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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Ubiquitination-mediated protein degradation and modification:an emerging theme in plant-microbe interactions显示文摘translational 以后修正对蛋白质稳定性并且到蛋白质活动的调整中央。蛋白质修正的各种各样的类型例如 phosphorylation, methylation, acetylation, myristoylation, glycosylation,和 ubiquitination,被报导了。在他们之中, ubiquitination 把自己与其它区分开来因为大多数 ubiquitinated 蛋白质为降级被指向到 26S proteasome。ubiquitin/26S proteasome 系统在房间组成主要蛋白质降级小径。在最近的年里,在众多的真核细胞的细胞的函数的控制的 ubiquitination 机械的重要性逐渐地被欣赏了。增加 E3 ubiquitin ligases 和他们的底层的数字,包括许多必要细胞的管理者被识别了。过去的几年里的研究表明了 ubiquitination 系统为大量植物是重要的发展过程和回答到不能生活、关於生命的压力。这评论从在植物微生物相互作用起重要作用的植物和病原体在联系 ubiquitination 的蛋白质的功能的分析讨论最近的进展。 | Li-Rong Zeng Miguel E Vega-Sánchez Tong Zhu Guo-Liang Wang | 2006 | Cell Research2006，16，5： | 25 |
| 3 | Adaptive fuzzy decentralized control for nonlinear large-scale systems based on high-gain observer显示文摘An adaptive fuzzy decentralized backstepping output-feedback control approach is proposed for a class of nonlinear large-scale systems with completely unknown functions,the interconnections mismatched in control inputs,and without the measurements of the states.Fuzzy logic systems are employed to approximate the unknown nonlinear functions,and an adaptive high-gain observer is developed to estimate the unmeasured states.Using the designed high-gain observer,and combining the fuzzy adaptive control theory with backstepping approach,an adaptive fuzzy decentralized backstepping output-feedback control scheme is developed.It is proved that the proposed control approach can guarantee that all the signals of the closed-loop system are semi-globally uniformly ultimately bounded(SUUB),and that the observer errors and the tracking errors converge to a small neighborhood of the origin by appropriate choice of the design parameters.Finally,a simulation example is provided to show the eectiveness of the proposed approach. | TONG ShaoCheng REN Chang'E LI YongMing | 2012 | Science China(Information Sciences)2012，55，1： | 6 |
| 4 | Influence of particle composition on thorium scavenging in the marginal China seas显示文摘Thorium-234 and particle composition (organic matter, biogenic silica, carbonate and lithogenic component) were examined in the East China Sea (ECS) and the northern South China Sea (NSCS) in order to constrain the particle types scavenging thorium isotopes. Good positive correlations be-tween particulate organic matter (POM) or carbonate and thorium-234 in suspended particulate matter (SPM) indicates that POM and carbonate are efficient to scavenge thorium-234. No relation-ship between biogenic silica and thorium-234 suggests that geochemical behavior of thorium-234 may be not influenced by biogenic silica. A simple model was used to evaluate the affinity of thorium-234 to different particle components. The results show that POM is the most efficient scavenger for thorium-234 in the ECS and the NSCS, followed by carbonate. The authors’ re-sults lend support to the utility of thorium-234 as a proxy of POC and carbonate in the upper layer. However, the strong dependence of thorium scavenging on particle composition challenges thorium-230 as a constant flux proxy. | YANG Weifeng CHEN Min CAO Jianping QIU Yusheng ZHANG Run MA Qiang TONG Jinlu YANG Junhong YANG Zhi LUE E | 2009 | Acta Oceanologica Sinica2009，28，2： | 4 |
| 5 | Groundwater Systems and Eco-hydrological Features in the Main Karst Regions of China显示文摘Different karst water features and related water resources are present both in southern and northern China.There are over 3,358 well-developed karst ground river systems with total discharges in the dry season of about 420×108 m3 in the main karst regions in the southern part of China.Exploitation rates are only 8-15%.Over 100 larger karst spring systems in the main karst regions of northern China cover a catchment area from 500 km2 to over 4,000 km2,of which the average discharge appears to be from about 1 m3/s to 13 m3/s and the exploitation rates are 70-80%.Six aspects of the eco-hydrological features of some typical karst regions in China comprising water environment,ecological features,materials and structures between parent rock and soil,bio-geological processes and palynological studies(spore-pollen)are discussed.Qualitative evaluation of eco-geology and rocky desertification in the karst regions should be based on the main karst ecological conditions as well as artificial,i.e.,man-made impacts. | LU Yaoru ZHANG Feng'e LIU Changli TONG Guobang ZHANG Yun | 2006 | Acta Geologica Sinica(English Edition)2006，80，5： | 3 |
| 6 | Experimental Study on Heterograft of Glomus Cells of Carotid Body for Hemiparkinsonian Rats显示文摘Summary: To observe the effects of heterograft of glomus cells of carotid body on hemiparkinsonian rat models, rats with unilateral 6-hydroxydopamine (6-OHDA)-induced lesions of the right dopaminergic neurons of substantia nigra received intrastriatal glomus cells heterograft. Apomorphine-induced rotation was monitored for 30 min at various time points after grafting. The striata were cut and examined for dopamine content by HPLC and for immunohistochemical staining of tyrosine hydroxylase positive neurons (TH +) at the end of the experiments. The results showed that apomorphine-induced rotational behavior was significantly reduced for 12 weeks and the dopamine contents were significantly elevated after grafting (P<0.01), and TH + cells survived better. The present study demonstrates that intrastriatal heterograft of glomus cells within carotid body in rats with 6-OHDA-elicited lesions could reduce apomorphine-induced rotational behavior and elevate the dopamine contents and numbers of TH + cell surviving within striatum, and can serve as a new and effective alternative for Parkinson disease. | CAO Xuebing(曹学兵) SUN Shenggang(孙圣刚) TONG E'tang(童萼塘) | 2002 | Journal of Huazhong University of Science and Technology(Medical Sciences)2002，22，2： | 2 |
| 7 | Interactions among age, adiposity, bodyweight, lifestyle factors and sex steroid hormones in healthy Singaporean Chinese men显示文摘瞄准:为了在年龄,生活方式因素,人体测量的参数,百分比身体脂肪和类固醇之中检验相互关系,在 531 个健康新加坡人中国人的荷尔蒙参数在 29 和 72 岁之间变老。方法:各种各样的生活方式参数通过调查,和睾丸激素被确定(T) , estradiol (E2 ) , dehydroepi 雄甾酮硫酸盐(DHEAS ) 和性别荷尔蒙绑定血球素(SHBG ) 用确定的方法被测量。人体测量的参数镇定、计算,并且百分比身体脂肪(Siri ) 用 DEXA 扫描仪被测量。结果:SHBG, DHEAS, bioavailable-T (Bio-T ) , E2, Siri, Ht, W/H, W/Ht 和工作应力独立地与年龄被相关。多使用变量分析并且好久调整,吸烟并且另外的相关因素,锻练并且白酒消费在雄激素层次和身体作文上有积极影响。然而,黑色和绿茶消费在身体作文上并且与 E2 和免费 Estradiol 索引(FEI ) 的高水平与否定效果被联系。有更短的睡觉持续时间的人与夜里的睡觉的 6 h 或更多作为与那些相比有显著地更低的 T 层次。更高的 T 层次与脂肪过多的底层和脂肪过多的另外的索引被联系,而更高的 E2 层次与脂肪过多的高水平有关。有更高的 DHEAS 的人比有低 DHEAS 层次的那些显著地更高、重。结论:学习在 gonadal/adrenal 和新陈代谢的分隔空间之中显示出靠近的相互作用,与是的年龄在他们的相互作用的一个关键决定因素。生活方式因素象锻练那样,吸烟,睡觉并且酒精和茶消费可能显著地在在人决定健康的地位起作用。 | Victor H. H. Goh Terry Y. Y. Tong Helen E E Mok Baharudin Said | 2007 | Asian Journal of Andrology2007，9，5： | 2 |
| 8 | QoS prediction algorithm used in location-aware hybrid Web service显示文摘Quality-of-Service(QoS) describes the non-functional characteristics of Web services. As such, the QoS is a critical parameter in service selection, composition and fault tolerance, and must be accurately determined by some type of QoS prediction method. However, with the dramatic increase in the number of Web services, the prediction failure caused by data sparseness has become a critical challenge. A new ‘hybrid user-location-aware prediction based on weighted Adamic-Adar(WAA)'(HUWAA) was proposed. The implicit neighbor search was optimized by incorporating location factors. Meanwhile, the ability of the improved algorithms to solve the data sparsity problem was validated in experiments on public real world datasets. The new algorithm outperforms the existing of item-based pearson correlation coefficient(IPCC), user-based pearson correlation coefficient(UPCC) and Web service recommender system(WSRec) algorithms. | E Haihong Tong Junjie Song Meina Song Junde | 2015 | The Journal of China Universities of Posts and Telecommunications2015，22，1： | 2 |
| 9 | Hybird wavelet - Kalman fil- ter method for forecasting显示文摘 | Tong X Girgis A Makram E | 2000 | Electric Power Systems Research2000，54，1： | 1 |
| 10 | SIRT3,a mitochondrial sirtuin deacetylase,regulates mitochondrial function and thermogenesis in brown adipocytes显示文摘 | Shi T Wang F Stieren E Tong Q | | 0，，： | 1 |
| 11 | Vascular endothelial growth factor splice variants and their prognostic value in breast and ovarian cancer显示文摘 | Stimpfl M Tong D Fasching B Schuster E Obermair A Leodolter S | 2002 | Clin Cancer Res2002，8，： | 1 |
| 12 | Loss of heterozygosity (LOH) at P53 is correlated with LOH at BRCA1 and BRCA2 in various human malignant tumors 显示文摘 | TONG D KUCERA E SCHUSTER E | 2000 | Int J Cancer2000，88，： | 1 |
| 13 | Ethanol impaired neuronal migration is associated with reduced aspartyl-asparaginylbeta-hydroxylase expression显示文摘 | Carter J J Tong M Silbermann E Lahousse S A Ding F F Longato L Roper N Wands J R | | 0，，03： | 1 |
| 14 | Kinematic approach to the mixed state geometric phase in nonunitary evolu-tion显示文摘 | SjOvist E Kwek L C | 2004 | Phys Rev Lett2004，93，8： | 1 |
| 15 | Control of shivering under regional anesthesia in obstetric patients with tramadol显示文摘 | Chan A M Ng K F Tong E W | | 0，，03： | 1 |
| 16 | Molecular characterization of the Entner-Doudoroff Pathway in Escherichia coli: sequence analysis and localization of promoters for the edd-eda operon显示文摘 | S E Egan R Fliege S Tong A Shibata J Richard E Wolf T Conway | 1992 | Bacteriol1992，，174： | 1 |
| 17 | Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase显示文摘 | Aino Soro-Paavonen Wei-Zeng Zhang Kylie Venardos Melinda T Coughlan Emma Harris David CK Tong Daniella Brasacchio Karri Paavonen Jaye Chin-Dusting Mark E Cooper David Kaye Merlin C Thomas Josephine M Forbes | 2010 | Journal of Hypertension2010，，4： | 1 |
| 18 | GABA neurons provide a rich input to microvessels but not nitric oxide neurons in the rat cerebral cortex:a means for direct regulation of local cerebral blood flow显示文摘 | Vaucher E Tong XK Cholet N | 2000 | J Comp Neurol2000，421，： | 1 |
| 19 | The self- incompatibility response in Papaver rhoeas is mediated by cytosolic free calcium显示文摘 | Ride J P Reed N | 1993 | Plant J1993，4，： | 1 |
| 20 | Extraction of Egg-Yolk Lecithin显示文摘 | Luz E Palacios a Tong Wang | 2005 | JAOCS2005，82，8： | 1 |
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