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| 1 | Correction of β-thalassemia mutant by base editor in human embryos显示文摘 | Puping Liang Chenhui Ding Hongwei Sun Xiaowei Xie Yanwen Xu Xiya Zhang Ying Sun Yuanyan Xiong Wenbin Ma Yongxiang Liu Yali Wang Jianpei Fang Dan Liu Zhou Songyang Canquan Zhou Junjiu Huang | 2017 | Protein & Cell2017，8，11： | 34 |
| 2 | Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior显示文摘为过去的几十年,在中国的传染疾病侧面在社会、经济的方面,环境,食物的质量,水,住房,和公共健康基础结构与快速的开发一直在变。尤其是, 5 应具报的传染疾病几乎被根除了,并且 18 另外的应具报的传染疾病的发生显著地被减少了。出人意料地,包括 HIV,普鲁斯病,梅毒,和登革热发烧,超过 10 应具报的传染疾病的发生一直在增加。不过,经常的传染疾病爆发 / 事件每年几乎被报导了,并且进口了传染疾病自从 2015,增加了。已知的病原体的新病原体和超过 100 新遗传型或 serotypes 被识别了。一些传染疾病似乎被各种各样的因素加重,包括快速的都市化,大量候鸟工人,在气候的变化,生态学,和政策,例如把农田还给森林。这评论在设法出现和 re-emerging 从中国总结当前的经验和课传染疾病,特别生态学的效果,气候,和行为,它应该在帮助另外的国家控制并且阻止传染疾病有优点。 | Qiyong Liu Wenbo Xu Shan Lu Jiafu Jiang Jieping Zhou Zhujun Shao Xiaobo Liu Lei Xu Yanwen Xiong Han Zheng Sun Jin Hai Jiang Wuchun Cao Jianguo Xu | 2018 | Frontiers of Medicine2018，12，1： | 23 |
| 3 | Functional and phylogenetic analysis of a DREB/CBF-like gene in perennial ryegrass (Lolium perenne L.)显示文摘 | Yanwen Xiong Shui-Zhang Fei | 2006 | Planta2006，，4： | 1 |
| 4 | Functional and phylogenetic analysis of a DREB/CBF-like gene in perennial ryegrass (Lolium perenne L.)显示文摘 | Yanwen Xiong Shui-Zhang Fei | 2006 | Planta2006，，4： | 1 |
| 5 | Discovery of a mammalian FASN inhibitor against xenografts of non-small cell lung cancer and melanoma显示文摘Dear Editor,Cancer cells need to reprogram fatty acid(FA)metabolism to promote cell growth and survival through exogenous lipid uptake and FA biosynthesis catalyzed by the multidomain containing mammalian FA synthase(FASN).1,2 The bidirectional relationships of oncogenic signaling and de novo lipogenesis(DNL)suggest that FASN is a druggable target in many cancers. | Danfeng Cao Jie Yang Youchao Deng Meng Su Yeji Wang Xueqiong Feng Yi Xiong Enhe Bai Yanwen Duan Yong Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 1 |
| 6 | Single-cell transcriptomic analysis uncovers the origin and intratumoral heterogeneity of parotid pleomorphic adenoma显示文摘Pleomorphic adenoma(PA)is the most common benign tumour in the salivary gland and has high morphological complexity.However,the origin and intratumoral heterogeneity of PA are largely unknown.Here,we constructed a comprehensive atlas of PA at single-cell resolution and showed that PA exhibited five tumour subpopulations,three recapitulating the epithelial states of the normal parotid gland,and two PA-specific epithelial cell(PASE)populations unique to tumours.Then,six subgroups of PASE cells were identified,which varied in epithelium,bone,immune,metabolism,stemness and cell cycle signatures.Moreover,we revealed that CD36+myoepithelial cells were the tumour-initiating cells(TICs)in PA,and were dominated by the PI3K-AKT pathway.Targeting the PI3K-AKT pathway significantly inhibited CD36+myoepithelial cell-derived tumour spheres and the growth of PA organoids.Our results provide new insights into the diversity and origin of PA,offering an important clinical implication for targeting the PI3K-AKT signalling pathway in PA treatment. | Xiuyun Xu Jiaxiang Xie Rongsong Ling Shengqi Ouyang Gan Xiong Yanwen Lu Bokai Yun Ming Zhang Wenjin Wang Xiqiang Liu Demeng Chen Cheng Wang | 2023 | International Journal of Oral Science2023，15，3： | 0 |
| 7 | Enhancement of SARS-CoV-2 vaccine-induced immunity by a Toll-like receptor 7 agonist adjuvant显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an enveloped positive-sense single-stranded RNA(ssRNA)virus responsible for the global COVID-19 pandemic.Although vaccines for SARS-CoV-2 have been developed and applied worldwide,research on vaccine adjuvant is lacking.Viral infections normally elicit a range of innate immune responses through the activation of pattern recognition receptors(PRRs). | Gen Li Meixing Yu Qiong Ke Jing Sun Yanwen Peng Chuanfeng Xiong Olivia Monteiro COVID-Infection and Immunity Investigation Group Jincun Zhao Andy P.Xiang | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 8 | Trust Evaluation Model Based on PSO and LSTM for Huge Information Environments显示文摘Due to the challenge of increasing data volume, the traditional trust model is unable to manage data with high efficiency and effectively extract useful information hidden in big data. To fully utilize big data and combine machine learning with trust evaluation, a trust evaluation model based on Long short-term memory(LSTM) is presented. The powerful learning ability,expressive ability and dynamic timing of LSTM can be applied to study data while avoiding the vanishing and exploding gradient phenomena of traditional Recurrent neural networks(RNNs) to ensure that the model can learn sequences of random length and provide accurate trust evaluation. Targeting the performance instability caused by the LSTM model’s random initialization of weights and thresholds, Particle swarm optimization(PSO), one of the intelligent algorithms, is introduced to find global optimal initial weights and thresholds.Experiments proved that the trust model proposed in this paper has high accuracy and contributes a new idea for trust evaluation in big data environments. | ZHANG Lin HUANG Yanwen XUAN Jie FU Xiong LIN Qiaomin WANG Ruchuan | 2021 | Chinese Journal of Electronics2021，30，1： | 0 |
| 9 | A regularization method in the electromagnetic inverse scattering problem显示文摘基于反的散布问题的测量数据方程的正规化,再,规则化矩阵被建议。它能消除在地点或来源点和 tsrget 区域之间的距离的差别引起的相反的效果,在规则化过程减少有用信息的损失,并且减少提出病的 pioblems 的条件数字。为二维的 axisymmetric 的传导性分发的倒置不同类的媒介被与弄歪的 Fk 梳这个新 regolarization 方法执行, m 反复的方法。模拟结果显示出那比较 th 常规方法,新规则化方法稳定性更好。 | XIONG Xiaoyun ZHAO Yanwen NIE Zaiping | 2007 | Progress in Natural Science:Materials International2007，17，3： | 0 |
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