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| 1 | Chemical Composition and Antimicrobial Activity of Essential Oil of Asarum caulescene显示文摘Both essential oils of fresh and air-dried Asarum caulescene (Maxim.) were analyzed by GC-MS in three different polarities. The results show that thirty-four components were identified in the oils, and main compounds of both oils were β-pinene (7.63% vs. 20.72%), 2-carene (8.94% vs. 7.99%), β-phellandrene (7.80% vs. 14.39%), 1,8-cineole (8.91% vs. 13.29%) and germacrone (46.64% vs. 6.64% ), however, the content of monoterpene hydrocarbons(30.29% vs. 52.30% ) and oxygenated sesquiterpenes( 47.69% vs. 10.65%) of both oils was different. The antimicrobial activity of the oil was evaluated against 3 fungi and 11 bacteria including 7 clinical isolated strains. Our results showed that both oils presented a broad antimicrobial spectrum, and compared with the essential oil from fresh herb, the extracted oil from dried herb had better antimicrobial activity, its minimum inhibitory concentration(c_ mi ) values of dried herb were 0.16-2.5 g/L and lowest minimum bactericidal concentration(c_ mb ) value was 0.31 g/L. | ZHU Shunying YANG Yang YU Huaidong YING Yue LONG Dong Zou Guolin | 2006 | Wuhan University Journal of Natural Sciences2006，11，3： | 7 |
| 2 | Unexpected catalytic activity of rhodium nanodendrites with nanosheet subunits for methanol electrooxidation in an alkaline medium显示文摘Rh 的 Nanocrystals,高贵金属催化剂家庭的一个重要成员,在异构的催化反应有宽应用。控制这些高贵金属 nanocrystals 的形态学为改进他们的催化活动和耐久性成为了有效策略。在这个工作,有很薄的三角形的分支的明确的 Rh nanodendrites 用一个灵巧的 diethylene 乙二醇减小方法作为子单元被综合,作为一个复杂形成的代理人和表面活化剂由 polyethyleneimine 帮助了。第一次,有明确的形态学的 Rh nanocrystals 上的甲醇氧化反应(粗腐殖质) 在碱的媒介用各种各样的电气化学的技术被调查。出人意料地,同样准备的 Rh nanodendrites 与 ultrathin nanosheet 子单元,在碱的媒介在 MOR 期间展出优异 electrocatalytic 活动和耐久性,与特定的形态学显示那 Rh nanocrystals 可以是在在碱的媒介的 MOR 的磅 electrocatalysts 的高度有希望的选择。 | Yongqiang Kang Fumin Li Shuni Li Pujun Jin Jinhui Zeng Jiaxing Jiang Yu Chen | 2016 | Nano Research2016，9，12： | 5 |
| 3 | A modified discrete element model for sea ice dynamics显示文摘Considering the discontinuous characteristics of sea ice on various scales,a modified discrete element model(DEM)for sea ice dynamics is developed based on the granular material rheology.In this modified DEM,a soft sea ice particle element is introduced as a self-adjustive particle size function.Each ice particle can be treated as an assembly of ice floes,with its concentration and thickness changing to variable sizes under the conservation of mass.In this model,the contact forces among ice particles are calculated using a viscous-elastic-plastic model,while the maximum shear forces are described with the Mohr-Coulomb friction law.With this modified DEM,the ice flow dynamics is simulated under the drags of wind and current in a channel of various widths.The thicknesses,concentrations and velocities of ice particles are obtained,and then reasonable dynamic process is analyzed.The sea ice dynamic process is also simulated in a vortex wind field.Taking the influence of thermodynamics into account,this modified DEM will be improved in the future work. | LI Baohui LI Hai LIU Yu WANG Anliang JI Shunying | 2014 | Acta Oceanologica Sinica2014，33，1： | 4 |
| 4 | PsyMuKB: An Integrative De Novo Variant Knowledge Base for Developmental Disorders显示文摘De novo variants(DNVs)are one of the most significant contributors to severe earlyonset genetic disorders such as autism spectrum disorder,intellectual disability,and other developmental and neuropsychiatric(DNP)disorders.Presently,a plethora of DNVs have been identified using next-generation sequencing,and many efforts have been made to understand their impact at the gene level.However,there has been little exploration of the effects at the isoform level.The brain contains a high level of alternative splicing and regulation,and exhibits a more divergent splicing program than other tissues.Therefore,it is crucial to explore variants at the transcriptional regulation level to better interpret the mechanisms underlying DNP disorders.To facilitate a better usage and improve the isoform-level interpretation of variants,we developed NeuroPsychiatric Mutation Knowledge Base(PsyMuKB).It contains a comprehensive,carefully curated list of DNVs with transcriptional and translational annotations to enable identification of isoformspecific mutations.PsyMuKB allows a flexible search of genes or variants and provides both table-based descriptions and associated visualizations,such as expression,transcript genomic structures,protein interactions,and the mutation sites mapped on the protein structures.It also provides an easy-to-use web interface,allowing users to rapidly visualize the locations and characteristics of mutations and the expression patterns of the impacted genes and isoforms.PsyMuKB thus constitutes a valuable resource for identifying tissue-specific DNVs for further functional studies of related disorders.PsyMuKB is freely accessible at http://gffzz08064908ab1147fdhkpnqxbwno5uv6xub.ffgz.tsg.suse.edu.cn. | Guan Ning Lin Sijia Guo Xian Tan Weidi Wang Wei Qian Weichen Song Jingru Wang Shunying Yu Zhen Wang Donghong Cui Han Wang | 2019 | Genomics, Proteomics & Bioinformatics2019，17，4： | 2 |
| 5 | Chemical composition and antimicrobial activity of the essential oils of Chrysanthemum indicum 显示文摘 | Zhu Shunying Yang Yang Yu Huaidong | 2005 | Journal of Ethnopharmacology2005，96，： | 1 |
| 6 | Chem ical Composition and Antimicrobial Activity of the Es sential Oils of Chrysanthemum indicum 显示文摘 | Zhu Shunying Yang Yang Yu Huaidong | 2005 | J Ethnopharmaco12005，96，： | 1 |
| 7 | Enhanced Sensitivity and Selectivity of Chemosensor for Malonate by Anchoring on Gold Nanoparticles显示文摘有 bis-thiourea 的 4 functionalized 武装的新奇器官无机的 nanohybrided 受体然后集合在金 nanoparticles 上被综合。preorganized 系统为 dicarboxylates 察觉到的 spectrophotometric 拥有 phenylthiourea 单位,特别 malonate,基于在金 nanoparticles (GNP ) 的表面电浆子吸收的变化。吸收度乐队的紧张与 dicarboxylates 增加的集中逐渐地增加。但是在电浆子乐队的如此的一个离子选择的变化没在测试由 mono-thiourea-modified GNP 执行了的控制被观察,受体第 3a 免费 receptor2。当它从协会常数被显示出,源于量的滴定,受体 4 能有选择地认出更短的碳链的 dicarboxylate 阴离子,并且有最高的亲密关系到 malonate。为受体 4 的阴离子的相互作用性质被 1H NMR 和紫外力的分光镜的方法评估。 | Liu, Yanyun Liu, Yun Liang, Zhongshi Li, Xiangyang Liu, Shunying Yu, Jiahui | 2011 | Chinese Journal of Chemistry2011，29，3： | 1 |
| 8 | Expression, Purification, and Characterization of a Novel Soluble Form of Human Delta-like-1显示文摘 | Mei Zhao Mingyuan Wu Lingchen Guo Junfen Jiang Weiwei Huang Xiaojuan Lin Zhonghui Zhang Di Xiang Huili Lu Shunying Zhu Yan Yu Anja Moldenhauer Wei Han | 2010 | Applied Biochemistry and Biotechnology2010，，5： | 1 |
| 9 | Chemi- cal composition and antimicrobial activity of the essential oils of Chrysanthemum indicum 显示文摘 | ZHU Shunying YANG Yong YU Huaidong | 2005 | J Ethnopharm acol2005，96，12： | 1 |
| 10 | Chemical composi- tion and antimicrobial activity of the essential oils of Chrysanthemum indicum显示文摘 | ZHU Shunying YANG Yang YU Huaidong | 2005 | Journal of Ethnopharmacology2005，96，12： | 1 |
| 11 | Interleukin 1 receptor antagonist reduces lethality and intestinal toxicity of 5-Fluorouracil in a mouse mucositis model显示文摘 | Zhenqian Wu Xiaodong Han Shenyin Qin Qi Zheng Zhigang Wang Di Xiang Jing Zhang Huili Lu Mingyuan Wu Shunying Zhu Yan Yu Yu Wang Wei Han | 2011 | Biomedicine & Pharmacotherapy2011，，5： | 1 |
| 12 | Identification of de novo Mutations in the Chinese Autism Spectrum Disorder Cohort via Whole-Exome Sequencing Unveils Brain Regions Implicated in Autism显示文摘Autism spectrum disorder(ASD)is a highly heritable neurodevelopmental disorder characterized by deficits in social interactions and repetitive behaviors.Although hundreds of ASD risk genes,implicated in synaptic formation and transcriptional regulation,have been identified through human genetic studies,the East Asian ASD cohorts are still under-represented in genome-wide genetic studies.Here,we applied whole-exome sequencing to 369 ASD trios including probands and unaffected parents of Chinese origin.Using a joint-calling analytical pipeline based on GATK toolkits,we identified numerous de novo mutations including 55 high-impact variants and 165 moderate-impact variants,as well as de novo copy number variations containing known ASD-related genes.Importantly,combined with single-cell sequencing data from the developing human brain,we found that the expression of genes with de novo mutations was specifically enriched in the pre-,post-central gyrus(PRC,PC)and banks of the superior temporal(BST)regions in the human brain.By further analyzing the brain imaging data with ASD and healthy controls,we found that the gray volume of the right BST in ASD patients was significantly decreased compared to healthy controls,suggesting the potential structural deficits associated with ASD.Finally,we found a decrease in the seed-based functional connectivity between BST/PC/PRC and sensory areas,the insula,as well as the frontal lobes in ASD patients.This work indicated that combinatorial analysis with genome-wide screening,single-cell sequencing,and brain imaging data reveal the brain regions contributing to the etiology of ASD. | Bo Yuan Mengdi Wang Xinran Wu Peipei Cheng Ran Zhang Ran Zhang Shunying Yu Jie Zhang Yasong Du Xiaoqun Wang Zilong Qiu | 2023 | Neuroscience Bulletin2023，39，10： | 0 |
| 13 | Association between SLC17A7 gene polymorphisms and venlafaxine for major depressive disorder in a Chinese Han population:a prospective pharmacogenetic case-control study显示文摘Objective: Venlafaxine is a common antidepressant and its therapeutic effect varies among people with different genetic backgrounds. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in theSLC17A7 gene are associated with the treatment outcome of venlafaxine in a Chinese Han population with major depressive disorder.Methods: This prospective pharmacogenetic case-control study that involved genotyping of four SNPs ofSLC17A7 was conducted on 175 major depressive disorder patients of Chinese Han origin, aged 18 to 65 years, participated in the study from April 2005 to September 2006. Comparisons of allele and genotype frequencies of all SNPs were performed between the responder/remission group and the nonresponder/nonremission group. This study was approved by the Institutional Ethics Committee of Sichuan University (approval No. 20151112-265).Results: The allele and genotype frequencies of the four candidate SNPs inSCL17A7 showed no significant difference between responders and nonresponders. Meanwhile, no significant difference was detected in the four investigatedSLC17A7 SNPs between patients who did and did not exhibit remission. Although one of the investigatedSLC17A7 variants (rs1578944) demonstrated a significant association (P=0.022) with a response to venlafaxine after 6 weeks of treatment in the survival analysis, the association was unclear after a Bonferroni multiple comparisons test was conducted.Conclusion: No significant association exists between the four candidate SNPs (rs1043558, rs1320301, rs1578944, and rs74174284) inSLC17A7 and venlafaxine treatment in the Chinese Han population. | Liangile Liu Decheng Ren Fan Yuan Yan Bi Zhenming Guo Gaini Ma Fei Xu Binyin Hou Lei Ji Zhixuan Chen Lin An Naixin Zhang Tao Yu Xingwang Li Fengping Yang Xueli Sun Zaiquan Dong Shunying Yu Zhenghui Yi Yifeng Xu Lin He Shaochang Wu Longyou Zhao Changqun Cai Guang He Yi Shi | 2021 | Journal of Bio-X Research2021，4，3： | 0 |
| 14 | Effectiveness of pharmacogenomics on the response and remission of treatment-resistant depression: a metaanalysis of randomised controlled trials显示文摘Background Pharmacogenomics(PGx)is a promising tool to realise tailored drug therapy for depression.Aims To investigate the treatment efficacy of PGxfor treatment-resistant depression(TRD)compared with treatmentas usual.Methods A systematic search was conducted in PubMed,Embase,the Cochrane Library,Web of Science and PsyclNFO to identify relevant studies published from inception to 15 April 2023.Two-arm randomised controlled trials(RCTs)exploring the efficacy of PGx-guided versus unguided treatment for TRD were included.The risk of bias in the included studies was evaluated using the Cochrane risk of bias assessment tool.The overall quality of evidence was assessed using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Results Seven RCTs(n=3003)comparing PGx-guided(n=1492)and unguided(n=1511)groups were identified and analysed.PGx-guided treatment was superior to treatment as usual in response(relative risk(RR)=1.31;95%confidence interval(95%Cl):1.15 to 1.49;p<0.001)and remission(RR=1.40;95%Cl:1.09 to 1.80;p=0.009)improvements.Effect sizes for acceptability(RR=0.90;95%Cl:0.80 to 1.02;p=0.100)and side effect burden(RR=0.58;95%Cl:0.29 to 1.15;p=0.120)between the two groups were not statistically different.The overall quality of evidence was rated from'very low'(25%)to low'(75%)based on the GRADE criteria.Conclusions PGx-guided treatment has shown a small overall effect in improving the response and remission rates for patients with TRD.However,these results should be interpreted cautiously because of the few included studies and the low quality of evidence.Further high-quality clinical trials are warranted to confirm the findings. | Yu Cheng Hongmei Liu Ruixue Yuan Kai Yuan Shunying Yu | 2023 | General Psychiatry2023，36，6： | 0 |
| 15 | Transmission of NOTCH4 and GRIK2 in a population of Han Chinese with schizophrenia and affective disorder显示文摘BACKGROUND: Increasing evidence suggests overlapped genetic susceptibility across traditional classification systems that divided psychotic disorders into schizophrenia or affective disorder. OBJECTIVE: This study aimed to explore whether schizophrenia and affective disorder share genetic susceptibility in NOTCH4 and GRIK2 loci in a population of Han Chinese. DESIGN: Repetitive measurements. SETTING: The experiment was carried out at Shanghai Mental Health Center and Hongkou Mental Health Center of Shanghai between January 2001 and June 2004. PARTICIPANTS: Sixty-five mixed pedigrees (suffering from various diseases, in combination with schizophrenia and affective disorder), composed of 45 completed trios and 20 single-parent families, were selected from Shanghai Mental Health Center and Hongkou Mental Health Center of Shanghai between January 2001 and June 2004. Probands received clinical diagnosis according to ICD-10; an independent clinician used identical criteria to review all diagnoses. All subjects were Han Chinese in origin and provided informed consent. There were 65 probands and 110 parents among the subjects. The probands comprised 30 males and 35 females: 33 with schizophrenia, 32 with affective disorder, mean age of (30.9 ± 9.8) years, mean age of onset (24.3 ± 8.8) years, mean duration (6.6 ± 7.0) years, and mean age of parents (58.8 ± 10.9) years. METHODS: DNA samples from probands and their biological parents were extracted from peripheral blood according to standard methods. Four polymorphisms, -1725T/G and -25T/C in NOTCH4, rs6922753T/C and rs2227283G/A in GRIK2, were amplified and genotyped with PCR-RFLP techniques. MAIN OUTCOME MEASURES: Association between NOTCH4, GRIK2 polymorphism, and schizophrenia was analyzed by transmission disequilibrium test (TDT). RESULTS: Sixty-five probands and 110 parents were included in the result analysis, with no dropouts. The results showed that the -25T/C polymorphism of NOTCH4 associated significantly with affective disorder and -1725G/-25T haplotype with schizophrenia. SNP rs6922753 of GRIK2 did not associate with the two diseases; SNP rs2227283 and haplotypes, TG and CA, were significantly associated with both diseases. CONCLUSION: Schizophrenia and affective disorder might share genetic susceptibility among mixed pedigrees of the Han Chinese population. NOTCH4 and GRIK2 might be two of the most common susceptibility genes for these psychoses. | Zuowei Wang Yiru Fang Shaoping Zhang Shunying Yu Sanduo Jiang | 2008 | Neural Regeneration Research2008，3，3： | 0 |
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