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| 1 | Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome显示文摘Hutchinson-Gilford 早衰症候群(HGPS ) 和沃纳症候群(WS ) 是二最好描绘的人的 progeroid 症候群。HGPS 被一个点变化在 lamin A (LMNA ) 基因引起,导致截断的蛋白质 productprogerin 的生产。WS 被变化在 WRN 基因引起,编码 loss-of-function RecQ DNA helicase。这里,由基因编辑,我们创造了 isogenic 人的胚胎的干细胞(转换字符) 与异质接合(G608G/+) 或同型结合(G608G/G608G ) LMNA 变化和 biallelic WRN 大美人为为 HGPS 和 WS 致病建模,分别地。当转换字符和 endothelial 房间(EC ) 没介绍早熟的老朽的任何特征时, HGPS 间充质、 WS 间充质的干细胞(MSC ) 与不同动力学显示出联系老化的显型。当 HGPS-MSCs 展出了迟了发作的尖锐早衰 characterisitcs 时, WS-MSCs 有早发作的温和早衰显型。一起拿,我们的学习比较并且形成对照不同病理 underpinning 二早衰混乱,并且提供可靠干细胞为病理学、生理的老化识别新治疗学的策略的基于的模型。 | Zeming Wu Weiqi Zhang Moshi Song Wei Wang Gang Wei Wei Li Jinghui Lei Yu Huang Yanmei Sang Piu Chan Chang Chen Jing Qu Keiichiro Suzuki Juan Carlos Izpisua Belmonte Guang-Hui Liu | 2018 | Protein & Cell2018，9，4： | 15 |
| 2 | CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs显示文摘 | Lixia Wang Fei Yi Lina Fu Jiping Yang Si Wang Zhaoxia Wang Keiichiro Suzuki Liang Sun Xiuling Xu Yang Yu Jie Qiao Juan Carlos Izpisua Belmonte Ze Yang Yun Yuan Jing Qu Guang-Hui Liu | 2017 | Protein & Cell2017，8，5： | 10 |
| 3 | Development of highly active coated monolith SCR catalyst with strong abrasion resistance for low-temperature application显示文摘与 V 2 O 5-WO3/TiO2 被改变文件夹和涂层厚度准备。与独块巨石作比较与 100% V 2 O 5-WO3/TiO2 粉末,有 260 的催化剂涂层层的涂的独块巨石吗? | Lina GAN Shan LEI Jian YU Hongtao MA Yo YAMAMOTO Yoshizo SUZUKI Guangwen XU Zhanguo ZHANG | 2015 | Frontiers of Environmental Science & Engineering2015，9，6： | 4 |
| 4 | Visualization of aging-associated chromatin alterations with an engineered TALE system显示文摘在实时房间的特定的 genomic loci 的可视化在多样的生物过程期间是为在染色质建筑学的动态变化的调查的一个前提,例如细胞的老化。然而,当前的精确 genomic 成像方法被缺乏妨碍荧光灯有高特性和 signal-to-noise 的探针形成对照。我们发现那常规抄写像使活跃之物的受动器(故事) 趋于形成蛋白质总数,从而在成像应用程序损害他们的性能。通过屏蔽,我们发现有故事的那熔化 thioredoxin 阻止了总数形成,开基于故事的 genomic 成像的完整的力量。用熔化 thioredoxin 的故事(TTALE ) ,我们在各种各样的 genomic loci 完成了高质量的成像并且观察联系老化(epi ) 在在人和老鼠早衰模型的 telomeres 和着丝点的 genomic 改变。重要地,我们鉴别 ribosomal DNA 的摩擦为人的老化作为一个分子的标记重复。我们的学习为精确在 vitro 并且在 vivo 监视染色质动力学建立一个简单、柔韧的成像方法。 | Ruotong Ren Liping Deng Yanhong Xue Keiichiro Suzuki Weiqi Zhang Yang Yu Jun Wu Liang Sun Xiaojun Gong Huiqin Luan Fan Yang Zhenyu Ju Xiaoqing Ren Si Wang Hong Tang Lingling Geng Weizhou Zhang Jian Li Jie Qiao Tao Xu Jing Qu Guang-Hui Liu | 2017 | Cell Research2017，27，4： | 4 |
| 5 | 一种基于sEMG评估上肢康复机器人有效性的方法显示文摘将表面肌电信号(sEMG)运用到上肢康复机器人的有效性评估方面,提供一种方便有效的针对外骨骼康复机器人的训练效果评估方法,有利于针对不同机械结构的外骨骼机器人采用不同的康复医疗方案。利用肌电信号时域分析的积分机电值iEMG和均方根值RMS等肌电信号特征,并结合对肌电图的分析设计出针对六自由度上肢外骨骼机器人的对应训练方案,并对该套机器人系统进行科学的有效性评估。 | 王源 于海龙 Suzuki Hiroyuki 谢叻 Yu Wenwei 李海丽 | 2013 | 中国数字医学2013，8，2： | 3 |
| 6 | Epididymis-specific lipocalin promoters显示文摘我们的目标是译解序列它 DNA 为附睾基因的 tissue-specificexpression 被要求。至少 6 epididymis 特定的 lipocalin 基因被知道。这些不同地在附睾被调整并且区域化。Lipocalin 5 (Lcn5 或 mE-RABP ) andLipocalin (Lcn8 或 mEP17 ) 8 是属于 epididymis 特定的 lipocalin 基因簇的相应基因。两个都, Lcn5 基因和 5.3 kb 倡导者的 5 kb 倡导者碎片直接 theLcn8 基因罐头碎裂在附睾(到远侧的头的 Lcn5 和到起始的片断的 Lcn8 ) 的 transgene 表示,显示这些倡导者碎片为 epididymis 特定的基因表示包含重要 cis-regulatoryelement。为了定义,推进调整基因表示的碎片, Lcn5 倡导者在转基因的鼠标被检查并且使附睾房间线不朽。在连续删除以后, Lcn5 基因的 1.8 kb 倡导者碎片是在转基因的老鼠的足够的 fortissue 特定、区域特定的基因表示。短暂 transfectionanalysis 表明抄写因素叉头框 A2 ( Foxa2 )与雄激素受体交往并且绑在 Lcn5 倡导者 activity.Immunohistochemistry 感应的雄激素依赖者显示了的 kb 和 1.3 kb 和 thatFoxa2 表示禁止的在 1.2 之间的 Lcn5 倡导者的 100 bp 碎片在附睾的 Foxa2 的一个限制表达式在哪儿 endogenousLcn5 基因表示被压制并且 Lcn5 倡导者的 Foxa2 抑制与在语料库和尾的 Lcn5 的表示的缺乏一致。我们的途径为附睾 lipocalin 基因规定的进一步的分析和 epididymalfunction 的灵活控制提供基本策略。 | Kichiya Suzuki Xiuping Yu Pierre Chaurand Yoshihiko Araki Jean-Jacques Lareyre Richard M. Caprioli Marie-Claire Orgebin-Crist Robert J. Matusik | 2007 | Asian Journal of Andrology2007，9，4： | 3 |
| 7 | Atomically phase-matched second-harmonic generation in a 2D crystal显示文摘Second-harmonic generation(SHG)has found extensive applications from hand-held laser pointers to spectroscopic and microscopic techniques.Recently,some cleavable van der Waals(vdW)crystals have shown SHG arising from a single atomic layer,where the SH light elucidated important information such as the grain boundaries and electronic structure in these ultra-thin materials.However,despite the inversion asymmetry of the single layer,the typical crystal stacking restores inversion symmetry for even numbers of layers leading to an oscillatory SH response,drastically reducing the applicability of vdW crystals such as molybdenum disulfide(MoS_(2)).Here,we probe the SHG generated from the noncentrosymmetric 3R crystal phase of MoS_(2).We experimentally observed quadratic dependence of second-harmonic intensity on layer number as a result of atomically phase-matched nonlinear dipoles in layers of the 3R crystal that constructively interfere.By studying the layer evolution of the A and B excitonic transitions in 3R-MoS_(2) using SHG spectroscopy,we also found distinct electronic structure differences arising from the crystal structure and the dramatic effect of symmetry and layer stacking on the nonlinear properties of these atomic crystals.The constructive nature of the SHG in this 2D crystal provides a platform to reliably develop atomically flat and controllably thin nonlinear media. | Mervin Zhao Ziliang Ye Ryuji Suzuki Yu Ye Hanyu Zhu Jun Xiao Yuan Wang Yoshihiro Iwasa Xiang Zhang | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 8 | Pedunculated gastric tube interposition in an esophageal cancer patient with prepyloric adenocarcinoma显示文摘Gastric carcinoma is one of the malignancies that are most frequently associated with esophageal carcinoma.We describe herein our device for advanced esophageal cancer associated with early gastric cancer in the antrum.A 57-year-old man presenting with dysphagia and upper abdominal pain was admitted to our hospital.Preoperative examinations revealed locally advanced squamous cell carcinoma (SCC) of the middle thoracic esophagus (T3N0M0 Stage ⅡA) and mucosal signetring cell carcinoma of the gastric antrum (T1N0M0 Stage ⅠA).Although the gastric tumor appeared to be an intramucosal carcinoma,its margin was obscure,so endoscopic en-bloc resection was considered inadequate.We chose surgical resection of the gastric tumor as well as the esophageal SCC after neoadjuvant chemotherapy with 5-fluorouracil and cisplatin for advanced esophageal cancer.Following transthoracic esophagectomy with three-field lymph node dissection,the gastric carcinoma was removed by gastric antrectomy,which preserved the right gastroepiploic vessels,and a pedunculated short gastric tube was used as the esophageal substitute.Twenty-eight months after the surgery,the patient is well with no evidence of cancer recurrence.Because it minimizes surgical stress and organ sacrifice,gastric tube interposition is a potentially useful technique for esophageal cancer associated with localized early gastric cancer. | Tatsuo Kanda Yu Sato Kazuhito Yajima Shin-ichi Kosugi Atsushi Matsuki Takashi Ishikawa Takeo Bamba Hajime Umezu Tsutomu Suzuki Katsuyoshi Hatakeyama | 2011 | World Journal of Gastrointestinal Oncology2011，3，5： | 2 |
| 9 | CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system显示文摘 | Suzuki T Kiyokawa N Taguchi T Sekino T Katagiri YU Fujimoto J | 2001 | J Immunol2001，166，： | 1 |
| 10 | Recovery of Hot Ductility by Improving Thermal Pattern of Continuously Cast Low Carbon and Ultra Low Carbon Steel Slabs for Hot Direct Rolling显示文摘 | Suzuki M Yu C H Shibata H | 1997 | IS1J International1997，37，9： | 1 |
| 11 | Anti- AIDS agents 66: Synthesis and anti-HIV activity of phenolic and aza 3' ,d'-di-O-( - )-comphanoyl-( + )-cis- khellactone (DCK) derivatives 显示文摘 | Suzuki M Yu DL Morris-Natschke SL | 2007 | Bioorg Med Chem2007，15，： | 1 |
| 12 | Prognosis of recurrent non?small cell lung cancer following completeresection显示文摘 | Hidefumi Sasaki Ayumi Suzuki Tsutomu Tatematsu Masayuki Shitara Yu Hikosaka Katsuhiro Okuda Satoru Moriyama Motoki Yano Yoshitaka Fujii | 2014 | Oncology Letters2014，，4： | 1 |
| 13 | A novel adenovirus expressing human 4–1BB ligand enhances antitumor immunity显示文摘 | Hiroshi Yoshida Yu Katayose Michiaki Unno Masanori Suzuki Hideaki Kodama Shin-ichi Takemura Ryutaro Asano Hiroki Hayashi Kuniharu Yamamoto Seiki Matsuno Toshio Kudo | 2003 | Cancer Immunology Immunotherapy2003，，2： | 1 |
| 14 | Direct Inhibition and Down-regulation by Uremic Plasma Components of Hepatic Uptake Transporter for SN-38, an Active Metabolite of Irinotecan, in Humans显示文摘 | Ken-ichi Fujita Tomoko Sugiura Hidenori Okumura Saki Umeda Noritaka Nakamichi Yusuke Watanabe Hiromichi Suzuki Yu Sunakawa Ken Shimada Kaori Kawara Yasutsuna Sasaki Yukio Kato | 2014 | Pharmaceutical Research2014，，1： | 1 |
| 15 | Recent progress in the development of coumarin derivatives as potenl anti-HIV agents显示文摘 | YU DL SUZUKI M XIE L | 2003 | Med Res Rev2003，23，3： | 1 |
| 16 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 17 | A novel blue light emitting diode using tris (2,3-methyl-8-hydroxyquinoline) aluminum (Ⅲ) as emitter显示文摘 | Yu J Chen J Sakuratani Y Suzuki H Tokita M Miyata S | 1999 | Jpn J Appl Phys1999，38，： | 1 |
| 18 | Reactions of model compounds of phenol resin in sub-and supercritical water under an argon atmosphere 显示文摘 | Hideyuki Tagaya Yu - ichi Suzuki Naomi Komuro | 2001 | Journal of Material Cycles Waste Manage2001，3，1： | 1 |
| 19 | Hypomethylation of Noncoding DNA Regions and Overexpression of the Long Noncoding RNA, AFAP1-AS1 , in Barrett’s Esophagus and Esophageal Adenocarcinoma显示文摘 | Wenjing Wu Tushar D. Bhagat Xue Yang Jee Hoon Song Yulan Cheng Rachana Agarwal John M. Abraham Sariat Ibrahim Matthias Bartenstein Zulfiqar Hussain Masako Suzuki Yiting Yu Wei Chen Charis Eng John Greally Amit Verma Stephen J. Meltzer | 2013 | Gastroenterology2013，，5： | 1 |
| 20 | Decomposition of prepolymers and molding materials of phenol resin in subcritical and supercritical water under an Ar atmosphere显示文摘 | Yu - ichi Suzuki Hideyuki Tagaya | 1999 | Industry Engineering Chemic Research1999，38，4： | 1 |
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