^(2),power density of 201.0 W/m^(2),and energy-conversion efficiency of 31.4%have been achieved based on the dynamic black phosphorus/AlN/Si heterojunction,which can be used to directly and synchronously light up light-emitting diodes.This direct-current generator has the potential to convert ubiquitous mechanical energy into electric energy and is a promising candidate for novel portable and miniaturized power sources in the in situ energy acquisition field. | Yanghua Lu Sirui Feng Runjiang Shen Yujun Xu Zhenzhen Hao Yanfei Yan Haonan Zheng Xutao Yu Qiuyue Gao Panpan Zhang Shisheng Lin | 2019 | Research2019，，1： | 2 |
| 5 | Metal-organic-framework-derived formation of Co–N-doped carbon materials for efficient oxygen reduction reaction显示文摘Non-precious metal nitrogen-doped carbonaceous materials have attracted tremendous attention in the field of electrochemical energy storage and conversion.Herein,we report the designed synthesis of a novel series of Co-N-C nanocomposites and their evaluation of electrochemical properties.Novel yolkshell structured Co nanoparticles@polymer materials are fabricated from the facile coating polymer strategy on the surface of ZIF-67.After calcination in nitrogen atmosphere,the Co–N–C nanocomposites in which cobalt metal nanoparticles are embedded in the highly porous and graphitic carbon matrix are successfully achieved.The cobalt nanoparticles containing cobalt metal crystallites with an oxidized shell and/or smaller(or amorphous)cobalt-oxide deposits appear on the surface of graphitic carbons.The prepared Co–N–C nanoparticles showed favorable electrocatalytic activity for oxygen reduction reactions,which is attributed to its high graphitic degree,large surface area and the large amount existence of Co–N active sites. | Hao Tian Chi Zhang Panpan Su Zhangfeng Shen Hao Liu Guoxiu Wang Shaomin Liu Jian Liu | 2020 | Journal of Energy Chemistry2020，29，1： | 2 |
| 6 | Interfacial Built-In Electric Field-Driven Direct Current Generator Based on Dynamic Silicon Homojunction显示文摘Searching for light and miniaturized functional device structures for sustainable energy gathering from the environment is the focus of energy society with the development of the internet of things.The proposal of a dynamic heterojunction-based direct current generator builds up new platforms for developing in situ energy.However,the requirement of different semiconductors in dynamic heterojunction is too complex to wide applications,generating energy loss for crystal structure mismatch.Herein,dynamic homojunction generators are explored,with the same semiconductor and majority carrier type.Systematic experiments reveal that the majority of carrier directional separation originates from the breaking symmetry between carrier distribution,leading to the rebounding effect of carriers by the interfacial electric field.Strikingly,NN Si homojunction with different Fermi levels can also output the electricity with higher current density than PP/PN homojunction,attributing to higher carrier mobility.The current density is as high as 214.0 A/m^(2),and internal impedance is as low as 3.6 kΩ,matching well with the impedance of electron components.Furthermore,the N-i-N structure is explored,whose output voltage can be further improved to 1.3V in the case of the N-Si/Al2O3/N-Si structure,attributing to the enhanced interfacial barrier.This approach provides a simple and feasible way of converting low-frequency disordered mechanical motion into electricity. | Yanghua Lu Qiuyue Gao Xutao Yu Haonan Zheng Runjiang Shen Zhenzhen Hao Yanfei Yan Panpan Zhang Yu Wen Guiting Yang Shisheng Lin | 2020 | Research2020，，1： | 2 |
| 7 | A meta-analysis of the effects of statins on serum C-reactive protein in Chinese population with coronary heart disease or hyperlipidemia显示文摘There is little doubt that statins reduce cardiovascular events more than what the lipid lowering effect can account for. Additional mechanisms have been postulated including the anti-inflammatory effects manifested by reduced C-reactive protein (CRP). It is not known, however, whether statins can decrease CRP in Chinese population. The aim of this study is to investigate the effects of statins on serum CRP in Chinese patients with coronary heart disease (CHD) or hyperlipidemia. Trials were retrieved through Medline (1980 to May, 2009), bibliographies, and the author’s reference files limited to English-language articles. Data were extracted and meta-analysis was performed. Analysis showed statistically significant reduction in CRP after statin treatment (weighted mean difference [WMD] = -0.73, 95% confidence interval [CI] = [-0.80, -0.66], P < 0.00001) and lower CRP after statin treatment than non-statin routine treatment ([WMD] = -0.52, 95% CI [-0.86, -0.18], P = 0.002). In conclusion, statins significantly reduce serum CRP in Chinese population, which may contribute to statin-induced reduction in the cardiovascular risk in addition to the lipid lowering effect. | HAO PanPan CHEN YuGuo WANG XingLi XU Feng WANG JiaLi ZHANG Yun | 2009 | Chinese Science Bulletin2009，54，23： | 1 |
| 8 | Self-Floating Efficient Solar Steam Generators Constructed Using Super-Hydrophilic N,O Dual-Doped Carbon Foams from Waste Polyester显示文摘Solar evaporation is recognized as a prospective technique to produce freshwater from non-drinkable water using inexhaustible solar energy.However,it remains a challenge to fabricate low-cost solar evaporators with obviously reduced water evaporation enthalpy to achieve high evaporation rates.Herein,N,O dual-doped carbon foam(NCF)is fabricated from the lowtemperature carbonization of poly(ethylene terephthalate)(PET)waste by melamine/molten salts at 340℃.During carbonization,melamine reacts with carboxylic acids of PET degradation products to yield a crosslinking network,and then molten salts catalyze the decarboxylation and dehydration to construct a stable framework.Owing to rich N,O-containing groups,3D interconnected pores,super-hydrophilicity,and ultra-low thermal conductivity(0.0599 W m^(−1) K^(−1)),NCF not only achieves high light absorbance(ca.99%)and solar-to-thermal conversion,but also promotes the formation of water cluster to reduce water evaporation enthalpy by ca.37%.Consequently,NCF exhibits a high evaporation rate(2.4 kg m^(−2) h^(−1)),surpassing the-state-of-the-art solar evaporators,and presents good antiacid/basic abilities,long-term salt-resistance,and self-cleaning ability.Importantly,a large-scale NCF-based outdoor solar desalination device is developed to produce freshwater.The daily freshwater production amount per unit area(6.3 kg)meets the two adults’daily water consumption.The trash-to-treasure strategy will give impetus to the development of low-cost,advanced solar evaporators from waste plastics for addressing the global freshwater shortage. | Huiying Bai Ning Liu Liang Hao Panpan He Changde Ma Ran Niu Jiang Gong Tao Tang | 2022 | Energy & Environmental Materials2022，5，4： | 1 |
| 9 | Efficacy and safety of intensive insulin therapy for critically ill neurologic patients: A Meta-Analysis显示文摘 | Liang Shan Panpan Hao Yuguo Chen | 2011 | The Journal of Trauma Injury Infection and Critical Care2011，71，5： | 1 |
| 10 | Cardiomyocyte-specific knockout of ADAM17 ameliorates left ventricular remodeling and function in diabetic cardiomyopathy of mice显示文摘Angiotensin-converting enzyme 2(ACE2)has proven beneficial in attenuating diabetic cardiomyopathy(DCM)but has been found to be a substrate of a disintegrin and metalloprotease protein-17(ADAM17).However,whether ADAM17 plays a role in the pathogenesis and intervention of DCM is obscure.In this study,we created cardiomyocyte-specific knockout of ADAM17(A17^(α-MHCKO))mice,and left ventricular dimension,function,pathology and molecular biology were assessed in ADAM17^(fl/fl) control,A17^(α-MHCKO) control,ADAM17^(fl/fl) diabetic and A17^(α-MHCKO) diabetic mice.Both differentiated H9c2 cells and neonatal rat cardiomyocytes(NRCMs)were used to explore the molecular mechanisms underlying the effect of ADAM17 on DCM.The results showed that protein expression and activity of ADAM17 were upregulated whereas the protein expression of ACE2 was downregulated in the myocardium of diabetic mice.Cardiomyocyte-specific knockout of ADAM17 mitigated cardiac fibrosis and cardiomyocyte apoptosis and ameliorated cardiac dysfunction in mice with DCM.Bioinformatic analyses detected a number of genes enriched in metabolic pathways,in particular the AMPK signaling pathway,expressed differentially between the hearts of A17^(α-MHCKO)and ADAM17^(fl/fl)diabetic mice.The mechanism may involve activated AMPK pathway,increased autophagosome formation and improved autophagic flux,which reduced the apoptotic response in cardiomyocytes.In addition,hypoxia-inducible factor-1α(HIF-1α)might act as an upstream mediator of upregulated ADAM17 and ADAM17 might affect AMPK signaling viaα1 A-adrenergic receptor(ADRA1A).These results indicated that ADAM17 activity and ACE2 shedding were enhanced in DCM,which was reversed by cardiomyocyte-specific ADAM17 knockout.Thus,inhibition of ADAM17 may provide a promising approach to the treatment of DCM. | Fei Xue Jing Cheng Yanping Liu Cheng Cheng Meng Zhang Wenhai Sui Wenqiang Chen Panpan Hao Yun Zhang Cheng Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 1 |
| 11 | Laser-induced porous graphene on Polyimide/PDMS composites andits kirigami-inspired strain sensor显示文摘The laser-induced porous graphene(LIG)prepared in a straightforward fabrication method is presented,and its applications in stretchable strain sensors to detect the applied strain are also explored.The LIGformed on the polyimide/polydimethylsiloxane(PI/PDMS)composite exhibits a naturally high stretchabil-ity(over 30%),bypassing the transfer printing process compared to the one prepared by laser scribing onPI films.The PI/PDMS composite with LIG shows tunable mechanical and electronic performances withdifferent PI particle concentrations in PDMS.The good cyclic stability and almost linear response of theprepared LIG’s resistance with respect to tensile strain provide its access to wearable electronics.To im-prove the PDMS/PI composite stretchability,we designed and optimized a kirigami-inspired strain sensorwith LIG on the top surface,dramatically increasing the maximum strain value that in linear response toapplied strain from 3%to 79%. | Hao Wang Zifeng Zhao Panpan Liu Xiaogang Guo | 2021 | Theoretical & Applied Mechanics Letters2021，11，2： | 0 |
| 12 | High-temperature treatment to engineer the single-atom Pt coordination environment towards highly efficient hydrogen evolution显示文摘Development of high-performance and cost-effective catalysts for electrocatalytic hydrogen evolution reaction(HER)play crucial role in the growing hydrogen economy.Recently,the atomically dispersed metal catalysts have attracted increasing attention due to their ultimate atom utilization and great potential for highly cost-effective and high-efficiency HER electrocatalyst.Herein,we propose a hightemperature treatment strategy to furtherly improve the HER performance of atomically dispersed Ptbased catalyst.Interestingly,after appropriate high-temperature treatment on the atomically dispersed Pt0.8@CN,the Pt species on the designed N-doped porous carbon substrate with rich defect sites can be re-dispersed to single atom state with new coordination environment.The obtained Pt0.8@CN-1000 shows superior HER performance with overpotential of 13 m V at 10 m A cm^(-2)and mass activity of 11,284 m A/mgPtat-0.1 V,much higher than that of the pristine Pt0.8@CN and commercial Pt/C catalyst.The experimental and theoretical investigations indicate that the high-temperature treatment induces the restructuring of coordination environment and then the optimized Pt electronic state leads to the enhanced HER performances.This work affords new strategy and insights to develop the atomically dispersed high-efficiency catalysts. | Shanyong Chen Changchang Lv Ling Liu Muhong Li Jian Liu Jinyang Ma Panpan Hao Xuan Wang Weiping Ding Mingjiang Xie Xuefeng Guo | 2021 | Journal of Energy Chemistry2021，30，8： | 0 |
| 13 | An antibiotic composite electrode for improving the sensitivity of electrochemically active biofilm biosensor显示文摘Extensive research has been carried out for improved sensitivity of electroactive biofilm-based sensor(EAB-sensor),which is recognized as a useful tool in water quality early-warning.Antibiotic that is employed widely to treat infection has been proved feasible in this study to regulate the EAB and to increase the EAB-biosensor’s sensitivity.A novel composite electrode was prepared using azithromycin(AZM)and graphite powder(GP),namely AZM@GP electrode,and was employed as the anode in EAB-biosensor.Different dosages of AZM,i.e.,2 mg,4 mg,and 8 mg,referred to as 0.25%,0.5%and 1%AZM@GP were under examination.Results showed that EAB-biosensor was greatly benefited from appropriate dosage of AZM(0.5%AZM@GP)with reduced start-up time period,comparatively higher voltage output,more readable electrical signal and increased inhibition rate(30%-65%higher than control sensor with GP electrode)when exposing to toxic formaldehyde.This may be attributed to the fact that AZM inhibited the growth of non-EAM without much influence on the physiologic or metabolism activities of EAM under proper dosage.Further investigation of the biofilm morphology and microbial community analysis suggested that the biofilm formation was optimized with reduced thickness and enriched Geobacter with 0.5%AZM@GP dosage.This novel electrode is easily fabricated and equipped,and therefore would be a promising way to facilitate the practical application of EAB-sensors. | Shuyi Wang Xiang Qi Yong Jiang Panpan Liu Wen Hao Jinbin Han Peng Liang | 2022 | Frontiers of Environmental Science & Engineering2022，16，8： | 0 |
| 14 | Huoxue Jiedu Huayu recipe(活血解毒化瘀方)alleviates contralateral renal fibrosis in unilateral ureteral obstruction rats by inhibiting the transformation of macrophages to myofibroblast显示文摘OBJECTIVE:To investigate the action and underlying mechanisms of Huoxue Jiedu Huayu recipe(活血解毒化瘀方,HJHR)against unilateral ureteral obstruction(UUO)-induced injury in the contralateral kidney.METHODS:Forty-eight male Sprague-Dawley rats weighing(200±10)g were used in this study and randomly assigned to 4 groups:a sham group,a UUO group,a UUO+eplerenone(EPL)group,and a UUO+HJHR group.The contralateral kidneys were harvested for further study 180 d after surgery.Histological analysis,immunohistochemistry and immunofluorescence were used to study the fibrosis of the contralateral kidneys obtained from UUO rats.Contralateral kidney damagerelated pathway proteins were detected by real-time polymerase chain reaction and Western blot analysis.RESULTS:HJHR significantly inhibited fibrosis of the contralateral kidney in UUO rats by attenuating the UUOinduced macrophage-to-myofibroblast transition(MMT)in the contralateral kidney.Moreover,HJHR attenuated fibrosis in the contralateral kidney of UUO rats by preventing MMT through the aldosterone/mineralocorticoid receptor/serum/glucocorticoid regulated kinase 1 pathway.CONCLUSIONS:Our findings suggest that HJHR may be a potential treatment for renal interstitial fibrosis of obstructive nephropathy. | XIONG Yunzhao LIU Lingjin LIU Ziqian CHEN Gege HAO Juan GAO Xiaomeng QIANG Panpan WANG Zheng XU Qingyou | 2023 | Journal of Traditional Chinese Medicine2023，43，1： | 0 |
| 15 | HHV-6B infection after umbilical cord blood stem cell transplantation with pruritus as the first symptom显示文摘Bone marrow hematopoietic stem cell transplantation(BMT)is one of the most effective treatments for hematological malignancies,and cord blood hematopoietic stem cell transplantation is one of them[1].Human herpesvirus-6B(HHV-6B)is known as a series of broadly widespread herpes viruses.Primary infection occurs in infants and young children.After infection,the virus is in a state of quiescence,and often reactivates after bone marrow transplantation with a decline in immunity[2]. | Bin Xu Yan Jia Linlin Lv Lulu Chen Panpan Cheng Saisai Ren Haihui Liu Min Zhang Hao Zhang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，10： | 0 |
| 16 | A soft and stretchable electronics using laser-induced graphene on polyimide/PDMS composite substrate显示文摘The one-step fabricated laser-induced graphene(LIG)has the advantages of low cost,patterning of various desired geometries,and high sensitivity.However,the robustness of substrates imposes certain constraints on their applications in stretchable devices.In this paper,the substrate composed of polydimethylsiloxane(PDMS)and polyimide(PI)particles is proposed to serve as the platform to manufacture LIG.Ascribing to the inherent soft and stretchable attributes of the PI/PDMS composite substrate,the LIG based sensors can fit complex 3D configurations or bear a mechanical tension over 15%.Notably,the fluence of the laser is experimentally and theoretically determined as the only principle to characterize the formation of conductive LIG on PI/PDMS composite greatly facilitating the selection of the allowable laser scanning parameters to form the desired LIG-based devices.Three demonstrations are conducted to highlight the superiority and the potential of this soft and stretchable LIG-based system in wearable electronics and soft robots. | Hao Wang Zifen Zhao Panpan Liu Xiaogang Guo | 2022 | npj Flexible Electronics2022，6，1： | 0 |
| 17 | External-to-internal synergistic strategy to enable multi-scale stabilization of LiCoO_(2)at high-voltage显示文摘High-voltage LiCoO_(2)(LCO)offers a prelude to breaking the bottleneck of the energy density of lithium-ion batteries,however,LiCoO_(2)is subject to serious structural and interfacial degradation above voltages>4.55 V(vs.Li/Li^(+)).Herein,an in-situ Li_(6.25)La_(3)Zr_(2)A_(l0.25)O_(12)(LLZAO)layer is constructed on the LCO surface to achieve operating voltage at 4.6 V.The detailed characterizations(ex-situ XRD,ex-situ Raman,DFT,etc.)reveal that the LLZAO layer greatly enhances Li+conductivity attributed to the ionconducting layer on the surface/interface,and closely combines with LiCoO_(2)particle to ensure stable cathode/electrolyte interface,thus suppressing the highly reactive Co^(4+)and O^(-)triggered surface side reactions at high-voltage.Moreover,the introduction of La^(3+)/Zr^(4+)/Al^(3+)with a larger ionic radius(La^(3+)/Zr^(4+)are larger than Co^(3+))and weaker electronegativity(La/Zr/Al are weaker than Co)into Co^(3+)sites readjusts the electron cloud density between Co–O–Li,which reinforces the Co–O bond and widens the band-center gap of Co 3d and O 2p,thus restraining the detrimental phase transition(from H3 to H1-3 phase)and the formation of Co_(3)O_(4)spinel phase(attributed to lattice oxygen release),subsequently alleviating the particle cracking and structural collapse during repeated Li^(+)de/intercalation.Therefore,after 100 cycles at 3.0–4.6 V,LCO@1.0LLZAO exhibits a superior discharge capacity of 188.5 m A h g^(-1),with a capacity retention of 85.1%.The above research has brought about meaningful guidance for the evolution of cathode materials with high voltage. | Shuaipeng Hao Yunjiao Li Jiachao Yang Shan Wang Zhouliang Tan Xiaoming Xi Zhenjiang He Panpan Zhang | 2023 | Journal of Energy Chemistry2023，，1： | 0 |
| 18 | The optimal anticoagulation strategy for COVID-19,prophylactic or therapeutic?:a meta-analysis,trial sequential analysis,and meta-regression of more than 27,000 participants显示文摘Background:Anticoagulants are promising regimens for treating coronavirus disease 2019(COVID-19).However,whether prophylactic or intermediate-to-therapeutic dosage is optimal remains under active discussion.Methods:We comprehensively searched PubMed,Embase,Scopus,Web of Science,Cochrane Library,ClinicalTrials,and MedRxiv databases on April 26,2022.Two independent researchers conducted literature selection and data extraction separately according to predetermined criteria.Notably,this is the first meta-analysis on COVID-19,taking serious consideration regarding the dosage overlap between the 2 comparison groups of prophylactic anticoagulation(PA)and intermediate-to-therapeutic anticoagulation(I-TA).Results:We included 11 randomized controlled trials(RCTs)and 36 cohort studies with 27,051 COVID-19 patients.By analyzing all the RCTs,there was no significant difference in mortality between the PA and I-TA groups,which was further confirmed by trial sequential analysis(TSA)(odds ratio[OR]:0.93;95%confidence interval[CI]:0.71–1.22;P=0.61;TSA adjusted CI:0.71–1.26).The rate of major bleeding was remarkably higher in the I-TA group than in the PA group,despite adjusting for TSA(OR:1.73;95%CI:1.15–2.60;P=0.009;TSA adjusted CI:1.09–2.58).RCTs have supported the beneficial effect of I-TA in reducing thrombotic events.After including all studies,mortality in the I-TA group was significantly higher than in the PA group(OR:1.38;95%CI:1.15–1.66;P=0.0005).The rate of major bleeding was similar to the analysis from RCTs(OR:2.24;95%CI:1.86–2.69;P<0.00001).There was no distinct difference in the rate of thrombotic events between the 2 regimen groups.In addition,in both critical and noncritical subgroups,I-TA failed to reduce mortality but increased major bleeding rate compared with PA,as shown in meta-analysis of all studies,as well as RCTs only.Meta-regression of all studies suggested that there was no relationship between the treatment effect and the overall risk of mortality or major bleeding(P=0.14,P=0.09,respectively).Conclusion:I-TA is not superior to PA for treating COVID-19 because it fails to lower the mortality rate but increases the major bleeding rate in both critical and noncritical patients. | Mingyue Guo Qi Han Jiaxuan Xing Feng Xu Jiali Wang Chuanbao Li Zechen Shan Yuan Bian Hao Wang Li Xue Qiuhuan Yuan Chang Pan Yanshan De Xingfang Wang Panpan Hao Shengchuan Cao Jiaojiao Pang Yuguo Chen | 2022 | Emergency and Critical Care Medicine2022，2，3： | 0 |
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