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| 1 | Evaluation of the Xpert MTB/RIF assay for diagnosis of tuberculosis and rifampin resistance in county-level laboratories in Hunan province, China显示文摘 | Hu Peilei Bai Liqiong Liu Fengping Ou Xichao Zhang Zhiying Yi Songlin Chen Zhongnan Gong Daofang Liu Binbin Guo Jingwei Tan Yunhong | 2014 | Chinese Medical Journal2014，，21： | 24 |
| 2 | A review of road extraction from remote sensing images显示文摘As a significant role for traffic management,city planning,road monitoring,GPS navigation and map updating,the technology of road extraction from a remote sensing(RS) image has been a hot research topic in recent years.In this paper,after analyzing different road features and road models,the road extraction methods were classified into the classification-based methods,knowledge-based methods,mathematical morphology,active contour model,and dynamic programming.Firstly,the road features,road model,existing difficulties and interference factors for road extraction were analyzed.Secondly,the principle of road extraction,the advantages and disadvantages of various methods and research achievements were briefly highlighted.Then,the comparisons of the different road extraction algorithms were performed,including road features,test samples and shortcomings.Finally,the research results in recent years were summarized emphatically.It is obvious that only using one kind of road features is hard to get an excellent extraction effect.Hence,in order to get good results,the road extraction should combine multiple methods according to the real applications.In the future,how to realize the complete road extraction from a RS image is still an essential but challenging and important research topic. | Weixing Wang Nan Yang Yi Zhang Fengping Wang Ting Cao Patrik Eklund | 2016 | Journal of Traffic and Transportation Engineering(English Edition)2016，3，3： | 9 |
| 3 | Solution phase parallel synthesis of 4-aminophenyl ethers using a carboxyl-functionalized ionic liquid as support 显示文摘 | Peng Yanqing Yi Fengping Song Gonghua | 2005 | Monatshefte fur Chemie2005，136，： | 1 |
| 4 | Association between SLC17A7 gene polymorphisms and venlafaxine for major depressive disorder in a Chinese Han population:a prospective pharmacogenetic case-control study显示文摘Objective: Venlafaxine is a common antidepressant and its therapeutic effect varies among people with different genetic backgrounds. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in theSLC17A7 gene are associated with the treatment outcome of venlafaxine in a Chinese Han population with major depressive disorder.Methods: This prospective pharmacogenetic case-control study that involved genotyping of four SNPs ofSLC17A7 was conducted on 175 major depressive disorder patients of Chinese Han origin, aged 18 to 65 years, participated in the study from April 2005 to September 2006. Comparisons of allele and genotype frequencies of all SNPs were performed between the responder/remission group and the nonresponder/nonremission group. This study was approved by the Institutional Ethics Committee of Sichuan University (approval No. 20151112-265).Results: The allele and genotype frequencies of the four candidate SNPs inSCL17A7 showed no significant difference between responders and nonresponders. Meanwhile, no significant difference was detected in the four investigatedSLC17A7 SNPs between patients who did and did not exhibit remission. Although one of the investigatedSLC17A7 variants (rs1578944) demonstrated a significant association (P=0.022) with a response to venlafaxine after 6 weeks of treatment in the survival analysis, the association was unclear after a Bonferroni multiple comparisons test was conducted.Conclusion: No significant association exists between the four candidate SNPs (rs1043558, rs1320301, rs1578944, and rs74174284) inSLC17A7 and venlafaxine treatment in the Chinese Han population. | Liangile Liu Decheng Ren Fan Yuan Yan Bi Zhenming Guo Gaini Ma Fei Xu Binyin Hou Lei Ji Zhixuan Chen Lin An Naixin Zhang Tao Yu Xingwang Li Fengping Yang Xueli Sun Zaiquan Dong Shunying Yu Zhenghui Yi Yifeng Xu Lin He Shaochang Wu Longyou Zhao Changqun Cai Guang He Yi Shi | 2021 | Journal of Bio-X Research2021，4，3： | 0 |
| 5 | Advances in the Immunotherapeutic Potential of Isocitrate Dehydrogenase Mutations in Glioma显示文摘Isocitrate dehydrogenase(IDH)is an essential metabolic enzyme in the tricarboxylic acid cycle(TAC).The high mutation frequency of the IDH gene plays a complicated role in gliomas.In addition to affecting gliomas directly,mutations in IDH can also alter their immune microenvironment and can change immune-cell function in direct and indirect ways.IDH mutations mediate immune-cell infiltration and function by modulating immune-checkpoint gene expression and chemokine secretion.In addition,IDH mutation-derived D2-hydroxyglutarate can be absorbed by surrounding immune cells,also affecting their functioning.In this review,we summarize current knowledge about the effects of IDH mutations as well as other gene mutations on the immune microenvironment of gliomas.We also describe recent preclinical and clinical data related to IDH-mutant inhibitors for the treatment of gliomas.Finally,we discuss different types of immunotherapy and the immunotherapeutic potential of IDH mutations in gliomas. | Feng Tang Zhiyong Pan Yi Wang Tian Lan Mengyue Wang Fengping Li Wei Quan Zhenyuan Liu Zefen Wang Zhiqiang Li | 2022 | Neuroscience Bulletin2022，38，9： | 0 |
| 6 | Correlation of PCSK1 with nonalcoholic fatty liver disease in a Han Chinese population:a case-control observational study显示文摘Objective: This study aimed to investigate the association between single-nucleotide polymorphisms (SNPs) ofPCSK1 (proprotein convertase subtilisin/kexin type 1) related to obesity and nonalcoholic fatty liver disease (NAFLD).Methods: In this case-control observational study, four candidate SNPs (rs6234, rs155971, rs6232, rs3811951) ofPCSK1 were genotyped in 732 NAFLD patients and 823 healthy control participants, all of whom were of ethnic Han Chinese descent. All participants came from Shanghai, China, and joined our study during 2015 to 2016. The frequencies of each allele and genotype, paired linkage disequilibrium, and haplotype were calculated on the SHEsis platform. In addition to SHEsis, five different genetic models (codominant, dominant, recessive, overdominant, and log-additive) were employed to identify the correlation between genotype frequency and NAFLD. This study was approved by the Medical Ethics Committee of Shanghai University of Traditional Chinese Medicine (approved No. 2017LCSY069).Results: In a comparison of NAFLD patients and healthy participants, none of the fourPCSK1 SNPs were significantly correlated with the occurrence of NAFLD (P>0.05), in either genotypic or allelic distribution. The recessive model of rs3811951 appeared to show a correlation (odds ratio=1.077;95% confidence interval=0.924-1.256;P=0.04), but there was no statistical significance after Bonferroni correction (Pcorr>0.0125).Conclusions: Four obesity-relatedPCSK1 SNPs (rs6234, rs155971, rs6232, rs3811951) showed no significant correlation with the development of NAFLD in a Han Chinese population. | Xiao Yang Fan Yuan Na Wu Decheng Ren Liangjie Liu Yan Bi Lei Ji Ke Han Mofan Feng Kai Su Fengping Yang Xi Wu Qing Lu Siran Yue Fengyan Jiang Ruirui Wang Guang He Baocheng Liu Xingwang Li Yi Shi | 2022 | Journal of Bio-X Research2022，5，3： | 0 |
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