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| 1 | Analysis and Numerical Simulation of Rolling Contact between Sphere and Cone显示文摘In non-conforming rolling contact, the contact stress is highly concentrated in the contact area. However, there are some limitations of the special contact model and stress model used for the theoretical study of the phenomenon, and this has prevented in-depth analysis of the associated friction, wear, and failure. This paper is particularly aimed at investigating the area of rolling contact between a sphere and a cone, for which purpose the boundary is determined by the Hertz theory and the geometries of the non-conforming surfaces. The phenomenon of stick-slip contact is observed to occur in the contact area under the condition of no-full-slip(Q < μ·P). Using the two-dimensional rolling contact theory developed by CARTER, the relative positions of the stick and slip regions and the distribution of the tangential force over the contact area are analyzed. Furthermore, each stress component is calculated based on the Mc Ewen theory and the idea of narrow band. The stress equations for the three-dimensional rolling contact between the sphere and the cone are obtained by the principle of superposition, and are used to perform some numerical simulations. The results show that the stress components have a large gradient along the boundary between the stick and slip regions, and that the maximum stress is inversely proportional to the contact coefficient and proportional to the friction coefficient. A new method for investigating the stress during non-classical three-dimensional rolling contact is proposed as a theoretical foundation for the analysis of the associated friction, wear, and failure. | ZHAO Yanling XIA Chengtao WANG Hongbo XUAN Jiaping XIANG Jingzhong LIU Xianli SU Xiangguo | 2015 | Chinese Journal of Mechanical Engineering2015，28，3： | 18 |
| 2 | CecropinXJ, a silkworm antimicrobial peptide, induces cytoskeleton disruption in esophageal carcinoma cells显示文摘抗菌剂肽在有机体的非特定的免疫系统存在并且参予每种的天生的宿主防卫。CecropinXJ, cationic 抗菌剂肽,在癌症房间上优先地拥有有势力 anticancer 活动和行为而不是大部分未知的 cecropinXJ 遗体导致的癌症房间死亡的正常房间,而是机制。这研究被执行用扫描电子显微镜学观察,荧光成像,房间迁居和侵略试金在人的食道的癌房间线 Eca109 上调查 cecropinXJ 的破坏细胞骨架的效果,西方的弄污,并且量的反向的抄写聚合酶链反应(qRT-PCR ) 分析。电子显微镜和荧光成像观察建议 cecropinXJ 能导致词法变化并且以一种剂量依赖者方式导致损坏到 Eca109 房间的微导管和肌动朊。房间迁居和侵略试金证明 cecropinXJ 能禁止肿瘤房间的移植和侵略。西方的污点和 qRT-PCR 分析证明在 cecropinXJ 导致的微导管 depolymerization 和肌动朊聚合之间有明显的关联。而且, cecropinXJ 可能也在集中依赖者和时间依赖者礼貌引起 -actin,-actin,-actin,-tubulin, 和导管素基因的减少的表示。在摘要,这研究显示 cecropinXJ 通过导致细胞骨架破坏并且调整细胞骨架蛋白质的表示在 Eca109 房间触发 cytotoxicity。这调停 cecropinXJ 的细胞骨架破坏效果在我们在人的癌症房间的抗菌剂肽的详细行动的理解是有帮助的, cecropinXJ 以后可能是为癌症的治疗的一个潜在的治疗学的代理人。 | Lijie Xia Yanling Wu Su Kang Ji Ma Jianhua Yang Fuchun Zhang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，10： | 4 |
| 3 | Optimized coagulation pretreatment alleviates ultrafiltration membrane fouling: The role of floc properties and slow-mixing speed on mechanisms of chitosan-assisted coagulation显示文摘To alleviate ultrafiltration(UF) membrane fouling, the pre-coagulation of poly-aluminum chloride(PACl) with the aid of chitosan(CTS) was conducted for synthetic humic acid–kaolin water treatment. Pre-coagulation of three molecular weights(MW) CTSs(50–190 kDa(CTSL), 190–310 kDa(CTSM) and 310–375 kDa(CTSH)) was optimized with slow-mixing speeds of 30, 60 and 90 r/min, respectively. The removal efficiency and floc properties as well as membrane fouling were analyzed, and were compared to results obtained by conventional coagulation with PACl. Results showed that variations in floc properties could be ascribed to the coagulation mechanisms of CTS_L/CTS_M/CTS_H at different slow-mixing speeds, resulting in reduced UF membrane fouling. Specifically, at the low speed of 30 r/min, all three CTS types produced flocs with similar properties, while CTSLresulted in the lowest removal efficiency and aggravated irreversible fouling. At the appropriate speed of 60 r/min, CTSMgenerated the most compact flocs with the combined effects of bridging and path mechanisms. The compact cake layer formed could alleviate irreversible fouling,which was beneficial for prolonging the operation of the UF membrane. At the high speed of90 r/min, CTSHformed fragile flocs and aggravated irreversible membrane fouling. We considered membrane fouling to be affected by floc properties and the resultant removal efficiency, which was governed by the MW of the CTS used and the slow-mixing speed applied as well. | Peng Du Xing Li Yanling Yang Zhaoyang Su Hang Li Nan Wang Tingting Guo Tingting Zhang Zhiwei Zhou | 2019 | Journal of Environmental Sciences2019，31，8： | 3 |
| 4 | Adsorption behavior of EE 2 (17α-ethinylestradiol) onto the inactivated sewage sludge: Kinetics, thermodynamics and influence factors显示文摘 | Yujie Feng Zhaohan Zhang Peng Gao Hui Su Yanling Yu Nanqi Ren | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 5 | Antibody-engineered red blood cell interface for high-performance capture and release of circulating tumor cells显示文摘Circulating tumor cells(CTCs),as important liquid biopsy target,can provide valuable information for cancer progress monitoring and individualized treatment.However,current isolation platforms incapable of balancing capture efficiency,specificity,cell viability,and gentle release have restricted the clinical applications of CTCs.Herein,inspired by the structure and functional merits of natural membrane interfaces,we established an antibody-engineered red blood cell(RBC-Ab)affinity interface on microfluidic chip for high-performance isolation and release of CTCs.The lateral fluidity,pliability,and anti-adhesion property of the RBC microfluidic interface enabled efficient CTCs capture(96.5%),high CTCs viability(96.1%),and high CTCs purity(average 4.2-log depletion of leukocytes).More importantly,selective lysis of RBCs by simply changing the salt concentration was utilized to destroy the affinity interface for efficient and gentle release of CTCs without nucleic acid contamination.Using this chip,CTCs were successfully detected in colon cancer samples with 90%sensitivity and 100%specificity(20 patients and 10 healthy individuals).After the release process,KRAS gene mutations of CTCs were identified from all the 5 cancer samples,which was consistent with the results of tissue biopsy.We expect this RBC interface strategy will inspire further biomimetic interface construction for rare cell analysis. | Haicong Shen Rui Su Jiao Peng Lin Zhu Kunyue Deng Qi Niu Yanling Song Liu Yang Lingling Wu Zhi Zhu Chaoyong Yang | 2022 | Bioactive Materials2022，7，5： | 1 |
| 6 | Functional outcome of displaced intra-articular calcaneal fractures:a comparison between open reduction/internal fixation and a minimally invasive approach featured an anatomical plate and compression bohs显示文摘 | Zhan po Wu Yanling Su Wei | 2012 | The journal of trauma and acute care surgery2012，73，3： | 1 |
| 7 | Unusual Combination of Posterior Femoral Head Dislocation With Anterior and Posterior Wall Fractures in the lpsilateral Acetabulum显示文摘 | Wei Chen Yanling Su Yingze Zhang 等 | 2010 | Orthopedics2010，33，6： | 1 |
| 8 | Estimating submarine groundwater discharge at a subtropical river estuary along the Beibu Gulf,China显示文摘In certain regions,submarine groundwater discharge(SGD)into the ocean plays a significant role in coastal material fluxes and their biogeochemical cycle;therefore,the impact of SGD on the ecosystem cannot be ignored.In this study,SGD was estimated using naturally occurring radium isotopes(^(223)Ra and ^(224)Ra)in a subtropical estuary along the Beibu Gulf,China.The results showed that the Ra activities of submarine groundwater were approximately 10 times higher than those of surface water.By assuming a steady state and using an Ra mass balance model,the SGD flux in May 2018 was estimated to be 5.98×10^(6) m^(3)/d and 3.60×10^(6) m^(3)/d based on 224Ra and 223Ra,respectively.At the same time,the activities of Ra isotopes fluctuated within a tidal cycle;that is,a lower activity was observed at high tide and a higher activity was seen at low tide.Based on these variations,the average tidal pumping fluxes of SGD were 1.15×10^(6) m^(3)/d and 2.44×10^(6) m^(3)/d with 224Ra and 223Ra,respectively.Tidaldriven SGD accounts for 24%-51%of the total SGD.Therefore,tidal pumping is an important driving force of the SGD in the Dafengjiang River(DFJR)Estuary.Furthermore,the SGD of the DFJR Estuary in the coastal zone contributes significantly to the seawater composition of the Beibu Gulf and the material exchange between land and sea. | Xilong Wang Kaijun Su Juan Du Linwei Li Yanling Lao Guizhen Ning Li Bin | 2021 | Acta Oceanologica Sinica2021，40，9： | 1 |
| 9 | Effects of electroacupuncture on chronic unpredictable mild stress rats de- pression-dike behavior and expression of p-ERK/ERK and p- P38/P38显示文摘 | Jian Xu Yanling She Ning Su | 2015 | Evidence-Based Complementary and Alternative Medicine2015，18，： | 1 |
| 10 | Minimally Invasive Treatment of Calcaneal Fracture by Percutaneous Leverage, Anat- omical Plate, and Compression Bolts-The Clinical Evaluation of Cohort of 156 Patients 显示文摘 | Qingxian Wang Wei Chen Yanling Su | 2010 | The Journal of Trauma2010，69，： | 1 |
| 11 | An irreducible variant of femoral neck fracture: A minimally traumatic reduction technique显示文摘 | Yanling Su Wei Chen Qi Zhang Baojun Li Zhiyong Li Mingke Guo Jinshe Pan Yingze Zhang | 2010 | Injury2010，，2： | 1 |
| 12 | An irreducible variant of femoral neck fracture:A minimally traumatic reduction technique显示文摘 | Yanling Su Wei Chen Qi Zhang | 2011 | Injury2011，42，： | 1 |
| 13 | Peroneal Tenography to Evaluate Lateral Hiedfoot Pain After Calcaneal Fracture显示文摘 | Wei Chen Xicheng Li Yanling Su | 2011 | Faot and ankle imernational2011，32，8： | 1 |
| 14 | Alkylation of benzene with carbon dioxide to low-carbon aromatic hydrocarbons over bifunctional Zn-Ti/HZSM-5 catalyst显示文摘Alkylation of benzene to value-added,high octane number and low toxic toluene and xylenes provides a way to lower benzene content in gasoline pool,and is hence a method to promote fuel quality.On the other hand,CO_(2) accumulation in the atmosphere causes global warming and requires effective route for its valorization.Utilization of CO_(2) as a carbon source for benzene alkylation could achieve both goals.Herein,alkylation of benzene with CO_(2) and H2 was realized by a series of low-cost bifunctional catalysts containing zinc/titanium oxides(Zn/Ti oxides)and HZSM-5 molecular sieves in a fixed-bed reactor.By regulating and controlling oxygen vacancies of Zn/Ti oxides and the acidities of HZSM-5,benzene conversion and CO_(2) conversion reached 28.7%and 29.9%respectively,along with a total selectivity of toluene and xylene higher than 90%.In this process,more than 25%CO_(2) was effectively utilized and incorporated into the target products.Moreover,the mechanism of the reaction was analyzed and the course was simultaneously traced.CO_(2) was transformed into methanol firstly,and then methanol reacted with benzene generating toluene and xylene.The innovation provides a new method for upgrading of fuels and upcycling the emissions of CO_(2),which is of great environmental and economic benefits. | Xiangyu Liu Yanling Pan Peng Zhang Yilin Wang Guohao Xu Zhaojie Su Xuedong Zhu Fan Yang | 2022 | Frontiers of Chemical Science and Engineering2022，16，3： | 0 |
| 15 | Development characteristics of cloud-to-ground lightning with multiple grounding points显示文摘Using the optical images of a cloud-to-ground lightning flash with multiple grounding points obtained by a highspeed video system in the Qinghai Province of China along with synchronous radiated electric field information, the propagation characteristic and the electric field change features of the leaders and the grounding behavior of discharge channels are analyzed.In addition, the two-dimensional velocity of the leader was estimated and its correlation with the time interval of the corresponding subsequent return stroke, and that with the peak current of return stroke are investigated. The results show that the average distance between the three obvious grounded points of the first return stroke channel is about 512.7 m, and the average time interval between the pulses of the corresponding electric field fast changes is 3.8 μs. Further, the average time interval between electric field pulses from the stepped leader is smaller than that of normal single grounding lightning. The observed lightning in our study has two main channels, namely the left and right channels. Based on our observations, it is clear that the dart leader comes close to the ground in case of the left channel after the first return stroke, but it fails to form a return stroke.However, the right channel exhibits a relatively rare phenomenon in that the subsequent return stroke R2 occurred about 2.1 ms after the dart leader arrived at the ground, which was unusually long; this phenomenon might be attributed to the strong discharge of the first return stroke and insufficient charge accumulation near the grounded point in a timely manner. The two-dimensional velocities for the stepped leader of the two main channels are about 1.23×105 and 1.16×105 m s-1, respectively. A sub-branch of stepped leader for the left channel fails to reach the ground and develops into an attempt leader eventually; this might be attributed to the fact that the main branch connects considerably many sub-branches, which leads to the instantaneous decline of the potential difference between the sub-branch and ground. Furthermore, it might also be because the propagation direction of this sub-branch is almost perpendicular to the atmospheric electric field direction, which is not conducive to charge transfer. The two-dimensional velocities for the dart leaders of five subsequent return strokes are all in the normal range, and they positively correlate with the peak current of the subsequent return stroke. | Bin FAN Ping YUAN Xuejuan WANG Yang ZHAO Jianyong CEN Yanling SU | 2018 | Science China Earth Sciences2018，61，8： | 0 |
| 16 | μ-opioid receptor agonist facilitates circulating tumor cell formation in bladder cancer via the MOR/AKT/Slug pathway:a comprehensive study including randomized controlled trial显示文摘Background:μ-opioid receptor agonists(MORAs)are indispensable for analgesia in bladder cancer(BC)patients,both during surgery and for chronic pain treatment.Whether MORAs affect BC progression and metastasis remains largely unknown.This study focused on the effects of MORAs on the formation of circulating tumor cells(CTCs)in BC and aimed to provide potential therapeutic targets,which would retain the pain-relieving effects of MORAs in BC patients without sacrificing their long-term prognosis.Methods:Different preclinical models were used to identify the effects of MORAs on the progression of BC.A novel immunocapture microfluidic chip was utilized to analyze whether MORAs affected the number of CTCs in mouse models and clinical BC patients.Bioinformatic analyses,total transcriptome sequencing,and molecular biology methods were then used to investigate the underlying mechanisms in these models and in BC cell lines.Results:Mouse models of hematogenous metastasis and in situ BC demonstrated that tumor metastasis was significantly increased after MORA treatment.A significant increase in the number of mesenchymal and/or epithelial CTCs was detected after MORA treatment in both the mouse models and clinical trial patients.Mechanistically,MORAs facilitated the formation of CTCs by activating the MOR/PI3K/AKT/Slug signaling pathway,hereby promoting the epithelialmesenchymal transition(EMT)of BC cells,as knockdown of MOR,Slug or blockade of PI3K inhibited the EMT process and CTC formation.Conclusion:MORAs promoted BC metastasis by facilitating CTC formation.The EMT-CTC axis could be targeted for preventive measures during MORA treatment to inhibit the associated tumormetastasis or recurrence in BC patients. | Xiaoqiang Wang Song Zhang Di Jin Jiamei Luo Yumiao Shi Yiqi Zhang Lingling Wu Yanling Song Diansan Su Zhiying Pan Haige Chen Ming Cao Chaoyong Yang Weifeng Yu Jie Tian | 2023 | Cancer Communications2023，43，3： | 0 |
| 17 | Predicting the excretion of feces,urine and nitrogen using support vector regression:A case study with Holstein dry cows显示文摘Predicting the excretion of feces,urine and nitrogen(N)from dairy cows is an effective way to prevent and control the environmental pollution caused by scaled farming.The traditional prediction methods such as pollutant generation coefficient(PGC)and mathematical model based on linear regression(LR)may be limited by prediction range and regression function assumption,and sometimes may deviate from the actual condition.In order to solve these problems,the support vector regression(SVR)was applied for predicting the cows'feces,urine and N excretions,taking Holstein dry cows as a case study.SVR is a typical non-parametric machine learning model that does not require any specific assumptions about the regression function in advance and only by learning the training sample data,and also it can fit the function closest to the actual in most cases.To evaluate prediction accuracy effectively,the SVR technique was compared with the LR and radial basis function artificial neural network(RBF-ANN)methods,using the required sample data obtained from actual feeding experiments.The prediction results indicate that the proposed technique is superior to the other two conventional(especially LR)methods in predicting the main indicators of feces,urine,and N excretions of Holstein dry cows. | Qiang Fu Weizheng Shen Xiaoli Wei Yanling Yin Ping Zheng Yonggen Zhang Zhongbin Su Chunjiang Zhao | 2020 | International Journal of Agricultural and Biological Engineering2020，13，2： | 0 |
| 18 | Enhanced ORR performance of Pt catalysts in acidic media by coupling with topological C defects显示文摘Defect engineering is a promising strategy for supported catalysts to improve the catalytic activity and durability.Here,we selected the Cmatrix enriched with topological defects to serve as the substrate material,in which the topological defects can act as anchoring centers to trapPt nanoparticles for driving the O_(2) reduction reactions(ORRs).Both experimental characterizations and theoretical simulations revealed the strong Ptdefect interaction with enhanced charge transfer on the interface.Despite a low Pt loading,the supported catalyst can still achieve a remarkable 55 mV positive shift of half-wave potential toward ORR in O_(2)-saturated 0.1 M HClO_(4) electrolyte compared with the commercial Pt catalyst on graphitized C.Moreover,the degeneration after 5,000 voltage cycles was negligible.This finding indicates that the presence of strong interaction between Pt and topological C defects can not only stabilize Pt nanoparticles but also optimize the electronic structures of Pt/C catalysts toward ORR. | Yan Dong Yuan Wang Ziqi Tian Kemin Jiang Yanle Li Yichao Lin Colin W.Oloman Elod L.Gyenge Jianwei Su Liang Chen | 2021 | The Innovation2021，2，4： | 0 |
| 19 | Exploration of Infection Prevention and Control Practice of Designated Hospitals in During Corona Virus Disease 2019 Epidemic Period显示文摘Corona Virus Disease 2019(COVID-19)is a new infectious disease that appeared in whan in December 2019 Since January23,the national health and fitmess commission has required hospitals to be designated in accordance with the principle of'concentrating patients,experts,resources and treatment'.Designated hospitals are often the strength of the general hospital and general hospital complex layers of various kinds of personnel,campus area is large,multi-channel,ordinary outpatient accepts people more,for emergency and severe cases treatment in patients with normal difficulty pressuure big,suspected/confirmed cases,combined with the COVID-19 occurred when the traditional holiday,the country launched the emergency response since,process reform faces a difficult labor,shortage of mampower,protective shortages,short time limit,and many other difficulties,hospital infection prevention and control is facing unprecedented pressure.In this paper,the West China-Guang'an Hospital,Sichuan University(Guang'an people's hospital)as a designated hospital,on the basis of the relevant scheme of the national health committee,epidemic prevention and control of the actual,combined with comprehensive hospital leadership,mampower allocation,protection,security,patient management,disinfection isolation,preview triage,preventive measures,training,monitoring,etc.,with practical experience summary for the COVID-19 diring the hospital infection prevention and control to improve the practice exploration. | Haiquan Luo Maojun Fu Xiantao Chen Yunliang Chen Yichuan Li Xiaochuan Liu Xiaolan Su Yanling Chen | 2020 | Journal of Clinical and Nursing Research2020，4，4： | 0 |
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