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| 1 | 新型均相酶法检测sd LDL—C试剂盒的性能评价显示文摘目的 评价小而密低密度脂蛋白胆固醇(sd LDL-C)均相酶法检测试剂盒的性能.方法参照CLSI EP文件及其它文献,评估新型sd LDL-C均相酶法液态双试剂检测试剂盒的灵敏度、精密度、线性范围、抗干扰能力和携带污染率,并以密度梯度超速离心法(DUGC)为参比方法,评价新型sd LDL-C均相酶法液态试剂盒的准确度.结果均相法各项精密度及特异度良好,灵敏度可达0.048 mmol/L,低值样本和高值样本的总精密度分别为8.69%和4.64%,测定结果与DUGC法相关性良好(Y=1.065 4X-1.8354),线性范围上限可达2.634 mmol/L,可以抵抗临床中常见的干扰现象,符合试剂说明书的参数和临床应用的要求.结论新型sd LDL-C均相酶法检测试剂盒各项性能良好,是一种可用于临床常规的快速简便sd LDL-C检测方法. | 林文涛 李江 孙菲 赵兴波 Yasuki Ito Motoko Ohta 鄢盛恺 | 2013 | 现代检验医学杂志2013，28，3： | 4 |
| 2 | Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis显示文摘BACKGROUND The gut-liver axis has attracted much interest in the context of chronic liver disease pathogenesis.Prebiotics such as dietary fibers were shown to attenuate non-alcoholic fatty liver disease(NAFLD)by modulating gut microbiota.Partially hydrolyzed guar gum(PHGG),a water-soluble dietary fiber,has been reported to alleviate the symptoms of various intestinal diseases and metabolic syndromes.However,its effects on NAFLD remain to be fully elucidated.To determine whether treatment with PHGG attenuates NAFLD development in mice through the gut-liver axis.METHODS Seven-week-old male C57BL/6J mice with increased intestinal permeability were fed a control or atherogenic(Ath)diet(a mouse model of NAFLD)for 8 wk,with or without 5%PHGG.Increased intestinal permeability was induced through chronic intermittent administration of low-dose dextran sulfate sodium.Body weight,liver weight,macroscopic findings in the liver,blood biochemistry[aspartate aminotransferase(AST)and alanine aminotransferase(ALT),total cholesterol,triglyceride,free fatty acids,and glucose levels],liver histology,myeloperoxidase activity in liver tissue,mRNA expression in the liver and intestine,serum endotoxin levels in the portal vein,intestinal permeability,and microbiota and short-chain fatty acid(SCFA)profiles in the cecal samples were investigated.RESULTS Mice with increased intestinal permeability subjected to the Ath diet showed significantly increased serum AST and ALT levels,liver fat accumulation,liver inflammatory(tumor necrosis factor-αand monocyte chemotactic protein-1)and fibrogenic(collagen 1a1 andαsmooth muscle actin)marker levels,and liver myeloperoxidase activity,which were significantly attenuated by PHGG treatment.Furthermore,the Ath diet combined with increased intestinal permeability resulted in elevated portal endotoxin levels and activated toll-like receptor(TLR)4 and TLR9 expression,confirming that intestinal permeability was significantly elevated,as observed by evaluating the lumen-to-blood clearance of fluorescein isothiocyanate-conjugated dextran.PHGG treatment did not affect fatty acid metabolism in the liver.However,it decreased lipopolysaccharide signaling through the gut-liver axis.In addition,it significantly increased the abundance of cecal Bacteroides and Clostridium subcluster XIVa.Treatment with PHGG markedly increased the levels of SCFAs,particularly,butyric acid,acetic acid,propionic acid,and formic acid,in the cecal samples.CONCLUSION PHGG partially prevented NAFLD development in mice through the gut-liver axis by modulating microbiota and downstream SCFA profiles. | Shun Takayama Kazuhiro Katada Tomohisa Takagi Takaya Iida Tomohiro Ueda Katsura Mizushima Yasuki Higashimura Mayuko Morita Tetsuya Okayama Kazuhiro Kamada Kazuhiko Uchiyama Osamu Handa Takeshi Ishikawa Zenta Yasukawa Tsutomu Okubo Yoshito Itoh Yuji Naito | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 3 | 在有 vasospastic 咽峡炎的病人的冠的 microvascular 功能的评估显示文摘 AIM: To investigate endothelium-dependent and independent coronary microvascular functions in patients with vasospastic angina (VSA). METHODS: Thirty-six patients with VSA (30 men and 6 women; mean age, 58 years) were enrolled in this study. VSA was defined as ≥ 90% narrowing of the epicardial coronary arteries on angiography performed during a spasm provocation test, presence of chest pain, and/or ST-segment deviation on an electrocardiogram (ECG). Patients (n = 36) with negative spasm provocation test results and those matched for age and sex were enrolled as a control group (nonVSA group). Low-dose acetylcholine (ACh; 3 μg/min) was infused into the left coronary ostium for 2 min during the spasm provocation test. Following the spasm provocation test, nitroglycerin (0.2 mg) was administered intracoronally. Coronary blood flow (was calculated from quantitativeangiography and Doppler flow velocity measurements, and the coronary flow reserve was calculated as the ratio of coronary flow velocity after injection of adenosine triphosphate (20 μg) to the baseline value. Changes in the coronary artery diameter in response to ACh and nitroglycerin infusion were expressed as percentage changes from baseline measurements. RESULTS: Body mass index was significantly lower in the VSA group than in the nonVSA group. The fre- quency of conventional coronary risk factors and the rate of statin use were similar between the 2 groups. The left ventricular ejection fraction as evaluated by echocardiography was similar between the 2 groups. The duration of angina was 9 ± 2 mo. The results of blood chemistry analysis were similar between the 2 groups. Low-dose ACh did not cause coronary spasms. The change in coronary artery diameter in response to ACh was lower in the VSA group (-1.4% ± 9.3%) than in the nonVSA group (3.1% ± 6.5%, P < 0.05), whereas nitroglycerin-induced coronary artery dilatation and coronary blood flow increase in response to ACh or coronary flow reserve did not differ significantly between the 2 groups. CONCLUSION: These findings suggest that microvascular coronary function may be preserved despite endothelial dysfunction of the epicardial coronary arteries in patients with VSA. | Hiroki Teragawa Naoya Mitsuba Ken Ishibashi Kenji Nishioka Satoshi Kurisu Yasuki Kihara | 2013 | World Journal of Cardiology2013，5，1： | 2 |
| 4 | Impaired coronary microvascular endothelial function in men with metabolic syndrome显示文摘AIM: To assess coronary endothelial function of conduit and resistance vessels in patients with metabolic syndrome (MS). METHODS: Seventy-eight men (mean age, 57 years) with chest pain and angiographically normal coronary arteries were included in the study. Patients with coronary spastic angina were excluded. Changes in coronary artery diameter and coronary blood flow (CBF) in response to acetylcholine (ACh) were determined using quantitative coronary angiography and Doppler velocity measurements. Coronary flow reserve was calculated as the ratio of coronary blood velocity after adenosine triphosphate infusion relative to baseline values. Patients were divided into two groups based on the presence or absence of MS. RESULTS: There were 24 patients in the MS group (31%). The increase in CBF in response to ACh infusion was impaired in the MS group (P < 0.0001) compared to the non-MS group, whereas changes in coronary artery diameter in response to ACh infusion did not differ between the two groups. Multivariate regression analysis revealed that MS was a significant factor associated with the lesser change in CBF induced by ACh infusion at 30 μg/min (P < 0.0001, r 2 = 0.46). CONCLUSION: Coronary endothelial dysfunction was present at the level of resistance vessels but not conduit vessels in the MS patients included in our study. | Hiroki Teragawa Naoya Mitsuba Kenji Nishioka Kentaro Ueda Shingo Kono Yukihito Higashi Kazuaki Chayama Yasuki Kihara | 2010 | World Journal of Cardiology2010，2，7： | 2 |
| 5 | Classification of lactic acid bacteria isolated from chigee and mare milk collected in Inner Mongolia显示文摘 | YingAn Yoshikazu Adachi Yasuki Ogawa | 2004 | Animal science journal2004，75，3： | 1 |
| 6 | A randomized trial of postoperative UFT therapy in p stage Ⅰ , Ⅱ non-small cell lung cancer: North-East Japan Study Group for Lung Cancer Surgery 显示文摘 | Chiaki E Yasuki S Hiroshi I | 2003 | Lung Cancer2003，40，： | 1 |
| 7 | Self-tuning PID controller based on the Lyapunov approach 显示文摘 | YASUKI K LI J MIN S C | 2008 | Chemical Engi- neering Science2008，63，： | 1 |
| 8 | Plant regeneration from patchouli protoplasts encapsulated in alginate beads 显示文摘 | YASUSHI Kageyama YASUKI Honda YUKIO Sugimura | 1995 | Plant Cell Tissue and Organ Culture1995，41，： | 1 |
| 9 | Characterization of texture and mechanical properties of heat-induced soy protein gels显示文摘 | Jun KangII Yasuki Matsumura Tomohiko Mori | 1990 | Journal of the American Oil Chemists Society1990，，5： | 1 |
| 10 | Gelation and gel properties of soybean glycinin in a transglutaminase-catalyzed system 显示文摘 | Kang I K Yasuki M Koji I | 1994 | Agric Food Chem1994，42，： | 1 |
| 11 | Advanced energy saving in distillation process with self- heat recuperation technology显示文摘 | Kazuo Matsuda Kenichi Kawazuishi Yasuki Kansha | 2011 | Energy2011，36，： | 1 |
| 12 | A Retrospective Analysis of Oral and Maxillofacial Injuries in Motor Vehicle Accidents显示文摘 | Tomoko Yokoyama Yasuki Motozawa Tadaaki Sasaki Masahito Hitosugi | 2006 | Journal of Oral and Maxillofacial Surgery2006，，12： | 1 |
| 13 | Endothelin-1 plays a critical role in the functional deterioration of left ventricles during the transition from compensatory hypertrophy to congestive heart failure in salt-sensitive hypertensive rats显示文摘 | Yoshitaka I Yasuki K Koji H | 1998 | Circulation1998，98，： | 1 |
| 14 | Oral infection-inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease显示文摘 | Yukihito Higashi Chikara Goto Takayuki Hidaka Junko Soga Shuji Nakamura Yuichi Fujii Takaki Hata Naomi Idei Noritaka Fujimura Kazuaki Chayama Yasuki Kihara Akira Taguchi | 2009 | Atherosclerosis2009，，2： | 1 |
| 15 | Microstructure and strength of interface in joint of WC-40mass% Co alloy/carbon steel 显示文摘 | Yasuki Miyakoshi Kohji Takazawa Kohsuke Tagashira | 1997 | Funtai Oyobi Fummatsu Yakin/Journal of the Japan Society of Powder and Powder Metallurgy1997，44，10： | 1 |
| 16 | Characterization of Noncalcified Coronary Plaques and Identification of Culprit Lesions in Patients With Acute Coronary Syndrome by 64-Slice Computed Tomography显示文摘 | Toshiro Kitagawa Hideya Yamamoto Jun Horiguchi Norihiko Ohhashi Futoshi Tadehara Tomoki Shokawa Yoshihiro Dohi Eiji Kunita Hiroto Utsunomiya Nobuoki Kohno Yasuki Kihara | 2009 | JACC: Cardiovascular Imaging2009，，2： | 1 |
| 17 | Effect of carbon addition on mechanical properties of WC-37mass% Fe alloy显示文摘 | Yasuki Miyakoshi Kohji Takazawa Kohsuke Tagashira | 2002 | Funtai Oyobi Fummatsu Yakin/Journal of the Japan Society of Powder and Powder Metallurgy2002，49，3： | 1 |
| 18 | The new cooperative medical scheme in China显示文摘 | YOU X D YASUKI K | 2009 | Health policy2009，91，1： | 1 |
| 19 | Internal organisation,business groups and corporate performance:An empirical test of the multidivisional hypothesis in Japan显示文摘 | CABLE J YASUKI H | 1985 | International Joumal of Industrial Organization1985，3，： | 1 |
| 20 | Filler effects of oil droplets on the viscoelastic properties of emulsion gels 显示文摘 | Yasuki Matsumura Hiroko Sakamoto | 1993 | Food Hydrocolloids1993，7，： | 1 |
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