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| 1 | Efficient production of chemicals from microorganism by metabolic engineering and synthetic biology显示文摘The use of traditional chemical catalysis to produce chemicals has a series of drawbacks,such as high dependence on fossil resources,high energy consumption,and environmental pollution.With the development of synthetic biology and metabolic engineering,the use of renewable biomass raw materials for chemicals synthesis by constructing efficient microbial cell factories is a green way to replace traditional chemical catalysis and traditional microbial fermentation.This review mainly summarizes several types of bulk chemicals and high value-added chemicals using metabolic engineering and synthetic biology strategies to achieve efficient microbial production.In addition,this review also summarizes several strategies for effectively regulating microbial cell metabolism.These strategies can achieve the coupling balance of material and energy by regulating intracellular material metabolism or energy metabolism,and promote the efficient production of target chemicals by microorganisms. | Yang Zhang Jing Yu Yilu Wu Mingda Li Yuxuan Zhao Haowen Zhu Changjing Chen Meng Wang Biqiang Chen Tianwei Tan | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 2 |
| 2 | Review of Lagrangian stochastic models for turbulent combustion显示文摘Predictive simulation of the combustion process in engine is crucial to understand the complex underlying physicochemical processes, improve engine performance, and reduce pollutant emissions. Key issues such as the physical modeling of the interaction between turbulence, chemistry and droplets, and the incorporation of the detailed chemistry in high-fidelity simulations of complex flows remain essential though challenging. This paper reviews the transported probability density function method for turbulent dilute spray flames in the dual-Lagrangian framework that shows potential to address some critical modeling issues. An overview is presented for the contributions made within the last decade or so for the three key ingredients for modeling the interaction between turbulence, chemistry and droplets, i.e., micro-mixing, subgrid dispersion and two-phase coupling. Then, various methods for detailed chemistry acceleration are reviewed to address the issue of high computational cost for its use in multidimensional simulations. Finally, some applications of the dual-Lagrangian method in both laboratory-scale and device-scale configurations are provided to demonstrate its capability as well as deficiency at the current stage. Some open modeling challenges are raised and recommended for further investigation. | Tianwei Yang Yu Yin Hua Zhou Zhuyin Ren | 2021 | Acta Mechanica Sinica2021，37，10： | 2 |
| 3 | Differential gene network analysis from single cell RNA-seq显示文摘Study of gene expression has been arguably the most activeresearch field in functional genomics. Over the last two decades,various high-throughput technologies, from gene expressionmicroarray to RNA-seq, have been widely applied to the whole-genome profiling of gene expression. The commonality of these ex-periments is that they measure the gene expression levels of"bulk"sample, which pools a large number (often in the scale of millions)of cells, and thus the measurements reflect the average expressionof a population of cells. | Yikai Wang Hao Wu Tianwei Yu | 2017 | Journal of Genetics and Genomics2017，44，6： | 2 |
| 4 | An novel immobilization method of Saccharomyces cerevisiae to sorghum bagasse for ethanol production 显示文摘 | YU Jianliang ZHANG Xu TAN Tianwei | 2007 | J Biotech2007，129，3： | 1 |
| 5 | Ethanol production by solid state fermentation of sweet sorghum using thermotolerant yeast strain显示文摘 | Yu Jianliang Zhang Xu Tan Tianwei | 2008 | Fuel Processing Technology2008，89，11： | 1 |
| 6 | Characteristics of an Immobilized Yeast Cell System Using Very High Gravity for the Fermentation of Ethanol显示文摘 | Hairui Ji Jianliang Yu Xu Zhang Tianwei Tan | 2012 | Applied Biochemistry and Biotechnology2012，，1： | 1 |
| 7 | An novel immobilization method of Saccharomyces cerevisiae to sorghum bagasse for ethanol production显示文摘 | Jianliang Yu Xu Zhang Tianwei Tan | 2007 | Journal of Biotechnology2007，，3： | 1 |
| 8 | ^(234)U/^(238)U as a potential tracer for tracking water masses mixing in the northern East China Sea显示文摘The optimum multiparameter(OMP) method was often used to determine the percentages of water masses based on temperature, salinity and other parameters, like nutrient or dissolved oxygen(DO). There are a number of water masses in the East China Sea(ECS), a marginal sea of the western Pacific Ocean. However, it is difficult to clarify the proportion of water masses using traditional parameters, such as temperature, salinity, nutrient or DO because of the occurring of intensive biogeochemical processes in the near shore and shelf areas. Here, we reported the use of ^(234)U/^(238)Uactivity ratio embedded in the OMP method. The results indicate that seawater in the northern ECS mainly consisted of the estuarine water of Changjiang River(CEW), Kuroshio water(KW), and Yellow Sea Coastal Current(YSCC). In March 2017, the CEW only influenced the offshore waters shallower than30 m;the KW affected the east edge and the YSCC contributed more than 75% in the northern ECS. | Tianwei Shang Xueyan Jiang Chenqing Yu | 2021 | Acta Oceanologica Sinica2021，40，4： | 1 |
| 9 | Hierarchical clustering of high-throughput expression data based on general dependences显示文摘 | Yu Tianwei Peng H S | 2013 | IEEE/ACM Trans on Computational Biology and Bioinformatics2013，10，4： | 1 |
| 10 | Decentralized robust control of building structures under seismic excitations 显示文摘 | MA Tianwei XU Ningshou TANG Yu | 2008 | Earth Quake Engineering and Structural Dynamics2008，37，1： | 1 |
| 11 | Immobilized lipase Y1Lip2-catalyzed resolution of (±)α-phenylethyl amine in a medium with organic cosolvent显示文摘 | Wen Sai Tan Tianwei Yu Mingrui | 2008 | Process Biochemistry2008，43，11： | 1 |
| 12 | Volitinib, a potent and highly selective c-Met inhibitor, effectively blocks c-Met signaling and growth in c-MET amplified gastric cancer patient-derived tumor xenograft models显示文摘 | Paul R. Gavine Yongxin Ren Lu Han Jing Lv Shiming Fan Wei Zhang Wen Xu Yuan Jie Liu Tianwei Zhang Haihua Fu Yongjuan Yu Huiying Wang Shirlian Xu Feng Zhou Xinying Su XiaoLu Yin Liang Xie Linfang Wang Weiguo Qing Longxian Jiao Weiguo Su Q. May Wang | 2014 | Molecular Oncology2014，，： | 1 |
| 13 | Ethanol production from sweet sorghum residual显示文摘In this work,the ethanol production from sweet sorghum residue was studied.Sweet sorghum res-idue was hydrolyzed with phosphoric acid under mild conditions.The liquid hydrolysate was fermented by Pachysolen tannophilus,and the hydrolysis residue was fermented by the simultaneous saccharification and fer-mentation(SSF)using Saecharomyces cerevisiae with cel-lulase(60 FPU/g dry materials).Orthogonal experiments were carried out to investigate the effects of main reaction condition factors,such as temperature,acid concentra-tion,time and dry-matter content,on the reducing sugar yield.The results show that the optimal reaction condi-tions should be 120℃,80 g/L,80 min and 10%,respect-ively.Under these conditions,0.3024 g reducing sugar/g dry material was obtained.The liquid hydrolysate was then fermented by P.tannophilus with the highest ethanol concentration of 14.5 g/L.At a water-insoluble solid con-centration of 5%,5.4 g/L ethanol was obtained after 12 h of SSF.The total ethanol yield was 0.147 g/g dry material,which would be beneficial for the application of ethanol production from sweet sorghum residue. | Jingyang BAN Jianliang YU Xu ZHANG Tianwei TAN | 2008 | Frontiers of Chemical Science and Engineering2008，2，4： | 0 |
| 14 | Numerical simulation on the frosting and heat transfer characteristics of plate-fin heat exchanger considering confinement effect显示文摘In refrigerating industry,frost commonly deposits on the confined cold surfaces of heat exchangers,which affects the heat transfer performance.Along the confined flow path of the heat exchanger,the frosting at downstream is affected by the parameters from the upstream.In this study,a numerical model considering the confinement effect has been proposed to predict frosting characteristics in plate-fin heat exchanger.Convection-diffusion equations for humid air and empirical correlations for local frost density are employed in the numerical prediction.Frosting behavior and heat transfer in the confined channel are investigated with different humid air parameters and cold surface temperatures.The results indicate that frost thickness in the confined channel is thicker than that in open space under the same inlet parameters.The frost layer is thicker and fluffier along the confined channel.In addition,the air temperature difference between inlet and outlet of the confined channel enlarges with frosting.Under the same average temperature of upper and lower surfaces,the heat and mass transfer of frosting are enhanced with diminishing temperature difference of upper and lower surfaces.In such condition,frosting is mainly influenced by the cold surface with the lower temperature. | Xiaoling Yang Xue Liu Xiaojun Dong Yang Meng Yu Hou Tianwei Lai | 2022 | Energy Storage and Saving2022，1，3： | 0 |
| 15 | Numerical prediction of spatio-temporal frosting patterns of curved surface considering varying working parameters显示文摘Accurate numerical prediction of frosting patterns is essential for the efficient layout and timing defrosting of heat exchangers under frosting conditions.In this study,a numerical model is developed to predict the spatio-temporal frosting habits on curved surfaces in combination with the correlations of frost density and thermal conductivity.In the model,frost melting is considered.After verification,the frosting and heat transfer characteristics along the flow path are investigated under various structural and operating conditions.Frost thickness along the path is mainly affected by the cooling surface temperature,while the heat and mass transfer rates are strongly correlated with the humidity ratio.The proportions of latent heat and sensible heat are distributed more unevenly in parallel flow case than in counter flow case.Frost deposition is facilitated by a smaller radius of curvature of the cooling surface.More uniform frosting characteristics along the path and smaller heat transfer obstruction are presented with a smaller length-to-height ratio of the flow path. | Xue Liu Xiaojun Dong Shaohang Yan Yu Hou Tianwei Lai | 2023 | Energy Storage and Saving2023，2，1： | 0 |
| 16 | Flexible Transparent Electrochemical Energy Conversion and Storage: From Electrode Structures to Integrated Applications显示文摘The rapid progress of flexible electronics tremendously stimulates the urgent demands for the matching power supply systems. Flexible transparent electrochemical energy conversion and storage devices (FT–EECSDs), with endurable mechanical flexibility, outstanding optical transmittance, excellent electrochemical performance, and additional intelligent functions, are considered as preferable energy supplies for future self-powered flexible electronic systems. A comprehensive review of the reasonable design of flexible transparent electrode and recent progress on the FT–EECSDs is presented herein. The manufacturing techniques of generally classified three types of flexible transparent electrodes are systematically summarized. Emphasis is given to the recent developments in the transparent solid-state electrolyte, flexible transparent energy conversion, and storage devices. The standard evaluation methods and reasonable evaluation parameters to evaluate the flexibility and transparency of FT–EECSDs are highlighted. Additionally, the typical integrated applications of FT–EECSDs are also described. Finally, the current challenges and a future perspective on the research and development direction are further outlined. | Yanli Zhao Huaizhi Liu Yu Yan Tianwei Chen Huihuang Yu Lucky Ogheneakpobo Ejeta Guanhua Zhang Huigao Duan | 2023 | Energy & Environmental Materials2023，6，1： | 0 |
| 17 | Multivalent neuraminidase hydrolysis resistant triazole-sialoside protein conjugates as influenza-adsorbents显示文摘We report the synthesis of pseudo triazole-sialoside protein conjugates of various valency that are resistant to neuraminidase for the adsorption of influenza viruses. The glycotriazole monomer bearing an amine-functionalized linker was synthesized by click chemistry and grafted to the lysine residues of bovine serum albumin(BSA) or human serum albumin(HSA) via diethyl squarate and adipate-based strategy. The binding of hemagglutinin(HA) and neuraminidase(NA) on the virion surface by the synthetic neoglycoproteins were evaluated by hemagglutination and neuraminidase inhibition assay,respectively. The results demonstrated that these synthetic glycoproteins have significantly higher affinity with NA than HA. The interactions between these neoglycoproteins and intact influenza viruses were further investigated by Dynamic Light Scattering(DLS) technique. The pronounced agglutination indicated that these glycoconjugates can be used as adsorbents to prevent virus from invading host cells as well as the release of newly synthesized viral particles, which are crucial in the life cycle of the influenza virus. With the high binding affinity to intact influenza viruses, these neoglycoproteins can also be used as probe to elucidate the molecular mechanism of the sialic acid-influenza recognition and biosensors for influenza detection. | Xin Meng Meibing Yang Yang Li Xiaobin Li Tianwei Jia Haojie He Qun Yu Na Guo Yun He Peng Yu Yang Yang | 2018 | Chinese Chemical Letters2018，29，1： | 0 |
| 18 | WCM-WTrA:A Cross-Project Defect Prediction Method Based on Feature Selection and Distance-Weight Transfer Learning显示文摘Cross-project defect prediction is a hot topic in the field of defect prediction.How to reduce the difference between projects and make the model have better accuracy is the core problem.This paper starts from two perspectives:feature selection and distance-weight instance transfer.We reduce the differences between projects from the perspective of feature engineering and introduce the transfer learning technology to construct a cross-project defect prediction model WCM-WTrA and multi-source model Multi-WCM-WTrA.We have tested on AEEEM and ReLink datasets,and the results show that our method has an average improvement of 23%compared with TCA+algorithm on AEEEM datasets,and an average improvement of 5%on ReLink datasets. | LEI Tianwei XUE Jingfeng WANG Yong NIU Zequn SHI Zhiwei ZHANG Yu | 2022 | Chinese Journal of Electronics2022，31，2： | 0 |
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