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| 1 | Raman lasing and soliton mode-locking in lithium niobate microresonators显示文摘The recent advancement in lithium-niobite-on-insulator(LNOI)technology is opening up new opportunities in optoelectronics,as devices with better performance,lower power consumption and a smaller footprint can be realised due to the high optical confinement in the structures.The LNOI platform offers both largeχ(2)andχ(3)nonlinearities along with the power of dispersion engineering,enabling brand new nonlinear photonic devices and applications for the next generation of integrated photonic circuits.However,Raman scattering and its interaction with other nonlinear processes have not been extensively studied in dispersion-engineered LNOI nanodevices.In this work,we characterise the Raman radiation spectra in a monolithic lithium niobate(LN)microresonator via selective excitation of Raman-active phonon modes.The dominant mode for the Raman oscillation is observed in the backward direction for a continuous-wave pump threshold power of 20mW with a high differential quantum efficiency of 46%.We explore the effects of Raman scattering on Kerr optical frequency comb generation.We achieve mode-locked states in an X-cut LNOI chip through sufficient suppression of the Raman effect via cavity geometry control.Our analysis of the Raman effect provides guidance for the development of future chip-based photonic devices on the LNOI platform. | Mengjie Yu Yoshitomo Okawachi Rebecca Cheng Cheng Wang Mian Zhang Alexander L.Gaeta Marko Loncar | 2020 | Light(Science & Applications)2020，9，1： | 5 |
| 2 | Y chromosome microdeletion screening using a new molecular diagnostic method in 1030 Japanese males with infertility显示文摘The azoospermia factor(AZF)region is important for spermatogenesis,and deletions within these regions are a common cause of oligozoospermia and azoospermia.Although several studies have reported this cause,the present research,to the best of our knowledge,is the first large-scale study assessing this factor in Japan.In this study,1030 male patients with infertility who were examined for Y chromosome microdeletion using the polymerase chain reaction-reverse sequence-specific oligonucleotide(PCR-rSSO)method,a newly developed method for Y chromosome microdeletion screening,were included.The study enrolled 250 patients with severe oligospermia and 717 patients with azoospermia.Among the 1030 patients,4,4,10,and 52 had AZFa,AZFb,AZFb+c,and AZFc deletions,respectively.The sperm recovery rate(SRR)of microdissection testicular sperm extraction in patients with AZFc deletions was significantly higher than that in those without AZF deletions(60.0%vs 28.7%,P=0.04).In patients with gr/gr deletion,SRR was 18.7%,which was lower than that in those without gr/gr deletion,but was not statistically significant.In conclusion,our study showed that the frequency of Y chromosome microdeletion in male patients in Japan was similar to that reported in patients from other countries,and SRR was higher in patients with AZFc deletion. | Masashi Iijima Kazuyoshi Shigehara Hideki Igarashi Koichi Kyono Yasuo Suzuki Yuji Tsuji Yoshitomo Kobori Hideyuki Kobayashi Atsushi Mizokami | 2020 | Asian Journal of Andrology2020，22，4： | 4 |
| 3 | Evaluation of the sperm DNA fragmentation index in infertile Japanese men by in-house flow cytometric analysis显示文摘Semen analysis has long been used to evaluate male fertility.Recently,several sperm function tests have been developed.Of those,the sperm DNA fragmentation index(DFI),which describes the status of the sperm DNA,is thought to be a suitable parameter for evaluating male fertility.However,there have been no large-scale studies on the sperm DFI of Japanese men.Therefore,we investigated the feasibility of using an in-house flow cytometry-based sperm DFI analysis based on the sperm DNA fragmentation test of sperm chromatin structure assay(SCSA)to assess male fertility in Japan.This study enrolled 743 infertile and 20 fertile Japanese men.To evaluate reproducibility,inter-and intraobserver precision was analyzed.A receiver operating characteristic curve analysis was used to set a cutoff value for the sperm DFI to identify men who could father children by timed intercourse or intrauterine insemination.The variability of the sperm DFI among fertile volunteers was determined.The relationship between semen parameters and the sperm DFI was assessed by Spearman’s rho test.A precision analysis revealed good reproducibility of the sperm DFI.The cutoff value of sperm DNA fragmentation in infertile men was 24.0%.Semen volume had no relationship with the sperm DFI.Sperm concentration,sperm motility,total motile sperm count,and percentage of normal-shaped sperm were significantly and negatively correlated with the sperm DFI.The median sperm DFI was smaller in fertile volunteers(7.7%)than that in infertile men(19.4%).Sperm DNA fragmentation analysis can be used to assess sperm functions that cannot be evaluated by ordinary semen analysis. | Akiyoshi Osaka Hiroshi Okada Sae Onozuka Takashi Tanaka Toshiyuki Iwahata Yukihito Shimomura Yoshitomo Kobori Kazutaka Saito Kouhei Sugimoto | 2022 | Asian Journal of Andrology2022，24，1： | 2 |
| 4 | Construction and characterization of a full length-enriched and a 5'-endenri chedlibrary 显示文摘 | Suzuki Y Yoshitomo N Maruy A K | 1997 | Gene1997，200，12： | 1 |
| 5 | Prolonged artificial liver support in a child with fulminant hepatic failure显示文摘 | Kazufumi O Mitsuro K Yoshitomo I | 1996 | ASAIO J1996，42，： | 1 |
| 6 | Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library 显示文摘 | SUZUKI Y YOSHITOMO N K MARUYAMA K | 1997 | Gene1997，200，12： | 1 |
| 7 | Ultrafast waveform compression using a time domain telescope 显示文摘 | MARK A F REZA S YOSHITOMO O | 2009 | Na ture Photonics2009，3，10： | 1 |
| 8 | Auto-ignited kernels during knocking combustion in a spark-ignition engine显示文摘 | Nobuyuki K Eiji T Yoshitomo S | 2007 | Proceedings of the Combustion Institute2007，31，2： | 1 |
| 9 | Epigenetic thera-py upregulates the tumor suppressor microRNA-126 and itshost gene EGFL7 in human cancer cells显示文摘 | Yoshimasa S Jeffrey MF Yoshitomo C | 2009 | Biochem BiophysRes Commun2009，379，3： | 1 |
| 10 | In vivo efficacy and pharmacokinetics of biapenem in a murine model of ventilator-associated pneumonia with Pseudomonas aeruginosa显示文摘 | Koichi Yamada Yoshihiro Yamamoto Katsunori Yanagihara Nobuko Araki Yosuke Harada Yoshitomo Morinaga Koichi Izumikawa Hiroshi Kakeya Hiroo Hasegawa Shigeru Kohno Shimeru Kamihira | 2012 | Journal of Infection and Chemotherapy2012，，4： | 1 |
| 11 | Vesicocutaneous Fistula caused by giant bladder calculus 显示文摘 | Yoshitomo K Kazuyoshi S Tosbiyasu A | 2007 | Int Urological Research2007，35，： | 1 |
| 12 | Quantification of fat-soluble vitamins in human breast milk by liquidchromatography-tandem mass spectrometry显示文摘 | MAYA K NAOKO T YOSHITOMO S | 2007 | Journal of Chromatography2007，859，： | 1 |
| 13 | Effects of endothelium-derived hyperpolarizing factor and nitric oxide on endothelial function in femoral resistance arteries of spontaneously hypertensive rats显示文摘 | Yoshitomo MORI Mitsumasa OHYANAGI Satsuki KOIDA | 2006 | Hypertens Res2006，29，： | 1 |
| 14 | Diversity of Wolbachia Endosymbi-onts in Heteropteran Bugs显示文摘 | Yoshitomo K Takema F | 2003 | Appl Environ Microbiol2003，，10： | 1 |
| 15 | RANKL^(+) senescent cells under mechanical stress: a therapeutic target for orthodontic root resorption using senolytics显示文摘In dentistry,orthodontic root resorption is a long-lasting issue with no effective treatment strategy,and its mechanisms,especially those related to senescent cells,remain largely unknown.Here,we used an orthodontic intrusion tooth movement model with an L-loop in rats to demonstrate that mechanical stress-induced senescent cells aggravate apical root resorption,which was prevented by administering senolytics(a dasatinib and quercetin cocktail). | Yue Zhou Aki Nishiura Hidetoshi Morikuni Wenqi Deng Toru Tsujibayashi Yoshihiro Momota Yuki Azetsu Masamichi Takami Yoshitomo Honda Naoyuki Matsumoto | 2023 | International Journal of Oral Science2023，15，2： | 1 |
| 16 | Separation of Ivermectin Components by High-speed Counter-current Chromatograpby显示文摘 | HISTO O YOSHITOMO I JUNKO H | 1996 | Journal of Chromatography A1996，723，： | 1 |
| 17 | Preparation and characterization of porous alginate scaffolds containing various amounts of octacalcium phosphate (OCP) crystals显示文摘 | Naru Shiraishi Takahisa Anada Yoshitomo Honda | 2009 | J Mater Sci: Mater Med2009，，： | 1 |
| 18 | Wide bandwidth slow light using a Rflman fiber amplifier 显示文摘 | Sharping Jay E Okawachi Yoshitomo Gaeta Alexan- der L | 2005 | Optics Express2005，13，16： | 1 |
| 19 | Free-to-total prostate-specific antigen (PSA) ratio contributes to an increased rate of prostate cancer detection in a Japanese population screened using a PSA level of 2.1–10.0 ng/ml as a criterion显示文摘 | Yoshitomo Kobori Yasuhide Kitagawa Atsushi Mizokami Kazuto Komatsu Mikio Namiki | 2008 | International Journal of Clinical Oncology2008，，3： | 1 |
| 20 | Quantification of fat-soluble vitamins in human breast milk by liquid chromatography–tandem mass spectrometry显示文摘 | Maya Kamao Naoko Tsugawa Yoshitomo Suhara Akimori Wada Toshiyuki Mori Kazuo Murata Riichiro Nishino Tetsuya Ukita Kazuhiro Uenishi Kiyoshi Tanaka Toshio Okano | 2007 | Journal of Chromatography B2007，，2： | 1 |
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