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| 1 | Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior显示文摘为过去的几十年,在中国的传染疾病侧面在社会、经济的方面,环境,食物的质量,水,住房,和公共健康基础结构与快速的开发一直在变。尤其是, 5 应具报的传染疾病几乎被根除了,并且 18 另外的应具报的传染疾病的发生显著地被减少了。出人意料地,包括 HIV,普鲁斯病,梅毒,和登革热发烧,超过 10 应具报的传染疾病的发生一直在增加。不过,经常的传染疾病爆发 / 事件每年几乎被报导了,并且进口了传染疾病自从 2015,增加了。已知的病原体的新病原体和超过 100 新遗传型或 serotypes 被识别了。一些传染疾病似乎被各种各样的因素加重,包括快速的都市化,大量候鸟工人,在气候的变化,生态学,和政策,例如把农田还给森林。这评论在设法出现和 re-emerging 从中国总结当前的经验和课传染疾病,特别生态学的效果,气候,和行为,它应该在帮助另外的国家控制并且阻止传染疾病有优点。 | Qiyong Liu Wenbo Xu Shan Lu Jiafu Jiang Jieping Zhou Zhujun Shao Xiaobo Liu Lei Xu Yanwen Xiong Han Zheng Sun Jin Hai Jiang Wuchun Cao Jianguo Xu | 2018 | Frontiers of Medicine2018，12，1： | 23 |
| 2 | Influence of t-ZrO_2 addition on mechanical property and electrical conductivity of YSZ electrolyte显示文摘8YSZ material that has high electrical conductivity is widely used as electrolytes for solid oxide fuel cells (SOFCs). But its low strength and low fracture toughness hampered the development of SOFCs. In order to find a best method to improve the capability of YSZ electrolyte, the effects of 3Y-TZP additive on the density, strength, conductivity and microstructure were studied by means of X-ray diffraction and Vicker′s hardness apparatus. The strength and conductivity of YSZ electrolyte doped with different amounts of 3Y-TZP were determined. It is shown that the samples sintered at 1450 ℃ for 2 h are the best in properties. When 3Y-TZP powders are added to the YSZ system, the results demonstrate that strength of the electrolyte increases remarkably, and the fracture toughness is improved. The electrical conductivity is lowered only slightly. The results display that the flexural strength and the fracture toughness of ceramics with 30wt.% TZP reach 300 MPa and 3.7 MPa·m1/2, respectively, and the conductivity at 1000 ℃ reaches 0.11 S·cm-1. | LU Zhixin YU Yanwen GUO Ruisong LI Hailong GUO Qian | 2006 | Rare Metals2006，25，z1： | 1 |
| 3 | High-performance,nanostructure LiMnPO_4/C composites synthesized via onestep solid state reaction显示文摘 | ZHENG Jugong NI Liang LU Yanwen | 2015 | J Power Sources2015，282，： | 1 |
| 4 | Reuse and reproduction of used refractories 显示文摘 | Lu Zhixin Yu Yanwen | 2007 | Acta Scientiarum Naturalium Universitatis Sunyatseni2007，46，1： | 1 |
| 5 | Fabrication and characteristics of nano LiFePO 4 /C composites with high capacity and high rate using nano Fe 2 O 3 as raw materials显示文摘 | BaoHua Rong YanWen Lu XueWen Liu QingLin Chen Kun Tang HuaZhen Yang XingYun Wu Fei Shen YanBin Chen YueFeng Tang YanFeng Chen | 2014 | Nano Energy2014，，： | 1 |
| 6 | Reuse and reproduction of used refracto- ries显示文摘 | Lu Zhixin Yu Yanwen | 2007 | Acta Scientiarum Naturalium Universitatis Sunyatseni2007，46，1： | 1 |
| 7 | The identification, typing, and antimicrobial susceptibility of Pseudomonas aeruginosa isolated from mink with hemorrhagic pneumonia显示文摘 | Jing Qi Lulu Li Yijun Du Shourong Wang Jinwen Wang Yanbo Luo Jie Che Jinxing Lu Hui Liu Guangchun Hu Jixia Li Yanwen Gong Guisheng Wang Ming Hu ShiganYan Yuqing Liu | 2014 | Veterinary Microbiology2014，，： | 1 |
| 8 | A New Text Detec- tion Approach Based on BP Neural Network for Vehicle Li- cense Plate Detection in Complex Background 显示文摘 | Yanwen Li Meng Li Yinghua Lu | 2007 | Lecture Notes in Computer Science Part II2007，4492，： | 1 |
| 9 | Direct Electrochemistry of Horseradish Peroxidase Immobilized in a Low Molecular Weight Gel显示文摘The ternary system of dodecylpyridinium bromide(DDPB)/acetone/H2O with appropriate composition can form a gel spontaneously and the gel is stable in hydrophobic ionic liquid 1-butyl-3-methylimidazolium hexafluorophos-phate([Bmim]PF_(6)).Based on the gelation phenomenon we observed,the low molecular weight gelator(LMWG)was first tried to immobilize horseradish peroxidase(HRP)on glassy carbon electrode(GCE).The scanning elec-tron microscope(SEM)images,the UV-Vis spectra and the bioactivity measurement indicate that the gel is suitable for the immobilization of HRP.The direct electrochemistry of the HRP-gel modified GCE(HRP-gel/GCE)in[Bmim]PF_(6)shows a pair of well-defined and quasi-reversible redox peaks with the heterogeneous electron transfer rate constant(ks)being 14.4 s^(−1),indicating that the direct electron transfer between HRP and GCE is fast.The HRP-gel/GCE is stable and reproducible.Also the electrode exhibits good electrocatalytic effect on the reduction of trichloroacetic acid(TCA),showing good promise in bioelectrocatalysis. | Yan Hu Yanwen Sun Lu Lu Xirong Huang | 2014 | Chinese Journal of Chemistry2014，32，3： | 0 |
| 10 | The chemical reprogramming of unipotent adult germ cells towards authentic pluripotency and de novo establishment of imprinting显示文摘Although somatic cells can be reprogrammed to pluripotent stem cells(PsCs)with pure chemicals,authentic pluripotency of chemically induced pluripotent stem celis(CipsCs)has never been achieved through tetraploid complementation assay.Spontaneous reprogramming of spermatogonial stem cells(ssCs)was another non-transgenic way to obtain PsCs,but this process lacks mechanistic explanation.Here,we reconstructed the trajectory of mouse SsC reprogramming and developed a five-chemical combination,boosting the reprogramming effciency by nearly 80-to 100-folds.More importantly,chemical induced germline-derived PsCs(5C-gPSCs),but not gpsCs and chemical induced pluripotent stem cells,had authentic pluripotency,as determined by tetraploid complementation.Mechanistically,ssCs traversed through an inverted pathway of in vivo germ ceil development,exhibiting the expression signatures and DNA methylation dynamics from spermatogonia to primordial germ cells and further to epiblasts.Besides,ssC-specific imprinting control regions switched from biallelic methylated states to monoallelic methylated states by imprinting demethylation and then re-methylation on one of the two alleles in 5c-gPsCs,which was apparently distinct with the imprinting reprogramming in vivo as DNA methylation simultaneously occurred on both alleles.Our work sheds ight on the unique regulatory network underpinning SsC reprogramming,providing insights to understand generic mechanisms for cell-fate decision and epigenetic-relateddisorders in regenerative medicine. | Yuhan Chen Jiansen Lu Yanwen Xu Yaping Huang Dazhuang Wang Peiling Liang Shaofang Ren Xuesong Hu Yewen Qin Wei Ke Ralf Jauch Andrew Paul Hutchins Mei Wang Fuchou Tang Xiao-Yang Zhao | 2023 | Protein & Cell2023，14，7： | 0 |
| 11 | Study on the Effect between Dynamics of MgO Grain Growth and Additive of Y_2O_3显示文摘In this paper,samples of CaO-riched MgO-CaO added with Y2O3 were prepared and the growth rate of MgO grains were investigated, and the calculation of the grain growth active energy at different temperatures was done for the high performance anti-hydration CaO-riched MgO-CaO clinker. It is of significance for decreasing the synthetic temperature in industry production. | YU Yanwen LU Zhixin | 2006 | China's Refractories2006，15，2： | 0 |
| 12 | Single-cell transcriptomic analysis uncovers the origin and intratumoral heterogeneity of parotid pleomorphic adenoma显示文摘Pleomorphic adenoma(PA)is the most common benign tumour in the salivary gland and has high morphological complexity.However,the origin and intratumoral heterogeneity of PA are largely unknown.Here,we constructed a comprehensive atlas of PA at single-cell resolution and showed that PA exhibited five tumour subpopulations,three recapitulating the epithelial states of the normal parotid gland,and two PA-specific epithelial cell(PASE)populations unique to tumours.Then,six subgroups of PASE cells were identified,which varied in epithelium,bone,immune,metabolism,stemness and cell cycle signatures.Moreover,we revealed that CD36+myoepithelial cells were the tumour-initiating cells(TICs)in PA,and were dominated by the PI3K-AKT pathway.Targeting the PI3K-AKT pathway significantly inhibited CD36+myoepithelial cell-derived tumour spheres and the growth of PA organoids.Our results provide new insights into the diversity and origin of PA,offering an important clinical implication for targeting the PI3K-AKT signalling pathway in PA treatment. | Xiuyun Xu Jiaxiang Xie Rongsong Ling Shengqi Ouyang Gan Xiong Yanwen Lu Bokai Yun Ming Zhang Wenjin Wang Xiqiang Liu Demeng Chen Cheng Wang | 2023 | International Journal of Oral Science2023，15，3： | 0 |
| 13 | Differentiate Xp11.2 Translocation Renal Cell Carcinoma from Computed Tomography Images and Clinical Data with ResNet-18 CNN and XGBoost显示文摘This study aims to apply ResNet-18 convolutional neural network(CNN)and XGBoost to preoperative computed tomography(CT)images and clinical data for distinguishing Xp11.2 translocation renal cell carcinoma(Xp11.2 tRCC)from common subtypes of renal cell carcinoma(RCC)in order to provide patients with individualized treatment plans.Data from45 patients with Xp11.2 tRCC fromJanuary 2007 to December 2021 are collected.Clear cell RCC(ccRCC),papillary RCC(pRCC),or chromophobe RCC(chRCC)can be detected from each patient.CT images are acquired in the following three phases:unenhanced,corticomedullary,and nephrographic.A unified framework is proposed for the classification of renal masses.In this framework,ResNet-18 CNN is employed to classify renal cancers with CT images,while XGBoost is adopted with clinical data.Experiments demonstrate that,if applying ResNet-18 CNN or XGBoost singly,the latter outperforms the former,while the framework integrating both technologies performs similarly or better than urologists.Especially,the possibility of misclassifying Xp11.2 tRCC,pRCC,and chRCC as ccRCC by the proposed framework is much lower than urologists. | Yanwen Lu Wenliang Ma Xiang Dong Mackenzie Brown Tong Lu Weidong Gan | 2023 | Computer Modeling in Engineering & Sciences2023，，7： | 0 |
| 14 | Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation显示文摘Excessive inflammatory responses contribute to the pathogenesis and lethality of highly pathogenic human coronaviruses,but the underlying mechanism remains unclear.In this study,the N proteins of highly pathogenic human coronaviruses,including severe acute respiratory syndrome coronavirus(SARS-CoV),middle east respiratory syndrome coronavirus(MERS-CoV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),were found to bind MASP-2,a key serine protease in the lectin pathway of complement activation,resulting in excessive complement activation by potentiating MBL-dependent MASP-2 activation,and the deposition of MASP-2,C4b,activated C3 and C5b-9.Aggravated inflammatory lung injury was observed in mice infected with adenovirus expressing the N protein.Complement hyperactivation was also observed in SARS-CoV-2-infected patients.Either blocking the N protein:MASP-2 interaction,MASP-2 depletion or suppressing complement activation can significantly alleviate N protein-induced complement hyperactivation and lung injury in vitro and in vivo.Altogether,these data suggested that complement suppression may represent a novel therapeutic approach for pneumonia induced by these highly pathogenic coronaviruses. | Ting Gao Lin Zhu Hainan Liu Xiaopeng Zhang Tingting Wang Yangbo Fu Hongzhen Li Qincai Dong Yong Hu Zhang Zhang Jing Jin Zijing Liu Weihong Yang Yaoning Liu Yanwen Jin Kaitong Li Yongjiu Xiao Junli Liu Huailong Zhao Yue Liu Ping Li Jibo Song Lu Zhang Yuwei Gao Sisi Kang Shoudeng Chen Qingjun Ma Xiuwu Bian Wei Chen Xuan Liu Qing Mao Cheng Cao | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 0 |
| 15 | Carbon dots modified nanoflower petals with super enhanced nitrogen electro-reduction efficiency显示文摘Nitrogen electro-reduction reaction(NERR)is a promising alternative method for ammonia production to the Haber-Bosch approach due to mild reaction conditions and free harmful by-product emission.A formidable challenge in bringing NERR closer to the practical application is developing an electrocatalyst which can simultaneously improve the Faraday efficiency and reduce the reaction over-potential.Herein,we fabricated a catalyst of nitrogen-doped carbon dots modified copper-phosphate nanoflower petals(Cu Po-NCDs NF)via a self-assembly method.The flower structure endowed the Cu Po-NCDs NF with large specific surface area,and thus enabled more active sites to be exposed.In particular,we demonstrated that the NCDs modified Cu Po petals with flower-like structure can accelerate the interfacial proton-electron transfer,suppressing the competing hydrogen evolution reaction and promoting the desired NERR process.Ultimately,for the CuPo-NCDs NF catalyzed NERR,the FE_(NH_(3))and the reaction potential both were boosted,the resultant energy efficiency of NERR reached a record-breaking value of 56.5%,and the NH_(3)yield rate increased by 7 times compared to NCDs.This study provides a novel catalyst with a new pathway to boost the NERR. | Yang Zhou Xuanzhao Lu Yu-chung Chang Yanwen Ma Linlin Wang Jianrong Zhang Junjie Zhu | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 16 | Four-junction AlGaAs/GaAs laser power converter显示文摘Four-junction AlGaAs/GaAs laser power converters (LPCs) with n^+-Ga As/p^+-Al_(0.37)Ga_(0.63)As hetero-structure tunnel junctions (TJs) have been designed and grown by metal-organic chemical vapor deposition(MOCVD) for converting the power of 808 nm lasers. A maximum conversion efficiency ηc of 56.9% ± 4% is obtained for cells with an aperture of 3.14 mm^2 at an input laser power of 0.2 W, while dropping to 43.3% at 1.5 W.Measured current–voltage (I–V) characteristics indicate that the performance of the LPC can be further improved by increasing the tunneling current density of TJs and optimizing the thicknesses of sub-cells to achieve current matching in LPC. | Jie Huang Yurun Sun Yongming Zhao Shuzhen Yu Jianrong Dong Jiping Xue Chi Xue Jin Wang Yunqing Lu Yanwen Ding | 2018 | Journal of Semiconductors2018，39，4： | 0 |
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