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| 1 | Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation显示文摘The outcome of early intravenous thrombolysis for ischemic stroke in patients with atrial fibrillation(AF)is worse than that without thrombosis. How to increase the efficacy of intravenous thrombolysis for AF-related ischemic stroke remains largely unknown. In this study, we investigated factors that influence the effect of intravenous thrombolysis in these patients. Our results showed that thrombolysis was independently associated with a favorable outcome(P \ 0.001) and did not influence the mortality of AF-related ischemic stroke, although it increased the risk of hemorrhage within 24 h after treatment. Risk factors for a poor outcome at admission were:heart failure(P = 0.045); high systolic pressure(P = 0.039); high blood glucose(P = 0.030); and a high National Institutes of Health Stroke Scale(NIHSS) score(P \ 0.001). Moreover, high systolic pressure at admission(P = 0.007), high blood glucose(P = 0.027), and a high NIHSS score(P \ 0.001) were independent risk factors for mortality at 3 months. Besides thrombolysis, a high NIHSS score(P = 0.006) and warfarin taken within 48 h before stroke onset(P = 0.032) were also independent risk factors for symptomatic hemorrhage within 24 h after treatment. Ischemic stroke patients with AF benefited from intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 h after stroke. | Qiuyun Zhao Xiaobo Li Wanli Dong Min Ye Yongjun Cao Meijuan Zhang Qiantao Cheng Junshan Zhou Guofang Chen Ming Yu Shanshan Hong Xiue Wei Bei Wang Guiyun Cui Peng Zhang Hong Ding Rongzhen Xu Yan Chen Yun Xu | 2016 | Neuroscience Bulletin2016，32，2： | 13 |
| 2 | Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics显示文摘Background and purpose Stroke is the second leading cause of death worldwide and the leading cause of mortality and long-term disability in China,but its underlying risk genes and pathways are far from being comprehensively understood.We here describe the design and methods of whole genome sequencing(WGS)for 10914 patients with acute ischaemic stroke or transient ischaemic attack from the Third China National Stroke Registry(CNSR-III).Methods Baseline clinical characteristics of the included patients in this study were reported.DNA was extracted from white blood cells of participants.Libraries are constructed using qualified DNA,and WGS is conducted on BGISEQ-500 platform.The average depth is intended to be greater than 30×for each subject.Afterwards,Sentieon software is applied to process the sequencing data under the Genome Analysis Toolkit best practice guidance to call genotypes of single nucleotide variants(SNVs)and insertion-deletions.For each included subject,21 fingerprint SNVs are genotyped by MassARRAY assays to verify that DNA sample and sequencing data originate from the same individual.The copy number variations and structural variations are also called for each patient.All of the genetic variants are annotated and predicted by bioinformatics software or by reviewing public databases.Results The average age of the included 10914 patients was 62.2±11.3 years,and 31.4%patients were women.Most of the baseline clinical characteristics of the 10914 and the excluded patients were balanced.Conclusions The WGS data together with abundant clinical and imaging data of CNSR-III could provide opportunity to elucidate the molecular mechanisms and discover novel therapeutic targets for stroke. | Si Cheng Zhe Xu Yang Liu Jinxi Lin Yong Jiang Yilong Wang Xia Meng Anxin Wang Xinying Huang Zhimin Wang Guohua Chen Songdi Wu Zhengchang Jia Yongming Chen Xuerong Qiu Jun Wu Binbin Song Weizhong Ji Zhongping An Wenjun Xue Lili Zhao Yu Geng Hongyan Li Hao Li Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 8 |
| 3 | Uniform arrays of carbon nanotubes applied in the field emission devices显示文摘Carbon nanotubes(CNTs)were grown into anodic aluminum oxide(AAO)channels by chemical vapor deposition(CVD)using C2H2/N2mixtures as feeding gas,which can be used as field emitters.The bottom surface of AAO template was etched slightly and the tips of CNTs were explored as the field emission arrays which were uniform and vertical.Field emission characterization showed a low turn-on field about 3.25 V/m and high emission current about 30 mA/cm2with the electric field about 4 V/m.These superior field emission characteristics could be attributed to low density of vertical CNTs and higher conductivity of the substrate. | LI DeTian CHENG YongJun CAI Min YAO JinLi CHANG Peng | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，11： | 7 |
| 4 | Different contribution of SBP and DBP variability to vascular events in patients with stroke显示文摘Background High blood pressure variability(BPV)is a novel risk factor for cardiovascular disease.However,the heterogeneity of systolic blood pressure variability(SBPV)and diastolic blood pressure variability(DBPV)for different vascular events remains unclear.This study aims to investigate whether SBPV or DBPV has different contribution to vascular events in patients with acute ischaemic stroke(IS)or transient ischaemic attack(TIA).Methods Data from the BOSS(blood pressure and clinical outcome in TIA or IS)study were examined for vascular events at 3-month and 1-year follow-up.BPV was defined as the SD and coefficient of variation(CV)of day-to day measurements within 3 months after IS/TIA.Vascular events include cardiovascular events(myocardial infarction,unstable angina,cardiac death and congestive heart failure)and cerebrovascular events(ischaemic or haemorrhagic stroke).Logistic regression model was used to test the associations between BPV and vascular events.results Of 2325 patients with IS or TIA,103(4.43%)experienced a recurrent stroke and 64(2.75%)had cardiovascular events within 3 months.Day-to day SBPV was only associated with stroke recurrence(BPVSD:OR,1.72,95%CI 1.09 to 2.71;BPVCV:1.86,95%CI 1.19 to 2.92),but not cardiovascular events(BPVSD:1.67,95%CI 0.94 to 2.94;BPVCV:1.51,95%CI 0.86 to 2.64).However,DBPV seems to be related to both stroke(BPVSD:1.60,95%CI 1.02 to 2.49;BPVCV:1.53,95%CI 0.99 to 2.37)and cardiovascular events(BPVSD:2.48,95%CI 1.37 to 4.48;BPVCV:1.92,95%CI 1.09 to 3.36).Similar results were found at 1 year.Conclusions For patients with IS/TIA,stroke recurrence was associated with both SBPV and DBPV;however,cardiovascular events seem to be only related to DBPV. | Liye Dai Aichun Cheng Xiwa Hao Jie Xu Yingting Zuo Anxin Wang Xia Meng Hao Li Yilong Wang Xingquan Zhao Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 6 |
| 5 | Lanthanum-doped Cu-Mn composite oxide catalysts for catalytic oxidation of toluene显示文摘CuMn mixed oxides catalysts doped with La were prepared following a co-precipitation method and used for the catalytic oxidation of toluene. Catalysts properties of the catalysts were investigated by X-ray diffraction, N_2 adsorption/desorption,scanning electron microscopy, H_2-temperature-programmed reduction(H_2-TPR), O_2-temperature-programmed desorption(O_2-TPD) and X-ray photoelectron spectroscopy techniques. Characterization data reveal that the phase change and decrease in crystallinity of the La-doped catalysts increase the number of oxygen vacancies. Improvements in reducibility and an increase in the amount of chemisorbed oxygen of the La-doped catalysts were also verified by H_2-TPR and O_2-TPD. The activity of the CuMn mixed oxides catalysts is significantly improved by the addition of a nominal amount of La. The CuMn/La-4 mol% catalyst exhibits the best catalytic activity, with a 90%conversion temperature of 255 ℃,attributed to a high Mn^(3+)ratio, superficial chemisorbed oxygen,and high surface area. This study indicates La to be a promising dopant for Cu-Mn catalysts toward toluene oxidation. | Jing Pan Wentao Du Yongjun Liu Yan Cheng Shandong Yuan | 2019 | Journal of Rare Earths2019，37，6： | 5 |
| 6 | Digital Continuity Guarantee Approach of Electronic Record Based on Data Quality Theory显示文摘Since the British National Archive put forward the concept of the digital continuity in 2007,several developed countries have worked out their digital continuity action plan.However,the technologies of the digital continuity guarantee are still lacked.At first,this paper analyzes the requirements of digital continuity guarantee for electronic record based on data quality theory,then points out the necessity of data quality guarantee for electronic record.Moreover,we convert the digital continuity guarantee of electronic record to ensure the consistency,completeness and timeliness of electronic record,and construct the first technology framework of the digital continuity guarantee for electronic record.Finally,the temporal functional dependencies technology is utilized to build the first integration method to insure the consistency,completeness and timeliness of electronic record. | Yongjun Ren Jian Qi Yaping Cheng Jin Wang Osama Alfarraj | 2020 | Computers, Materials & Continua2020，，6： | 3 |
| 7 | Antimicrobial Chlorinated Carbazole Alkaloids from the Sponge-Associated Actinomycete Streptomyces diacarni LHW51701显示文摘Four new chlorinated carbazole alkaloids,chlocarbazomycins(CCBs)A-D,were isolated from sponge associated bacterium Streptomyces diacarni LHW51701.Their structures were elucidated via spectroscopic techniques(including HRESIMS,ID&2D NMR),and X-ray crystallographic analysis.Structurally,the 4-chloro coupled with 3-methoxyl substituents in the tricycle nucleus of CCBs A-D and the A/-methoxyl group of CCB-D are rare in naturally occurred tricyclic carbazole alkaloids.Moreover,CCBs A-D do not bear the typical Cl poro-alkyl and C2 meto-methyl side chains of bacterial tricycle carbazoles,suggesting a novel mechanism of aromatic ring formation in biosynthesis.The biological evaluation showed that CCB-C possessed inhibitory activities against pathogenic microorganisms including methicillin-resistant Staphylococcus aureus(MRSA),Mycobacterium smegmatis,Bacillus mycoides,and Candida albicans. | Yijia Cheng Nannan Chen Jing Li Jun-Cheng Su Jingya Yang Cui-Xian Zhang Hou-Wen Lin Yongjun Zhou | 2021 | Chinese Journal of Chemistry2021，39，5： | 3 |
| 8 | Robust nonlinear control of spacecraft formation flying using constraint forces显示文摘A robust nonlinear control method is presented for spacecraft precise formation flying.With the constraint forces and consid-ering nonlinearity and perturbations,the problem of the formation keeping is changed to the Lagrange systems with the holonomic constraints and the differential algebraic equations (DAE).The nonlinear control laws are developed by solving the DAE.Because the traditional numerical solving methods of DAE are very sensitive to the various errors and the resulting con-trol laws are not robust in engineering application,the robust control law designed method is further developed by designing the correct coefficients to correct the errors of the formation array constraints.A numeral study simulated the robustness of this method for the various errors in the formation flying mission,including the initial errors of spacecraft formation,the reference satellite orbit determination errors,the relative perturbation forces model errors,and so on. | XING JianJun TANG GuoJin CHENG WenKe LEI YongJun | 2011 | Science China(Technological Sciences)2011，54，9： | 2 |
| 9 | Investigation of carbonyl amidation and O-methylation during biosynthesis of the pharmacophore pyridyl of antitumor piericidins显示文摘Piericidins are a large family of bacterialα-pyridone antibiotics with antitumor activities such as their anti-renal carcinoma activity exhibited recently in nude mice.The backbones of piericidins are derived fromβ,δ-diketo carboxylic acids,which are offloaded from a modular polyketide synthase(PKS)and putatively undergo a carbonyl amidation beforeα-pyridone ring formation.The tailoring modifications to theα-pyridone structure mainly include the verified hydroxylation and O-methylation of the C-4′position and an unidentified C-5′O-methylation.Here,we describe a piericidin producer,terrestrial Streptomyces conglobatus,which contains a piericidin biosynthetic gene cluster in two different loci.Deletion of the amidotransferase gene pieD resulted in the accumulation of two fatty acids that should be degraded from the nascent carboxylic acid released by the PKS,supporting the carbonyl amidation function of PieD duringα-pyridone ring formation.Deletion of the O-methyltransferase gene pieB1 led to the production of three piericidin analogues lacking C-5′O-methylation,therefore confirming that PieB1 specifically catalyses the tailoring modification.Moreover,bioactivity analysis of the mutant-derived products provided clues regarding the structure-function relationship for antitumor activity.The work addresses two previously unidentified steps involved in pyridyl pharmacophore formation during piericidin biosynthesis,facilitating the rational bioengineering of the biosynthetic pathway towards valuable antitumor agents. | Wanlu Li Wenyu Zhang Yijia Cheng Yaoyao Shen Jianzhao Qi Hou-Wen Lin Yongjun Zhou | 2022 | Synthetic and Systems Biotechnology2022，7，3： | 2 |
| 10 | Geology and Geochemistry of the Shizitou Molybdenum Deposit, Jiangxi Province: Implications for Geodynamic Setting and Metallogenesis显示文摘The Shizitou molybdenum(Mo) deposit in Yongping, Jiangxi, is an important, recently discovered deposit in the eastern section of the Qin–Hang metallogenic belt. The Mo deposit is located in the outer contact zone between the porphyritic biotite granite and the Neoproterozoic migmatite, and present in the deep central part of the intrusion. Re–Os dating and S and Pb isotopic analysis have been conducted to assess the metallogenesis of the Shizitou Mo deposit. S, Pb and Re isotopes show that the ore–forming materials were derived from the porphyritic biotite granitic magma, which originated from the mixing of mantle and crust. Re–Os dating of molybdenite from the ores gives a model age from 156.9±2.2 to 158.5±2.4 Ma, with a weighted mean age of 158±1 Ma and an isochron age of 158.0±2.5 Ma. Geological and geochemical characteristics of the ore deposit and the related granitoids indicate that the Shizitou deposit is a Climax–type Mo deposit. Based on previous studies of the Qin–Hang metallogenic belt, two metallogenic events are believed to have occurred during 172–145 Ma and 137–132 Ma. These two metallogenic periods are consistent with the timing of two metallogenic peaks during the middle to late Jurassic and the Cretaceous in South China. These events represent responses to the partial back–arc extension associated with the subduction of the Izanagi plate beneath the Eurasian continent and the rapid northeastward movement of the subducting Izanagi plate. | WANG Cheng SHAO Yongjun LIU Zhongfa LIU Qingquan ZHANG Yu | 2018 | Acta Geologica Sinica(English Edition)2018，92，4： | 2 |
| 11 | Nonlinear control of multiple spacecraft formation flying using the constraint forces in Lagrangian systems显示文摘Getting inspiration from the constraint forces in the classical mechanics, we presented the nonlinear control method of multiple spacecraft formation flying to accurately keep the desired formation arrays. Considering nonlinearity and perturbation, we changed the question of the formation array control to the Lagrange equations with the holonomic constraints and the differential algebraic equations (DAE), and developed the nonlinear control for design of the follower spacecraft tracking control laws by solving the DAE. Because of using the idea of the constraint forces, this approach can adequately utilize the characteristic of the dynamic equations, i.e., the space natural forces, and accurately keep the arbitrary formation array. Simulation results of the circular formation keeping with the linear and nonlinear dynamical equations were included to illuminate the control performance. | XING JianJun LEI YongJun CHENG WenKe TANG GuoJin | 2009 | Science China(Technological Sciences)2009，52，10： | 2 |
| 12 | Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes显示文摘Dear Editor,Obesity is caused by an imbalance between energy intake and expenditure,and has become a global epidemic with over 650 million adults affected.Adipose tissues in mammals are composed of white adipose tissue(WAT)and classical brown adipose tissue(BAT),and their balance is highly related to the occurrence of obesity.The browning of white adipocytes results in“beige”or“brite”adipocytes,which appear functionally similar to classical brown adipocytes,and can be detected in WAT deposits of animals that have been exposed to cold or other inducers(Fu et al.,2015). | Zhaomeng Cui Yang Liu Wei Wan Yuyan Xu Yehui Hu Meng Ding Xin Dou Ruina Wang Hailing Li Yongmei Meng Wei Li Wei Jiang Zengxia Li Yiming Li Minjia Tan Dengke KMa Yu Ding Jun OLiu Cheng Luo Biao Yu Qiqun Tang Yongjun Dang | 2021 | Protein & Cell2021，12，6： | 1 |
| 13 | Controlled synthesis of CeO2 nano particles from the coupling route of homogenous precipitation with mieroemulsion显示文摘 | He Yongjun Yang Bolun Cheng Guangxu | 2003 | Materials letters2003，57，6： | 1 |
| 14 | On the oxidative coupling of methane with carbon dioxide over CeOJZnO nanocatalysts显示文摘 | He Yongjun Yang Bolun Cheng Guangxu | 2004 | Catalysis Today2004，98，4： | 1 |
| 15 | Preparation of a graphene-based magnetic nanocomposite for the removal of an or-ganic dye from aqueous solution显示文摘 | Wang Chun Feng Cheng Gao Yongjun | 2011 | Chemical Engineering Journal2011，173，1： | 1 |
| 16 | Gap engineering of sandwich plasmonic gap nanostructures for boosting plasmon-enhanced electrocatalysis显示文摘Plasmonic catalysis is emerging as a dynamic field in heterogeneous catalysis and holds great promise for the efficient utilization of solar energy.Central to the development of plasmonic catalysis is the design of efficient plasmonic nanocatalysts.In this report,plasmonic gap nanostructures(PGNs)on the basis of Au@poly(o-phenylenediamine)(POPD)@Pd sandwich nanostructures are synthesized as plasmonic nanocatalysts by an in-situ reduction synthetic strategy,which allows for the precise engineering of the POPD gap size between plasmonic Au and catalytic Pd components.The introduction of conducting POPD nanogap in PGNs not only effectively enhances their light harvesting capability,but also provides an effective charge transfer channel for harnessing the photogenerated hot charge carriers.In this respect,distinct gap-dependent performances in plasmon-enhanced electrocatalysis of ethanol oxidation reactions(EOR)are demonstrated with the PGN nanocatalysts and over 2.5 folds of enhancement can be achieved.A volcano plot is derived to describe the relationship between the catalytic activities and gap size of the PGN nanocatalysts,which is well explained by the interplay of their light harvesting and charge transport capabilities.These results highlight the importance of gap engineering in PGNs for plasmonic catalysis and offer the promise of developing efficient plasmonic nanocatalysts for other heterogeneous catalytic reactions. | Lu Cheng Fengxia Wu Yu Tian Xiali Lv Fenghua Li Guobao Xu Hsien-Yi Hsu Yongjun Zhang Wenxin Niu | 2023 | Nano Research2023，16，7： | 1 |
| 17 | Phytoremediation of the polluted Waigang River and general survey on variation of phytoplankton population显示文摘 | Changwei Hu Yuxiong Ou Dayi Zhang Hui Zhang Cheng Yan Yongjun Zhao Zheng Zheng | 2012 | Environmental Science and Pollution Research2012，，9： | 1 |
| 18 | Controlled synthesis of CeO2 nanoparticles from the coupling route of homogeneous precipitation with microemulsion 显示文摘 | HE Yongjun YANG Bolun CHENG Guangxu | 2003 | Mater Lett2003，57，1314： | 1 |
| 19 | Moth sex pheromones affect interspecific competition among sympatric species and possibly population distribution by modulating pre-mating behavior显示文摘Premating behaviors mediated by pheromones play pivotal roles in animal mating choices.In natural populations of the striped stem borer Chilo suppressalis and the rice leaf roller Cnaphalocrocis medinalis in the rice field habitat,we discovered that Z11-16:Ald,a major component of the C.suppressalis pheromone,modulated the premating behavior of C.medinalis.Z11-16:Ald evoked a strong olfactory response in male antennae and strongly inhibited the sex pheromone trapping of male C.medinalis in the field.The functions of three C.medinalis sex pheromone receptor genes(CmedPR1–3)were verified through heterologous expression in Xenopus oocytes.CmedPR1 responded to Z11-18:OH and Z11-18:Ald,as well as the interspecific pheromone compound Z11-16:Ac of sympatric species;CmedPR2 responded to Z13-18:OH and Z13-18:Ald,as well as the sex pheromone compounds Z11-16:Ald and Z9-16:Ald of sympatric species;and CmedPR3 responded to Z11-18:OH and Z13-18:OH,as well as the interspecific pheromones Z11-16:OH,Z9-16:Ald,Z11-16:Ac,and Z11-16:Ald of sympatric species.Thus,CmedPR2 and CmedPR3 share the ligand Z11-16:Ald,which is not a component of the C.medinalis sex pheromone.Therefore,the sex pheromones of interspecific species affected the input of neural signals by stimulating the sex pheromone receptors on the antennae of male C.medinalis moths,thereby inhibiting the olfactory responses of the male moths to the sex pheromones.Our results demonstrate chemical communication among sympatric species in the rice field habitat,the recognition of intra-and interspecific sex pheromones by olfactory receptors,and how insect premating behaviors are modulated to possibly affect resource partitioning. | Jianjun Cheng Qinghua Chen Qianshuang Guo Yongjun Du | 2023 | Insect Science2023，30，2： | 1 |
| 20 | Somatic mutation contributing to clonal haematopoiesis is a risk factor of recurrent stroke in first-ever acute ischaemic stroke:a prospective cohort study显示文摘Background Somatic mutation contributes to clonal haematopoiesis of indeterminate potential(CHIP)is related to age and associated with a higher risk of stroke and atherosclerotic cardiovascular disease.Here,we investigated the prognostic significance of CHIP in a large first-ever acute ischaemic stroke(AIS)cohort and explored the underlying mechanisms.Methods We studied a prospective cohort of 6016 patients who had a first-ever AIS in China.Whole-genome sequencing was performed to identify CHIP.High-sensitivity C reactive protein(hs-CRP)levels above 3 mg/L at baseline were defined as hyperinflammation.Recurrent stroke during the 3-month follow-up was the primary outcome.Results Among the 6016 patients who had a first-ever AIS,with a median age was 62 years(IQR,54.0‒70.0),3.70%were identified as CHIP carriers.The most common mutations occurred in the DNMT3A(30.0%)and TET2(11.4%)genes.During a follow-up of 3 months,the presence of CHIP was associated with recurrent stroke(HR 1.62,95%CI 1.04 to 2.51,p=0.03),recurrent ischaemic stroke(HR 1.64,95%CI 1.04 to 2.58,p=0.03)and combined vascular events(HR 1.58,95%CI 1.02 to 2.44,p=0.04)after adjusting for hsCRP levels at baseline in patients who had a first-ever AIS.Subgroup analysis demonstrated that CHIP was only associated with recurrent stroke when patients under hyperinflammation(OR 3.10,95%CI 1.92 to 5.00,p<0.001)but not in those without hyperinflammation(OR 0.18,95%CI 0.03 to 1.04,p=0.06,Pinteraction=0.002).Conclusion Our results suggest that somatic mutations contributing to CHIP increase the risk of short-term recurrent stroke in patients who had a first-ever AIS.Hyperinflammation may be important in the relationship between CHIP and recurrent stroke. | Xin Qiu Yalun Dai Si Cheng Hong-Qiu Gu Yong Jiang Xia Meng Yilong Wang Xingquan Zhao Yingyu Jiang Zhe Xu Xinying Huang Meng Wang Tian Jie Lyu Yubo Wang Jiaxu Weng Lingyun Cui Yi Shangguan Hao Li Yongjun Wang Zixiao Li | 2023 | Stroke & Vascular Neurology2023，8，2： | 1 |
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