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| 1 | miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ显示文摘 | Yanqing Liu Uzair-ur-Rehman Yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu Mengchao Yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-Yu Zhang Feng Zhi Xi Chen | 2016 | Protein & Cell2016，7，10： | 14 |
| 2 | Research and Practice in Three-Dimensional City Modeling显示文摘我们与空间数据交往的方法从 2D 地图被改变了到 3D 虚拟地理环境(VGE ) 。当 VGE,和特别地 3D 城市模型提供一个有效方法在城市的区域集成巨大的、异质的 geospatial 信息和 georeferenced 信息,一台计算机上的地理信息的三维的代表被知道。(3DCM ) 3D 城市建模是在不同申请区域的一个活跃研究和实践话题。这篇论文介绍在 3D GIS,虚拟环境,和 AEC/FM 采用的不同当模特儿的范例。新 3DCM 技术正在演变为数据集成和合作途径代表一个城市的完整的空间范围,到未葬、地下的模型,室外、室内的环境包括人造有 3D 几何学,外观,拓扑学和语义的目标和自然特征。 | ZHU Qing | 2009 | Geo-Spatial Information Science2009，12，1： | 10 |
| 3 | GeoScope:Full 3D Geospatial Information System Case Study显示文摘Aiming at the integrative management and comprehensive applications of large-scale 3D geospatial information covering the full 3D space of a city,this paper briefly introduces the design and implementation of a full 3D GIS platform:GeoScope,which provides a professional solution for the massive full three-dimensional geospatial data integration,management,analysis,visualization,and applications.GeoScope is characterized by:(1) extendible software architecture based on the hierarchical message bus,facilitates multimodal integrative applications of 2D GIS and 3D GIS;(2) unified 3D city models,support multiscale semantic representation of outdoor & indoor and aboveground & underground 3D objects;(3) high-efficient 3D geospatial database engine,supports integrated management of massive 3D geospatial data for real-time applications;and (4) high-performance visualization engine exploiting the massively parallel computation architecture of modern GPUs,supports real-time realistic rendering of large-scale complicated 3D geospatial environments.The successful pilot application of GeoScope is also illustrated with the 3D city models of 8494 km2 of the whole Wuhan City,the largest city in middle China. | ZHANG Yeting ZHU Qing LIU Gang ZHENG Wenting LI Zhonghua DU Zhiqiang | 2011 | Geo-Spatial Information Science2011，14，2： | 7 |
| 4 | Spatial and temporal distribution of Neolithic sites in coastal China:Sea level changes, geomorphic evolution and human adaption显示文摘The East China coastal plain is one of the most important Neolithic culture areas in China, where rich archaeological sites including those producing the earliest domesticated rice are observed. It is also a place where landscape has experienced dramatic evolution during the Holocene when both sea level and climate changed, such that it is an ideal place for studying human-environment interaction. This study investigated over 2000 sites of pre-history and Shang and Zhou Dynasties, with 655 of which being Neolithic ages, by using DEM and GIS methods. The results suggest that the spatial and temporal distribution of Neolithic sites has largely been controlled by landscape evolution(particularly changes in coastal line), which ultimately governed by sea level changes. During early Holocene, Neolithic sites sparsely distributed in the intermountain basins of east Zhejiang Province, far from the influence of ocean. Over the period of 9–7 ka, the coastal plain(including the shelf) was largely submerged,only the feet of low hills to the south and southwest of the study area, and islands protruding the estuary, cradled limited number of settlements with characteristic 'maritime components'. At about 7 ka, sea level rise decelerated prominently, while sediments supply in the drainage remained high value, the combination of which led to land formation and propagation. Vast space during this period facilitated the growth of settlements in both size and number. In the mean time, however, the coastal plain was vulnerable to extreme environmental events such as storms and flooding owning to its geomorphic nature, which exerted great influence on the rise and fall of Neolithic culture. | ZHENG HongBo ZHOU YouSheng YANG Qing HU ZhuJun LING GuangJiu ZHANG JuZhong GU ChunGuang WANG YingYing CAO YeTing HUANG XianRong CHENG Yue ZHANG XiaoYu WU WenXiang | 2018 | Science China Earth Sciences2018，61，2： | 7 |
| 5 | Three-Dimensional TIN Algorithm for Digital Terrain Modeling显示文摘The problem of taking an unorganized point cloud in 3D space and fitting a polyhedral surface to those points is both important and difficult. Aiming at increasing applications of full three dimensional digital terrain surface modeling, a new algorithm for the automatic generation of three dimensional triangulated irregular network from a point cloud is pro- posed. Based on the local topological consistency test, a combined algorithm of constrained 3D Delaunay triangulation and region-growing is extended to ensure topologically correct reconstruction. This paper also introduced an efficient neighbor- ing triangle location method by making full use of the surface normal information. Experimental results prove that this algo- rithm can efficiently obtain the most reasonable reconstructed mesh surface with arbitrary topology, wherein the automati- cally reconstructed surface has only small topological difference from the true surface. This algorithm has potential applica- tions to virtual environments, computer vision, and so on. | ZHU Qing ZHANG Yeting LI Fengchun | 2008 | Geo-Spatial Information Science2008，11，2： | 6 |
| 6 | Design and Implementation of 3D Model Database for General-Purpose 3D GIS显示文摘改进可重用性三维(3D ) 当模特儿并且简化自然景色重建的复杂性,这份报纸为通用 3D GIS 论述一个 3D 模型数据库。在它的可扩展的功能建筑学的介绍以后,在 3D GIS 的任何重建的景色由模型的含蓄的空间时间的层次的结论伴随了为通用,几个关键问题详细被讨论例如 3D 模型和相关检索和负担方法的存储和管理,象为进一步按需的开发的接口一样。最后,这个模型数据库的有效性和可行性在铁路操作的 3D 可视化系统的开发通过它的应用程序被证明。 | XU Weiping ZHU Qing DU Zhiqiang ZHANG Yeting | 2010 | Geo-Spatial Information Science2010，13，3： | 2 |
| 7 | Efficacy of rigosertib, a small molecular RAS signaling disrupter for the treatment of KRAS-mutant colorectal cancer显示文摘Objective:Mutant KRAS,the principal isoform of RAS,plays a pivotal role in the oncogenesis of colorectal cancer by constitutively activating the RAF/MEK/ERK and PI3K/AKT pathways.Effective targeted therapies are urgently needed.We investigated whether rigosertib,a benzyl styryl sulfone RAS signaling disruptor,could selectively kill KRAS-mutant colorectal cancer cells.Methods:CCK-8 was used to determine the cell viability.Patient-derived tumor and cancer cell xenograft models were used to detect the inhibitory efficacy of rigosertib.Flow cytometry was used to evaluate the apoptosis and cell cycle progression.Apoptosis and cell cycle arrest markers were detected by Western blot.DCFH-DA was used to determine the reactive oxygen species.Immunohistochemistry staining and Western blot were performed to characterize RAS signaling markers in colorectal cancer tissues and cells.Results:Rigosertib(RGS)exhibited a cytotoxic effect against colorectal cancer cells,which was greater in KRAS-mutant cells.Furthermore,RGS induced mitotic arrest and oxidative stress-dependent apoptosis in KRAS-mutant DLD1 and HCT116 cells.Besides,RGS disrupted RAS signaling,and the inhibition of RAS/MEK/ERK was independent of cellular oxidative stress.Using patient-derived xenograft models,the response and tumor inhibition of RGS were significantly higher in the KRAS-mutant subgroup,while p-MEK,p-ERK,and p-AKT levels of RGS-treated tumors were significantly decreased.Finally,in a KRAS-mutant,chemotherapy-resistant patient-derived xenograft model,RGS showed a stronger therapeutic effect than the combination standard therapy involving fluoropyrimidine+oxaliplatin/irinotecan+bevacizumab.Conclusions:These data showed that targeting RAS signaling using RGS could be a therapeutic treatment for KRAS-mutant colorectal cancer patients. | Xinyi Zhou Qian Xiao Dongliang Fu Haochen Zhang Yang Tang Jinjie He Yeting Hu Xiangxing Kong Fei Teng Xiangrui Liu Ying Yuan Kefeng Ding | 2022 | Cancer Biology & Medicine2022，19，2： | 2 |
| 8 | CARs:a new approach for the treatment of autoimmune diseases显示文摘The development of chimeric antigen receptor(CAR)-based therapeutic interventions represented a breakthrough in cancer treatment.Following the success of the CAR-T-cell strategy,this novel therapeutic approach has been applied to other diseases,including autoimmune diseases.Using CAR-T cells to deplete pathological immune cells(i.e.,B cells,autoreactive B or T cells,and accessory antigen-presenting cells(APCs))has resulted in favorable outcomes in diseases characterized by excessive autoantibody levels or hyperactive lymphocyte cell numbers.The importance of immunosuppressive regulatory Tcells(Tregs)in restoring immune tolerance has been well established,and CAR-Tregs have shown promising therapeutic potential in treating autoimmune diseases.Moreover,prior experience from the cancer field has provided sufficient paradigms for understanding how to optimize the structure and function of CARs to improve their function,persistence,stability and safety.In this review,we describe the potential application of CAR-T cells and CAR-Tregs in the treatment of autoimmune diseases,and we summarize the currently available strategies of gene editing and synthetic biological tools that have improved the practical application of CAR-based therapies. | Yeting Sun Yeshuang Yuan Bo Zhang Xuan Zhang | 2023 | Science China(Life Sciences)2023，66，4： | 2 |
| 9 | Integration method of TINs and Grids for multi-resolution surface modeling显示文摘Highly detailed surface models and their real-time applications are increasingly popular in architecture,construction and other design and engineering fields.However,new and related problems have emerged concerning the efficient management of the resulting large datasets and the seamless integration of heterogeneous data.Moreover,the increasingly common requirements of local high-fidelity modeling combined with large-scale landscapes lead to difficulty in the seamless multi-resolution representation of hybrid triangulated irregular networks(TINs)and Grids.This paper presents a hybrid data structure with high-efficiency and a related organizational method for the seamless integration of multi-resolution models.This approach is characterized by(1)a self-adaptive algorithm for feature-preserving surface partitioning,(2)an efficient hybrid index structure for combined Grid and TIN surfaces,and(3)a view-dependent scheduling strategy with access to Grids of necessary resolution,giving priority to the dynamic loading of TINs.Experiments using typical real design datasets of highway constructions are able to achieve accuracy-preserved and real-time availability of results that prove the validity and efficiency of this approach. | Xie XIAO Xu WEIPING Zhu QING Zhang YETING Du ZHIQIANG | 2013 | Geo-Spatial Information Science2013，16，1： | 2 |
| 10 | GIS(CCGIS), Intergration of DEMs,Images, and 3D Models Photogrammetric Engineering & Remote Sensing 显示文摘 | Qing zhu Deren Li Yeting Zhang Zheng Zhong Duo Huang | 2002 | CyberCity GIS(CCGIS)2002，68，4： | 1 |
| 11 | An efficient 3D R-tree spatial index method for virtual geographic environment显示文摘 | ZHU Qing GONG Jun ZHANG Yeting | 2007 | ISPRS Journal of Photogrammetry & Remote Sensing2007，62，3： | 1 |
| 12 | An efficient 3D R-tree spatial index method for virtual geographic environments显示文摘 | Zhu Qing Gong Jun Zhang Yeting | 2007 | ISPRS Journal of Photogrammertry and Remote Sensing2007，62，3： | 1 |
| 13 | An efficient 3-D R-tree spatial index method for virtual geographic environments显示文摘 | ZHU Qing GONG Jun ZHANG Yeting | 2007 | ISPRS Journal of Photogrammetry and Remote Sensing2007，62，3： | 1 |
| 14 | An efficient 3D R-tree spatial index method for virtual geographic environments显示文摘 | ZHU Qing GONG Jun ZHANG Yeting | 2007 | ISPRS Journal of Photogrammertry and Remote Sensing2007，62，3： | 1 |
| 15 | An efficient 3D R-tree spatial index method for virtual geographic environments显示文摘 | Zhu Qing Gong Jun Zhang Yeting | 2007 | ISPRS Journal of Photogrammertry and Remote Sensing2007，62，3： | 1 |
| 16 | An efficient 3D R-tree gpa- tial index method for virtual geographic environments显示文摘 | Zhu Qing Gong Jun Zhang Yeting | 2007 | ISPRS Journal of Photogrammertry and Remote Sensing2007，62，3： | 1 |
| 17 | An efficient 3 D R-tree spatial index method for virtual geographic environments 显示文摘 | Zhu Qing Gong Jun Zhang Yeting | 2007 | ISPRS Journal of Photogrammertry and Remote Sensing2007，623，： | 1 |
| 18 | CyberCity GIS (CCGIS):Integration of DEMs,images and 3D models显示文摘 | Zhu Qing Li Deren Zhang Yeting | 2002 | Photogrammetric Engineering and Remote Sensing2002，68，4： | 1 |
| 19 | CyberCity GIS (CC-GIS):Integration of DEMs,Images and 3D Models 显示文摘 | Zhu Qing Li Deren Zhang Yeting | 2002 | Photogrammetric Engineering and Remote Sensing2002，68，4： | 1 |
| 20 | An efficient 3D R- tree spatial index method for virtual geographic environments 显示文摘 | Qing Zhu Jun Gong Yeting Zhang | 2007 | ISPRS Journal of Photogrammetry & Remote Sensing2007，，62： | 1 |
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