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| 1 | Effects of stress dependent electrochemical reaction on voltage hysteresis of lithium ion batteries显示文摘Intercalation of lithium ions into the electrodes of lithium ion batteries is affected by the stress of active materials, leading to energy dissipation and stress dependent voltage hysteresis. A reaction-diffusion-stress coupling model is established to investigate the stress effects under galvanostatic and potentiostatic operations. It is found from simulations that the stress hysteresis contributes to the voltage hysteresis and leads to the energy dissipation. In addition, the stress induced voltage hysteresis is small in low rate galvanostatic operations but extraordinarily significant in high rate cases. In potentiostatic operations, the stresses and stress induced overpotentials increase to a peak value very soon after the operation commences and decays all the left time. Therefore,a combined charge-discharge operation is suggested, i.e., first the galvanostatic one and then the potentiostatic one. This combined operation can not only avoid the extreme stress during operations so as to prevent electrodes from failure but also reduce the voltage hysteresis and energy dissipation due to stress effects. | Haoliang LI Yicheng SONG Bo LU Junqian ZHANG | 2018 | Applied Mathematics and Mechanics(English Edition)2018，39，10： | 3 |
| 2 | Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases显示文摘DNA sensing and timely activation of interferon(IFN)-mediated innate immunity are crucial for the defense against DNA virus infections and the clearance of abnormal cells.However,overactivation of immune responses may lead to tissue damage and autoimmune diseases;therefore,these processes must be intricately regulated.STING is the key adaptor protein,which is activated by cyclic GMP-AMP,the second messenger derived from cGAS-mediated DNA sensing.Here,we report that CCDC50,a newly identified autophagy receptor,tunes STING-directed type I IFN signaling activity by delivering K63-polyubiquitinated STING to autolysosomes for degradation.Knockout of CCDC50 significantly increases herpes simplex virus 1(HSV-1)-or DNA ligand-induced production of type I IFN and proinflammatory cytokines.Ccdc50-deficient mice show increased production of IFN,decreased viral replication,reduced cell infiltration,and improved survival rates compared with their wild-type littermates when challenged with HSV-1.Remarkably,the expression of CCDC50 is downregulated in systemic lupus erythematosus(SLE),a chronic autoimmune disease.CCDC50 levels are negatively correlated with IFN signaling pathway activation and disease severity in human SLE patients.CCDC50 deficiency potentiates the cGAS-STING-mediated immune response triggered by SLE serum.Thus,our findings reveal the critical role of CCDC50 in the immune regulation of viral infections and autoimmune diseases and provide insights into the therapeutic implications of CCDC50 manipulation. | Panpan Hou Yuxin Lin Zibo Li Ruiqing Lu Yicheng Wang Tian Tian Penghui Jia Xi Zhang Liu Cao Zhongwei Zhou Chunmei Li Jieruo Gu Deyin Guo | 2021 | Cellular & Molecular Immunology2021，18，10： | 3 |
| 3 | Neutrophil-derived heparin binding protein triggers vascular leakage and synergizes with myeloperoxidase at the early stage of severe burns(With video)显示文摘Background:Burn shock caused by vascular leakage is one of the main causes of high mortality in severe burn injury.However,the pathophysiological mechanism of vascular leakage is still unclear.The purpose of this study was to explore the molecular mechanism of vascular leakage in the early stage of severe burn and provide a new target for the treatment of severe burns.Methods:Neutrophils were isolated from human peripheral blood by magnetic beads sorting.ELISA was used to detect neutrophil-derived granule proteins and glycocalyx injury products in plasma.The vascular leakage and neutrophil movement were assessed by in vivo laser confocal imaging in mice,and high-quality video were provided.Adhesion-related molecules were investigated by qRT-PCR.The damage to glycocalyx of mice vascular endothelial cellswas observed by transmission electron microscope and scanning electron microscope.Proteomic analysis,flow cytometry and immunofluorescence were used to further study the relationship between human peripheral blood neutrophil-derived hypochlorite(HOCl)and CD44 of human vascular endothelial cells.Results:In this study,we found that rapidly increasing activated neutrophils secrete heparin binding protein(HBP)andmyeloperoxidase(MPO)after severe burn injury.Increased HBP triggers vascular leakage with synergy of MPO,results in systemic edema and burn shock.Furthermore,we found that the MPO catalytic product HOCl but not MPO triggers CD44 extracellular domain shedding from vascular endothelial cells to damage the glycocalyx.Damage to the glycocalyx results in firm adhesion of neutrophils and increases vascular leakage.However,MPO inhibitors partially protect the glycocalyx of vascular endothelial cells.The combination of HBP and MPO inhibitors markedly reduces vascular leakage and systemic edema in the early stage of severe burns.Conclusions:Taken together,these data reveal that neutrophil-derived HBP and MPO play an important synergies role in triggering vascular leakage at the early stage of severe burns.Targeted intervention in these two biomolecules may introduce new strategies for helping to reduce large amount of fluid loss and subsequent burn shock. | Lu Liu Yiming Shao Yixuan Zhang Yunxi Yang Jiamin Huang Linbin Li Ran Sun Yuying Zhou Yicheng Su Bingwei Sun | 2021 | Burns & Trauma2021，9，1： | 3 |
| 4 | A critical review on lead migration, transformation and emission control in Chinese coal-fired power plants显示文摘Coal is widely utilized as an important energy source,but coal-fired power plant was considered to be an important anthropogenic lead emission source.In the present study,the distribution characteristics of lead in coal and combustion by-products are reviewed.Specifically,lead is mainly transferred to ash particles and the formation and migration mechanisms of particulate lead are summarized.Also,targeted measures are proposed to control the formation of fine particulate lead as well as to increase the removal efficiency during the low-temperature flue gas clean process.In detail,interactions between gaseous lead and some coal-bearing minerals or added adsorbents could obviously suppress the formation of fine particulate lead.On the other hand,some efforts(including promoting capture of fine particles,reducing resistivity of particles and strengthening the gas-liquid contact)could be made to improve the fine particulate lead removal capacity.Notably,the formation mechanism of fine particulate lead is still unclear due to the limitations of research methods.Some differences in the removal principles of fine particles and particulate lead make the lead emission precisely control a great challenge.Finally,the environmental potential risk of lead emission from flue gas and ash residues is addressed and further discussed. | Yicheng Wang Hongyun Hu Xinye Wang Huimin Liu Lu Dong Guangqian Luo Yongchun Zhao Hong Yao | 2023 | Journal of Environmental Sciences2023，，2： | 2 |
| 5 | Two-way coupled analysis of lithium diffusion and diffusion induced finite elastoplastic bending of bilayer electrodes in lithium-ion batteries显示文摘A fully coupling model for the diffusion induced finite elastoplastic bending of bilayer electrodes in lithium-ion batteries is proposed. The effect of the mechanical stress on the lithium diffusion is accounted for by the mechanical part of the chemical potential derived from the Gibbs free energy along with the logarithmic stress and strain. Eight dimensionless parameters, governing the stress-assisted diffusion and the diffusion induced elastoplastic bending, are identified. It is found that the finite plasticity starting from the interface of the bilayer increases the chemical potential gradient and thereby facilitates the lithium diffusion. The full plastic flow makes the abnormal lithium concentration distribution possible, i.e., the concentration at the lithium inlet can be lower than the concentration at the interface(downstream). The increase in the thickness of the active layer during charging is much larger than the eigen-stretch due to lithiation, and this excess thickening is found to be caused by the lithiation induced plastic yield. | Jun YIN Xianjun SHAO Bo LU Yicheng SONG Junqian ZHANG | 2018 | Applied Mathematics and Mechanics(English Edition)2018，39，11： | 2 |
| 6 | Polarization behavior of microbial fuel cells under stack operation显示文摘The polarization behavior of microbial fuel cells(MFCs)was evaluated under different stack operation modes,including series,parallel,series–parallel,and parallel–series.During the stack operation,voltages of individual MFCs,subunit stacks,and overall stacks were recorded as a function of the current.Meanwhile,the potentials of individual MFCs’anode and cathode were also determined via Ag/AgCl electrodes to study the change in potentials under stack operations.The results demonstrated that the MFCs with relatively low ability to generate current were easier to suffer polarity reversal in the series stack,which was confirmed in the series subunit of the series–parallel stack.MFCs with high electroactivity would be enhanced to generate larger maximum power;however,MFCs with low electroactivity outputted smaller maximum power in a parallel stack.The changes in individual MFCs’behavior under stack operation mode were determined primarily caused by the influences on the behavior of the anode.Results of the present study provide valuable information for optimization of stack operation of MFCs. | Zejie Wang Yicheng Wu Lu Wang Feng Zhao | 2014 | Chinese Science Bulletin2014，59，18： | 2 |
| 7 | 端粒酶活性及其结构基因在人脑胶质瘤中的表达显示文摘目的 研究分析端粒酶活性及相关结构基因在不同级别脑胶质瘤中的表达 ,探讨端粒酶与脑胶质瘤的相关性及其临床意义。方法 采集 40例脑胶质瘤手术切除标本、4例正常脑组织 ,通过半定量端粒重复序列扩增 (TRAP) 银染方法检测端粒酶活性水平 ;通过半定量逆转录 聚合酶链反应 (RT PCR)检测端粒酶相关结构基因hTR、TP1、hTRT的mRNA表达水平。结果 在40例胶质瘤标本的 3 3例 (82 .5 % )中检测出端粒酶活性 ,而在正常脑组织中无端粒酶活性的表达 ,不同级别脑胶质瘤之间端粒酶活性水平差异有显著性 ,脑胶质瘤端粒酶活性水平与hTRT基因的表达呈显著正相关 ,而与TP1、hTR的表达无显著相关。结论 端粒酶活性可以作为脑胶质瘤的恶性标记之一 ,hTRT基因是一个端粒酶的正调控结构基因 ,hTRT的表达与细胞永生化和恶性肿瘤形成过程中的端粒酶的激活机制有关 ,hTR基因是端粒酶活性必须的组分 。 | 刘平 LU Yicheng 卢亦成 袁国梁 朱诚 夏放 | 2001 | 中华实验外科杂志2001，18，2： | 2 |
| 8 | The first discovery of eclogite and Palaeoproterozoic granitoids in the Beishan area,northwestern Gansu Province,China显示文摘The eclogite, discovered in Liuyuan, occurs as lenticular enclave within granitic gneiss. It has typical features of eclogite in petrology and mineralogy. The eclogite provides an important wirdow to reconstruct the tectonic border of the Tarim block. The granitoids, located in Baihu area, yield U-Pb zircon ages of 1 660—2 000 Ma (Palaeoproterozoic), which irrplies an early Precambrian basement in the area. | Hualin Mei Haifeng Yu Quan Li Songnian Lu Huimin Li Yicheng Zuo Guochao Zuo Dejin Ye Jincheng Liu | 1999 | Chinese Science Bulletin1999，44，4： | 1 |
| 9 | Small-Animal PET of Tumor Damage Induced by Photothermal Ablation with ^sup 64^Cu-Bis-DOTA-Hypericin显示文摘 | Song Shaoli Xiong Chiyi Zhou Min Lu Wei Huang Qian Ku Geng Zhao Jun Flores Leo G Ni Yicheng Li Chun | 2011 | The Journal of Nuclear Medicine2011，，5： | 1 |
| 10 | Upregulated expression of ubiquitin-conjugating enzyme E2Q1 (UBE2Q1) is associated with enhanced cell proliferation and poor prognosis in human hapatocellular carcinoma显示文摘 | Renan Chang Lixian Wei Yuhua Lu Xiaopeng Cui Cuihua Lu Luoliang Liu Dawei Jiang YiCheng Xiong Gang Wang Chunhua Wan Haixin Qian | 2015 | Journal of Molecular Histology2015，，1： | 1 |
| 11 | Real-time welding quality control and assessment system显示文摘 | Fenn Robert Lu Yicheng | 1997 | International Journal for the joining of Material1997，9，3： | 1 |
| 12 | Phonon engineering in Yb:La_(2)CaB_(10)O_(19)crystal for extended lasing beyond the fluorescence spectrum显示文摘Since the first invention of the laser in 1960,direct lasing outside the fluorescence spectrum is deemed impossible owing to the“zero-gain”cross-section.However,when electron-phonon coupling meets laser oscillation,an energy modulation by the quantized phonon can tailor the electronic transitions,thus directly creating some unprecedented lasers with extended wavelengths by phonon engineering.Here,we demonstrate a broadband lasing(1000-1280 nm)in a Yb-doped La_(2)CaB_(10)O_(19)(Yb:LCB)crystal,far beyond its spontaneous fluorescence spectrum.Numerical calculations and in situ Raman verify that such a substantial laser emission is devoted to the multiphonon coupling to lattice vibrations of a dangling“quasi-free-oxygen”site,with the increasing phonon numbers step-by-step(n=1–6).This new structural motif provides more alternative candidates with strong-coupling laser materials.Moreover,the quantitative relations between phonon density distribution and laser wavelength extension are discussed.These results give rise to the search for on-demand lasers in the darkness and pave a reliable guideline to study those intriguing electron-phonon-photon coupled systems for integrated photonic applications. | Yanling Cheng Fei Liang Dazhi Lu Jingcheng Feng Guochun Zhang Haohai Yu Huaijin Zhang Yicheng Wu | 2023 | Light(Science & Applications)2023，12，9： | 1 |
| 13 | MEK2 is a prognostic marker and potential chemo-sensitizing target for glioma patients undergoing temozolomide treatment显示文摘尽管 temozolomide (TMZ ) 是为 glioblastoma 的首要的化学疗法的代理人,它经常由于药抵抗是非药品。克服 glioblastoma 房间的抵抗到 TMZ,为结果预言识别预示的标记并且开发敏化 chemo 代理人是必要的。这里, TMZ 抵抗、 TMZ 敏感的样品的基因表示侧面被 microarray 分析,和激活 mitogen 的蛋白质 kinase kinase 比较(MEK2 ) 2 在抵抗 glioma 房间然而并非在敏感肿瘤房间或非肿瘤纸巾明确地是 upregulated。而且,耐心的数据的全面分析表明 MEK2 表示的增加的水平响应 TMZ 治疗与 glioma 等级和更坏的预后的前进相关很好。而且,在 U251 glioma 房间线或 xenografted glioma 减少 MEK2 的水平通过调停 shRNA 的基因为击倒的禁止的房间增长建模并且向 TMZ 治疗提高了房间的敏感。从由即时 PCR 的 glioma 病人的肿瘤样品的进一步的分析显示增加的 MEK2 表示水平仔细与许多药抵抗基因的激活被联系。最后,在 MEK2 是在 vitro 的 silenced 以后,这些抵抗基因是 downregulated,建议导致 MEK2 的 chemo 抵抗的机制能被这些抵抗基因的 transcriptional 激活调停。一起,我们的数据显示 MEK2 的表示水平能为 glioma 化疗用作一个预示的标记并且 MEK2 对手能被用作 chemo-sensitizers 提高 TMZ 的治疗功效。 | Hua He Maojin Yao Wenhao Zhang Bangbao Tao Feili Liu Shu Li Yan Dong Chenran Zhang Yicheng Meng Yuxin Li Guohan Hu Chun Luo Hui Zong Yicheng Lu | 2016 | Cellular & Molecular Immunology2016，13，5： | 1 |
| 14 | Clinical analysis of 103 elderly patients with pituitary adenomas: transsphenoidal surgery and follow-up 显示文摘 | Hang Jingfang Ding Xuehua Lu Yicheng | 2008 | J Clin Neurosci2008，15，10： | 1 |
| 15 | High Q - factor inductors integrated on MCM Si substrates 显示文摘 | Zu Larry Lu Yicheng Frye Robert C | 1996 | IEEE Transactions on Components Packaging and Manufacturing Technology Part B: Advanced Packaging1996，19，3： | 1 |
| 16 | MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme显示文摘 | Yiming Li Weiqing Li Yongji Yang Yicheng Lu Cheng He Guohan Hu Huimin Liu Juxiang Chen Jin He Hongyu Yu | 2009 | Brain Research2009，，： | 1 |
| 17 | Justifying videoassisted thoracic surgery for spontaneous hemopneumothorax显示文摘 | WU Yicheng LU Mingshian YEH Chihsiao | 2002 | Chest2002，122，： | 1 |
| 18 | Dye-Sensitized Solar Cells Combining ZnO Nanotip Arrays and Nonliquid Gel Electrolytes显示文摘 | Hanhong Chen Ziqing Duan Yicheng Lu Aurelien Pasquier | 2009 | Journal of Electronic Materials2009，，8： | 1 |
| 19 | Magnetic Resonance Imaging of Acute Reperfused Myocardial Infarction: Intraindividual Comparison of ECIII-60 and Gd-DTPA in a Swine Model显示文摘 | Jiyang Jin Gaojun Teng Yi Feng Yanping Wu Qindi Jin Yu Wang Zhen Wang Qin Lu Yibo Jiang Shengqi Wang Feng Chen Guy Marchal Yicheng Ni | 2007 | CardioVascular and Interventional Radiology2007，，2： | 1 |
| 20 | Predicting missing links via local information 显示文摘 | ZHOU Tao Lu Linyuan ZI-IANG Yicheng | 2009 | The european physical journal B2009，71，4： | 1 |
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