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| 1 | Ischemic postconditioning alleviates lung injury and maintains a better expression of aquaporin-1 during cardiopulmonary bypass显示文摘 | Cheng Chi Li Shanshan Wang Yong Chen Song You Lu Zhang Hong | 2014 | Chinese Medical Journal2014，，23： | 20 |
| 2 | Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation显示文摘The outcome of early intravenous thrombolysis for ischemic stroke in patients with atrial fibrillation(AF)is worse than that without thrombosis. How to increase the efficacy of intravenous thrombolysis for AF-related ischemic stroke remains largely unknown. In this study, we investigated factors that influence the effect of intravenous thrombolysis in these patients. Our results showed that thrombolysis was independently associated with a favorable outcome(P \ 0.001) and did not influence the mortality of AF-related ischemic stroke, although it increased the risk of hemorrhage within 24 h after treatment. Risk factors for a poor outcome at admission were:heart failure(P = 0.045); high systolic pressure(P = 0.039); high blood glucose(P = 0.030); and a high National Institutes of Health Stroke Scale(NIHSS) score(P \ 0.001). Moreover, high systolic pressure at admission(P = 0.007), high blood glucose(P = 0.027), and a high NIHSS score(P \ 0.001) were independent risk factors for mortality at 3 months. Besides thrombolysis, a high NIHSS score(P = 0.006) and warfarin taken within 48 h before stroke onset(P = 0.032) were also independent risk factors for symptomatic hemorrhage within 24 h after treatment. Ischemic stroke patients with AF benefited from intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 h after stroke. | Qiuyun Zhao Xiaobo Li Wanli Dong Min Ye Yongjun Cao Meijuan Zhang Qiantao Cheng Junshan Zhou Guofang Chen Ming Yu Shanshan Hong Xiue Wei Bei Wang Guiyun Cui Peng Zhang Hong Ding Rongzhen Xu Yan Chen Yun Xu | 2016 | Neuroscience Bulletin2016，32，2： | 13 |
| 3 | Human organoids in basic research and clinical applications显示文摘Organoids are three-dimensional(3D)miniature structures cultured in vitro produced from either human pluripotent stem cells(hPSCs)or adult stem cells(AdSCs)derived from healthy individuals or patients that recapitulate the cellular heterogeneity,structure,and functions of human organs.The advent of human 3D organoid systems is now possible to allow remarkably detailed observation of stem cell morphogens,maintenance and differentiation resemble primary tissues,enhancing the potential to study both human physiology and developmental stage.As they are similar to their original organs and carry human genetic information,organoids derived from patient hold great promise for biomedical research and preclinical drug testing and is currently used for personalized,regenerative medicine,gene repair and transplantation therapy.In recent decades,researchers have succeeded in generating various types of organoids mimicking in vivo organs.Herein,we provide an update on current in vitro differentiation technologies of brain,retinal,kidney,liver,lung,gastrointestinal,cardiac,vascularized and multi-lineage organoids,discuss the differences between PSC-and AdSC-derived organoids,summarize the potential applications of stem cell-derived organoids systems in the laboratory and clinic,and outline the current challenges for the application of organoids,which would deepen the understanding of mechanisms of human development and enhance further utility of organoids in basic research and clinical studies. | Xiao-Yan Tang Shanshan Wu Da Wang Chu Chu Yuan Hong Mengdan Tao Hao Hu Min Xu Xing Guo Yan Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 10 |
| 4 | Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy显示文摘Objective:Hepatocellular carcinoma(HCC),the main type of liver cancer,has a high morbidity and mortality,and a poor prognosis.RNA helicase DDX5,which acts as a transcriptional co-regulator,is overexpressed in most malignant tumors and promotes cancer cell growth.Heat shock protein 90(HSP90)is an important molecular chaperone in the conformational maturation and stabilization of numerous proteins involved in cell growth or survival.Methods:DDX5 m RNA and protein expression in surgically resected HCC tissues from 24 Asian patients were detected by quantitative real-time PCR and Western blot,respectively.The interaction of DDX5-HSP90 was determined by molecular docking,immunoprecipitation,and laser scanning confocal microscopy.The autophagy signal was detected by Western blot.The cell functions and signaling pathways of DDX5 were determined in 2 HCC cell lines.Two different murine HCC xenograft models were used to determine the function of DDX5 and the therapeutic effect of an HSP90 inhibitor.Results:HSP90 interacted directly with DDX5 and inhibited DDX5 protein degradation in the AMPK/ULK1-regulated autophagy pathway.The subsequent accumulation of DDX5 protein induced the malignant phenotype of HCC by activating theβ-catenin signaling pathway.The silencing of DDX5 or treatment with HSP90 inhibitor both blocked in vivo tumor growth in a murine HCC xenograft model.High levels of HSP90 and DDX5 protein were associated with poor prognoses.Conclusions:HSP90 interacted with DDX5 protein and subsequently protected DDX5 protein from AMPK/ULK1-regulated autophagic degradation.DDX5 and HSP90 are therefore potential therapeutic targets for HCC. | Ting Zhang Xinrui Yang Wanping Xu Jing Wang Dawei Wu Zhixian Hong Shengxian Yuan Zhen Zeng Xiaodong Jia Shanshan Lu Rifaat Safadi Sen Han Zhihong Yang Leonard M.Neckers Suthat Liangpunsakul Weiping Zhou Yinying Lu | 2021 | Cancer Biology & Medicine2021，18，3： | 7 |
| 5 | Tumor-homing peptide-based NIR-II probes for targeted spontaneous breast tumor imaging显示文摘Fluorescence imaging in the second near-infrared window(NIR-Ⅱ,1000-1700 nm)is a promising modality for real-time imaging of cancer and image-guided surgery with superior in vivo optical properties.So far,very few NIR-Ⅱfluorophores have been reported for in vivo biomedical imaging of chemically-induced spontaneous breast carcinoma.Herein,a NIR-Ⅱfluorescent probe CH1055-F3 with the nucleolin-targeted tumor-homing peptide F3 was demonstrated to prefe rentially accumulate in 4 T1 tumors.More importantly,CH1055-F3 exhibited specific NIR-Ⅱsignals with high spatial and temporal resolution,strong tumor uptake,and remarkable NIR-Ⅱimage-guided surgery in dimethylbenzanthracene(DMBA)-induced spontaneous breast tumor rats.This report presents the first tumor-homing peptide-based NIR-Ⅱprobe to diagnose transplantable and spontaneous breast tumors by the active targeting. | Hui Zhou Shanshan Li Xiaodong Zeng Mengxian Zhang Lin Tang Qianqian Li Deliang Chen Xianli Meng Xuechuan Hong | 2020 | Chinese Chemical Letters2020，31，6： | 6 |
| 6 | Impacts of exercise interventions on different diseases and organ functions in mice显示文摘Background'. In recent years, much evidence has emerged to indicate that exercise can benefit people when performed properly. This reviewsummarizes the exercise interventions used in studies involving mice as they are related to special diseases or physiological status. To furtherunderstand the effects of exercise interventions in treating or preventing diseases, it is important to establish a template for exercise interventionsthat can be used in future exercise-related studies.Methods'. PubMed was used as the data resource for articles. To identify studies related to the effectiveness of exercise interventions for treatingvarious diseases and organ functions in mice, we used the following search language: (exercise [Title] OR training [Title] OR physical activity[Title]) AND (mice [title/abstract] OR mouse [title/abstract] OR mus [title/abstract]). To limit the range of search results, we included 2 filters:one that limited publication dates to 'in 10 years,^ and one that sorted the results as 'best match^^. Then we grouped the commonly used exercisemethods according to their similarities and differences. We then evaluated the effectiveness of the exercise interventions for their impact on diseasesand organ functions in 8 different systems.Results'. A total of 331 articles were included in the analysis procedure. The articles were then segmented into 8 systems for which the exerciseinterventions were used in targeting and treating disorders: motor system (60 studies), metabolic system (45 studies), cardio-cerebral vascularsystem (58 studies), nervous system (74 studies), immune system (32 studies), respiratory system (7 studies), digestive system (1 study), and thesystem related to the development of cancer (54 studies). The methods of exercise interventions mainly involved the use of treadmills, voluntarywheel-running, forced wheel-running, swimming, and resistance training. It was found that regardless of the specific exercise method used, mostof them demonstrated positive effects on various systemic diseases and organ functions. Most diseases were remitted with exercise regardless ofthe exercise method used, although some diseases showed the best remission effects when a specific method was used.Conclusion-. Our review strongly suggests that exercise intervention is a cornerstone in disease prevention and treatment in mice. Because exerciseinterventions in humans typically focus on chronic diseases, national fitness, and body weight loss, and typically have low intervention com・pliance rates, it is important to use mice models to investigate the molecular mechanisms underlying the health benefits from exerciseinterventions in humans. | Shanshan Guo Yiru Huang Yan Zhang He Huang Shangyu Hong Tiemin Liu | 2020 | Journal of Sport and Health Science2020，9，1： | 5 |
| 7 | Development of nanoscale drug delivery systems of dihydroartemisinin for cancer therapy: A review显示文摘Dihydroartemisinin(DHA),a first-line antimalarial drug,has demonstrated great anticancer effects in many types of tumors,including liver cancer,glioblastoma,and pancreatic cancer.Due to its abilities to induce programmed cell death(PCD;apoptosis,autophagy and ferroptosis),inhibit tumor metastasis and angiogenesis,and modulate the tumor microenvironment,DHA could become an antineoplastic agent in the foreseeable future.However,the therapeutic efficacy of DHA is compromised owing to its inherent disadvantages,including poor stability,low aqueous solubility,and short plasma halflife.To overcome these drawbacks,nanoscale drug delivery systems(NDDSs),such as polymeric nanoparticles(NPs),liposomes,and metal-organic frameworks(MOFs),have been introduced to maximize the therapeutic efficacy of DHA in either single-drug or multidrug therapy.Based on the beneficial properties of NDDSs,including enhanced stability and solubility of the drug,prolonged circulation time and selective accumulation in tumors,the outcomes of DHA-loaded NDDSs for cancer therapy are significantly improved compared to those of free DHA.This reviewfirst summarizes the current understanding of the anticancer mechanisms of DHA and then provides an overview of DHA-including nanomedicines,aiming to provide inspiration for further application of DHA as an anticancer drug. | Ka Hong Wong Donglin Yang Shanshan Chen Chengwei He Meiwan Chen | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，4： | 3 |
| 8 | Preparation and Evaluation of Insulin-loaded Nanoparticles based on Hydroxypropyl-β-cyclodextrin Modified Carboxymethyl Chitosan for Oral Delivery显示文摘Novel insulin-loaded nanoparticles based on hydroxypropyl-β-cyclodextrin modified carboxymethyl chitosan(CMC-HP-β-CD) were prepared to improve the oral bioavailability of insulin. The CMC-HP-β-CD was characterized by FT-IR spectroscopy and 1H-NMR spectra. The insulin-loaded nanoparticles were prepared through crosslinking with calcium ions, and the morphology and size of the prepared nanoparticles were characterized by transmission electron microscopy(TEM) and dynamic light scattering(DLS). Cumulative release in vitro study was performed respectively in simulated gastric medium fluid(SGF, p H=1.2), simulated intestinal fluid(SIF, p H=6.8) and simulated colonic fluid(SCF, p H=7.4). The encapsulation efficiency of insulin was up to 87.14 ± 4.32% through high-performance liquid chromatography(HPLC). Statistics indicated that only 15% of the encapsulated insulin was released from the CMC-HP-β-CD nanoparticles in 36 h in SGF, and about 50% of the insulin could be released from the nanoparticles in SIF, whereas more than 80% was released in SCF. In addition, the solution containing insulin nanoparticles could effectively reduce the blood glucose level of diabetic mice. The cytotoxicity test showed that the samples had no cytotoxicity. CMC-HP-β-CD nanoparticles are promising candidates as potential carriers in oral insulin delivery systems. | 宋豪源 马晓玲 XIONG Fuliang HONG Hui LI Chunfu LI Lianghong WU Shanshan ZHANG Xueqiong 张娟 胡建华 | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，6： | 3 |
| 9 | Stochastic Multi-Symplectic Integrator for Stochastic Nonlinear Schrodinger Equation显示文摘In this paper we propose stochastic multi-symplectic conservation law for stochastic Hamiltonian partial differential equations,and develop a stochastic multisymplectic method for numerically solving a kind of stochastic nonlinear Schrodinger equations.It is shown that the stochasticmulti-symplecticmethod preserves themultisymplectic structure,the discrete charge conservation law,and deduces the recurrence relation of the discrete energy.Numerical experiments are performed to verify the good behaviors of the stochastic multi-symplectic method in cases of both solitary wave and collision. | Shanshan Jiang Lijin Wang Jialin Hong | 2013 | Communications in Computational Physics2013，14，7： | 3 |
| 10 | Metal-organic frameworks and their derivatives for Li-air batteries显示文摘Metal-organic frameworks(MOFs)are a class of outstanding materials in Li-air batteries because of their high surface areas,tailorable pore sizes and diverse catalytic centers.However,MOF-based batteries are facing challenges such as poor electronic conductivity and inferior long-cycle stability that limit their further development.This review first summarizes the progress of pristine MOFs and MOF-derived materials in Li-air batteries in the past 5 years,then provides a perspective for subsequent development of MOFs and their derivatives in this emerging field. | Yu Dong Siwu Li Shanshan Hong Lu Wang Bo Wang | 2020 | Chinese Chemical Letters2020，31，3： | 3 |
| 11 | Comparative transcriptome analysis of purple-fleshed sweet potato provides insights into the molecular mechanism of anthocyanin biosynthesis显示文摘Sweet potato, Ipomoea batatas, is a globally important food crop. The purple-fleshed sweet potato, rich in anthocyanins, has great potential for both nutritional and pharmaceutical uses. In this study, we characterized the root transcriptomes of the purple-fleshed sweet potato cv.Jingshu 6 and its mutant JS6-5 with high anthocyanin content by high-throughput RNA sequencing. A total of22873364 and 27955097 high quality reads were obtained from Jingshu 6 and JS6-5, respectively, and assembled into35592 unigenes. In all, we obtained 1566 differentially expressed genes(DEGs). Among them, 994 were upregulated and 572 were downregulated in JS6-5 compared to the expression in Jingshu 6. A total of 1436 DEGs were annotated, in which 847 DEGs had gene ontology(GO) terms and 329 DEGs were assigned to 84 Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways. Most importantly, 23 differentially expressed genes and 24 transcription factors were identified as candidate genes involved in anthocyanin biosynthesis. In addition, 2349 SSRs were detected. This study not only provides the candidate genes but also provides insights into the molecular mechanism of anthocyanin biosynthesis in sweet potato. | Hongyuan ZHAO Shanshan ZHANG Feibing WANG Ning ZHAO Shaozhen HE Qingchang LIU Hong ZHAI | 2018 | Frontiers of Agricultural Science and Engineering2018，5，2： | 2 |
| 12 | Ultrasensitive and stable all graphene field-effect transistor-based Hg^(2+)sensor constructed by using different covalently bonded RGO films assembled by different conjugate linking molecules显示文摘As'molecular bridge,'coupling agents can not only realize the covalent connection of composites,but also affect their properties,thus affecting the properties of devices based on them.Herein,leveraging differences in charge conduction properties of the(3-aminopropyl)trimethoxysilane and 5,10,15,20-tetrakis(4-aminophenyl)-21H,23H-porphine caused by conjugacy structural differences,two kinds of layerby-layer assembled smart carbon materials with different electrical properties are obtained at the same reduction temperature.The two graphene ultrathin films are then“planted”on Si/SiO2 substrates,respectively,as semiconductor layer and source/drain electrodes to fabricate an ultra-stable all-graphene field effect transistor(AG-FET).Enabled by the covalent functionalized configuration and the functionally diverse of coupling agents,the AG-FET obtained by this simple method won the high electrical characteristics,the hole,electron mobility,and the shelflife could reach 3.79 cm2/(V·s),3.78 cm2/(V·s),and 18months,respectively.In addition,good material stability and excellent device structure endow the device exceptional stability,electrical stability,and solvent resistance,improving its application prospect in solution phase sensing/detection.Such characteristics could be used to sense,transduce,and respond to external stimuli,especially in solution phase to monitor the important analytes,such as Hg^(2+)in a flowing sewage environment.We believe that such easy-to-manufacture AG-FETs with ultrahigh performance and ultrahigh stability could also show great application prospects in other significant fields. | Mingyuan Sun Congcong Zhang Duo Chen Jian Wang Yanchen Ji Na Liang Haoyang Gao Shanshan Cheng Hong Liu | 2021 | SmartMat2021，2，2： | 2 |
| 13 | Delay-Differentiated Scheduling in Optical Packet Switches for Cloud Data Centers显示文摘We consider differentiated timecritical task scheduling in a N×N input queued optical packet s w itch to ens ure 100% throughput and meet different delay requirements among various modules of data center. Existing schemes either consider slot-by-slot scheduling with queue depth serving as the delay metric or assume that each input-output connection has the same delay bound in the batch scheduling mode. The former scheme neglects the effect of reconfiguration overhead, which may result in crippled system performance, while the latter cannot satisfy users' differentiated Quality of Service(Qo S) requirements. To make up these deficiencies, we propose a new batch scheduling scheme to meet the various portto-port delay requirements in a best-effort manner. Moreover, a speedup is considered to compensate for both the reconfiguration overhead and the unavoidable slots wastage in the switch fabric. With traffic matrix and delay constraint matrix given, this paper proposes two heuristic algorithms Stringent Delay First(SDF) and m-order SDF(m-SDF) to realize the 100% packet switching, while maximizing the delay constraints satisfaction ratio. The performance of our scheme is verified by extensive numerical simulations. | LI Yaofang XIAO Jie WU Bin WEN Hong YU Hongfang YANG Shu XIN Shanshan GUO Jianing | 2015 | China Communications2015，12，8： | 2 |
| 14 | Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases显示文摘The NLRP3 inflammasome’s core and most specific protein,NLRP3,has a variety of functions in inflammation-driven diseases.Costunolide(COS)is the major active ingredient of the traditional Chinese medicinal herb Saussurea lappa and has anti-inflammatory activity,but the principal mechanism and molecular target of COS remain unclear.Here,we show that COS covalently binds to cysteine 598 in NACHT domain of NLRP3,altering the ATPase activity and assembly of NLRP3 inflammasome.We declare COS’s great anti-inflammasome efficacy in macrophages and disease models of gouty arthritis and ulcerative colitis via inhibiting NLRP3 inflammasome activation.We also reveal that theα-methylene-γ-butyrolactone motif in sesquiterpene lactone is the certain active group in inhibiting NLRP3 activation.Taken together,NLRP3 is identified as a direct target of COS for its anti-inflammasome activity.COS,especially theα-methylene-γ-butyrolactone motif in COS structure,might be used to design and produce novel NLRP3 inhibitors as a lead compound. | Haowen Xu Jiahao Chen Pan Chen Weifeng Li Jingjing Shao Shanshan Hong Yi Wang Lingfeng Chen Wu Luo Guang Liang | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 2 |
| 15 | Technologies and applications of silicon-based micro-optical electromechanical systems:A brief review显示文摘Micro-optical electromechanical systems(MOEMS)combine the merits of micro-electromechanical systems(MEMS)and micro-optics to enable unique optical functions for a wide range of advanced applications.Using simple external electromechanical control methods,such as electrostatic,magnetic or thermal effects,Si-based MOEMS can achieve precise dynamic optical modulation.In this paper,we will briefly review the technologies and applications of Si-based MOEMS.Their basic working principles,advantages,general materials and micromachining fabrication technologies are introduced concisely,followed by research progress of advanced Si-based MOEMS devices,including micromirrors/micromirror arrays,micro-spectrometers,and optical/photonic switches.Owing to the unique advantages of Si-based MOEMS in spatial light modulation and high-speed signal processing,they have several promising applications in optical communications,digital light processing,and optical sensing.Finally,future research and development prospects of Si-based MOEMS are discussed. | Shanshan Chen Yongyue Zhang Xiaorong Hong Jiafang Li | 2022 | Journal of Semiconductors2022，43，8： | 2 |
| 16 | Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats显示文摘 | Rutao Cui Jinchun He Baoen Wang Fukui Zhang Guangyong Chen Shanshan Yin Hong Shen | 2003 | Cancer Chemotherapy and Pharmacology2003，，1： | 1 |
| 17 | Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats显示文摘 | Rutao Cui Jinchun He Baoen Wang Fukui Zhang Guangyong Chen Shanshan Yin Hong Shen | 2003 | Cancer Chemotherapy and Pharmacology2003，，1： | 1 |
| 18 | A new de- hydroabietic acid-based arylamine fluorescent probe, syn- thesis, structure analysis and in vitro biodiagnose function 显示文摘 | Gao Hong Chen Shanshan Rao Xiaoping | 2013 | Bioorg Med Chem Lett2013，23，7： | 1 |
| 19 | Authenticating cherry tomato juices--Discussion of different data standardization and fusion approaches based on electronic nose and tongue显示文摘 | Hong Xuezhen Wang Jun Qiu Shanshan | 2013 | Food Research International2013，，10： | 1 |
| 20 | Operational procedures of auricular point sticking technology显示文摘As an external treatment technique of traditional Chinese medicine(TCM),auricular point sticking,which is rooted in holographic biology theory and TCM viscera and meridian theory,is a safe and effective treatment method.This article introduces the technology overview and development process.The auricular point sticking technique for constipation is taken as an example to specify the basic requirements,assessment,operational points,acupoint selection and matters needing attention during the implementation of the auricular acupressure technique,providing a reference for the operating procedures of this technique in the clinical treatment of other diseases such as insomnia,diarrhea,colds,hypertension,headache,and dysmenorrhea. | Hong CHEN Shanshan LIU Kexin LIU Suna LI Ling TANG | 2022 | Journal of Integrative Nursing2022，4，2： | 1 |
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